Estadísticas

 array:24 [
  "pii" => "S1578219019300563"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2019.02.017"
  "estado" => "S300"
  "fechaPublicacion" => "2019-04-01"
  "aid" => "2131"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2018"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "rev"
  "cita" => "Actas Dermosifiliogr. 2019;110:182-92"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 24
    "formatos" => array:3 [
      "EPUB" => 2
      "HTML" => 21
      "PDF" => 1
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731018305763"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2018.10.019"
      "estado" => "S300"
      "fechaPublicacion" => "2019-04-01"
      "aid" => "2131"
      "copyright" => "AEDV"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "rev"
      "cita" => "Actas Dermosifiliogr. 2019;110:182-92"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 586
        "formatos" => array:3 [
          "EPUB" => 1
          "HTML" => 436
          "PDF" => 149
        ]
      ]
      "es" => array:14 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">REVISI&#211;N</span>"
        "titulo" => "Reacciones capilares de las nuevas terapias diana dirigidas contra el c&#225;ncer"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:3 [
          0 => "es"
          1 => "es"
          2 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "182"
            "paginaFinal" => "192"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Adverse Hair Reactions to New Targeted Therapies for Cancer"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 1
          "multimedia" => array:5 [
            "identificador" => "fig0030"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => false
            "mostrarDisplay" => true
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "fx1.jpeg"
                "Alto" => 1085
                "Ancho" => 1285
                "Tamanyo" => 120436
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46;F&#46; Mir-Bonaf&#233;, D&#46; Saceda-Corralo, S&#46; Va&#241;&#243;-Galv&#225;n"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "J&#46;F&#46;"
                "apellidos" => "Mir-Bonaf&#233;"
              ]
              1 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Saceda-Corralo"
              ]
              2 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Va&#241;&#243;-Galv&#225;n"
              ]
            ]
          ]
        ]
        "resumen" => array:1 [
          0 => array:3 [
            "titulo" => "Graphical abstract"
            "clase" => "graphical"
            "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0030"></elsevierMultimedia></p></span>"
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219019300563"
          "doi" => "10.1016/j.adengl.2019.02.017"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300563?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018305763?idApp=UINPBA000044"
      "url" => "/00017310/0000011000000003/v1_201904030618/S0001731018305763/v1_201904030618/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219019300411"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2019.02.007"
    "estado" => "S300"
    "fechaPublicacion" => "2019-04-01"
    "aid" => "2089"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "ssu"
    "cita" => "Actas Dermosifiliogr. 2019;110:193-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 7
      "formatos" => array:3 [
        "EPUB" => 1
        "HTML" => 3
        "PDF" => 3
      ]
    ]
    "en" => array:14 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">NOVELTIES IN DERMATOLOGY</span>"
      "titulo" => "Derm Dotting&#58; A New Technique That Improves Diagnostic Precision in the Evaluation of Skin Lesions"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:3 [
        0 => "en"
        1 => "en"
        2 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "193"
          "paginaFinal" => "196"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "<span class="elsevierStyleItalic">Derm dotting</span>&#58; una t&#233;cnica novedosa para mejorar la precisi&#243;n diagn&#243;stica de lesiones cut&#225;neas"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 1
        "multimedia" => array:5 [
          "identificador" => "fig0030"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => false
          "mostrarDisplay" => true
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "fx1.jpeg"
              "Alto" => 1085
              "Ancho" => 677
              "Tamanyo" => 67385
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;A&#46; Moreno Romero, N&#46; P&#233;rez Mu&#241;oz, A&#46; Campoy S&#225;nchez, M&#46; Urbano Carrillo, M&#46;T&#46; Fern&#225;ndez Figueras"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "J&#46;A&#46;"
              "apellidos" => "Moreno Romero"
            ]
            1 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "P&#233;rez Mu&#241;oz"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Campoy S&#225;nchez"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Urbano Carrillo"
            ]
            4 => array:2 [
              "nombre" => "M&#46;T&#46;"
              "apellidos" => "Fern&#225;ndez Figueras"
            ]
          ]
        ]
      ]
      "resumen" => array:1 [
        0 => array:3 [
          "titulo" => "Graphical abstract"
          "clase" => "graphical"
          "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0030"></elsevierMultimedia></p></span>"
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731018304861"
        "doi" => "10.1016/j.ad.2018.09.012"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018304861?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300411?idApp=UINPBA000044"
    "url" => "/15782190/0000011000000003/v1_201904030645/S1578219019300411/v1_201904030645/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219019300460"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2018.10.023"
    "estado" => "S300"
    "fechaPublicacion" => "2019-04-01"
    "aid" => "2104"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2019;110:181"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 7
      "formatos" => array:3 [
        "EPUB" => 1
        "HTML" => 5
        "PDF" => 1
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>"
      "titulo" => "Azathioprine in the Treatment of Severe Pediatric Atopic Dermatitis&#58; Experience in a Referral Hospital in Spain"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "181"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Azatioprina en el tratamiento de la dermatitis at&#243;pica grave en pediatr&#237;a&#46; Experiencia en un hospital de referencia en Espa&#241;a"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Vicente Villa"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Vicente Villa"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731018305015"
        "doi" => "10.1016/j.ad.2018.10.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018305015?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300460?idApp=UINPBA000044"
    "url" => "/15782190/0000011000000003/v1_201904030645/S1578219019300460/v1_201904030645/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
    "titulo" => "Adverse Hair Reactions to New Targeted Therapies for Cancer"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "182"
        "paginaFinal" => "192"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46;F&#46; Mir-Bonaf&#233;, D&#46; Saceda-Corralo, S&#46; Va&#241;&#243;-Galv&#225;n"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "J&#46;F&#46;"
            "apellidos" => "Mir-Bonaf&#233;"
            "email" => array:1 [
              0 => "jmirb&#64;santpau&#46;cat"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Saceda-Corralo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Va&#241;&#243;-Galv&#225;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de la Santa Creu i Sant Pau&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario Ram&#243;n y Cajal&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Reacciones capilares de las nuevas terapias diana dirigidas contra el c&#225;ncer"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 1
      "multimedia" => array:5 [
        "identificador" => "fig0030"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "fx1.jpeg"
            "Alto" => 1085
            "Ancho" => 1285
            "Tamanyo" => 120868
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Since their introduction&#44; targeted therapies have radically changed the treatment of cancer&#46; These drugs target specific molecules implicated in tumor growth and proliferation &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; They represent a change in approach for combating cancer&#44; given that they act more specifically than traditional cytotoxic agents&#46; The introduction of these agents has also led to a change in the management of these patients and the adverse effects resulting from cancer therapy&#46; Although the new targeted therapies are generally less toxic for hair&#44; they also have side effects that may impact hair&#44; whether it is the follicular cycle&#44; form&#44; or color&#44; or cause immune disorders leading to hair loss&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">EGFR Inhibitors&#58; Afatinib&#44; Cetuximab&#44; Erlotinib&#44; Gefitinib&#44; Necitumumab&#44; Osimertinib&#44; Panitumumab&#44; Vandetanib</span><p id="par0010" class="elsevierStylePara elsevierViewall">The role of epidermal growth factor receptors &#40;EGFR&#41; in tumor formation and development of skin and skin appendages is well known&#46; Moreover&#44; we know that this molecule plays an important role in the equilibrium of the follicular cycle&#46;<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">1</span></a> For this reason&#44; the main adverse effects of these treatments are dermatological&#46; These effects are essentially divided into those that affect the skin &#40;follicular or acneiform eruption&#44; xerosis&#44; and pruritus&#41;&#44; which usually have an early onset&#44; and those that affect the appendages &#40;paronychia and hair changes&#41;&#44; which have a later onset&#46;<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">2&#8211;4</span></a> Hair changes occur in almost 80&#37; of patients after 6 months of treatment&#46; Several types of impact on hair have been reported&#58; alopecia&#44; hair growth&#44; and changes in rate of growth&#44; hair thickness&#44; and even form&#44; with hair taking on a curly or straight appearance&#46;<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">2</span></a> Rarer are changes in hair pigmentation&#46; Two types have been reported&#58; poliosis<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">5</span></a> and repigmentation of grey hair&#46;<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">6</span></a> One of the most characteristic effects is&#44; without doubt&#44; persistent or accelerated hair growth&#44; an effect known as trichomegaly&#46;<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">7</span></a> Hypertrichosis of the eye lashes is particularly striking and characteristic&#44;<a class="elsevierStyleCrossRefs" href="#bib0530"><span class="elsevierStyleSup">5&#44;7&#44;8</span></a> and usually occurs between 2 and 5 months of treatment &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; This abnormal growth&#44; in addition to the cosmetic impact&#44; leads to an aberrant form of eyelashes with the possibility&#44; in some cases&#44; of causing corneal trauma&#46; For this reason&#44; it is recommended to trim them carefully&#46;<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">4</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Alopecia related to these drugs occurs at different rates according to the drug&#58; 11&#46;9&#37; with afatinib and 8&#46;9&#37; with cetuximab and erlotinib&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> In addition&#44; less frequently&#44; EGFR inhibitors can induce the onset of inflammatory alopecia&#46; This may present as inflammatory nonscarring alopecia<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">10</span></a> or as follicular pustules on the scalp&#44; leading to scarring alopecia&#44;<a class="elsevierStyleCrossRefs" href="#bib0525"><span class="elsevierStyleSup">4&#44;11</span></a> which may correspond to scalp involvement in typical follicular reaction &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; However&#44; some authors are of the opinion that this is a form of erosive pustular dermatosis of the scalp because of the trichoscopic findings&#44; characteristic of such processes&#46;<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">12</span></a> In any case&#44; treatment is with topical corticosteroids&#44; while addition of antibiotics with antistaphylococcal action may be useful as <span class="elsevierStyleItalic">Staphylococcus aureus</span> infection has been reported in some cases&#46;<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">11</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">HER-2 Inhibitors&#58; Trastuzumab&#44; Lapatinib&#44; Neratinib</span><p id="par0020" class="elsevierStylePara elsevierViewall">Within the pharmacological class of HER-2 inhibitors&#44; trastuzumab is the most widely used drug as an adjuvant treatment for HER-2 positive breast cancer&#46; Alopecia due to this drug does not appear to be a common adverse reaction&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">13</span></a> Lapatinib&#44; in contrast&#44; is an inhibitor of both HER-2 and EGFR&#44; and so can show effects characteristic of this latter group of inhibitors&#46;<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">14</span></a> Clinical trials conducted with neratinib to date have not reported any effects on hair&#46;<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">15</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Moreover&#44; anecdotally&#44; there have been 2 cases of tufted-hair folliculitis induced by HER-2 inhibitors&#44; one with trastuzumab<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">16</span></a> and the other with lapatinib&#46;<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">17</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Anti-PD-1&#47;PD-L1&#47;CTLA-4&#58; Nivolumab&#44; Pembrolizumab&#47;Atezolizumab&#44; Durvalumab&#47;Ipilimumab</span><p id="par0030" class="elsevierStylePara elsevierViewall">PD-1&#44; PD-L1&#44; and CTLA-4 inhibitors are a heterogeneous group of drugs familiar to dermatologists because they are used in the treatment of metastatic melanoma&#46; In the case of ipilimumab&#44; the onset of vitiligo-like hypopigmentation is common &#40;particularly in patients with melanoma&#41;&#44; and in initial studies&#44; up to 14&#37; of patients experienced hypopigmentation of hair of the scalp&#44; eyebrows&#44; or eye lashes&#46;<a class="elsevierStyleCrossRefs" href="#bib0595"><span class="elsevierStyleSup">18&#44;19</span></a> Subsequently&#44; there have been 2 reports of poliosis with this class of drugs&#44; 1 with ipilimumab<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">20</span></a> and the other with pembrolizumab&#46;<a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">21</span></a> However&#44; the reverse effect seems more frequent with PD-1&#47;PD-L1 inhibitors&#44; as a series of 14 patients was recently published of scalp repigmentation after receiving treatment with 1 of these PD-1&#47;PD-L1 agents for nonsmall cell lung cancer &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">22</span></a> Of note is that 13 of the 14 patients were men&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Although alopecia arising from anti-PD-1 agents occurs in 1&#37; to 2&#37; of patients&#44; there are no studies that adequately characterize this effect&#46;<a class="elsevierStyleCrossRef" href="#bib0620"><span class="elsevierStyleSup">23</span></a> With ipilimumab&#44; the proportion of patients with alopecia is around 5&#46;1&#37; &#40;ranging from 1&#46;3&#37; to 18&#46;3&#37; according to the series&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> Recently&#44; a series of 4 cases has been published of patients during combined treatment with PD-1&#47;PD-L1<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>ipilimumab&#44; who developed a clinical picture indicative of alopecia areata &#40;AA&#41;&#59; 3 of them in plaque form and 1 case of alopecia universalis with nail involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0620"><span class="elsevierStyleSup">23</span></a> Two cases of AA related to ipilimumab use have been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0625"><span class="elsevierStyleSup">24&#44;25</span></a> In 1 of them&#44; AA was associated with extensive vitiligo and the authors argued that the presence of autoimmune phenomena could be a marker of longer survival&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Another anecdotal case involved a change to a persistent curly hair phenotype in a patient receiving treatment with nivolumab&#46;<a class="elsevierStyleCrossRef" href="#bib0635"><span class="elsevierStyleSup">26</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">BRAF Inhibitors&#58; Vemurafenib&#44; Dabrafenib</span><p id="par0045" class="elsevierStylePara elsevierViewall">BRAF inhibitors were pioneers in targeted therapy for metastatic melanoma&#46; These treatments have a complex safety profile&#44; which has been improved through combination with MEK inhibitors&#46;<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">27</span></a> The effects of BRAF inhibitors on hair are varied and common&#46; Alopecia&#44; typically of the diffuse&#44; nonscarring form of mild intensity &#40;grade <span class="elsevierStyleSmallCaps">i</span>-<span class="elsevierStyleSmallCaps">ii</span>&#41;&#44; is a common side effect&#44; present in 8&#37; in the first clinical trials of vemurafenib and up to 100&#37; in a prospective study of 11 patients&#46;<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">28</span></a> However&#44; the most reliable data probably are derived from a cohort of 3219 patients treated with vemurafenib&#44; up to 25&#37; of whom had some form of alopecia&#46;<a class="elsevierStyleCrossRef" href="#bib0650"><span class="elsevierStyleSup">29</span></a> This rate was similar to that reported in a metaanalysis &#40;23&#46;7&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> We have less extensive data on the percentage of dabrafenib-treated patients who develop alopecia&#46; A series of 119 patients showed an incidence of 14&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0655"><span class="elsevierStyleSup">30</span></a> which in the aforementioned metanalysis increased to 18&#46;9&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> Furthermore&#44; of note is that this type of alopecia is often accompanied by changes in hair morphology &#40;to curly phenotype&#41;&#44; hair thickness&#44; and hair color &#40;typically grey hair may appear or&#44; occasionally&#44; repigmentation is reported&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0640"><span class="elsevierStyleSup">27&#44;31</span></a> This occurs in 16&#46;7&#37; of patients with vemurafenib and 13&#37; to 60&#37; of those with dabrafenib &#40;usually in mild form&#41;&#44; depending on the series&#46;<a class="elsevierStyleCrossRefs" href="#bib0655"><span class="elsevierStyleSup">30&#44;32</span></a> This set of findings has been denoted RASopathic alopecia by some authors&#46;<a class="elsevierStyleCrossRef" href="#bib0660"><span class="elsevierStyleSup">31</span></a> In addition&#44; the appearance of interfollicular yellow dots in the scalp is characteristically observed in association with these changes&#46;<a class="elsevierStyleCrossRef" href="#bib0665"><span class="elsevierStyleSup">32</span></a> In most cases&#44; these effects occur at the start of treatment&#44; although recently a late-onset case has been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0670"><span class="elsevierStyleSup">33</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Finally&#44; the appearance of seborrheic dermatitis of the scalp is not uncommon&#44; and management can be challenging&#44;<a class="elsevierStyleCrossRef" href="#bib0675"><span class="elsevierStyleSup">34</span></a> with some of the most affected patients developing forms of pityriasis amiantecea&#46;<a class="elsevierStyleCrossRef" href="#bib0680"><span class="elsevierStyleSup">35</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">MEK Inhibitors&#58; Trametinib&#44; Cobimetinib&#44; Binimetinib&#44; Selumetinib</span><p id="par0055" class="elsevierStylePara elsevierViewall">As we have already pointed out&#44; MEK inhibitors are usually used in combination with BRAF inhibitors &#40;vemurafenib and dabrafenib&#41;&#44; not just to increase survival but to reduce side effects&#46;<a class="elsevierStyleCrossRefs" href="#bib0635"><span class="elsevierStyleSup">26&#44;27</span></a> Therefore&#44; specific reports on their side effects on hair when used as monotherapy are limited&#46; In one of the phase <span class="elsevierStyleSmallCaps">iii</span> clinical trials that included 323 patients with trametinib&#44; alopecia was reported in 19&#37;&#44; in almost all cases of grade <span class="elsevierStyleSmallCaps">i</span> severity&#46;<a class="elsevierStyleCrossRef" href="#bib0685"><span class="elsevierStyleSup">36</span></a> According to a metaanalysis&#44; the overall percentage of such events among patients treated with trametinib was close to 13&#46;3&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> In another small series of 11 patients&#44; selumetinib was reported to cause alopecia in 9&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0690"><span class="elsevierStyleSup">37</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">However&#44; the most important aspect of these drugs is&#44; without doubt&#44; their capacity to improve the safety profile of BRAF inhibitors&#44; the agents with which they are almost always used in combination&#46; Comparative studies between BRAF inhibitors alone and a combination of BRAF and MEK inhibitors show that most of the usual side effects occur at a lower frequency with combination therapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0635"><span class="elsevierStyleSup">26&#44;30&#44;37</span></a> This however is not the case with photosensitivity and keratosis pilaris&#44; whose incidence may increase with combination therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">27</span></a> With regards hair&#44; the combination does seem to improve the safety profile&#44; as shown in a comparative study in which the incidence of alopecia was compared for patients treated with dabrafenib &#40;14&#37;&#41; and those treated with a combination of dabrafenib and trametinib &#40;3&#46;3&#37;&#41;&#59; the incidences of curly hair and grey hair was also compared &#40;12&#46;6&#37; vs&#46; 3&#46;3&#37;&#44; respectively&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0655"><span class="elsevierStyleSup">30</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Recently&#44; a case of trichorrhexis nudosa was reported in a 14-year-old girl&#44; associated with treatment with trametinib&#46;<a class="elsevierStyleCrossRef" href="#bib0695"><span class="elsevierStyleSup">38</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">KIT&#47;BCR-ABL Inhibitors&#58; Axitinib&#44; Imatinib&#44; Regorafenib&#47;Bosutinib&#44; Dasatinib&#44; Nilotinib&#44; Ponatinib</span><p id="par0070" class="elsevierStylePara elsevierViewall">This heterogenous class of drugs inhibit tyrosine kinases produced by c-kit&#44; platelet growth factor receptors&#44; and BCR-ABL fusion&#46; They are mainly used for hematological malignancies&#44; such as chronic myeloid leukemia&#44; although they have a wide range of other indications&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">13</span></a> The most characteristic side effects of this group are associated with pigmentation disorders&#44;<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">19</span></a> given the role of c-kit in melanocyte physiology&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">13</span></a> Multiple patterns of skin hypopigmentation or depigmentation have been described with imatinib&#44;<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">19</span></a> with possible hair involvement<a class="elsevierStyleCrossRefs" href="#bib0700"><span class="elsevierStyleSup">39&#44;40</span></a> &#40;sometimes in form of grey hair&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0710"><span class="elsevierStyleSup">41&#44;42</span></a> These alterations are more common in patients with dark phototypes and they usually respond to decreased doses or remit on suspending the drug&#46;<a class="elsevierStyleCrossRef" href="#bib0720"><span class="elsevierStyleSup">43</span></a> Several cases have also been reported of leukotrichia caused by dasatinib&#44; whether or not associated with skin hypopigmentation&#44;<a class="elsevierStyleCrossRefs" href="#bib0725"><span class="elsevierStyleSup">44&#8211;46</span></a> and by regorafenib&#46;<a class="elsevierStyleCrossRef" href="#bib0740"><span class="elsevierStyleSup">47</span></a> The opposite effect &#40;repigmentation&#41;&#44; although less frequent&#44; has also been reported both in skin&#44; mucosas&#44; and nails<a class="elsevierStyleCrossRefs" href="#bib0600"><span class="elsevierStyleSup">19&#44;43</span></a> and in hair&#44; in 2 different series with imatinib&#58; a series of 9 cases out of 133 treated patients &#40;median duration&#44; 5&#46;7 months&#41;<a class="elsevierStyleCrossRef" href="#bib0745"><span class="elsevierStyleSup">48</span></a> and another of 8 cases &#40;out of 58&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0750"><span class="elsevierStyleSup">49</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Another adverse effect on hair observed frequently is alopecia&#44; particularly in women&#46; Regorafenib is the agent in this class with the highest rate of alopecia &#40;23&#46;7&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> Although nilotinib also shows high rates of alopecia &#40;6&#37;-8&#37; according to pivotal studies&#44; with one metaanalysis finding an incidence as high as 15&#46;9&#37;&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0720"><span class="elsevierStyleSup">43&#44;50</span></a> this effect is not well characterized&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">13</span></a> In one case&#44; the onset of complete diffuse alopecia of an inflammatory nature is described in detail &#40;affecting the scalp and eyebrows but not the eyelashes&#44; body hair&#44; or nails&#41; in a female patient&#44; associated with an eruption of multiple flesh-colored follicular papules on the trunk&#44; several weeks after starting nilotinib&#46;<a class="elsevierStyleCrossRef" href="#bib0760"><span class="elsevierStyleSup">51</span></a> In addition&#44; the event coincided with a recent postpartum period&#46; Given that alopecia in these cases does not resemble the usual form of onset&#44; the authors proposed the term nilotinib-induced alopecia&#46; To date&#44; there have not been any further reports on this specific type of alopecia&#46; Imatinib can also cause alopecia&#44; which is reported in 6&#46;6&#37; of patients&#44;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> although complete alopecia is uncommon&#46;<a class="elsevierStyleCrossRef" href="#bib0765"><span class="elsevierStyleSup">52</span></a> In a comparative study of axitinib and sorafenib &#40;both of which are indicated for metastatic renal cancer&#41;&#44; alopecia was reported in 4&#37; of patients treated with axitinib&#46;<a class="elsevierStyleCrossRef" href="#bib0770"><span class="elsevierStyleSup">53</span></a> Dasatinib has an alopecia rate of approximately 7&#46;8&#37;&#44; although this may vary from 3&#37; to 19&#46;1&#37; according to the series&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In addition to alopecia and pigmentation disorders&#44; other types of side effects that impact hair can be observed&#46; Keratosis pilaris caused by nilotinib is common<a class="elsevierStyleCrossRef" href="#bib0775"><span class="elsevierStyleSup">54</span></a>&#59; this may be atrophic and is described as associated with plaque AA&#46;<a class="elsevierStyleCrossRef" href="#bib0780"><span class="elsevierStyleSup">55</span></a> Of note also is that lichenoid reactions are common in this group of drugs and&#44; at times&#44; this may affect hair in the form of lichen planopilaris&#46;<a class="elsevierStyleCrossRef" href="#bib0785"><span class="elsevierStyleSup">56</span></a> Moreover&#44; with some of these drugs &#40;nilotinib&#44; dasatinib&#44; and ponatinib&#41;&#44; cases have been reported in which the clinical manifestations could be mixed&#44; typically combining a finding of lichen planopilaris with skin eruptions such as keratosis pilaris&#44; reminiscent of Graham-Little syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0790"><span class="elsevierStyleSup">57</span></a> In addition&#44; anecdotally&#44; there have been reports of imatinib associated with a case of madarosis in a pediatric patient<a class="elsevierStyleCrossRef" href="#bib0795"><span class="elsevierStyleSup">58</span></a> and of nilotinib with a case of perforating folliculitis&#46;<a class="elsevierStyleCrossRef" href="#bib0800"><span class="elsevierStyleSup">59</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">VEGF&#47;VEGFR Inhibitors&#58; Bevacizumab&#44; Pazopanib&#44; Sorafenib&#44; Sunitinib&#47;Lenvatinib&#44; Ramucirumab</span><p id="par0085" class="elsevierStylePara elsevierViewall">Drugs that belong to the class of VEGF&#47;VEGFR inhibitors are also called multikinase inhibitors because&#44; in addition to inhibiting activity of the intracellular portion of the VEGF receptor&#44; they act on many other tyrosine kinases either directly or indirectly&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">13</span></a> For this reason&#44; they exhibit a wide range of adverse effects and many of these coincide with adverse effects characteristic of other classes of drug&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The most frequent adverse effect on hair is alopecia&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">13</span></a> Several studies support this affirmation&#58; different metaanalyses cite the percentage of patients with alopecia at 6&#37; &#40;5&#37;-21&#37;&#41; with sunitinib&#44;<a class="elsevierStyleCrossRef" href="#bib0805"><span class="elsevierStyleSup">60</span></a> 10&#37; &#40;3&#46;3&#37;-26&#46;8&#37;&#41; with bevacizumab&#44;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> 12&#46;3&#37; &#40;9&#37;-16&#37;&#41; with pazopanib&#44;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> and 25&#46;5&#37;-29&#37; with sorafenib&#44;<a class="elsevierStyleCrossRef" href="#bib0810"><span class="elsevierStyleSup">61</span></a> the drug with the highest percentage of affected patients&#46; Furthermore&#44; sorafenib-associated alopecia has its own distinctive characteristics&#46; Onset usually occurs between week 3 and week 15 of treatment and may at times be accompanied by slow growth of facial hair&#46;<a class="elsevierStyleCrossRef" href="#bib0815"><span class="elsevierStyleSup">62</span></a> Another study reported that up to 19&#37; of patients experienced loss of body hair&#44; not always associated with alopecia of scalp hair&#46;<a class="elsevierStyleCrossRef" href="#bib0820"><span class="elsevierStyleSup">63</span></a> Management is complex&#44; as there is no specific treatment available&#44; but the disorder is not usually permanent and the patient regains hair density once treatment is complete &#40;and sometimes even before completion&#41;&#46; When hair regrows&#44; it may appear brittle and curly&#46;<a class="elsevierStyleCrossRef" href="#bib0825"><span class="elsevierStyleSup">64</span></a> Other authors have reported that the event in some patients may have characteristics that overlap with AA&#46;<a class="elsevierStyleCrossRef" href="#bib0830"><span class="elsevierStyleSup">65</span></a> With regards the VEGFR inhibitors lenvatinib and ramucirumab&#44; limited data are currently available&#46; Ramucirumab&#44; according to a metaanalysis of 6 randomized clinical trials&#44; does not show an increase in the proportion of patients with alopecia compared with placebo&#44;<a class="elsevierStyleCrossRef" href="#bib0835"><span class="elsevierStyleSup">66</span></a> whereas with lenvatinib&#44; 11&#37; of patients had alopecia in a phase <span class="elsevierStyleSmallCaps">iii</span> clinical trial with 261 patients&#46;<a class="elsevierStyleCrossRef" href="#bib0840"><span class="elsevierStyleSup">67</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Through direct or indirect activity on c-kit&#44; these drugs are also often associated with skin and hair pigmentation disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">13</span></a> In this case&#44; sunitinib is typically the most widely implicated drug&#44;<a class="elsevierStyleCrossRef" href="#bib0815"><span class="elsevierStyleSup">62</span></a> with depigmentation of the hair&#44; eyebrows&#44; and eyelashes in up to 8&#37; to 14&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0715"><span class="elsevierStyleSup">42&#44;68&#8211;70</span></a> Onset usually occurs after 5 to 6 weeks of treatment&#44; with hair acquiring a greyish color&#46; The effect usually remits within 2 to 3 weeks of finishing treatment&#44; and so it is possible that there are intermittent cases of depigmentation&#44; depending on the periodicity of treatment &#40;due to transient inhibition of c-kit&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0815"><span class="elsevierStyleSup">62&#44;69</span></a> Although this effect is usually attributed to sunitinib&#44; in some series&#44; the proportion of hair depigmentation with pazopanib is even higher&#44; reaching 38&#37;<a class="elsevierStyleCrossRef" href="#bib0860"><span class="elsevierStyleSup">71</span></a> at high doses&#44; with rapid onset<a class="elsevierStyleCrossRef" href="#bib0865"><span class="elsevierStyleSup">72</span></a> and an odds ratio of 4&#46;54&#46;<a class="elsevierStyleCrossRef" href="#bib0870"><span class="elsevierStyleSup">73</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Hedgehog Inhibitors&#58; Vismodegib&#44; Sonidegib&#44; Erismodegib</span><p id="par0100" class="elsevierStylePara elsevierViewall">Hedgehog inhibitors are primarily indicated for advanced and metastatic basal cell carcinoma&#46;<a class="elsevierStyleCrossRef" href="#bib0660"><span class="elsevierStyleSup">31</span></a> In this case&#44; alopecia is&#44; without doubt&#44; the most frequent adverse effect involving hair &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; The rates are very high&#44; reaching 63&#37; in the first pivotal clinical trials with vismodegib&#46;<a class="elsevierStyleCrossRef" href="#bib0875"><span class="elsevierStyleSup">74</span></a> In fact&#44; vismodegib is the cancer drug with the highest rate of alopecia according to a comparative metaanalysis&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> Furthermore&#44; of note is that 10&#37;-14&#37; have grade <span class="elsevierStyleSmallCaps">ii</span> alopecia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>50&#37; hair loss&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0875"><span class="elsevierStyleSup">74</span></a> Another important study published recently of 694 patients with advanced and metastatic basal cell carcinoma treated with vismodegib reported a percentage of patients with alopecia of 62&#37;&#44; with the event occurring constantly throughout the first 12 months of treatment&#58; it was responsible for withdrawal from treatment in 3&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0880"><span class="elsevierStyleSup">75</span></a> Of note is that this alopecia resolves spontaneously on stopping treatment &#40;usually during the first year&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0880"><span class="elsevierStyleSup">75</span></a> 4 cases have been reported of persistent alopecia &#40;mean duration of follow-up of 15 months&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0885"><span class="elsevierStyleSup">76</span></a> In addition&#44; other authors report 2 cases in which spontaneous improvement in this process during treatment was accompanied by treatment failure&#44; and they speculate whether this could be an early marker of therapeutic failure and disease progression&#46;<a class="elsevierStyleCrossRef" href="#bib0890"><span class="elsevierStyleSup">77</span></a> Alopecia associated with sonidegib&#44; although not as common&#44; is still present in more than 10&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0895"><span class="elsevierStyleSup">78</span></a> The Hedgehog pathway shows high signaling levels in growing follicles&#44; which would explain the high rates of alopecia when this pathway is inhibited&#46;<a class="elsevierStyleCrossRef" href="#bib0900"><span class="elsevierStyleSup">79</span></a> In fact&#44; agonists of the Hedgehog pathway have been studied as potential treatments for androgenic alopecia &#40;and have been ruled out due to their numerous adverse effects&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0905"><span class="elsevierStyleSup">80</span></a> A recent study characterized in detail the pattern of alopecia associated with these drugs in 5 patients &#40;4 with vismodegib and 1 with sonidegib&#47;erismodegib&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0910"><span class="elsevierStyleSup">81</span></a> In all cases&#44; the authors describe the cases as a diffuse&#44; noninflammatory alopecia &#40;without an androgenic pattern&#41;&#44; with slow and gradual onset&#44; and regrowth of increasingly fine and weak hair&#46; This process occurred between 2 and 9 months &#40;median of 3&#46;1 months&#41; of treatment and often affected body hair and eyebrows &#40;in 4 out of 5 cases&#41; and nails &#40;3 out of 5&#41;&#46; In no case were signs of AA observed&#46; The only histopathological findings were an increase in the telogen to anagen ratio&#44; consistent with telogen effluvium&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Another curious effect associated with vismodegib treatment&#44; reported once anecdotally&#44; is trichodysplasia spinulosa&#46;<a class="elsevierStyleCrossRef" href="#bib0915"><span class="elsevierStyleSup">82</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Proteasome Inhibitors&#58; Bortezomib&#44; Carfilzomib&#44; Ixazomib</span><p id="par0110" class="elsevierStylePara elsevierViewall">Proteasome inhibitors are drugs used mainly in the treatment of hematological malignancies&#46; Alopecia caused by bortezomib is considered uncommon&#44;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> with incidences ranging from 0&#46;4&#37; to 10&#46;9&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0920"><span class="elsevierStyleSup">83&#44;84</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">mTOR Inhibitors&#58; Everolimus&#44; Temsirolimus&#44; Sirolimus</span><p id="par0115" class="elsevierStylePara elsevierViewall">mTOR inhibitors are drugs with many wide-ranging indications that generally have limited impact on hair&#46;<a class="elsevierStyleCrossRefs" href="#bib0660"><span class="elsevierStyleSup">31&#44;85</span></a> These agents are considered as an uncommon cause of hair loss&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> The percentage of patients with alopecia is 5&#46;3&#37; &#40;1&#46;9&#37;-14&#46;3&#37;&#41; with everolimus and 5&#46;2&#37; &#40;0&#46;9&#37;-25&#46;9&#37;&#41; with temsirolimus&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> With sirolimus&#44; the prevalence of alopecia&#44; usually mild and diffuse&#44; is 9&#37;&#44; and occasionally&#44; it may also affect body hair&#46;<a class="elsevierStyleCrossRef" href="#bib0935"><span class="elsevierStyleSup">86</span></a> The following effects have also been reported for sirolimus&#58; hypertrichosis &#40;face and body&#41;&#44; 2 cases of AA&#44; and folliculitis of the scalp in up to 25&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0935"><span class="elsevierStyleSup">86</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">PI3K Inhibitors&#58; Idelalisib&#44; Copanlisib&#44; Dactolisib</span><p id="par0120" class="elsevierStylePara elsevierViewall">PI3K is a promising target for hematological malignancies and brain tumors&#44; with limited data on capillary reactions&#46; The presence of high PI3K activity in hair follicle cells would seem to indicate that inhibition of this pathway could lead to a high percentage of alopecia&#46;<a class="elsevierStyleCrossRef" href="#bib0940"><span class="elsevierStyleSup">87</span></a> In fact&#44; in murine models with dactolisib&#44; alopecia was the most frequently observed adverse effect&#46;<a class="elsevierStyleCrossRef" href="#bib0945"><span class="elsevierStyleSup">88</span></a> However&#44; the data available to date with idelalisib &#40;the PI3K inhibitor for which most clinical experience is available&#41; suggest that the percentage of patients with alopecia is low&#46;<a class="elsevierStyleCrossRef" href="#bib0950"><span class="elsevierStyleSup">89</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Anti-CD52&#58; Alemtuzumab</span><p id="par0125" class="elsevierStylePara elsevierViewall">Alemtuzumab is an anti-CD52 agent with a range of indications&#46; Characteristically&#44; it is associated with several autoimmune adverse effects&#46;<a class="elsevierStyleCrossRef" href="#bib0955"><span class="elsevierStyleSup">90</span></a> In this context&#44; there have been reports of AA associated with alemtuzumab&#44; both in plaque form and the universalis form&#44; which can be accompanied by other events of autoimmune origin &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0960"><span class="elsevierStyleSup">91</span></a> Furthermore&#44; the rate of alopecia is 5&#46;3&#37; &#40;0&#46;7&#37;-29&#46;4&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a></p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">ALK Inhibitors&#58; Alectinib&#44; Ceritinib&#44; Crizotinib</span><p id="par0130" class="elsevierStylePara elsevierViewall">ALK inhibitors are indicated mainly for nonsmall cell lung cancer&#46; The rate of alopecia caused by crizotinib is 8&#37; &#40;4&#46;9&#37;-13&#46;2&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0550"><span class="elsevierStyleSup">9&#44;92</span></a> Data for other ALK inhibitors are limited&#44; although a case of diffuse alopecia caused by alectinib has been reported in a patient who had already received crizotinib without alopecia occurring&#46;<a class="elsevierStyleCrossRef" href="#bib0970"><span class="elsevierStyleSup">93</span></a></p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">HDAC Inhibitors&#58; Belinostat&#44; Panobinostat&#44; Romidepsin&#44; Vorinostat</span><p id="par0135" class="elsevierStylePara elsevierViewall">There are limited data on HDAC inhibitors to date&#46; A study of 6 patients with advanced cutaneous T-cell lymphoma who received treatment with vorinostat detected 2 cases of mild alopecia and 1 case of moderate alopecia&#44; with no other effects of note on hair&#46;<a class="elsevierStyleCrossRef" href="#bib0975"><span class="elsevierStyleSup">94</span></a></p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">RANKL Inhibitors&#58; Denosumab</span><p id="par0140" class="elsevierStylePara elsevierViewall">Denosumab is the main drug in this class and is indicated for the treatment of osteoporosis and bone metastases&#46; Alopecia has not been reported among the common adverse effects after 10 years of use&#46;<a class="elsevierStyleCrossRef" href="#bib0980"><span class="elsevierStyleSup">95</span></a> One case of AA universalis has been reported related to use of denosumab after only 2 weeks of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0985"><span class="elsevierStyleSup">96</span></a> The authors discussed whether the fact that RANKL belongs to the TNF-&#945; family might bear some relation on the appearance of this effect&#44; given that anti-TNF-&#945; agents have been frequently associated with onset of paradoxical AA&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">PARP Inhibitors&#58; Olaparib&#44; Rucaparib&#44; Veliparib&#44; Talazoparib&#44; Iniparib</span><p id="par0145" class="elsevierStylePara elsevierViewall">PARP inhibitors are drugs in development mainly for metastatic ovarian cancer&#46; In a clinical trial of 306 patients&#44; it was shown that there was no increase in the proportion of patients with alopecia in the veliparib arm compared with placebo&#46;<a class="elsevierStyleCrossRef" href="#bib0990"><span class="elsevierStyleSup">97</span></a> Another trial also showed a statistically significant decrease in the percentage of patients with alopecia who received veliparib&#47;temozolomide instead of the traditional chemotherapy regimen with carboplatin&#47;paclitaxel&#46;<a class="elsevierStyleCrossRef" href="#bib0995"><span class="elsevierStyleSup">98</span></a> Olaparib was also able to reduce the rate of alopecia when combined with traditional chemotherapy in comparison with a chemotherapy-only regimen&#46;<a class="elsevierStyleCrossRef" href="#bib1000"><span class="elsevierStyleSup">99</span></a></p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Anti-CD30&#58; Brentuximab</span><p id="par0150" class="elsevierStylePara elsevierViewall">Brentuximab is any anti-CD30 agent indicated mainly for refractory Hodgkin lymphoma&#46;<a class="elsevierStyleCrossRef" href="#bib1005"><span class="elsevierStyleSup">100</span></a> The proportion of patients with alopecia after receiving brentuximab is 14&#37; &#40;9&#46;9&#37;-19&#46;6&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">9</span></a> Furthermore&#44; anecdotally&#44; there is a case report of complete hair repigmentation in a 72-year-old man after 6 months of treatment with brentuximab&#46;<a class="elsevierStyleCrossRef" href="#bib1010"><span class="elsevierStyleSup">101</span></a></p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusions</span><p id="par0155" class="elsevierStylePara elsevierViewall">Hair-related side effects are common with new targeted therapies used in cancer &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; All dermatologists should be aware of the most important ones to enable appropriate management of these patients&#44; who are seen increasingly frequently in our clinics &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Several different types of hair reactions have been reported depending on the pharmacological class&#46; These can be associated with the morphology of the hair&#44; such as characteristic trichomegaly with EGFR inhibitors&#46; Pigmentary changes are also frequent and range from typical depigmentation with c-kit or VEGF&#47;VEGFR inhibitors to surprising repigmentation associated with PD-1&#47;PDL-1 inhibitors&#46; Even the most typical reactions&#44; such as alopecia with Hedgehog inhibitors&#44; show specific and differentiated characteristics according to the drug used&#46; Other effects reported less often include entities that resemble classic hair diseases&#44; such as AA&#44; lichen planopilaris&#44; and erosive pustular dermatosis of the scalp&#46; Although the rapid advance of targeted therapy does not afford any rest&#44; this review may serve as an initial guide for consultation and study of adverse effects on hair related with these drugs so far&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflicts of Interest</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:26 [
        0 => array:3 [
          "identificador" => "xres1174024"
          "titulo" => "Graphical abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:3 [
          "identificador" => "xres1174022"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        2 => array:2 [
          "identificador" => "xpalclavsec1097943"
          "titulo" => "Keywords"
        ]
        3 => array:3 [
          "identificador" => "xres1174023"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0015"
            ]
          ]
        ]
        4 => array:2 [
          "identificador" => "xpalclavsec1097944"
          "titulo" => "Palabras clave"
        ]
        5 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        6 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "EGFR Inhibitors&#58; Afatinib&#44; Cetuximab&#44; Erlotinib&#44; Gefitinib&#44; Necitumumab&#44; Osimertinib&#44; Panitumumab&#44; Vandetanib"
        ]
        7 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "HER-2 Inhibitors&#58; Trastuzumab&#44; Lapatinib&#44; Neratinib"
        ]
        8 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Anti-PD-1&#47;PD-L1&#47;CTLA-4&#58; Nivolumab&#44; Pembrolizumab&#47;Atezolizumab&#44; Durvalumab&#47;Ipilimumab"
        ]
        9 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "BRAF Inhibitors&#58; Vemurafenib&#44; Dabrafenib"
        ]
        10 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "MEK Inhibitors&#58; Trametinib&#44; Cobimetinib&#44; Binimetinib&#44; Selumetinib"
        ]
        11 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "KIT&#47;BCR-ABL Inhibitors&#58; Axitinib&#44; Imatinib&#44; Regorafenib&#47;Bosutinib&#44; Dasatinib&#44; Nilotinib&#44; Ponatinib"
        ]
        12 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "VEGF&#47;VEGFR Inhibitors&#58; Bevacizumab&#44; Pazopanib&#44; Sorafenib&#44; Sunitinib&#47;Lenvatinib&#44; Ramucirumab"
        ]
        13 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Hedgehog Inhibitors&#58; Vismodegib&#44; Sonidegib&#44; Erismodegib"
        ]
        14 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Proteasome Inhibitors&#58; Bortezomib&#44; Carfilzomib&#44; Ixazomib"
        ]
        15 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "mTOR Inhibitors&#58; Everolimus&#44; Temsirolimus&#44; Sirolimus"
        ]
        16 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "PI3K Inhibitors&#58; Idelalisib&#44; Copanlisib&#44; Dactolisib"
        ]
        17 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Anti-CD52&#58; Alemtuzumab"
        ]
        18 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "ALK Inhibitors&#58; Alectinib&#44; Ceritinib&#44; Crizotinib"
        ]
        19 => array:2 [
          "identificador" => "sec0075"
          "titulo" => "HDAC Inhibitors&#58; Belinostat&#44; Panobinostat&#44; Romidepsin&#44; Vorinostat"
        ]
        20 => array:2 [
          "identificador" => "sec0080"
          "titulo" => "RANKL Inhibitors&#58; Denosumab"
        ]
        21 => array:2 [
          "identificador" => "sec0085"
          "titulo" => "PARP Inhibitors&#58; Olaparib&#44; Rucaparib&#44; Veliparib&#44; Talazoparib&#44; Iniparib"
        ]
        22 => array:2 [
          "identificador" => "sec0090"
          "titulo" => "Anti-CD30&#58; Brentuximab"
        ]
        23 => array:2 [
          "identificador" => "sec0095"
          "titulo" => "Conclusions"
        ]
        24 => array:2 [
          "identificador" => "sec0100"
          "titulo" => "Conflicts of Interest"
        ]
        25 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2018-02-12"
    "fechaAceptado" => "2018-10-13"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1097943"
          "palabras" => array:6 [
            0 => "Cancer treatment"
            1 => "Trichology"
            2 => "Hair"
            3 => "Alopecia"
            4 => "Targeted therapies"
            5 => "Hair reactions"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1097944"
          "palabras" => array:6 [
            0 => "Tratamiento oncol&#243;gico"
            1 => "Tricolog&#237;a"
            2 => "Pelo"
            3 => "Alopecia"
            4 => "Terapias diana"
            5 => "Alteraciones capilares"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The advent of immune targeted therapies for cancer has radically changed the treatment and prognosis of many cancers&#46; These drugs are called <span class="elsevierStyleItalic">targeted</span> therapies because they target specific pathophysiological mechanisms of cancer&#46; This paradigm shift in cancer treatment&#44; however&#44; has resulted in new adverse dermatologic effects involving both the skin and its appendages&#46; In the case of hair&#44; targeted drugs can cause immune alterations and changes in hair growth&#44; color&#44; and shape&#46; Because most targeted therapies are new&#44; there is no single document describing all these adverse effects&#46; We performed an exhaustive review of the literature to characterize adverse hair effects associated with the use of targeted therapies&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las nuevas terapias inmunol&#243;gicas dirigidas contra el c&#225;ncer han supuesto un cambio radical en el tratamiento y el pron&#243;stico de muchas neoplasias&#46; Estos medicamentos se dirigen de manera mucho m&#225;s espec&#237;fica contra los mecanismos fisiopatog&#233;nicos del c&#225;ncer&#44; por lo que adquieren el sobrenombre de &#171;terapias diana&#187;&#46; Este cambio de paradigma ha supuesto la aparici&#243;n de nuevos efectos adversos dermatol&#243;gicos&#44; que afectan tanto la piel como sus anejos&#46; Los efectos adversos en el pelo pueden manifestarse en alteraciones de su ciclo&#44; forma&#44; color o inmunolog&#237;a&#46; Debido a que son tratamientos nuevos en su mayor&#237;a y no existe un documento que englobe todos estos efectos adversos&#44; hemos realizado una exhaustiva revisi&#243;n bibliogr&#225;fica para caracterizar de manera concreta cu&#225;les son los efectos adversos tricol&#243;gicos que pueden inducir cada uno de estos f&#225;rmacos&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mir-Bonaf&#233; JF&#44; Saceda-Corralo D&#44; Va&#241;&#243;-Galv&#225;n S&#46; Reacciones capilares de las nuevas terapias diana dirigidas contra el c&#225;ncer&#46; Actas Dermosifiliogr&#46; 2019&#59;110&#58;182&#8211;192&#46;</p>"
      ]
    ]
    "multimedia" => array:9 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1618
            "Ancho" => 1133
            "Tamanyo" => 226568
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A&#44; Trichomegaly of the eyelashes and facial hypertrichosis caused by erlotinib &#40;anti-EGFR agent&#41;&#46; B&#44; Hypertrichosis of the arm of the same patient&#46; Courtesy of Dr&#46; M&#46;P&#46; Garcia-Muret&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 638
            "Ancho" => 850
            "Tamanyo" => 124057
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Follicular reaction on scalp caused by cetuximab &#40;anti-EGFR agent&#41;&#44; resembling erosive pustular dermatosis of the scalp&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1162
            "Ancho" => 1667
            "Tamanyo" => 175838
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A&#44; Patient with grey hair&#46; B&#44; Same patient with hair repigmentation after nivolumab &#40;anti-PD1&#41; treatment&#46; Courtesy of Dr&#46; N&#46; Rivera&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1770
            "Ancho" => 2000
            "Tamanyo" => 488079
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Diffuse alopecia caused by vismodegib &#40;Hedgehog inhibitor&#41; in patients included in the STEVIE study&#46; A&#44; Male patient before starting treatment&#46; B&#44; After 8 months of treatment&#46; C&#44; At 3 months after discontinuation of treatment&#46; D&#44; Female patient before starting treatment&#46; E&#44; After 9 months of treatment&#46; F&#44; At 3 months after discontinuation of treatment&#46; Courtesy of Dr&#46; V&#46; Ruiz-Salas&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 1943
            "Ancho" => 1667
            "Tamanyo" => 226429
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Alopecia areata &#40;AA&#41; universalis caused by alemtuzumab &#40;anti-CD52 agent&#41;&#46; A&#44; Appearance before treatment&#46; B&#44; Initial plaques of AA on the legs&#46; C and D&#44; Final phase of AA universalis&#46;</p> <p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Source&#58; Van der Zwan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0960"><span class="elsevierStyleSup">91</span></a>&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Target&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Main Agents&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">EGFR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Afatinib&#44; cetuximab&#44; erlotinib&#44; gefitinib&#44; necitumumab&#44; osimertinib&#44; panitumumab&#44; vandetanib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HER-2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trastuzumab&#44; lapatinib&#44; neratinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PD-1&#47;PD-L1&#47;CTLA-4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nivolumab&#44; pembrolizumab&#47;atezolizumab&#44; avelumab&#44; durvalumab&#47;ipilimumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BRAF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Dabrafenib&#44; vemurafenib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MEK&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trametinib&#44; cobimetinib&#44; binimetinib&#44; selumetinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">KIT&#47;BCR-ABL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Axitinib&#44; imatinib&#44; regorafenib&#47;bosutinib&#44; dasatinib&#44; nilotinib&#44; ponatinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">VEGF&#47;VEGFR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bevacizumab&#44; pazopanib&#44; sorafenib&#44; sunitinib&#47;lenvatinib&#44; ramucirumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hedgehog&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Vismodegib&#44; sonidegib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Proteasome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bortezomib&#44; carfilzomib&#44; ixazomib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">mTOR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Everolimus&#44; temsirolimus&#44; sirolimus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CD52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alemtuzumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ALK&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alectinib&#44; ceritinib&#44; crizotinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDAC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Belinostat&#44; panobinostat&#44; romidepsin&#44; vorinostat&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">RANKL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Denosumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PARP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Olaparib&#44; rucaparib&#44; veliparib&#44; talazoparib&#44; iniparib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CD30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Brentuximab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2003813.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Main Molecular Targets for Targeted Cancer Therapy and the Corresponding Agents&#46;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Position&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drug&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Percentage of Patients With Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mechanism of Action&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Vismodegib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#46;9 &#40;5&#46;6-63&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hedgehog inhibition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sorafenib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29 &#40;23&#46;9-34&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">VEGFR inhibition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Vemurafenib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;7 &#40;9&#46;6-47&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BRAF inhibition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Regorafenib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;5 &#40;9&#46;7-46&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">KIT inhibition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Dabrafenib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#46;9 &#40;10&#46;5-31&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BRAF inhibition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Nilotinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;9 &#40;12&#46;4-20&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">KIT inhibition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Brentuximab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;9&#46;9-19&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Anti-CD30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trametinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;3 &#40;6&#46;2-26&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MEK inhibition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pazopanib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;3 &#40;9-16&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">VEGFR inhibition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Afatinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;9 &#40;9&#46;1-15&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">EGFR inhibition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2003814.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The 10 Drugs With Highest Incidence of Alopecia and Their Mechanism of Action&#46;</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Target&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Main Capillary Reactions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Secondary Capillary Reactions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">EGFR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Morphological changes&#44; trichomegaly&#44; inflammatory alopecia&#44; follicular reaction of the scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Changes in pigmentation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HER-2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Tufted-hair folliculitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PD-1&#47;PD-L1&#47;CTLA-4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Changes in pigmentation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Morphological changes&#44; AA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BRAF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RASopathic alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Seborrheic dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MEK&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Reduction of adverse effects of BRAF inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alopecia&#44; trichorrhexis nudosa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">KIT&#47;BCR-ABL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Changes in pigmentation&#44; nilotinib-induced alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Keratosis pilaris&#44; lichenoid reactions&#44; AA&#44; madarosis&#44; perforating folliculitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">VEGF&#47;VEGFR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alopecia&#44; hair depigmentation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">All the effects of EGFR inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hedgehog&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trichodysplasia spinulosa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Proteasome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">mTOR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alopecia &#40;scalp and body&#41;&#44; hypertrichosis&#44; AA&#44; folliculitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CD52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">AA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ALK&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDAC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">RANKL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">AA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PARP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CD30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hair repigmentation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2003815.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Summary of the Main and Secondary Capillary Reactions of Targeted Cancer Therapy by Pharmacological Class&#46;</p>"
        ]
      ]
      8 => array:5 [
        "identificador" => "fig0030"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "fx1.jpeg"
            "Alto" => 1085
            "Ancho" => 1285
            "Tamanyo" => 120868
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:101 [
            0 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal growth factor as a biologic switch in hair growth cycle"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Biol Chem&#46;"
                        "fecha" => "2003"
                        "volumen" => "278"
                        "paginaInicial" => "26120"
                        "paginaFinal" => "26126"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jfma.2017.03.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Formos Med Assoc&#46;"
                        "fecha" => "2017"
                        "volumen" => "116"
                        "paginaInicial" => "413"
                        "paginaFinal" => "423"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal growth factor receptor inhibitors&#58; Cutaneous side effects and their management"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Skin Therapy Lett&#46;"
                        "fecha" => "2017"
                        "volumen" => "22"
                        "paginaInicial" => "5"
                        "paginaFinal" => "7"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidermal growth factor receptor inhibitors&#58; A review of cutaneous adverse events and management"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2014/734249"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Res Pract&#46;"
                        "fecha" => "2014"
                        "volumen" => "2014"
                        "paginaInicial" => "734249"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichomegaly and poliosis of the eyelashes during cetuximab treatment of metastatic colorectal cancer"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2011.34.6858"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol&#46;"
                        "fecha" => "2011"
                        "volumen" => "29"
                        "paginaInicial" => "e532"
                        "paginaFinal" => "e533"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Erlotinib-induced hair repigmentation"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4632.2011.05422.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2014"
                        "volumen" => "53"
                        "paginaInicial" => "e55"
                        "paginaFinal" => "e57"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cetuximab-induced hypertrichosis of the scalp and eyelashes"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2009.02.023"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2010"
                        "volumen" => "62"
                        "paginaInicial" => "531"
                        "paginaFinal" => "533"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichomegaly and scalp hair changes following treatment with erlotinib in pulmonary adenocarcinoma patients&#58; A case report and literature review"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3892/etm.2016.3460"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Ther Med&#46;"
                        "fecha" => "2016"
                        "volumen" => "12"
                        "paginaInicial" => "1287"
                        "paginaFinal" => "1292"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia in patients treated with molecularly targeted anticancer therapies"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/annonc/mdv390"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Oncol&#46;"
                        "fecha" => "2015"
                        "volumen" => "26"
                        "paginaInicial" => "2496"
                        "paginaFinal" => "2502"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case report of inflammatory nonscarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0560.2009.01275.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol&#46;"
                        "fecha" => "2009"
                        "volumen" => "36"
                        "paginaInicial" => "1303"
                        "paginaFinal" => "1307"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of cicatricial alopecia associated with erlotinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Dermatol&#46;"
                        "fecha" => "2011"
                        "volumen" => "23"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "S350"
                        "paginaFinal" => "S353"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trichoscopic findings of erosive pustular dermatosis of the scalp associated with gefitinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000475543"
                      "Revista" => array:6 [
                        "tituloSerie" => "Case Rep Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "9"
                        "paginaInicial" => "44"
                        "paginaFinal" => "49"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous adverse effects of targeted therapies&#58; Part I&#58; Inhibitors of the cellular membrane"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2014.07.032"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "72"
                        "paginaInicial" => "203"
                        "paginaFinal" => "218"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of dermatologic events in patients with cancer treated with lapatinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10549-008-0020-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Breast Cancer Res Treat&#46;"
                        "fecha" => "2009"
                        "volumen" => "114"
                        "paginaInicial" => "485"
                        "paginaFinal" => "493"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer &#40;ExteNET&#41;&#58; 5-year analysis of a randomised&#44; double-blind&#44; placebo-controlled&#44; phase 3 trial"
                      "autores" => array:1 [
                        0 => array:3 [ …3]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1470-2045(17)30717-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Oncol&#46;"
                        "fecha" => "2017"
                        "volumen" => "18"
                        "paginaInicial" => "1688"
                        "paginaFinal" => "1700"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tufted hair folliculitis in a woman treated with trastuzumab"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11523-010-0162-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Target Oncol&#46;"
                        "fecha" => "2010"
                        "volumen" => "5"
                        "paginaInicial" => "295"
                        "paginaFinal" => "296"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tufted hair folliculitis in a woman treated with lapatinib for breast cancer"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2230.2008.02882.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol&#46;"
                        "fecha" => "2008"
                        "volumen" => "33"
                        "paginaInicial" => "790"
                        "paginaFinal" => "791"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0595"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.seminoncol.2010.09.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Oncol"
                        "fecha" => "2010"
                        "volumen" => "37"
                        "paginaInicial" => "499"
                        "paginaFinal" => "507"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0600"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "902&#46;e2-910&#46;e2"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pigmentary changes in patients treated with targeted anticancer agents&#58; A systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "77"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0605"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Ipilimumab-induced poliosis&#93; Spanish"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medcli.2013.07.005"
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;&#46;"
                        "fecha" => "2014"
                        "volumen" => "142"
                        "paginaInicial" => "234"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0610"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case report of disappearing pigmented skin lesions associated with pembrolizumab treatment for metastatic melanoma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.15354"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2018"
                        "volumen" => "178"
                        "paginaInicial" => "265"
                        "paginaFinal" => "269"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0615"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair repigmentation during immunotherapy treatment with an anti-programmed cell death 1 and anti-programmed cell death ligand 1 agent for lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2017.2106"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "153"
                        "paginaInicial" => "1162"
                        "paginaFinal" => "1165"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0620"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune-related alopecia &#40;areata and universalis&#41; in cancer patients receiving immune checkpoint inhibitors"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.15237"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "176"
                        "paginaInicial" => "1649"
                        "paginaFinal" => "1652"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0625"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata under ipilimumab"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.annder.2018.03.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Dermatol Venereol&#46;"
                        "fecha" => "2018"
                        "volumen" => "145"
                        "paginaInicial" => "465"
                        "paginaFinal" => "466"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0630"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune toxicities and long remission duration after ipilimumab therapy for metastatic melanoma&#58; Two illustrative cases"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3747/co.20.1265"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Oncol&#46;"
                        "fecha" => "2013"
                        "volumen" => "20"
                        "paginaInicial" => "e165"
                        "paginaFinal" => "e169"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0635"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistently curly hair phenotype with the use of nivolumab for squamous cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Oncol Pharm Pract&#46;"
                        "fecha" => "2017"
                        "volumen" => "23"
                        "paginaInicial" => "638"
                        "paginaFinal" => "640"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0640"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous adverse events of new anti-melanoma therapies&#58; Classification and management"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiogr"
                        "fecha" => "2017"
                        "volumen" => "108"
                        "paginaInicial" => "6"
                        "paginaFinal" => "16"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0645"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative safety of BRAF and MEK inhibitors &#40;vemurafenib&#44; dabrafenib and trametinib&#41; in first-line therapy for BRAF-mutated metastatic melanoma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3892/mco.2016.978"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Clin Oncol&#46;"
                        "fecha" => "2016"
                        "volumen" => "5"
                        "paginaInicial" => "458"
                        "paginaFinal" => "462"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0650"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Open-label&#44; multicentre safety study of vemurafenib in 3219 patients with BRAF V600 mutation-positive metastatic melanoma&#58; 2-year follow-up data and long-term responders&#8217; analysis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejca.2017.04.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cancer&#46;"
                        "fecha" => "2017"
                        "volumen" => "79"
                        "paginaInicial" => "176"
                        "paginaFinal" => "184"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0655"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous toxic effects of BRAF inhibitors alone and in combination with MEK inhibitors for metastatic melanoma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2015.1745"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "151"
                        "paginaInicial" => "1103"
                        "paginaFinal" => "1109"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0660"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "RASopathic alopecia&#58; Hair changes associated with vemurafenib therapy"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2015.01.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "72"
                        "paginaInicial" => "738"
                        "paginaFinal" => "741"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0665"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair and nail adverse events during treatment with targeted therapies for metastatic melanoma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "26"
                        "paginaInicial" => "232"
                        "paginaFinal" => "239"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0670"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Late-onset robust curly hair growth in a patient with BRAF-mutated metastatic melanoma responding to dabrafenib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1078155216635854"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oncol Pharm Pract&#46;"
                        "fecha" => "2017"
                        "volumen" => "23"
                        "paginaInicial" => "309"
                        "paginaFinal" => "312"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0675"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous adverse effects of targeted therapies&#58; Part II&#58; Inhibitors of intracellular molecular signaling pathways"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "72"
                        "paginaInicial" => "221"
                        "paginaFinal" => "236"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0680"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vemurafenib-induced pityriasis amiantacea&#58; A case report"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/15569527.2015.1100635"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cutan Ocul Toxicol&#46;"
                        "fecha" => "2016"
                        "volumen" => "35"
                        "paginaInicial" => "329"
                        "paginaFinal" => "331"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0685"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improved survival with MEK inhibition in BRAF-mutated melanoma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1203421"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2012"
                        "volumen" => "367"
                        "paginaInicial" => "107"
                        "paginaFinal" => "114"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0690"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermatologic side effects associated with the MEK 1&#47;2 inhibitor selumetinib &#40;AZD6244&#44; ARRY-142886&#41;"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10637-010-9567-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Invest New Drugs&#46;"
                        "fecha" => "2011"
                        "volumen" => "29"
                        "paginaInicial" => "1114"
                        "paginaFinal" => "1121"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0695"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Giacaman A&#44; Quintero A&#44; Boix-Vilanova J&#44; Corral-Maga&#241;a O&#44; Escalas J&#44; del Pozo LJ&#44; et al&#46; Cambios en el pelo de una ni&#241;a en tratamiento con trametinib&#46; XIX Reuni&#243;n del Grupo Espa&#241;ol de Dermatolog&#237;a Pedi&#225;trica&#46; M&#225;laga&#44; 26 y 27 de enero de 2018&#46;"
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0700"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Severe toxicity of skin rash&#44; fever and diarrhea associated with imatinib&#58; Case report and review of skin toxicities associated with tyrosine kinase inhibitors"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Drug Des Devel Ther&#46;"
                        "fecha" => "2009"
                        "volumen" => "2"
                        "paginaInicial" => "215"
                        "paginaFinal" => "219"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0705"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reversible hair depigmentation in a patient treated with imatinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.leukres.2010.11.028"
                      "Revista" => array:6 [
                        "tituloSerie" => "Leuk Res&#46;"
                        "fecha" => "2011"
                        "volumen" => "35"
                        "paginaInicial" => "e64"
                        "paginaFinal" => "e66"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0710"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pigmentary changes in a patient treated with imatinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Drugs Dermatol&#46;"
                        "fecha" => "2011"
                        "volumen" => "10"
                        "paginaInicial" => "1062"
                        "paginaFinal" => "1066"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0715"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tyrosine kinase inhibition and grey hair"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(03)12806-1"
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet&#46;"
                        "fecha" => "2003"
                        "volumen" => "361"
                        "paginaInicial" => "1056"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0720"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adverse cutaneous reactions secondary to tyrosine kinase inhibitors including imatinib mesylate&#44; nilotinib&#44; and dasatinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1529-8019.2011.01431.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2011"
                        "volumen" => "24"
                        "paginaInicial" => "386"
                        "paginaFinal" => "395"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0725"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair depigmentation during chemotherapy with dasatinib&#44; a dual Bcr-Abl&#47;Src family tyrosine kinase inhibitor"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Drugs Dermatol&#46;"
                        "fecha" => "2009"
                        "volumen" => "8"
                        "paginaInicial" => "395"
                        "paginaFinal" => "398"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0730"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair depigmentation and vitiligo-like lesions in a leukaemic paediatric patient during chemotherapy with dasatinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Derm Venereol&#46;"
                        "fecha" => "2012"
                        "volumen" => "92"
                        "paginaInicial" => "193"
                        "paginaFinal" => "220"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0735"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reversible skin and hair depigmentation during chemotherapy with dasatinib for chronic myeloid leukemia"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1346-8138.13150"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "43"
                        "paginaInicial" => "106"
                        "paginaFinal" => "107"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0740"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eruptive nevi and hair depigmentation related to regorafenib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1684/ejd.2014.2462"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "25"
                        "paginaInicial" => "85"
                        "paginaFinal" => "86"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0745"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Imatinib mesylate and gray hair"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2002"
                        "volumen" => "347"
                        "paginaInicial" => "446"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0750"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adverse cutaneous reactions to imatinib &#40;STI-571&#41; in Philadelphia chromosome positive leukemias&#58; A prospective study of 54 patients"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mjd.2003.44"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2003"
                        "volumen" => "48"
                        "paginaInicial" => "201"
                        "paginaFinal" => "206"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0755"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tyrosine kinase inhibitors for the treatment of chronic-phase chronic myeloid leukemia&#58; Long-term patient care and management"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Adv Pract Oncol&#46;"
                        "fecha" => "2016"
                        "volumen" => "7"
                        "paginaInicial" => "42"
                        "paginaFinal" => "54"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0760"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of inflammatory nonscarring alopecia associated with the tyrosine kinase inhibitor nilotinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "JAMA Dermatol&#46;"
                        "fecha" => "2013"
                        "volumen" => "149"
                        "paginaInicial" => "330"
                        "paginaFinal" => "332"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0765"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous adverse reactions of imatinib therapy in patients with chronic myeloid leukemia&#58; A six-year follow up"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "26"
                        "paginaInicial" => "133"
                        "paginaFinal" => "137"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0770"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma&#58; A randomised open-label phase 3 trial"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1470-2045(13)70465-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Oncol&#46;"
                        "fecha" => "2013"
                        "volumen" => "14"
                        "paginaInicial" => "1287"
                        "paginaFinal" => "1294"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0775"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nilotinib-induced keratosis pilaris"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000445676"
                      "Revista" => array:6 [
                        "tituloSerie" => "Case Rep Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "8"
                        "paginaInicial" => "91"
                        "paginaFinal" => "96"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0780"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nilotinib-induced keratosis pilaris associated with alopecia areata and eyebrow thinning"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/ijt.ijt_1_17"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Trichology&#46;"
                        "fecha" => "2017"
                        "volumen" => "9"
                        "paginaInicial" => "87"
                        "paginaFinal" => "89"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0785"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lichen planopilaris-like eruption during treatment with tyrosine kinase inhibitor nilotinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/abd1806-4841.20164724"
                      "Revista" => array:7 [
                        "tituloSerie" => "An Bras Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "91"
                        "numero" => "5 Suppl 1"
                        "paginaInicial" => "45"
                        "paginaFinal" => "47"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0790"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unique cutaneous reaction to second- and third-generation tyrosine kinase inhibitors for chronic myeloid leukemia"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000437383"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology&#46;"
                        "fecha" => "2016"
                        "volumen" => "232"
                        "paginaInicial" => "122"
                        "paginaFinal" => "125"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0795"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Target-driven exploratory study of imatinib mesylate in children with solid malignancies by the Innovative Therapies for Children with Cancer &#40;ITCC&#41; European Consortium"
                      "autores" => array:1 [
                        0 => array:3 [ …3]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Cancer&#46;"
                        "fecha" => "2009"
                        "volumen" => "45"
                        "paginaInicial" => "2342"
                        "paginaFinal" => "2351"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0800"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Perforating folliculitis in a patient treated with nilotinib&#58; A further evidence of c-kit involvement"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/DAD.0b013e31828cf3b7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol&#46;"
                        "fecha" => "2014"
                        "volumen" => "36"
                        "paginaInicial" => "592"
                        "paginaFinal" => "593"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0805"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advances in the management of cutaneous toxicities of targeted therapies"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.seminoncol.2012.01.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Oncol&#46;"
                        "fecha" => "2012"
                        "volumen" => "39"
                        "paginaInicial" => "227"
                        "paginaFinal" => "240"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0810"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Meta-analysis of dermatological toxicities associated with sorafenib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Exp Dermatol&#46;"
                        "fecha" => "2011"
                        "volumen" => "36"
                        "paginaInicial" => "344"
                        "paginaFinal" => "350"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0815"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antiangiogenic agents and the skin&#58; Cutaneous adverse effects of sorafenib&#44; sunitinib&#44; and bevacizumab"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2014"
                        "volumen" => "105"
                        "paginaInicial" => "900"
                        "paginaFinal" => "912"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0820"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective study of the cutaneous adverse effects of sorafenib&#44; a novel multikinase inhibitor"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Dermatol&#46;"
                        "fecha" => "2008"
                        "volumen" => "144"
                        "paginaInicial" => "886"
                        "paginaFinal" => "892"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0825"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recognizing and managing toxicities of molecular targeted therapies for colorectal cancer"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Oncology &#40;Williston Park&#41;&#46;"
                        "fecha" => "2006"
                        "volumen" => "20"
                        "numero" => "14 Suppl 10"
                        "paginaInicial" => "21"
                        "paginaFinal" => "28"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0830"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Case of alopecia induced by sorafenib&#44; possible mechanism similar to alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1346-8138.14125"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol&#46;"
                        "fecha" => "2018"
                        "volumen" => "45"
                        "paginaInicial" => "e78"
                        "paginaFinal" => "e79"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0835"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Meta-analysis of individual patient safety data from six randomized&#44; placebo-controlled trials with the antiangiogenic VEGFR2-binding monoclonal antibody ramucirumab"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/annonc/mdx514"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Oncol&#46;"
                        "fecha" => "2017"
                        "volumen" => "28"
                        "paginaInicial" => "2932"
                        "paginaFinal" => "2942"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0840"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lenvatinib versus placebo in radioiodine-refractory thyroid cancer"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1406470"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2015"
                        "volumen" => "372"
                        "paginaInicial" => "621"
                        "paginaFinal" => "630"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0845"
              "etiqueta" => "68"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermatological reactions to the multitargeted tyrosine kinase inhibitor sunitinib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00520-008-0409-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Support Care Cancer&#46;"
                        "fecha" => "2008"
                        "volumen" => "16"
                        "paginaInicial" => "557"
                        "paginaFinal" => "566"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0850"
              "etiqueta" => "69"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sunitinib and periodic hair depigmentation due to temporary c-KIT inhibition"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.144.11.1525"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol&#46;"
                        "fecha" => "2008"
                        "volumen" => "144"
                        "paginaInicial" => "1525"
                        "paginaFinal" => "1526"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0855"
              "etiqueta" => "70"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Severe toxicity of skin rash&#44; fever and diarrhea associated with imatinib&#58; Case report and review of skin toxicities associated with tyrosine kinase inhibitors"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Drug Des Devel Ther&#46;"
                        "fecha" => "2009"
                        "volumen" => "2"
                        "paginaInicial" => "215"
                        "paginaFinal" => "219"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0860"
              "etiqueta" => "71"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pazopanib in locally advanced or metastatic renal cell carcinoma&#58; Results of a randomized phase <span class="elsevierStyleSmallCaps">iii</span> trial"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2009.23.9764"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol&#46;"
                        "fecha" => "2010"
                        "volumen" => "28"
                        "paginaInicial" => "1061"
                        "paginaFinal" => "1068"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib0865"
              "etiqueta" => "72"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "pii&#58; bcr-2018-224209"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rapid hair depigmentation in patient trated with pazopanib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bcr-2018-226181"
                      "Revista" => array:4 [
                        "tituloSerie" => "BMJ Case Rep&#46;"
                        "fecha" => "2018"
                        "volumen" => "2018"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib0870"
              "etiqueta" => "73"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of distinctive hair changes associated with pazopanib in patients with renal cell carcinoma &#40;RCC&#41; versus patients without RCC&#58; A comparative systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clgc.2016.12.018"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Genitourin Cancer&#46;"
                        "fecha" => "2017"
                        "volumen" => "15"
                        "paginaInicial" => "e325"
                        "paginaFinal" => "e335"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib0875"
              "etiqueta" => "74"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of vismodegib in advanced basal-cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2012"
                        "volumen" => "366"
                        "paginaInicial" => "2171"
                        "paginaFinal" => "2179"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            74 => array:3 [
              "identificador" => "bib0880"
              "etiqueta" => "75"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vismodegib in patients with advanced basal cell carcinoma&#58; Primary analysis of STEVIE&#44; an international&#44; open-label trial"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejca.2017.08.022"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cancer&#46;"
                        "fecha" => "2017"
                        "volumen" => "86"
                        "paginaInicial" => "334"
                        "paginaFinal" => "348"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib0885"
              "etiqueta" => "76"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "1671- C 1672"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistent alopecia induced by vismodegib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "172"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            76 => array:3 [
              "identificador" => "bib0890"
              "etiqueta" => "77"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Can hair re-growth be considered an early clinical marker of treatment resistance to Hedgehog inhibitors in patients with advanced basal cell carcinoma&#63; A report of two cases"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.13754"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol&#46;"
                        "fecha" => "2016"
                        "volumen" => "30"
                        "paginaInicial" => "1726"
                        "paginaFinal" => "1729"
                        "link" => array:1 [ …1]
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            77 => array:3 [
              "identificador" => "bib0895"
              "etiqueta" => "78"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A phase <span class="elsevierStyleSmallCaps">i</span>&#44; multicenter&#44; open-label&#44; first-in-human&#44; dose-escalation study of the oral smoothened inhibitor sonidegib &#40;LDE225&#41; in patients with advanced solid tumors"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1078-0432.CCR-13-1710"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res&#46;"
                        "fecha" => "2014"
                        "volumen" => "20"
                        "paginaInicial" => "1900"
                        "paginaFinal" => "1909"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            78 => array:3 [
              "identificador" => "bib0900"
              "etiqueta" => "79"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "From basal cell carcinoma morphogenesis to the alopecia induced by Hedgehog inhibitors&#58; Connecting the dots"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.15738"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2017"
                        "volumen" => "177"
                        "paginaInicial" => "1485"
                        "paginaFinal" => "1494"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            79 => array:3 [
              "identificador" => "bib0905"
              "etiqueta" => "80"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modulation of hair growth with small molecule agonists of the Hedgehog signaling pathway"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0022-202X.2005.23867.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2005"
                        "volumen" => "125"
                        "paginaInicial" => "638"
                        "paginaFinal" => "646"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            80 => array:3 [
              "identificador" => "bib0910"
              "etiqueta" => "81"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair loss and Hedgehog inhibitors&#58; A class effect&#63;"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bjd.13619"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "173"
                        "paginaInicial" => "262"
                        "paginaFinal" => "264"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            81 => array:3 [
              "identificador" => "bib0915"
              "etiqueta" => "82"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of trichodysplasia spinulosa&#58; Case report of a patient with Gorlin syndrome treated with vismodegib"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2013.9322"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol&#46;"
                        "fecha" => "2014"
                        "volumen" => "150"
                        "paginaInicial" => "1016"
                        "paginaFinal" => "1018"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            82 => array:3 [
              "identificador" => "bib0920"
              "etiqueta" => "83"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomized phase <span class="elsevierStyleSmallCaps">ii</span> study of bortezomib alone and bortezomib in combination with docetaxel in previously treated advanced non-small-cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2006.06.1853"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2006"
                        "volumen" => "24"
                        "paginaInicial" => "5025"
                        "paginaFinal" => "5033"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            83 => array:3 [
              "identificador" => "bib0925"
              "etiqueta" => "84"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomized phase <span class="elsevierStyleSmallCaps">iii</span> study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma&#58; Combination therapy improves time to progression"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2006.10.5460"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "3892"
                        "paginaFinal" => "3901"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            84 => array:3 [
              "identificador" => "bib0930"
              "etiqueta" => "85"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy&#44; tolerance&#44; and safety of mammalian target of rapamycin inhibitors as rescue immunosuppressants in liver transplantation"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Transplant Proc&#46;"
                        "fecha" => "2009"
                        "volumen" => "41"
                        "paginaInicial" => "21813"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            85 => array:3 [
              "identificador" => "bib0935"
              "etiqueta" => "86"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation&#46;"
                        "fecha" => "2005"
                        "volumen" => "79"
                        "paginaInicial" => "476"
                        "paginaFinal" => "482"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            86 => array:3 [
              "identificador" => "bib0940"
              "etiqueta" => "87"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current clinical development of PI3K pathway inhibitors in glioblastoma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neuro Oncol&#46;"
                        "fecha" => "2012"
                        "volumen" => "14"
                        "paginaInicial" => "819"
                        "paginaFinal" => "829"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            87 => array:3 [
              "identificador" => "bib0945"
              "etiqueta" => "88"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dactolisib &#40;NVP-BEZ235&#41; toxicity in murine brain tumour models"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12885-016-2712-4"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Cancer&#46;"
                        "fecha" => "2016"
                        "volumen" => "16"
                        "paginaInicial" => "657"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            88 => array:3 [
              "identificador" => "bib0950"
              "etiqueta" => "89"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PI3K inhibitors&#58; Understanding toxicity mechanisms and management"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncology &#40;Williston Park&#41;&#46;"
                        "fecha" => "2017"
                        "volumen" => "31"
                        "paginaInicial" => "821"
                        "paginaFinal" => "828"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            89 => array:3 [
              "identificador" => "bib0955"
              "etiqueta" => "90"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Review of the clinical pharmacokinetics and pharmacodynamics of alemtuzumab and its use in kidney transplantation"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s40262-017-0573-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Pharmacokinet&#46;"
                        "fecha" => "2018"
                        "volumen" => "57"
                        "paginaInicial" => "191"
                        "paginaFinal" => "207"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            90 => array:3 [
              "identificador" => "bib0960"
              "etiqueta" => "91"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia universalis following alemtuzumab treatment in multiple sclerosis&#58; A barely recognized manifestation of secondary autoimmunity-Report of a case and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fneur.2017.00569"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Neurol&#46;"
                        "fecha" => "2017"
                        "volumen" => "8"
                         …2
                      ]
                    ]
                  ]
                ]
              ]
            ]
            91 => array:3 [
              "identificador" => "bib0965"
              "etiqueta" => "92"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Crizotinib versus chemotherapy in advanced ALK-positive lung cancer"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1214886"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            92 => array:3 [
              "identificador" => "bib0970"
              "etiqueta" => "93"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alectinib-induced alopecia in a patient with anaplastic lymphoma kinase-positive non-small cell lung cancer"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000445288"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            93 => array:3 [
              "identificador" => "bib0975"
              "etiqueta" => "94"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T-cell lymphoma"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3816/CLM.2009.n.082"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            94 => array:3 [
              "identificador" => "bib0980"
              "etiqueta" => "95"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "10 years of denosumab treatment in postmenopausal women with osteoporosis&#58; Results from the phase 3 randomised FREEDOM trial and open-label extension"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-8587(17)30138-9"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            95 => array:3 [
              "identificador" => "bib0985"
              "etiqueta" => "96"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata after denosumab treatment for osteoporosis"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [ …5]
                    ]
                  ]
                ]
              ]
            ]
            96 => array:3 [
              "identificador" => "bib0990"
              "etiqueta" => "97"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Veliparib in combination with whole-brain radiation therapy for patients with brain metastases from non-small cell lung cancer&#58; Results of a randomized&#44; global&#44; placebo-controlled study"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11060-016-2275-x"
                      "Revista" => array:7 [ …7]
                    ]
                  ]
                ]
              ]
            ]
            97 => array:3 [
              "identificador" => "bib0995"
              "etiqueta" => "98"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Veliparib with temozolomide or carboplatin&#47;paclitaxel versus placebo with carboplatin&#47;paclitaxel in patients with BRCA1&#47;2 locally recurrent&#47;metastatic breast cancer&#58; Randomized phase <span class="elsevierStyleSmallCaps">ii</span> study"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/annonc/mdx505"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            98 => array:3 [
              "identificador" => "bib1000"
              "etiqueta" => "99"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer&#58; A randomised phase 2 trial"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [ …5]
                    ]
                  ]
                ]
              ]
            ]
            99 => array:3 [
              "identificador" => "bib1005"
              "etiqueta" => "100"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interim results of brentuximab vedotin in combination with nivolumab in patients with relapsed or refractory Hodgkin lymphoma"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2017-10-811224"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            100 => array:3 [
              "identificador" => "bib1010"
              "etiqueta" => "101"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair repigmentation associated with the use of brentuximab"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jdcr.2017.09.027"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000011000000003/v1_201904030645/S1578219019300563/v1_201904030645/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6150"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Review"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011000000003/v1_201904030645/S1578219019300563/v1_201904030645/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300563?idApp=UINPBA000044"
]