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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Actinic keratoses are intraepidermal skin tumors that appear in the context of a type of chronic actinic damage known as field cancerization&#46; New treatments tend to cover not only clinically visible lesions&#44; but also those that harbor subclinical dysplastic changes&#46; Therefore&#44; classic drugs such as imiquimod have returned to the fore because of their formulation&#44; which is available in various concentrations&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> and the search for an optimal regimen that enables us to adapt the inflammatory reaction as much as possible to the clinical response&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In this article&#44; Serra-Guill&#233;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> investigate a new regimen of imiquimod 5&#37; cream for the treatment of actinic keratosis&#46; The authors propose a concentrated regimen in which they apply the drug daily for 12 consecutive days with the aim of finding a better response to therapy and a shorter duration of local cutaneous responses&#46; The data obtained show the regimen to be slightly more effective than that reported in the summary of product characteristics&#44; albeit at the cost of poorer tolerance&#46; Furthermore&#44; the linear correlation between the severity of the local reactions and the degree of clinical response can help us to predict the response to imiquimod&#44; which is sometimes quite erratic&#44; depending on the patient&#46; In this interesting article&#44; our colleagues from Instituto Valenciano de Oncolog&#237;a use high-quality data to reinforce the trend observed in daily clinical practice and the philosophy of &#8220;no pain&#44; no gain&#8221;&#44; which we try to transmit to patients so that a correct understanding of the mechanism of action of this drug leads to appropriate adherence and&#44; therefore&#44; a successful outcome&#46;</p></span>"
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Imiquimoid 5%: In Pursuit of New Treatment Regimens for Actinic Keratosis
Búsqueda de nuevas pautas terapéuticas de imiquimod 5% para el tratamiento de las queratosis actínicas
R. Salido Vallejo
Servicio de Dermatología, Hospital Reina Sofía, Córdoba, España
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ISSN: 15782190
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