array:23 [
  "pii" => "S1578219019301064"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2018.11.021"
  "estado" => "S300"
  "fechaPublicacion" => "2019-05-01"
  "aid" => "2115"
  "copyrightAnyo" => "2019"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2019;110:260"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3
    "HTML" => 3
  ]
  "Traduccion" => array:1 [
    "es" => array:18 [
      "pii" => "S0001731018305337"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2018.11.003"
      "estado" => "S300"
      "fechaPublicacion" => "2019-05-01"
      "aid" => "2115"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2019;110:260"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 327
        "formatos" => array:3 [
          "EPUB" => 1
          "HTML" => 210
          "PDF" => 116
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Comentarios Editoriales</span>"
        "titulo" => "Qui&#233;n lo ha visto y qui&#233;n lo ve&#63; Tratando la urticaria cr&#243;nica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:1 [
            "paginaInicial" => "260"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "A Sea Change in the Treatment of Chronic Urticaria"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46;M&#46; Gim&#233;nez-Arnau"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "A&#46;M&#46;"
                "apellidos" => "Gim&#233;nez-Arnau"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219019301064"
          "doi" => "10.1016/j.adengl.2018.11.021"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019301064?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018305337?idApp=UINPBA000044"
      "url" => "/00017310/0000011000000004/v2_201905040606/S0001731018305337/v2_201905040606/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S157821901930143X"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2019.03.018"
    "estado" => "S300"
    "fechaPublicacion" => "2019-05-01"
    "aid" => "2198"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2019;110:261"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2
      "HTML" => 2
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>"
      "titulo" => "Hidradenitis Suppurativa&#58; Need for Early Diagnosis and Management of the Disease and Associated Conditions"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "261"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Hidradenitis Supurativa&#58; Necesidad de Un Diagn&#243;stico e Intervenci&#243;n Precoz Sobre La Enfermedad y Sus Comorbilidades"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "G Roustan"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "G"
              "apellidos" => "Roustan"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173101930064X"
        "doi" => "10.1016/j.ad.2019.01.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101930064X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901930143X?idApp=UINPBA000044"
    "url" => "/15782190/0000011000000004/v1_201905070820/S157821901930143X/v1_201905070820/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219019300873"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2018.12.010"
    "estado" => "S300"
    "fechaPublicacion" => "2019-05-01"
    "aid" => "2129"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2019;110:259"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 9
      "formatos" => array:2 [
        "HTML" => 7
        "PDF" => 2
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>"
      "titulo" => "Hidradenitis Suppurativa as a Systemic Disease&#58; Association With Metabolic Syndrome"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "259"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "La hidradenitis supurativa como enfermedad sist&#233;mica&#58; asociaci&#243;n a s&#237;ndrome metab&#243;lico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Martorell"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Martorell"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173101830574X"
        "doi" => "10.1016/j.ad.2018.12.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101830574X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300873?idApp=UINPBA000044"
    "url" => "/15782190/0000011000000004/v1_201905070820/S1578219019300873/v1_201905070820/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>"
    "titulo" => "A Sea Change in the Treatment of Chronic Urticaria"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "260"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "A&#46;M&#46; Gim&#233;nez-Arnau"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "A&#46;M&#46;"
            "apellidos" => "Gim&#233;nez-Arnau"
            "email" => array:1 [
              0 => "anamariagimenezarnau&#64;gmail&#46;com"
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital del Mar&#44; Institut Hospital del Mar d&#8217;Investigacions M&#232;diques &#40;IMIM&#41;&#44; Universitat Aut&#242;noma de Barcelona&#44; Barcelona&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Qui&#233;n lo ha visto y qui&#233;n lo ve&#63; Tratando la urticaria cr&#243;nica"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic urticaria is primarily an autoimmune disease&#44; mediated either by immunoglobulin &#40;Ig&#41; E or IgG&#44; acting on the high-affinity IgE receptor &#40;Fc&#603;IgERI&#41;&#44; which is overexpressed both in skin mastocytes and circulating basophils&#46; Different exacerbating factors contribute to the manifestation of the condition as well as its conversion to a chronic process&#46; Regardless of whether the spontaneous or inducible type of disease is present&#44; the chosen therapy should be effective and safe&#44; and it needs to be maintained for long periods of between 1 to 5 years&#46; The therapeutic goal is to keep the patient completely free of symptoms so that she or he can lead a normal life&#46; With this aim&#44; omalizumab has become an essential addition to the therapeutic armamentarium for the treatment of chronic urticaria&#46; The authors of the commented article reflect on their experience with the use of this monoclonal antibody in daily clinical practice in accordance with the recommendations of the most recent treatment guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> In daily clinical practice&#44; their patients achieve better therapeutic outcomes than in clinical trials&#44; measured in terms of the urticaria activity score &#40;UAS&#41; in the 7 days before the study visit&#46; Only 1 phase II study&#44; EXCUISITE&#44; reports percentages of complete control similar to those observed in clinical practice&#46; That study only included patients with IgE anti-peroxidase&#59; that is&#44; patients were selected for an Fc&#603;IgERI activation mechanism or autoallergy&#46; This suggest that this type I autoimmunity mechanism is the predominant one&#46; In contrast&#44; IgG anti-Fc&#603;IgERI&#44; implicated in type 2<span class="elsevierStyleHsp" style=""></span>b autoimmunity mechanism&#44; is less frequent&#46; The authors of the commented article analyzed clinical response and complete response at 3 and 6 months of treatment and found higher percentages of responders than those reported in the clinical trials&#46; To define predictors of response&#44; they link later complete response with those patients with longer-standing urticaria &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>18 months&#41;&#44; who are perhaps the most refractory patients&#46; The article does not discuss studies that suggested that this group of patients might be affected by type IIb autoimmunity as indicated by a positive autologous serous skin test &#40;ASST&#41; or positivity for functional serum autoantibodies&#46; The authors report agreement with previous studies such as the study by Curto-Barredo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> that the slowest response to omalizumab can also be linked to the use immediately beforehand of immunosuppressive medication&#44; such as ciclosporin A&#46; This was the observation of the authors of the Xarxa d&#8217;Urtic&#224;ria Catalana i Balear &#40;XUrCB&#41; in a cohort of 286 patients in a bivariate analysis&#46; To finish&#44; we would like to congratulate the authors on the efforts to systematize their experience in the management of chronic urticaria using omalizumab&#46; This is the only way to properly evaluate our day-to-day work&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gim&#233;nez-Arnau A&#46; Qui&#233;n lo ha visto y qui&#233;n lo ve&#63; Tratando la urticaria cr&#243;nica&#46; Actas Dermosifiliogr&#46; 2019&#59;110&#58;260&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:2 [
            0 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La efectividad del tratamiento con omalizumab en la vida real es menor en pacientes con urticaria cr&#243;nica de m&#225;s de 18 meses de evoluci&#243;n y tratamiento inmunosupresor previo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "X&#46; Cubir&#243;"
                            1 => "J&#46; Spertino"
                            2 => "E&#46; Rozas-Mu&#241;oz"
                            3 => "E&#46; Serra-Baldrich"
                            4 => "L&#46; Puig"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2018.09.009"
                      "Revista" => array:2 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2018"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Omalizumab updosing allows disease activity control in refractory patients with chronic spontaneous urticaria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Curto-Barredo"
                            1 => "J&#46; Spertino"
                            2 => "I&#46; Figueras-Nart"
                            3 => "V&#46; Exp&#243;sito-Serrano"
                            4 => "A&#46; Guilabert"
                            5 => "G&#46; Mel&#233;-Ninot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.16379"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2018"
                        "volumen" => "179"
                        "paginaInicial" => "210"
                        "paginaFinal" => "212"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29368377"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000011000000004/v1_201905070820/S1578219019301064/v1_201905070820/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "66476"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Commentaries"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011000000004/v1_201905070820/S1578219019301064/v1_201905070820/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019301064?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Commentaries
A Sea Change in the Treatment of Chronic Urticaria
Quién lo ha visto y quién lo ve? Tratando la urticaria crónica
A.M. Giménez-Arnau
Servicio de Dermatología, Hospital del Mar, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona, Barcelona, Spain
Leído
3415
Veces
se ha leído el artículo
1424
Total PDF
1991
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S1578219019301064"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2018.11.021"
  "estado" => "S300"
  "fechaPublicacion" => "2019-05-01"
  "aid" => "2115"
  "copyrightAnyo" => "2019"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2019;110:260"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3
    "HTML" => 3
  ]
  "Traduccion" => array:1 [
    "es" => array:18 [
      "pii" => "S0001731018305337"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2018.11.003"
      "estado" => "S300"
      "fechaPublicacion" => "2019-05-01"
      "aid" => "2115"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2019;110:260"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 327
        "formatos" => array:3 [
          "EPUB" => 1
          "HTML" => 210
          "PDF" => 116
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Comentarios Editoriales</span>"
        "titulo" => "Qui&#233;n lo ha visto y qui&#233;n lo ve&#63; Tratando la urticaria cr&#243;nica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:1 [
            "paginaInicial" => "260"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "A Sea Change in the Treatment of Chronic Urticaria"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46;M&#46; Gim&#233;nez-Arnau"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "A&#46;M&#46;"
                "apellidos" => "Gim&#233;nez-Arnau"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219019301064"
          "doi" => "10.1016/j.adengl.2018.11.021"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019301064?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018305337?idApp=UINPBA000044"
      "url" => "/00017310/0000011000000004/v2_201905040606/S0001731018305337/v2_201905040606/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S157821901930143X"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2019.03.018"
    "estado" => "S300"
    "fechaPublicacion" => "2019-05-01"
    "aid" => "2198"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2019;110:261"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2
      "HTML" => 2
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>"
      "titulo" => "Hidradenitis Suppurativa&#58; Need for Early Diagnosis and Management of the Disease and Associated Conditions"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "261"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Hidradenitis Supurativa&#58; Necesidad de Un Diagn&#243;stico e Intervenci&#243;n Precoz Sobre La Enfermedad y Sus Comorbilidades"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "G Roustan"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "G"
              "apellidos" => "Roustan"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173101930064X"
        "doi" => "10.1016/j.ad.2019.01.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101930064X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901930143X?idApp=UINPBA000044"
    "url" => "/15782190/0000011000000004/v1_201905070820/S157821901930143X/v1_201905070820/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219019300873"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2018.12.010"
    "estado" => "S300"
    "fechaPublicacion" => "2019-05-01"
    "aid" => "2129"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2019;110:259"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 9
      "formatos" => array:2 [
        "HTML" => 7
        "PDF" => 2
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>"
      "titulo" => "Hidradenitis Suppurativa as a Systemic Disease&#58; Association With Metabolic Syndrome"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "259"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "La hidradenitis supurativa como enfermedad sist&#233;mica&#58; asociaci&#243;n a s&#237;ndrome metab&#243;lico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Martorell"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Martorell"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173101830574X"
        "doi" => "10.1016/j.ad.2018.12.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101830574X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300873?idApp=UINPBA000044"
    "url" => "/15782190/0000011000000004/v1_201905070820/S1578219019300873/v1_201905070820/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>"
    "titulo" => "A Sea Change in the Treatment of Chronic Urticaria"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "260"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "A&#46;M&#46; Gim&#233;nez-Arnau"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "A&#46;M&#46;"
            "apellidos" => "Gim&#233;nez-Arnau"
            "email" => array:1 [
              0 => "anamariagimenezarnau&#64;gmail&#46;com"
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital del Mar&#44; Institut Hospital del Mar d&#8217;Investigacions M&#232;diques &#40;IMIM&#41;&#44; Universitat Aut&#242;noma de Barcelona&#44; Barcelona&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Qui&#233;n lo ha visto y qui&#233;n lo ve&#63; Tratando la urticaria cr&#243;nica"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic urticaria is primarily an autoimmune disease&#44; mediated either by immunoglobulin &#40;Ig&#41; E or IgG&#44; acting on the high-affinity IgE receptor &#40;Fc&#603;IgERI&#41;&#44; which is overexpressed both in skin mastocytes and circulating basophils&#46; Different exacerbating factors contribute to the manifestation of the condition as well as its conversion to a chronic process&#46; Regardless of whether the spontaneous or inducible type of disease is present&#44; the chosen therapy should be effective and safe&#44; and it needs to be maintained for long periods of between 1 to 5 years&#46; The therapeutic goal is to keep the patient completely free of symptoms so that she or he can lead a normal life&#46; With this aim&#44; omalizumab has become an essential addition to the therapeutic armamentarium for the treatment of chronic urticaria&#46; The authors of the commented article reflect on their experience with the use of this monoclonal antibody in daily clinical practice in accordance with the recommendations of the most recent treatment guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> In daily clinical practice&#44; their patients achieve better therapeutic outcomes than in clinical trials&#44; measured in terms of the urticaria activity score &#40;UAS&#41; in the 7 days before the study visit&#46; Only 1 phase II study&#44; EXCUISITE&#44; reports percentages of complete control similar to those observed in clinical practice&#46; That study only included patients with IgE anti-peroxidase&#59; that is&#44; patients were selected for an Fc&#603;IgERI activation mechanism or autoallergy&#46; This suggest that this type I autoimmunity mechanism is the predominant one&#46; In contrast&#44; IgG anti-Fc&#603;IgERI&#44; implicated in type 2<span class="elsevierStyleHsp" style=""></span>b autoimmunity mechanism&#44; is less frequent&#46; The authors of the commented article analyzed clinical response and complete response at 3 and 6 months of treatment and found higher percentages of responders than those reported in the clinical trials&#46; To define predictors of response&#44; they link later complete response with those patients with longer-standing urticaria &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>18 months&#41;&#44; who are perhaps the most refractory patients&#46; The article does not discuss studies that suggested that this group of patients might be affected by type IIb autoimmunity as indicated by a positive autologous serous skin test &#40;ASST&#41; or positivity for functional serum autoantibodies&#46; The authors report agreement with previous studies such as the study by Curto-Barredo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> that the slowest response to omalizumab can also be linked to the use immediately beforehand of immunosuppressive medication&#44; such as ciclosporin A&#46; This was the observation of the authors of the Xarxa d&#8217;Urtic&#224;ria Catalana i Balear &#40;XUrCB&#41; in a cohort of 286 patients in a bivariate analysis&#46; To finish&#44; we would like to congratulate the authors on the efforts to systematize their experience in the management of chronic urticaria using omalizumab&#46; This is the only way to properly evaluate our day-to-day work&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gim&#233;nez-Arnau A&#46; Qui&#233;n lo ha visto y qui&#233;n lo ve&#63; Tratando la urticaria cr&#243;nica&#46; Actas Dermosifiliogr&#46; 2019&#59;110&#58;260&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:2 [
            0 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La efectividad del tratamiento con omalizumab en la vida real es menor en pacientes con urticaria cr&#243;nica de m&#225;s de 18 meses de evoluci&#243;n y tratamiento inmunosupresor previo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "X&#46; Cubir&#243;"
                            1 => "J&#46; Spertino"
                            2 => "E&#46; Rozas-Mu&#241;oz"
                            3 => "E&#46; Serra-Baldrich"
                            4 => "L&#46; Puig"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2018.09.009"
                      "Revista" => array:2 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2018"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Omalizumab updosing allows disease activity control in refractory patients with chronic spontaneous urticaria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Curto-Barredo"
                            1 => "J&#46; Spertino"
                            2 => "I&#46; Figueras-Nart"
                            3 => "V&#46; Exp&#243;sito-Serrano"
                            4 => "A&#46; Guilabert"
                            5 => "G&#46; Mel&#233;-Ninot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.16379"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2018"
                        "volumen" => "179"
                        "paginaInicial" => "210"
                        "paginaFinal" => "212"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29368377"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000011000000004/v1_201905070820/S1578219019301064/v1_201905070820/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "66476"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Commentaries"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011000000004/v1_201905070820/S1578219019301064/v1_201905070820/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019301064?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 7 6 13
2024 Octubre 56 44 100
2024 Septiembre 62 23 85
2024 Agosto 88 60 148
2024 Julio 59 33 92
2024 Junio 72 32 104
2024 Mayo 60 36 96
2024 Abril 61 18 79
2024 Marzo 57 30 87
2024 Febrero 51 30 81
2024 Enero 51 37 88
2023 Diciembre 46 19 65
2023 Noviembre 74 26 100
2023 Octubre 51 21 72
2023 Septiembre 30 28 58
2023 Agosto 24 16 40
2023 Julio 26 32 58
2023 Junio 39 20 59
2023 Mayo 28 19 47
2023 Abril 22 17 39
2023 Marzo 20 22 42
2023 Febrero 30 26 56
2023 Enero 28 27 55
2022 Diciembre 25 34 59
2022 Noviembre 21 19 40
2022 Octubre 26 17 43
2022 Septiembre 21 37 58
2022 Agosto 23 39 62
2022 Julio 19 41 60
2022 Junio 24 28 52
2022 Mayo 29 31 60
2022 Abril 32 25 57
2022 Marzo 35 39 74
2022 Febrero 23 20 43
2022 Enero 27 35 62
2021 Diciembre 31 36 67
2021 Noviembre 25 39 64
2021 Octubre 36 51 87
2021 Septiembre 18 30 48
2021 Agosto 23 25 48
2021 Julio 15 18 33
2021 Junio 16 18 34
2021 Mayo 33 35 68
2021 Abril 65 22 87
2021 Marzo 76 20 96
2021 Febrero 68 23 91
2021 Enero 42 16 58
2020 Diciembre 39 10 49
2020 Noviembre 10 15 25
2020 Octubre 13 6 19
2020 Septiembre 19 8 27
2020 Agosto 21 11 32
2020 Julio 27 9 36
2020 Junio 21 20 41
2020 Mayo 10 7 17
2020 Abril 19 7 26
2020 Marzo 11 11 22
2020 Febrero 3 0 3
2019 Mayo 3 0 3
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?