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Zimman, M.V. Comparatore, A.F. Vulcano, M.L. Absi, L.D. Mazzuoccolo" "autores" => array:5 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Zimman" ] 1 => array:2 [ "nombre" => "M.V." "apellidos" => "Comparatore" ] 2 => array:2 [ "nombre" => "A.F." "apellidos" => "Vulcano" ] 3 => array:2 [ "nombre" => "M.L." "apellidos" => "Absi" ] 4 => array:2 [ "nombre" => "L.D." 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Una revisión para dermatólogos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1462 "Ancho" => 2500 "Tamanyo" => 252455 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Vitamin D Metabolism. The body acquires vitamin D from certain foods and through a reaction that occurs when the skin is exposed to sunlight in which UV-B radiation converts 7-dehydrocholersterol (synthesized in the skin) to pre-vitamin D<span class="elsevierStyleInf">3</span>, which then becomes inactive vitamin D. This is then converted in the liver to 25(OH)D by way of hepatic hydroxylation. In a second step, 25(OH)D is metabolized in the kidney to the active metabolite 1,25(OH)D, or calcitriol, through the action of renal alpha-1-hydroxylase. This mechanism is regulated by serum levels of calcium and inorganic phosphorus, among others, which are detected by the glands that secrete parathyroid hormone (PTH) and stimulate the activity of alpha-1-hydroxylase, when necessary. Calcitriol concentrations regulate the secretion of PTH. The 1,25(OH)D acts through the vitamin D receptors (VDR) within cells, which activate the transcription and translation of messenger RNA, leading to the synthesis of vitamin D-dependent proteins and their corresponding activity, which depend on the function of the target cell. The excretion of vitamin D through bile is mediated by the activity of 24 renal hydroxylase, which converts 1,25(OH)D to calcitroic acid.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F.J. Navarro-Triviño, S. Arias-Santiago, Y. Gilaberte-Calzada" "autores" => array:3 [ 0 => array:2 [ "nombre" => "F.J." "apellidos" => "Navarro-Triviño" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Arias-Santiago" ] 2 => array:2 [ "nombre" => "Y." "apellidos" => "Gilaberte-Calzada" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018305313" "doi" => "10.1016/j.ad.2018.08.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018305313?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901930112X?idApp=UINPBA000044" "url" => "/15782190/0000011000000004/v1_201905070820/S157821901930112X/v1_201905070820/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219019301064" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.11.021" "estado" => "S300" "fechaPublicacion" => "2019-05-01" "aid" => "2115" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2019;110:260" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3 "HTML" => 3 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>" "titulo" => "A Sea Change in the Treatment of Chronic Urticaria" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "260" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Quién lo ha visto y quién lo ve? Tratando la urticaria crónica" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.M. Giménez-Arnau" "autores" => array:1 [ 0 => array:2 [ "nombre" => "A.M." 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Zimman, M.V. Comparatore, A.F. Vulcano, M.L. Absi, L.D. Mazzuoccolo" "autores" => array:5 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Zimman" ] 1 => array:2 [ "nombre" => "M.V." "apellidos" => "Comparatore" ] 2 => array:2 [ "nombre" => "A.F." "apellidos" => "Vulcano" ] 3 => array:2 [ "nombre" => "M.L." "apellidos" => "Absi" ] 4 => array:2 [ "nombre" => "L.D." "apellidos" => "Mazzuoccolo" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0005"></elsevierMultimedia></p></span>" ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S000173101930064X" "doi" => "10.1016/j.ad.2019.01.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101930064X?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019301106?idApp=UINPBA000044" "url" => "/15782190/0000011000000004/v1_201905070820/S1578219019301106/v1_201905070820/en/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>" "titulo" => "Hidradenitis Suppurativa: Need for Early Diagnosis and Management of the Disease and Associated Conditions" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "261" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "G Roustan" "autores" => array:1 [ 0 => array:3 [ "nombre" => "G" "apellidos" => "Roustan" "email" => array:1 [ 0 => "groustan@gmail.com" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología. Hospital Universitario Puerta de Hierro Majadahonda, Madrid" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hidradenitis Supurativa: Necesidad de Un Diagnóstico e Intervención Precoz Sobre La Enfermedad y Sus Comorbilidades" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by the recurrence of nodular lesions that are abscess-like in appearance and mainly affect skinfolds. The lesions are painful and progress to fistulas, scarring, and fibrosis, thus generating considerable local morbidity and marked impairment of the patient's quality of life.</p><p id="par0010" class="elsevierStylePara elsevierViewall">This issue of Actas Dermosifiliográficas addresses the clinical characteristics of a series of 66 patients<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> that was remarkable for the long delay between onset of symptoms and diagnosis. This reached 7 years, entailing irreversible structural damage in many patients, who are unable to benefit from the latest advances in the management and treatment of HS. The authors also identify a specific patient profile (male, perianal and gluteal involvement), in which the risk of progression and poor prognosis is greater.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Another remarkable aspect of HS is the frequent association of comorbid conditions such as smoking and obesity. Associated psychiatric conditions (depression and anxiety) are also very common and may share pathogenic mechanisms with HS.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Knowledge of the different profiles of HS is essential, especially in cases with a greater disease burden, both for the dermatologist and other specialists (family physicians, gynecologists, general surgeons) involved in the care of these patients. HS should be managed based on an integrated approach, and health professionals should be fully familiarized with the scales used to evaluate severity, itching, pain, and quality of life. Imaging techniques such as skin ultrasound should be used to stage and monitor the disease appropriately.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">If we are to significantly reduce morbidity and sequelae, then early diagnosis and treatment to control inflammation and modify the natural history of HS are essential.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Roustangroustan@gmail.com G. Hidradenitis Suppurativa: Need for Early Diagnosis and Management of the Disease and Associated Conditions. Actas Dermosifiliogr. 2019;110:261.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hidradenitis supurativa: una aproximación a su prevalencia, características clínicas, comorbilidades y tiempo al diagnóstico, en un hospital universitario de Buenos Aires, Argentina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Zimman" 1 => "M.V. Comparatore" 2 => "A.F. Vulcano" 3 => "M.L. Absi" 4 => "L.D. Mazzuoccolo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2019.01.004" "Revista" => array:2 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2019" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultrasound evaluation as a complementary test in hidradenitis suppurativa: proposal of standarizd report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:14 [ 0 => "Martorell A1" 1 => "X. Wortsman" 2 => "F. Alfageme" 3 => "G. Roustan" 4 => "S. Arias-Santiago" 5 => "O. Catalano" 6 => "M. Scotto di Santolo" 7 => "K. Zarchi" 8 => "M. Bouer" 9 => "D. Gaitini" 10 => "C. Gonzalez" 11 => "R. Bard" 12 => "F.J. García-Martínez" 13 => "A. Mandava" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DSS. 0000000000001147" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg." "fecha" => "2017 Aug" "volumen" => "43" "paginaInicial" => "1065" "paginaFinal" => "1073" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28538033" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011000000004/v1_201905070820/S157821901930143X/v1_201905070820/en/main.assets" "Apartado" => array:4 [ "identificador" => "66476" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Commentaries" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011000000004/v1_201905070820/S157821901930143X/v1_201905070820/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901930143X?idApp=UINPBA000044" ]
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