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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">An 81-year-old man with a past history of type 2 diabetes mellitus&#44; hypertension&#44; hypercholesterolemia&#44; and chronic bronchitis presented with an asymptomatic lesion on the left popliteal fossa that had grown steadily in size since appearing 1 year earlier&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination revealed a 6-mm-long erythematous pedunculated papule on the left popliteal fossa that was firm in consistency&#44; showed no erosion or ulceration&#44; and was not adherent to deeper tissues &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The patient had no palpable locoregional lymph nodes&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Complete excision of the lesion was performed&#46; Pathologic examination revealed a nonencapsulated polypoid neoformation &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; composed of dermal tumor nodules separated by fibrous tracts&#46; The nodules consisted of 2 types of cells&#58; round cells with clear cytoplasm showing a positive periodic acid-Schiff reaction &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; and polyhedral cells with round nuclei and slightly basophilic cytoplasm&#46; No mitotic figures or angiolymphatic or perineural invasion were observed&#46; Also present were cysts containing homogeneous eosinophilic material&#44; surrounded by a layer of cuboidal epithelial cells&#44; with no evidence of decapitation secretion&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Nodular hidradenoma&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course</span><p id="par0030" class="elsevierStylePara elsevierViewall">Follow-up at 1 year showed no recurrence of the lesion&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Nodular hidradenoma &#40;also known as apocrine hidradenoma&#44; clear cell hidradenoma&#44; solid-cystic hidradenoma&#44; eccrine acrospiroma&#44; and clear cell acrospiroma&#41; is a benign tumor&#46; The apocrine or eccrine differentiation of this entity has been the subject of debate&#46; Some authors have reported decapitation secretion&#44; which suggests an apocrine origin&#59; others have noted the absence of apocrine secretion and the existence of ultrastructural features of immature eccrine glands&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> This entity is more common in women and tends to appear between the fourth and sixth decades of life&#44; but cases in children have also been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> The lesion tends to present as a single&#44; slow-growing&#44; skin-colored or erythematous-brownish nodule measuring less than 2-3<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; either firm in consistency or fluctuant if the cystic component is predominant&#46; The tumors are generally asymptomatic but erosion or ulceration can be present and&#44; in cystic lesions&#44; serous discharge can be present&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Pedunculated lesions&#8212;like that of our patient&#8212;have been reported but are very rare&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> The lesion can appear on any part of the body&#44; although the head and neck&#44; trunk&#44; and upper limbs are the most common sites&#46; Dermoscopy shows homogeneous reddish&#44; bluish&#44; bluish-red&#44; or brown areas comprising all or part of the lesion&#44; whitish vascular structures such as arborizing telangiectasias&#44; and polymorphous atypical vessels&#44; making these lesions difficult to distinguish from basal cell carcinomas and melanomas&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> Immunohistochemical analysis shows positivity for anticytokeratin CAM 5&#46;2 in most tumors&#46; Carcinoembryonic antigen&#44; epithelial membrane antigen&#44; S-100 protein&#44; smooth muscle actin&#44; and vimentin are also expressed in some cases&#46; Staining with antibodies targeting various cytokeratin subtypes is variable in different parts of the tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> However&#44; immunohistochemical analysis is not usually necessary because this entity can be diagnosed easily with conventional techniques such as hematoxylin-eosin staining&#46; Malignant transformation into hidradenocarcinoma is very rare and should be suspected when histologic examination reveals a pattern of infiltrative growth&#44; necrosis&#44; nuclear pleomorphism&#44; abundant mitotic figures&#44; and angiolymphatic or perineural invasion&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Surgical resection is curative&#59; 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Case for Diagnosis
Erythematous Pedunculated Papule on the Knee
Pápula eritematosa pediculada en la rodilla
M.C. García del Pozoa,
Autor para correspondencia
sakuragarciadelpozo@hotmail.com

Corresponding author.
, C. Martín de Hijasa, L. Íñiguez de Onzoñob
a Servicio de Dermatología Médico-Quirúrgica y Venereología, Complejo Hospitalario Universitario de Albacete, Albacete, Spain
b Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Albacete, Albacete, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">An 81-year-old man with a past history of type 2 diabetes mellitus&#44; hypertension&#44; hypercholesterolemia&#44; and chronic bronchitis presented with an asymptomatic lesion on the left popliteal fossa that had grown steadily in size since appearing 1 year earlier&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination revealed a 6-mm-long erythematous pedunculated papule on the left popliteal fossa that was firm in consistency&#44; showed no erosion or ulceration&#44; and was not adherent to deeper tissues &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The patient had no palpable locoregional lymph nodes&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Complete excision of the lesion was performed&#46; Pathologic examination revealed a nonencapsulated polypoid neoformation &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; composed of dermal tumor nodules separated by fibrous tracts&#46; The nodules consisted of 2 types of cells&#58; round cells with clear cytoplasm showing a positive periodic acid-Schiff reaction &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; and polyhedral cells with round nuclei and slightly basophilic cytoplasm&#46; No mitotic figures or angiolymphatic or perineural invasion were observed&#46; Also present were cysts containing homogeneous eosinophilic material&#44; surrounded by a layer of cuboidal epithelial cells&#44; with no evidence of decapitation secretion&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Nodular hidradenoma&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course</span><p id="par0030" class="elsevierStylePara elsevierViewall">Follow-up at 1 year showed no recurrence of the lesion&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Nodular hidradenoma &#40;also known as apocrine hidradenoma&#44; clear cell hidradenoma&#44; solid-cystic hidradenoma&#44; eccrine acrospiroma&#44; and clear cell acrospiroma&#41; is a benign tumor&#46; The apocrine or eccrine differentiation of this entity has been the subject of debate&#46; Some authors have reported decapitation secretion&#44; which suggests an apocrine origin&#59; others have noted the absence of apocrine secretion and the existence of ultrastructural features of immature eccrine glands&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> This entity is more common in women and tends to appear between the fourth and sixth decades of life&#44; but cases in children have also been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> The lesion tends to present as a single&#44; slow-growing&#44; skin-colored or erythematous-brownish nodule measuring less than 2-3<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; either firm in consistency or fluctuant if the cystic component is predominant&#46; The tumors are generally asymptomatic but erosion or ulceration can be present and&#44; in cystic lesions&#44; serous discharge can be present&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Pedunculated lesions&#8212;like that of our patient&#8212;have been reported but are very rare&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> The lesion can appear on any part of the body&#44; although the head and neck&#44; trunk&#44; and upper limbs are the most common sites&#46; Dermoscopy shows homogeneous reddish&#44; bluish&#44; bluish-red&#44; or brown areas comprising all or part of the lesion&#44; whitish vascular structures such as arborizing telangiectasias&#44; and polymorphous atypical vessels&#44; making these lesions difficult to distinguish from basal cell carcinomas and melanomas&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> Immunohistochemical analysis shows positivity for anticytokeratin CAM 5&#46;2 in most tumors&#46; Carcinoembryonic antigen&#44; epithelial membrane antigen&#44; S-100 protein&#44; smooth muscle actin&#44; and vimentin are also expressed in some cases&#46; Staining with antibodies targeting various cytokeratin subtypes is variable in different parts of the tumor&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> However&#44; immunohistochemical analysis is not usually necessary because this entity can be diagnosed easily with conventional techniques such as hematoxylin-eosin staining&#46; Malignant transformation into hidradenocarcinoma is very rare and should be suspected when histologic examination reveals a pattern of infiltrative growth&#44; necrosis&#44; nuclear pleomorphism&#44; abundant mitotic figures&#44; and angiolymphatic or perineural invasion&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Surgical resection is curative&#59; however&#44; the rate of recurrence&#8212;due to incomplete resection&#8212;is approximately 10&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In this article&#44; we describe a case of nodular hidradenoma with a rare pedunculated presentation&#46; This unusual variety of the lesion must be differentiated from entities of similar morphology&#44; such as fibroepithelioma of Pinkus&#44; fibrolipoma&#44; and angioma&#46; The histologic differential diagnosis includes other clear cell malignancies such as metastatic cancer &#40;usually of renal cell carcinoma&#41; and primary cutaneous tumors with follicular&#44; sebaceous&#44; and sweat gland differentiation&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 7 12 19
2024 Octubre 91 56 147
2024 Septiembre 111 45 156
2024 Agosto 128 71 199
2024 Julio 82 43 125
2024 Junio 114 35 149
2024 Mayo 92 45 137
2024 Abril 98 23 121
2024 Marzo 91 33 124
2024 Febrero 80 38 118
2024 Enero 77 36 113
2023 Diciembre 80 19 99
2023 Noviembre 119 29 148
2023 Octubre 95 37 132
2023 Septiembre 95 48 143
2023 Agosto 65 16 81
2023 Julio 126 46 172
2023 Junio 104 29 133
2023 Mayo 84 30 114
2023 Abril 82 30 112
2023 Marzo 105 36 141
2023 Febrero 85 31 116
2023 Enero 54 50 104
2022 Diciembre 41 47 88
2022 Noviembre 35 27 62
2022 Octubre 37 30 67
2022 Septiembre 29 33 62
2022 Agosto 29 43 72
2022 Julio 27 34 61
2022 Junio 30 23 53
2022 Mayo 72 41 113
2022 Abril 50 43 93
2022 Marzo 64 43 107
2022 Febrero 59 27 86
2022 Enero 62 52 114
2021 Diciembre 40 43 83
2021 Noviembre 59 57 116
2021 Octubre 60 67 127
2021 Septiembre 53 43 96
2021 Agosto 77 49 126
2021 Julio 52 41 93
2021 Junio 51 43 94
2021 Mayo 43 61 104
2021 Abril 112 92 204
2021 Marzo 66 41 107
2021 Febrero 68 37 105
2021 Enero 48 52 100
2020 Diciembre 47 51 98
2020 Noviembre 35 42 77
2020 Octubre 28 20 48
2020 Septiembre 53 29 82
2020 Agosto 22 31 53
2020 Julio 28 21 49
2020 Junio 38 47 85
2020 Mayo 17 22 39
2020 Abril 16 16 32
2020 Marzo 27 10 37
2019 Mayo 2 1 3
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