COMMENTARIES
Oxybenzone and Solar Filters in General: The Good and the Bad
Luces y sombras de los filtros solares, específicamente de la oxibenzona
F.J. Ortiz de Frutos
Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, España
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The upper eyelids have been spared; other areas without any reaction are the retroauricular creases and the lower inframaxillary area.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.P. Russo, A. Ipiña, J.F. Palazzolo, A.B. Cannavó, R.D. Piacentini, B. Niklasson" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.P." "apellidos" => "Russo" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Ipiña" ] 2 => array:2 [ "nombre" => "J.F." "apellidos" => "Palazzolo" ] 3 => array:2 [ "nombre" => "A.B." "apellidos" => "Cannavó" ] 4 => array:2 [ "nombre" => "R.D." "apellidos" => "Piacentini" ] 5 => array:2 [ "nombre" => "B." "apellidos" => "Niklasson" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018300917" "doi" => "10.1016/j.ad.2018.02.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018300917?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018301677?idApp=UINPBA000044" "url" => "/15782190/0000010900000006/v1_201808010420/S1578219018301677/v1_201808010420/en/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">COMMENTARIES</span>" "titulo" => "Oxybenzone and Solar Filters in General: The Good and the Bad" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "468" "paginaFinal" => "469" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "F.J. Ortiz de Frutos" "autores" => array:1 [ 0 => array:3 [ "nombre" => "F.J." "apellidos" => "Ortiz de Frutos" "email" => array:1 [ 0 => "javierortiz@aedv.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, España" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Luces y sombras de los filtros solares, específicamente de la oxibenzona" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We start by noting that allergic contact photoezcemas are uncommon,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> and allergic contact photoezcemas caused by components of sunscreens are also rare.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> A study by the North American Contact Dermatitis Group found a rate of positive reactions of 0.9% to sunscreen components among 23 000 patients who underwent skin patch and photopatch testing because of suspicion of delayed contact hypersensitivity.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Although oxybenzone (benzophenone-3 according to the International Nomenclature of Cosmetic Ingredients) has been listed for more than 20 years among products that absorb ultraviolet radiation and that are allergenic or photoallergenic, reactions to this compound were uncommon.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In recent years, however, the frequency of oxybenzone reactions has increased to the point that it is now the main allergen or photoallergen in sunscreens,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a> and it was named allergen of the year in 2014 by the North American Contact Dermatitis Group.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> The frequent cross-reactions between benzophenones and other common photoallergens such as ketoprofen, fenofibrate, and octocrylene are also cause for much concern.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Little has been published on allergies or photoallergies to oxybenzone in Spain.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> However, in cases detected by the Spanish Photobiology Group, sunscreens were the second cause of allergic contact photosensitivity (10 of 103 positive results) after nonsteroidal antiinflammatory drugs. Of all sunscreen components, benzophenone-3 was the one responsible for most positive results in 2006 (5 of 103 positive results).<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In this issue of the journal, Russo et al.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> provide new information that points to oxybenzone as the main cause of allergic contact eczemas and photoeczemas in La Plata, Argentina.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Benzophenone-3 is, in contrast, an uncommon cause of contact urticaria induced by cosmetic components.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In addition to adverse cutaneous effects, the presence of these products in urine and breast milk, contamination of fresh water, and transformation to other even more toxic products in chlorinated water and possible hormonal disruption are of great concern to toxicologists.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Sunscreens are an essential part of the prevention and treatment of skin diseases, but like other interventions, they are not devoid of adverse effects.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ortiz de Frutos FJ. Luces y sombras de los filtros solares, específicamente de la oxibenzona. Actas Dermosifiliogr. 2018;109:468–469.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0060" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photoallergic contact dermatitis is uncommon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Darvay" 1 => "I.R. White" 2 => "R.J. Rycroft" 3 => "A.B. Jones" 4 => "J.L. Hawk" 5 => "J.P. 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| 2024 Enero | 67 | 31 | 98 |
| 2023 Diciembre | 95 | 16 | 111 |
| 2023 Noviembre | 98 | 37 | 135 |
| 2023 Octubre | 107 | 30 | 137 |
| 2023 Septiembre | 100 | 39 | 139 |
| 2023 Agosto | 82 | 22 | 104 |
| 2023 Julio | 116 | 54 | 170 |
| 2023 Junio | 90 | 24 | 114 |
| 2023 Mayo | 99 | 34 | 133 |
| 2023 Abril | 54 | 31 | 85 |
| 2023 Marzo | 82 | 33 | 115 |
| 2023 Febrero | 71 | 28 | 99 |
| 2023 Enero | 58 | 46 | 104 |
| 2022 Diciembre | 67 | 56 | 123 |
| 2022 Noviembre | 48 | 33 | 81 |
| 2022 Octubre | 59 | 29 | 88 |
| 2022 Septiembre | 100 | 41 | 141 |
| 2022 Agosto | 122 | 34 | 156 |
| 2022 Julio | 78 | 34 | 112 |
| 2022 Junio | 56 | 30 | 86 |
| 2022 Mayo | 86 | 46 | 132 |
| 2022 Abril | 64 | 40 | 104 |
| 2022 Marzo | 70 | 61 | 131 |
| 2022 Febrero | 64 | 30 | 94 |
| 2022 Enero | 58 | 48 | 106 |
| 2021 Diciembre | 61 | 53 | 114 |
| 2021 Noviembre | 66 | 54 | 120 |
| 2021 Octubre | 95 | 62 | 157 |
| 2021 Septiembre | 46 | 46 | 92 |
| 2021 Agosto | 50 | 38 | 88 |
| 2021 Julio | 58 | 39 | 97 |
| 2021 Junio | 38 | 48 | 86 |
| 2021 Mayo | 45 | 55 | 100 |
| 2021 Abril | 144 | 109 | 253 |
| 2021 Marzo | 77 | 45 | 122 |
| 2021 Febrero | 56 | 47 | 103 |
| 2021 Enero | 40 | 41 | 81 |
| 2020 Diciembre | 47 | 36 | 83 |
| 2020 Noviembre | 41 | 48 | 89 |
| 2020 Octubre | 50 | 13 | 63 |
| 2020 Septiembre | 31 | 24 | 55 |
| 2020 Agosto | 44 | 30 | 74 |
| 2020 Julio | 40 | 16 | 56 |
| 2020 Junio | 42 | 39 | 81 |
| 2020 Mayo | 27 | 18 | 45 |
| 2020 Abril | 27 | 14 | 41 |
| 2020 Marzo | 24 | 15 | 39 |
| 2018 Agosto | 1 | 0 | 1 |
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