Case and Research Letters
Cutaneous Solitary Fibrous Tumor: A Spindle Cell Neoplasm With Distinctive Immunohistochemical Features
Tumor fibroso solitario cutáneo: una neoplasia fusocelular con una inmunohistoquímica particular
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Tinción inmunohistoquímica difusa de las células tumorales para CD 34 (CD 34<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>200). B. Los núcleos expresan Stat 6 (Stat 6<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>200).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Santos-Juanes, B. García-García, Y. Hidalgo, B. Vivanco" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Santos-Juanes" ] 1 => array:2 [ "nombre" => "B." "apellidos" => "García-García" ] 2 => array:2 [ "nombre" => "Y." "apellidos" => "Hidalgo" ] 3 => array:2 [ "nombre" => "B." 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Combinación: colgajo de Karapandzic y colgajo de deslizamiento contralateral" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 732 "Ancho" => 975 "Tamanyo" => 172838 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tumor and planned incision mark.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Pérez-López, A. Martínez-López, J.C. Ruiz-Carrascosa, R. Ruiz-Villaverde" "autores" => array:4 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Pérez-López" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Martínez-López" ] 2 => array:2 [ "nombre" => "J.C." 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Toledo-Pastrana, I. Rodríguez Pérez, P. Eguino Gorrochategui" "autores" => array:3 [ 0 => array:2 [ "nombre" => "T." "apellidos" => "Toledo-Pastrana" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Rodríguez Pérez" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Eguino Gorrochategui" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0001731017303411" "doi" => "10.1016/j.ad.2017.02.031" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017303411?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018300404?idApp=UINPBA000044" "url" => "/15782190/0000010900000002/v1_201803020443/S1578219018300404/v1_201803020443/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Cutaneous Solitary Fibrous Tumor: A Spindle Cell Neoplasm With Distinctive Immunohistochemical Features" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "183" "paginaFinal" => "185" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Santos-Juanes, B. García-García, Y. Hidalgo, B. Vivanco" "autores" => array:4 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Santos-Juanes" "email" => array:1 [ 0 => "jorgesantosjuanes@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "García-García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Y." "apellidos" => "Hidalgo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "B." "apellidos" => "Vivanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Central de Asturias, Oviedo, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Dermatopatología, Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tumor fibroso solitario cutáneo: una neoplasia fusocelular con una inmunohistoquímica particular" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1250 "Ancho" => 1631 "Tamanyo" => 544530 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Polypoid, nonencapsulated lesion with a well-circumscribed dermal proliferation (hematoxylin-eosin, original magnification ×20). B and C, Note the abundant extracellular collagenous matrix in some areas of the tumor (hematoxylin-eosin, original magnification ×100 [A] and ×200 [B]). D, Detail of cells with monomorphic elongated, oval nuclei (hematoxylin-eosin, original magnification ×400).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Solitary fibrous tumor (SFT) is a mesenchymal tumor that typically arises in the pleural cavity. Extrapleural locations, such as the skin, are rare.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Cutaneous SFT, alongside dermatofibrosarcoma protuberans (DFSP), spindle cell lipoma, dendritic fibromyxolipoma, and superficial acral fibromyxoma, forms part of the family of spindle cell tumors that express CD34.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 44-year-old woman presented with a slow-growing lesion in the right inguinal region that had been present for 2 years. Physical examination revealed a firm pedunculated tumor with a wide base measuring 1.2<span class="elsevierStyleHsp" style=""></span>cm in diameter. The tumor was excised.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Histopathologic examination showed a polypoid, nonencapsulated lesion with a well-circumscribed dermal proliferation of variable cellular density composed of monomorphic, elongated, oval cells lacking atypia and with scant cytoplasm and no signs of necrosis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a><span class="elsevierStyleHsp" style=""></span>A-D). One mitotic figure was identified in 10 high-power fields. Immunohistochemical staining showed positive results for CD34, BCL-2, CD 99, and STAT-6 (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a> A and B) and negative results for epithelial membrane antigen (EMA), smooth muscle actin (SMA), and S-100 protein. The Ki67 index was 1%.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Cutaneous SFT mainly affects adults, is more common in men (male to female ratio of 4:1), and shows a predilection for the head and neck.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> The most characteristic histopathologic pattern in SFT is a “patternless spindle cell pattern”, with haphazardly arranged spindle cells that do not form a clear storiform, fascicular and/or herringbone, or wavy pattern. The cells are embedded in a collagenous matrix or in amorphous hyaline material, and a hemangiopericytoma-like vascular pattern is often seen in areas of the tumor. Diagnosis is challenging given the variable histopathologic findings. The main entity that should be considered in the differential diagnosis is DFSP. Apart from CD34, SFT expresses vimentin, bcl-2, and CD99 (with positive staining seen in between 40% and 100% of tumors in the case of bcl-2 and CD99). Staining is negative for EMA, SMA, desmin, and protein S-100. CD34 and CD99 positivity may also be observed in DFSP.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4,5</span></a> One recent study reported that <span class="elsevierStyleItalic">NAB2-STAT6</span> fusion genes were specific to SFT, indicating that the study of these genes could be of use in overlap cases.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> Nuclear immunostaining with STAT6 has high sensitivity and specificity, with positivity rates ranging from 91% in meningeal SFTs to 100% in soft tissue SFTs.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2,6,7</span></a> Immunohistochemical markers are important diagnostic tools in cutaneous SFT, and as occurs with SFTs in other locations, STAT6 has a key role in establishing an accurate diagnosis. Distant metastasis has not been observed in cutaneous SFT, but there have been 3 reports of local recurrence.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1,8,9</span></a> Cutaneous SFT, thus, like its counterparts in other locations, is considered to be a borderline tumor and hence complete surgical excision is recommended.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Santos-Juanes J, García-García B, Hidalgo Y, Vivanco B. Tumor fibroso solitario cutáneo: una neoplasia fusocelular con una inmunohistoquímica particular. Actas Dermosifiliogr. 2018;109:183–185.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1250 "Ancho" => 1631 "Tamanyo" => 544530 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Polypoid, nonencapsulated lesion with a well-circumscribed dermal proliferation (hematoxylin-eosin, original magnification ×20). B and C, Note the abundant extracellular collagenous matrix in some areas of the tumor (hematoxylin-eosin, original magnification ×100 [A] and ×200 [B]). D, Detail of cells with monomorphic elongated, oval nuclei (hematoxylin-eosin, original magnification ×400).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1472 "Ancho" => 967 "Tamanyo" => 429437 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Diffuse immunohistochemical staining of tumor cells for CD34 (CD34, original magnification ×200). B, Nuclear staining of Stat 6 (Stat 6, original magnification ×200).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Solitary fibrous tumor of the skin: A clinicopathologic study of 10 cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Erdag" 1 => "H.S. Qureshi" 2 => "J.W. Patterson" 3 => "M.R. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 15 | 8 | 23 |
| 2024 Octubre | 118 | 41 | 159 |
| 2024 Septiembre | 146 | 25 | 171 |
| 2024 Agosto | 184 | 54 | 238 |
| 2024 Julio | 122 | 27 | 149 |
| 2024 Junio | 140 | 26 | 166 |
| 2024 Mayo | 116 | 34 | 150 |
| 2024 Abril | 105 | 20 | 125 |
| 2024 Marzo | 128 | 32 | 160 |
| 2024 Febrero | 107 | 33 | 140 |
| 2024 Enero | 82 | 34 | 116 |
| 2023 Diciembre | 105 | 26 | 131 |
| 2023 Noviembre | 129 | 28 | 157 |
| 2023 Octubre | 112 | 32 | 144 |
| 2023 Septiembre | 102 | 31 | 133 |
| 2023 Agosto | 82 | 14 | 96 |
| 2023 Julio | 100 | 30 | 130 |
| 2023 Junio | 102 | 22 | 124 |
| 2023 Mayo | 101 | 24 | 125 |
| 2023 Abril | 100 | 18 | 118 |
| 2023 Marzo | 100 | 27 | 127 |
| 2023 Febrero | 88 | 27 | 115 |
| 2023 Enero | 70 | 38 | 108 |
| 2022 Diciembre | 75 | 49 | 124 |
| 2022 Noviembre | 45 | 30 | 75 |
| 2022 Octubre | 43 | 28 | 71 |
| 2022 Septiembre | 44 | 46 | 90 |
| 2022 Agosto | 42 | 38 | 80 |
| 2022 Julio | 41 | 33 | 74 |
| 2022 Junio | 41 | 29 | 70 |
| 2022 Mayo | 100 | 58 | 158 |
| 2022 Abril | 108 | 48 | 156 |
| 2022 Marzo | 108 | 72 | 180 |
| 2022 Febrero | 99 | 42 | 141 |
| 2022 Enero | 110 | 52 | 162 |
| 2021 Diciembre | 67 | 63 | 130 |
| 2021 Noviembre | 83 | 54 | 137 |
| 2021 Octubre | 62 | 60 | 122 |
| 2021 Septiembre | 76 | 51 | 127 |
| 2021 Agosto | 83 | 41 | 124 |
| 2021 Julio | 69 | 36 | 105 |
| 2021 Junio | 68 | 45 | 113 |
| 2021 Mayo | 90 | 44 | 134 |
| 2021 Abril | 137 | 85 | 222 |
| 2021 Marzo | 100 | 42 | 142 |
| 2021 Febrero | 62 | 55 | 117 |
| 2021 Enero | 66 | 45 | 111 |
| 2020 Diciembre | 76 | 39 | 115 |
| 2020 Noviembre | 51 | 47 | 98 |
| 2020 Octubre | 50 | 21 | 71 |
| 2020 Septiembre | 71 | 25 | 96 |
| 2020 Agosto | 47 | 38 | 85 |
| 2020 Julio | 34 | 26 | 60 |
| 2020 Junio | 44 | 43 | 87 |
| 2020 Mayo | 19 | 9 | 28 |
| 2020 Abril | 26 | 15 | 41 |
| 2020 Marzo | 51 | 19 | 70 |
| 2020 Febrero | 6 | 0 | 6 |
| 2020 Enero | 4 | 0 | 4 |
| 2019 Diciembre | 8 | 0 | 8 |
| 2019 Noviembre | 4 | 0 | 4 |
| 2019 Septiembre | 9 | 0 | 9 |
| 2019 Agosto | 4 | 0 | 4 |
| 2019 Julio | 4 | 0 | 4 |
| 2019 Junio | 4 | 0 | 4 |
| 2019 Mayo | 8 | 0 | 8 |
| 2019 Abril | 2 | 0 | 2 |
| 2019 Marzo | 2 | 0 | 2 |
| 2019 Febrero | 2 | 0 | 2 |
| 2018 Diciembre | 3 | 0 | 3 |
| 2018 Noviembre | 2 | 0 | 2 |
| 2018 Octubre | 1 | 2 | 3 |
| 2018 Septiembre | 2 | 0 | 2 |
| 2018 Febrero | 5 | 23 | 28 |
| 2018 Enero | 3 | 10 | 13 |
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