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1</a>B&#41;&#46; Some residual hyperpigmented macules were visible in these areas&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0020" class="elsevierStylePara elsevierViewall">Biopsies were taken of a crusted papular lesion and an erythematous plaque on the temple&#44; which the patient had stated were similar to those diagnosed as cutaneous lymphoma&#47;lymphoid hyperplasia&#59; both lesions were histologically similar &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#58; superficial perivascular dermal infiltrate &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41; and deep T lymphocyte infiltrate with abundant eosinophils &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Other Tests</span><p id="par0025" class="elsevierStylePara elsevierViewall">HLA determination revealed the HLA-DR4 variant &#40;DRB1&#42;04&#58;08&#41;&#46; The autoimmune study was negative and IgE was normal&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">What is your Diagnosis&#63;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0035" class="elsevierStylePara elsevierViewall">Actinic prurigo &#40;AP&#41;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Treatment and Course</span><p id="par0040" class="elsevierStylePara elsevierViewall">Narrow-band UVB phototherapy was instated to stimulate habituation&#44; with irregular compliance by the patient&#44; who finally abandoned this treatment despite some improvement of the condition&#46; Thalidomide does not currently appear to be an option because the patient suffers from bilateral carpal tunnel syndrome&#44; which makes monitoring potential neuropathy difficult&#46; The patient is currently undergoing treatment with topical corticosteroids&#44; 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predominantly in the areas exposed to sunlight&#44; although they may also appear in unexposed areas&#46; Associated clinical findings such as cheilitis &#40;46&#37; of cases&#41;&#44; conjunctivitis &#40;21&#37; of cases&#41;&#44; eczematous lesions&#44; and lichenification have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Histology may reveal nonspecific findings that are occasionally similar to the histology of polymorphic light eruptions&#58; a superficial and deep perivascular T lymphocyte infiltrate with presence of eosinophils under a dermis with few abnormalities&#46; Chronic lesions may reveal acanthosis and excoriation in the epidermis&#44; fibrosis&#44; and a larger infiltrate in the dermis&#46; Labial lesions may present infiltrates with follicular hyperplasia as a reactive phenomenon&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Association with B cell lymphoma occurred in only 2 patients&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> In our patient&#44; doubt remained regarding whether the nodular lesions corresponded to lymphoma or to florid follicular lymphoid hyperplasia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The differential diagnosis of PA includes bites and stings&#44; scabies&#44; porphyria&#44; adult atopic dermatitis&#44; and other photodermatoses&#44; which have different courses and histology and should be ruled out to reach diagnosis of this entity&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Different therapeutic approaches to AP have been reported&#44; including topical treatments &#40;photoprotection&#44; corticosteroids&#44; calcinuria inhibitors&#41; and phototherapy &#40;PUVA or narrowband UV-B&#41;&#46; Thalidomide&#44; cyclosporin&#44; azathioprine and pentoxifylline have been used in severe cases&#44; with varying results&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; AP is a rare entity in our setting but it cannot be ruled out&#46; Lymphoid hyperplasia may develop during the course of the disease and this should be remembered in order to avoid an erroneous diagnosis that may condition future treatment&#46; Diagnosis of this entity is based on clinical presentation and patient history&#44; and the presence of HLA-DR4 is a finding that supports the suspected diagnosis&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of Interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case for Diagnosis
Papular Eruption on Sun-Exposed Skin
Erupción papulosa fotodistribuida
L. Schneller-Pavelescu
Autor para correspondencia
lucapavelescu@gmail.com

Corresponding author.
, E. Vergara-de Caso, M.M. Blanes
Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 52-year-old woman presented with pruritic dermatitis that had been treated in different hospitals for more than 40 years&#46; Atopic dermatitis was suspected during childhood and the patient was treated with cyclosporin A with some improvement&#46; In 2002&#44; she presented with facial nodules that were histologically compatible with B-cell lymphoma &#40;CD20<span class="elsevierStyleSup">&#43;</span>&#44; BCL2<span class="elsevierStyleSup">&#43;</span>&#44; IgH rearrangement&#41; and treatment with cyclosporin was suspended&#46; After ruling out extracutaneous involvement&#44; she was given intravenous rituximab at a dosage of 375<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span> in 4 weekly cycles&#46; Symptoms improved but reappeared when treatment was suspended&#46; In 2013&#44; the patient presented again with facial nodules that were histologically compatible with B-cell lymphoid hyperplasia&#46; the patient was treated with rituximab and showed an identical response&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Due to a change of address&#44; she was sent to our department in 2016 with no definitive diagnosis&#46; On questioning&#44; she confirmed the recurrence of the lesions after long periods of exposure to sunlight&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0015" class="elsevierStylePara elsevierViewall">The patient presented erythematous papules&#44; many of which showed central excoriation&#44; that were confluent in some locations &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#44; predominantly in the areas exposed to sunlight &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Some residual hyperpigmented macules were visible in these areas&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0020" class="elsevierStylePara elsevierViewall">Biopsies were taken of a crusted papular lesion and an erythematous plaque on the temple&#44; which the patient had stated were similar to those diagnosed as cutaneous lymphoma&#47;lymphoid hyperplasia&#59; both lesions were histologically similar &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#58; superficial perivascular dermal infiltrate &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41; and deep T lymphocyte infiltrate with abundant eosinophils &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Other Tests</span><p id="par0025" class="elsevierStylePara elsevierViewall">HLA determination revealed the HLA-DR4 variant &#40;DRB1&#42;04&#58;08&#41;&#46; The autoimmune study was negative and IgE was normal&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">What is your Diagnosis&#63;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0035" class="elsevierStylePara elsevierViewall">Actinic prurigo &#40;AP&#41;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Treatment and Course</span><p id="par0040" class="elsevierStylePara elsevierViewall">Narrow-band UVB phototherapy was instated to stimulate habituation&#44; with irregular compliance by the patient&#44; who finally abandoned this treatment despite some improvement of the condition&#46; Thalidomide does not currently appear to be an option because the patient suffers from bilateral carpal tunnel syndrome&#44; which makes monitoring potential neuropathy difficult&#46; The patient is currently undergoing treatment with topical corticosteroids&#44; oral antihistamines&#44; and photoprotection&#44; and maintains mild symptoms&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Comment</span><p id="par0045" class="elsevierStylePara elsevierViewall">AP is a frequent photodermatosis in Native Americans and few cases have been reported in the European population&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> The forms that present in childhood&#44; generally before the age of 10 years&#44; may improve during adolescence&#46; Later onset&#44; though less frequent&#44; tends to be associated with persistence into adulthood&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> Half of patients present a family history of the disease and nearly 90&#37; have HLA-DR4&#44; and HLA-DRB1&#42;04&#58;07 is present in between 60&#37; and 70&#37; of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">3&#44;4</span></a> Our patient reported that her father had presented a similar dermatosis&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Clinical presentation consists of erythematous pruritic papulonodular lesions with excoriation due to scratching&#44; predominantly in the areas exposed to sunlight&#44; although they may also appear in unexposed areas&#46; Associated clinical findings such as cheilitis &#40;46&#37; of cases&#41;&#44; conjunctivitis &#40;21&#37; of cases&#41;&#44; eczematous lesions&#44; and lichenification have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Histology may reveal nonspecific findings that are occasionally similar to the histology of polymorphic light eruptions&#58; a superficial and deep perivascular T lymphocyte infiltrate with presence of eosinophils under a dermis with few abnormalities&#46; Chronic lesions may reveal acanthosis and excoriation in the epidermis&#44; fibrosis&#44; and a larger infiltrate in the dermis&#46; Labial lesions may present infiltrates with follicular hyperplasia as a reactive phenomenon&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Association with B cell lymphoma occurred in only 2 patients&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> In our patient&#44; doubt remained regarding whether the nodular lesions corresponded to lymphoma or to florid follicular lymphoid hyperplasia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The differential diagnosis of PA includes bites and stings&#44; scabies&#44; porphyria&#44; adult atopic dermatitis&#44; and other photodermatoses&#44; which have different courses and histology and should be ruled out to reach diagnosis of this entity&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Different therapeutic approaches to AP have been reported&#44; including topical treatments &#40;photoprotection&#44; corticosteroids&#44; calcinuria inhibitors&#41; and phototherapy &#40;PUVA or narrowband UV-B&#41;&#46; Thalidomide&#44; cyclosporin&#44; azathioprine and pentoxifylline have been used in severe cases&#44; with varying results&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; AP is a rare entity in our setting but it cannot be ruled out&#46; Lymphoid hyperplasia may develop during the course of the disease and this should be remembered in order to avoid an erroneous diagnosis that may condition future treatment&#46; Diagnosis of this entity is based on clinical presentation and patient history&#44; and the presence of HLA-DR4 is a finding that supports the suspected diagnosis&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of Interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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2024 Junio 161 33 194
2024 Mayo 170 40 210
2024 Abril 122 15 137
2024 Marzo 104 34 138
2024 Febrero 92 35 127
2024 Enero 86 37 123
2023 Diciembre 93 18 111
2023 Noviembre 128 40 168
2023 Octubre 105 19 124
2023 Septiembre 110 35 145
2023 Agosto 105 17 122
2023 Julio 114 30 144
2023 Junio 97 23 120
2023 Mayo 159 23 182
2023 Abril 136 19 155
2023 Marzo 118 30 148
2023 Febrero 133 26 159
2023 Enero 116 30 146
2022 Diciembre 82 34 116
2022 Noviembre 29 24 53
2022 Octubre 33 23 56
2022 Septiembre 44 38 82
2022 Agosto 59 42 101
2022 Julio 59 33 92
2022 Junio 41 33 74
2022 Mayo 95 42 137
2022 Abril 101 32 133
2022 Marzo 71 42 113
2022 Febrero 63 23 86
2022 Enero 60 36 96
2021 Diciembre 63 31 94
2021 Noviembre 71 45 116
2021 Octubre 130 60 190
2021 Septiembre 55 32 87
2021 Agosto 41 29 70
2021 Julio 34 25 59
2021 Junio 40 21 61
2021 Mayo 31 42 73
2021 Abril 74 47 121
2021 Marzo 55 17 72
2021 Febrero 31 19 50
2021 Enero 21 11 32
2020 Diciembre 23 12 35
2020 Noviembre 28 24 52
2020 Octubre 21 18 39
2020 Septiembre 30 9 39
2020 Agosto 22 13 35
2020 Julio 21 15 36
2020 Junio 25 24 49
2020 Mayo 18 15 33
2020 Abril 10 14 24
2020 Marzo 13 7 20
2020 Febrero 2 0 2
2020 Enero 1 0 1
2019 Mayo 7 0 7
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