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Physical examination showed an ulcer measuring 3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;5<span class="elsevierStyleHsp" style=""></span>cm with an indurated violaceous border&#44; a necrotic base&#44; and a fibropurulent exudate on the right edge &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;The only other remarkable finding was 2 small isolated pustular lesions on the right thigh and right chest&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">With a tentative diagnosis of pyoderma gangrenosum&#44; we performed a skin biopsy&#44; which showed intense epidermal hyperplasia with a pseudoepitheliomatous pattern&#44; areas of necrosis in the dermis&#44; and a mixed inflammatory infiltrate without vasculitis&#46; We also observed nests and squamous epithelial plaques with irregular borders at different levels of the reticular dermis together with central keratinization and discrete cellular atypia&#46; These findings were consistent with a well-differentiated squamous cell carcinoma &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;We also performed a complete blood count&#44; which showed no remarkable alterations&#44; an abdominal ultrasound&#44; which showed evidence of moderate hepatic steatosis&#44; and a computed tomography scan of the chest&#44; abdomen&#44; and pelvis&#44; which showed occult masses&#46; A colonoscopy performed by the gastroenterology department was normal&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Despite the discrepancy between the clinical and histologic findings&#44; a diagnosis of pyoderma gangrenosum was established and the patient was started on oral prednisone 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46; His initial response was good &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; but he subsequently developed progressive ulcerated lesions&#46; The treatment was switched to oral ciclosporin 5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#44; which resulted in partial response and poor blood pressure control&#46; The patient was finally treated with infliximab at a dosage of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg every 8 weeks&#46; This treatment achieved good clinical control and there have been no signs of recurrence in 18 months of follow-up&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Pyoderma gangrenosum is an uncommon neutrophilic skin disorder of unknown etiology that is clinically characterized by solitary or multiple pustules or nodules that progress rapidly to necrotic ulcers with a violaceous border&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> Fifty percent of cases are associated with systemic disease&#46; The most common diseases are inflammatory bowel disease&#44; seronegative arthritis&#44; and certain hematologic disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Establishing a definitive diagnosis can be complicated due to the lack of specific clinical&#44; laboratory&#44; and histopathologic findings&#46; The diagnostic workup in a patient with suspected pyoderma gangrenosum should&#44; therefore&#44; have 2 goals&#58; the exclusion of other cause of skin ulcers&#44; such as infections&#44; vasculitis&#44; and tumors&#44; and assessment of the presence of an associated systemic disorder&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4&#8211;10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In our case&#44; even though the pathology report suggested squamous cell carcinoma&#44; the morphology and location of the ulcer and the rapid progression were more indicative of pyoderma gangrenosum&#46; The diagnosis was confirmed by the subsequent appearance of similar lesions and rapid response to immunosuppressive therapy&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Two cases of pyoderma gangrenosum mimicking squamous cell carcinoma have been reported in the literature&#46; In 2012&#44; Wolfe et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> described the case of a patient with an ulcerated lesion on the left hand that was histologically compatible with a moderately differentiated squamous cell carcinoma but that progressed rapidly following excision&#46; Evaluation by the dermatology team and a second biopsy showed a neutrophilic infiltrate in the reticular dermis&#59; the patient was diagnosed with pyoderma gangrenosum and improved rapidly after initiation of treatment with oral prednisone&#46; In 2015&#44; &#268;uk Radovi&#263; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> published the case of a patient with large&#44; ulcerated lesions on the trunk who had been initially treated for chronic infection and subsequently for squamous cell carcinoma on observation of compatible histologic findings&#46; The lesions were treated with several wide local excisions&#44; but the disease recurred rapidly at the edges and there was additional progression of ulcers&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">We have presented a new case of pyoderma gangrenosum with histopathologic findings consistent with squamous cell carcinoma&#46; This case highlights the importance of integrating clinical and histologic findings to aid the establishment of a definitive diagnosis&#44; avoiding diagnostic delays and unnecessary treatments&#44; including invasive surgery&#44; which can lead to clinical exacerbation due to pathergy reactions&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Gonz&#225;lez-Sab&#237;n M&#44; Rodr&#237;guez-D&#237;az E&#44; Gonzalvo-Rodr&#237;guez P&#44; Astola-Hidalgo I&#46; Pioderma gangrenoso simulando un carcinoma epidermoide&#46; Actas Dermosifiliogr&#46; 2019&#59;110&#58;400&#8211;402&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ulcerated lesion measuring 3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;5<span class="elsevierStyleHsp" style=""></span>cm with an indurated violaceous border&#44; a necrotic base&#44; and a fibrinopurulent exudate at the right edge&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Epidermal hyperplasia with a pseudoepitheliomatous pattern and areas of necrosis in the dermis with a mixed inflammatory infiltrate &#40;hematoxylin-eosin&#44; original magnification &#215;4&#41;&#46; B&#44;C&#44; Nests and squamous epithelium plaques in the dermis with central keratinization and discrete cellular atypia &#40;hematoxylin-eosin&#44; original magnification &#215;20&#41;&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Rapid initial clinical improvement after 3 weeks of treatment with oral prednisone&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pyoderma Gangrenosum&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Squamous Cell Carcinoma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Biopsy findings may be nonspecific&#44; particularly in the case of mildly inflammatory or partially treated lesions&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Proliferation of tumor cells that invade the dermis and are characterized by a certain degree of pleomorphism and mitosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">Sterile neutrophilic infiltrate in the dermis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Cell with a variable degree of keratinization depending on the level of differentiation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Signs of leukocytoclastic vasculitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Varying degrees of nuclear atypia and cellular differentiation within and between tumors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">Pronounced tissue necrosis with perivascular mononuclear cell infiltrates in fully developed ulcers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Inflammatory infiltrates with considerable variations in intensity and mainly consisting of lymphocytes and plasma cells&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Absence of demonstrable fungi&#44; bacteria&#44; or mycobacteria with special stains and cultures&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Positive immunohistochemical staining for pancytokeratins for AE1&#47;AE3&#44; and p63&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">No specific immunohistochemical markers&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Differences in Histologic Findings Between Pyoderma Gangrenosum and Squamous Cell Carcinoma&#46;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></p>"
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      "titulo" => "References"
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Case and Research Letter
Pyoderma Gangrenosum Mimicking a Squamous Cell Carcinoma
Pioderma gangrenoso simulando un carcinoma epidermoide
M. González-Sabína,
Autor para correspondencia
martagonzalezsabin@gmail.com

Corresponding author.
, E. Rodríguez-Díaza, P. Gonzalvo-Rodrígueza, I. Astola-Hidalgob
a Servicio de Anatomía Patológica, Hospital Universitario de Cabueñes, Gijón, Asturias, Spain
b Servicio de Medicina Intensiva, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pyoderma gangrenosum is a rapidly progressing and potentially serious inflammatory skin disease characterized by painful ulcers&#46; It can occur in the absence of an underlying trigger or in association with certain systemic diseases&#44; the most common being inflammatory bowel disease and hematologic disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;8</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Establishing a definitive diagnosis is challenging as there are no specific clinical&#44; laboratory&#44; or histopathologic features&#46; A diagnosis is therefore reached following exclusion of other causes of skin ulceration&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4&#8211;6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We present the case of a patient who presented with an ulcerated abdominal lesion with clinical features of pyoderma gangrenosum but histologic features of cutaneous squamous cell carcinoma &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Report</span><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was a 54-year-old man without no remarkable past history referred to our department with recurrent outbreaks of small pruritic lesions on the trunk and extremities and a painful ulcer that had appeared spontaneously 3 weeks earlier&#46; Physical examination showed an ulcer measuring 3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;5<span class="elsevierStyleHsp" style=""></span>cm with an indurated violaceous border&#44; a necrotic base&#44; and a fibropurulent exudate on the right edge &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;The only other remarkable finding was 2 small isolated pustular lesions on the right thigh and right chest&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">With a tentative diagnosis of pyoderma gangrenosum&#44; we performed a skin biopsy&#44; which showed intense epidermal hyperplasia with a pseudoepitheliomatous pattern&#44; areas of necrosis in the dermis&#44; and a mixed inflammatory infiltrate without vasculitis&#46; We also observed nests and squamous epithelial plaques with irregular borders at different levels of the reticular dermis together with central keratinization and discrete cellular atypia&#46; These findings were consistent with a well-differentiated squamous cell carcinoma &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;We also performed a complete blood count&#44; which showed no remarkable alterations&#44; an abdominal ultrasound&#44; which showed evidence of moderate hepatic steatosis&#44; and a computed tomography scan of the chest&#44; abdomen&#44; and pelvis&#44; which showed occult masses&#46; A colonoscopy performed by the gastroenterology department was normal&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Despite the discrepancy between the clinical and histologic findings&#44; a diagnosis of pyoderma gangrenosum was established and the patient was started on oral prednisone 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46; His initial response was good &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; but he subsequently developed progressive ulcerated lesions&#46; The treatment was switched to oral ciclosporin 5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#44; which resulted in partial response and poor blood pressure control&#46; The patient was finally treated with infliximab at a dosage of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg every 8 weeks&#46; This treatment achieved good clinical control and there have been no signs of recurrence in 18 months of follow-up&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Pyoderma gangrenosum is an uncommon neutrophilic skin disorder of unknown etiology that is clinically characterized by solitary or multiple pustules or nodules that progress rapidly to necrotic ulcers with a violaceous border&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> Fifty percent of cases are associated with systemic disease&#46; The most common diseases are inflammatory bowel disease&#44; seronegative arthritis&#44; and certain hematologic disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Establishing a definitive diagnosis can be complicated due to the lack of specific clinical&#44; laboratory&#44; and histopathologic findings&#46; The diagnostic workup in a patient with suspected pyoderma gangrenosum should&#44; therefore&#44; have 2 goals&#58; the exclusion of other cause of skin ulcers&#44; such as infections&#44; vasculitis&#44; and tumors&#44; and assessment of the presence of an associated systemic disorder&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4&#8211;10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In our case&#44; even though the pathology report suggested squamous cell carcinoma&#44; the morphology and location of the ulcer and the rapid progression were more indicative of pyoderma gangrenosum&#46; The diagnosis was confirmed by the subsequent appearance of similar lesions and rapid response to immunosuppressive therapy&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Two cases of pyoderma gangrenosum mimicking squamous cell carcinoma have been reported in the literature&#46; In 2012&#44; Wolfe et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> described the case of a patient with an ulcerated lesion on the left hand that was histologically compatible with a moderately differentiated squamous cell carcinoma but that progressed rapidly following excision&#46; Evaluation by the dermatology team and a second biopsy showed a neutrophilic infiltrate in the reticular dermis&#59; the patient was diagnosed with pyoderma gangrenosum and improved rapidly after initiation of treatment with oral prednisone&#46; In 2015&#44; &#268;uk Radovi&#263; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> published the case of a patient with large&#44; ulcerated lesions on the trunk who had been initially treated for chronic infection and subsequently for squamous cell carcinoma on observation of compatible histologic findings&#46; The lesions were treated with several wide local excisions&#44; but the disease recurred rapidly at the edges and there was additional progression of ulcers&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">We have presented a new case of pyoderma gangrenosum with histopathologic findings consistent with squamous cell carcinoma&#46; This case highlights the importance of integrating clinical and histologic findings to aid the establishment of a definitive diagnosis&#44; avoiding diagnostic delays and unnecessary treatments&#44; including invasive surgery&#44; which can lead to clinical exacerbation due to pathergy reactions&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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      0 => array:2 [
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Gonz&#225;lez-Sab&#237;n M&#44; Rodr&#237;guez-D&#237;az E&#44; Gonzalvo-Rodr&#237;guez P&#44; Astola-Hidalgo I&#46; Pioderma gangrenoso simulando un carcinoma epidermoide&#46; Actas Dermosifiliogr&#46; 2019&#59;110&#58;400&#8211;402&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ulcerated lesion measuring 3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;5<span class="elsevierStyleHsp" style=""></span>cm with an indurated violaceous border&#44; a necrotic base&#44; and a fibrinopurulent exudate at the right edge&#46;</p>"
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      1 => array:7 [
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Epidermal hyperplasia with a pseudoepitheliomatous pattern and areas of necrosis in the dermis with a mixed inflammatory infiltrate &#40;hematoxylin-eosin&#44; original magnification &#215;4&#41;&#46; B&#44;C&#44; Nests and squamous epithelium plaques in the dermis with central keratinization and discrete cellular atypia &#40;hematoxylin-eosin&#44; original magnification &#215;20&#41;&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Rapid initial clinical improvement after 3 weeks of treatment with oral prednisone&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pyoderma Gangrenosum&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Squamous Cell Carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Biopsy findings may be nonspecific&#44; particularly in the case of mildly inflammatory or partially treated lesions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Proliferation of tumor cells that invade the dermis and are characterized by a certain degree of pleomorphism and mitosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Sterile neutrophilic infiltrate in the dermis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Cell with a variable degree of keratinization depending on the level of differentiation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Signs of leukocytoclastic vasculitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Varying degrees of nuclear atypia and cellular differentiation within and between tumors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Pronounced tissue necrosis with perivascular mononuclear cell infiltrates in fully developed ulcers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Inflammatory infiltrates with considerable variations in intensity and mainly consisting of lymphocytes and plasma cells&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">Absence of demonstrable fungi&#44; bacteria&#44; or mycobacteria with special stains and cultures&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Positive immunohistochemical staining for pancytokeratins for AE1&#47;AE3&#44; and p63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">No specific immunohistochemical markers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Adapted from Crowson et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> and Wolfe et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Differences in Histologic Findings Between Pyoderma Gangrenosum and Squamous Cell Carcinoma&#46;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
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              "etiqueta" => "1"
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                      "titulo" => "Pyoderma gangrenosum&#58; An updated review"
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                          "etal" => false
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                            0 => "J&#46;A&#46; Su&#225;rez-P&#233;rez"
                            1 => "E&#46; Herrera-Acosta"
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