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The appearance of the facial lesions coincided with worsening of pre-existing lesions on the scalp and associated hair loss&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed the presence of erythematous&#44; edematous&#44; infiltrated&#44; nondesquamative plaques on the face&#44; cervical region&#44; and upper chest &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#44; as well as erythematous&#44; desquamative&#44; alopecic plaques on the parietal and right retroauricular areas of the scalp &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Results of previous laboratory tests performed in another center revealed that the patient was positive for antinuclear antibodies &#40;ANA&#41; &#40;1&#58;320&#41; and negative for anti-Ro and anti-La antibodies&#46; All other parameters were within the normal range&#46; The results of a biopsy were consistent with lymphocytoma cutis&#46; Given the suspicion of a lymphoproliferative process induced in response to CLE&#44; new biopsies and laboratory tests were performed&#46; The results revealed a decrease in ANA levels to 1&#58;80&#46; The pathological report of the facial lesion described discrete epidermal atrophy and a perivascular and periadnexal lymphocytic infiltrate&#44; with no signs of interface dermatitis and abundant mucin deposition in the dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The results of the scalp biopsy were compatible with discoid lupus erythematosus &#40;DLE&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Based on these results the patient was diagnosed with CLE with concomitant DLE and TLE&#46; The patient began treatment with photoprotection&#44; 0&#46;05&#37; clobetasol propionate&#44; and hydroxychloroquine at an initial dose of 400&#160;mg&#47;24&#160;h followed by subsequent maintenance therapy at 200&#160;mg&#47;24&#160;h&#44; resulting in progressive clinical improvement&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The mean age of TLE patients is 36&#46;4 to 38&#46;5 years&#44; and women and men appear to be affected equally&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> Clinically&#44; TLE is characterized by the appearance in sun-exposed areas of erythematous&#44; succulent&#44; urticariform&#44; nondesquamative plaques that heal without scarring or hypopigmentation&#46; Other characteristic features are a higher frequency of photosensitivity&#44; as determined by phototesting&#44; and a lower percentage positivity for anti-double-stranded DNA &#40;dsDNA&#41;&#44; anti-Ro &#40;Sj&#246;gren&#39;s-syndrome-related antigen A&#41;&#44; and anti-La &#40;Sj&#246;gren&#39;s-syndrome-related antigen B&#41; antibodies than described for other CLE subtypes&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> Associated systemic disease in these patients appears to be very rare&#44; albeit possible&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> Histology reveals perivascular and periadnexal lymphocytic infiltrate and abundant deposition of interstitial mucin in the dermis&#46; Compared with other CLE subtypes&#44; the epidermis shows only mild alterations &#40;or is intact&#41;&#44; and basal vacuolization&#44; hyperkeratosis&#44; epidermal atrophy&#44; and follicular plugging are less marked&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Treatment with systemic antimalarials is effective in approximately 90&#37; of patients&#44; as compared with 50&#37; of DLE patients&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> In addition to other CLE subtypes&#44; the differential diagnosis should include polymorphic light eruption&#44; Jessner lymphocytic infiltrate&#44; reticular erythematous mucinosis&#44; and pseudolymphoma&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> all of which have clinical and microscopic characteristics that resemble those of TLE&#46; Consensus is lacking regarding several aspects of TLE&#44; including its differential diagnosis&#44; classification&#44; and microscopic characteristics&#46; Because several of its features are distinct from those of other forms of lupus&#44; some authors question the origin of TLE&#44; and consider it a photodermatosis outside the CLE spectrum&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> However&#44; we believe that classification of TLE as a true lupus subtype is justified based on the evidence published to date&#44; in particular the coexistence of TLE and DLE lesions in certain patients&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#8211;5&#44;9&#44;10</span></a> as in the present case&#46; Our description of a case of coexisting TLE and DLE adds to the small number of such cases reported in the literature&#44; and should help resolve some of the controversy surrounding TLE&#44; facilitating earlier diagnosis of this entity and better management of affected patients&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letters
Coexistence of Tumid Lupus Erythematosus and Discoid Lupus Erythematosus
Coexistencia de lupus eritematoso túmido y lupus eritematoso discoide
I. Abadías-Granadoa,
Autor para correspondencia
isabel.abadiasg@gmail.com

Corresponding author.
, J. Sánchez-Bernala, F. Felipo-Berlangab, M. Ara-Martína
a Servicio de Dermatología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España
b Servicio de Anatomía Patológica, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In 1909 the term lupus erythematosus tumidus was coined by Hoffmann&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> and in 1930 Gougerot and Burnier<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> described the cases of 5 patients with similar clinical pictures consisting of nonscarring&#44; erythematous&#44; indurated facial lesions without surface changes&#46; This condition&#44; also known as tumid lupus erythematosus &#40;TLE&#41;&#44; has been largely overlooked in the literature&#44; but has been recently characterized as a subtype of cutaneous lupus erythematosus &#40;CLE&#41; with peculiar clinical&#44; photobiological&#44; histological&#44; and prognostic features&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 70-year-old woman with a history of hypertension and Hashimoto thyroiditis was seen for asymptomatic skin lesions on the face that had appeared during the summer 5 months earlier and were not associated with any systemic clinical signs&#46; The appearance of the facial lesions coincided with worsening of pre-existing lesions on the scalp and associated hair loss&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed the presence of erythematous&#44; edematous&#44; infiltrated&#44; nondesquamative plaques on the face&#44; cervical region&#44; and upper chest &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#44; as well as erythematous&#44; desquamative&#44; alopecic plaques on the parietal and right retroauricular areas of the scalp &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Results of previous laboratory tests performed in another center revealed that the patient was positive for antinuclear antibodies &#40;ANA&#41; &#40;1&#58;320&#41; and negative for anti-Ro and anti-La antibodies&#46; All other parameters were within the normal range&#46; The results of a biopsy were consistent with lymphocytoma cutis&#46; Given the suspicion of a lymphoproliferative process induced in response to CLE&#44; new biopsies and laboratory tests were performed&#46; The results revealed a decrease in ANA levels to 1&#58;80&#46; The pathological report of the facial lesion described discrete epidermal atrophy and a perivascular and periadnexal lymphocytic infiltrate&#44; with no signs of interface dermatitis and abundant mucin deposition in the dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The results of the scalp biopsy were compatible with discoid lupus erythematosus &#40;DLE&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Based on these results the patient was diagnosed with CLE with concomitant DLE and TLE&#46; The patient began treatment with photoprotection&#44; 0&#46;05&#37; clobetasol propionate&#44; and hydroxychloroquine at an initial dose of 400&#160;mg&#47;24&#160;h followed by subsequent maintenance therapy at 200&#160;mg&#47;24&#160;h&#44; resulting in progressive clinical improvement&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The mean age of TLE patients is 36&#46;4 to 38&#46;5 years&#44; and women and men appear to be affected equally&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> Clinically&#44; TLE is characterized by the appearance in sun-exposed areas of erythematous&#44; succulent&#44; urticariform&#44; nondesquamative plaques that heal without scarring or hypopigmentation&#46; Other characteristic features are a higher frequency of photosensitivity&#44; as determined by phototesting&#44; and a lower percentage positivity for anti-double-stranded DNA &#40;dsDNA&#41;&#44; anti-Ro &#40;Sj&#246;gren&#39;s-syndrome-related antigen A&#41;&#44; and anti-La &#40;Sj&#246;gren&#39;s-syndrome-related antigen B&#41; antibodies than described for other CLE subtypes&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> Associated systemic disease in these patients appears to be very rare&#44; albeit possible&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> Histology reveals perivascular and periadnexal lymphocytic infiltrate and abundant deposition of interstitial mucin in the dermis&#46; Compared with other CLE subtypes&#44; the epidermis shows only mild alterations &#40;or is intact&#41;&#44; and basal vacuolization&#44; hyperkeratosis&#44; epidermal atrophy&#44; and follicular plugging are less marked&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Treatment with systemic antimalarials is effective in approximately 90&#37; of patients&#44; as compared with 50&#37; of DLE patients&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> In addition to other CLE subtypes&#44; the differential diagnosis should include polymorphic light eruption&#44; Jessner lymphocytic infiltrate&#44; reticular erythematous mucinosis&#44; and pseudolymphoma&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> all of which have clinical and microscopic characteristics that resemble those of TLE&#46; Consensus is lacking regarding several aspects of TLE&#44; including its differential diagnosis&#44; classification&#44; and microscopic characteristics&#46; Because several of its features are distinct from those of other forms of lupus&#44; some authors question the origin of TLE&#44; and consider it a photodermatosis outside the CLE spectrum&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> However&#44; we believe that classification of TLE as a true lupus subtype is justified based on the evidence published to date&#44; in particular the coexistence of TLE and DLE lesions in certain patients&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#8211;5&#44;9&#44;10</span></a> as in the present case&#46; Our description of a case of coexisting TLE and DLE adds to the small number of such cases reported in the literature&#44; and should help resolve some of the controversy surrounding TLE&#44; facilitating earlier diagnosis of this entity and better management of affected patients&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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