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    "titulo" => "The Rising Incidence of Merkel Cell Carcinoma"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Merkel cell carcinoma &#40;MCC&#41; is considered an orphan disease due to its very low incidence&#46; The article by Da&#241;ino-Garc&#237;a et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> reports on a series of 38 patients with MCC treated at their hospital over a period of 16 years&#46; The authors found a 116&#37; increase in the number of cases diagnosed in the second half of the study and also observed an increase in the age of diagnosis and the occurrence of tumors at atypical sites&#46; The increase in incidence is due to greater familiarity with the disease among dermatologists and pathologists and an increase in the at-risk population due to UV exposure&#44; aging&#44; and immunosuppression&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">MCC is a fast-growing&#44; highly aggressive tumor characterized by early lymph node metastasis and high mortality&#46; Mortality rates are much higher than for melanoma&#44; for example&#44; with a 10-year survival rate of 17&#46;7&#37; for MCC versus 61&#46;3&#37; for melanoma&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a> The overall 24-month survival rate in this series of 38 patients was 69&#46;3&#37; and the strongest prognostic factor was lymph node metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Effective medical treatment is needed for metastatic MCC&#46; Conventional first-line chemotherapy is associated with response rates of between 30&#37; and 55&#37;&#44; but response is short-lived &#40;<span class="elsevierStyleBold">&#60;<span class="elsevierStyleHsp" style=""></span></span>5 months&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">3</span></a> Second-line chemotherapy does not offer any significant survival benefit&#44; with a 12-month survival rate of 0&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">3</span></a> The European Medicines Agency recently approved avelumab for the treatment of metastatic MCC&#46; First-line avelumab induces rapid response in 62&#37; to 74&#37; of patients&#44; and 52&#37; of patients who receive this drug as second-line therapy are still alive at 12 months&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3&#44;4</span></a> The emergence of these new immunotherapy agents brings new hope to patients with MCC&#46;</p></span>"
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