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    "titulo" => "Inducing Light Tolerance With Narrowband UV-B Therapy in Solar Urticaria"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Chicharro et al&#46; review the results of induction of light tolerance in patients with solar urticaria &#40;SU&#41;&#46; The mechanism by which tolerance is induced by UV radiation or visible light remains partially unknown&#46; Patients with severe SU are rarely able to get enough exposure to acquire good tolerance&#46; In moderate cases&#44; however&#44; repeated exposure to natural light can have a natural hardening effect and rarely gives rise to lesions on areas such as the face and the back of the hands&#46; The proposed mechanisms include the saturation of IgE antigen-binding regions&#44; the alteration of chromophores in the skin&#44; and UV-induced immunosuppression &#40;mast cell depletion or degranulation&#41;&#46; The thickening and&#47;or pigmentation of the epidermis can also contribute to this natural hardening&#46; This phenomenon can be used to treat SU with incremental exposure to artificial light sources&#46; Various treatment alternatives exist&#58;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Systemic psoralen&#8211;UV-A &#40;PUVA&#41;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a>&#58; This treatment has yielded satisfactory results but is not the first-line option due to its stronger association with photocarcinogenesis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Hardening with the triggering light source&#58; This treatment can require long-term maintenance and the effects only last a few days&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Inhibition spectrum treatment&#58; In this treatment modality&#44; the therapeutic spectrum is different from that which triggered the condition &#40;narrowband UV-B radiation could be used in SU induced by UV-A and&#47;or visible light&#41;&#46; This modality&#44; previously reported by other authors&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">2&#44;3</span></a> is the one described by Chicharro et al&#46; in the present issue&#46; This is the second case series&#44; after that of Calzavara-Pinton et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> to describe the use of narrowband UV-B to treat patients with SU&#46;</p></span>"
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