Opinion Article
Psoriasis-Arthritis Units: Three Years On
Unidades psoriasis-artritis: 3 años después
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López-Ferrer, A. Láiz-Alonso" "autores" => array:2 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "López-Ferrer" "email" => array:1 [ 0 => "alopezfe@santpau.cat" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Láiz-Alonso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Unidades psoriasis-artritis: 3 años después" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Since the inclusion of psoriasis as one of the Caspar classification criteria<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">1</span></a> for psoriatic arthritis in 2006, a confirmed diagnosis of psoriasis by a dermatologist has become an almost essential requirement for the confirmation of a diagnosis of psoriatic arthritis by a rheumatologist in a patient in whom an arthritic condition is being investigated. The dermatologist's intervention is particularly important when the presentation of the skin disease is not one of the common forms—such as plaque psoriasis—that can be easily recognized by a rheumatologist experienced in diagnosing and treating psoriatic arthritis. When a patient has one of the rarer and more difficult-to-diagnose forms of the skin disease (for example, flexural psoriasis, scalp psoriasis, pustular psoriasis, or nail psoriasis), confirmation by a dermatologist specialized in the management of psoriasis becomes essential.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The emergence of a wide range of new treatments in both specialties also means that rheumatologists and dermatologists must collaborate to identify the best treatment for each patient. However, the chief motivation for the creation of units where rheumatologists and dermatologists in the same hospital can work together is the need to increase early detection of arthritis in patients with psoriasis.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Joint consultations are motivated by a need to confirm the diagnosis of psoriasis in patients with joint symptoms or to diagnose arthritis in patients with psoriasis. Given that psoriasis precedes psoriatic arthritis in as many as 80% of patients, it is very likely that patients with psoriasis requiring the care of a dermatologist will develop joint symptoms at some point in the course of their lives. This means that dermatologists play a key role in screening patients with psoriasis for psoriatic arthritis and in diagnosing the joint disease when the presentation is typical. With this in mind, dermatologists who specialize in the treatment of psoriasis should always obtain a targeted medical history and perform a basic physical examination when there is any suspicion of psoriatic arthritis. If the joint disease is more difficult to diagnose, the patient should be referred to a rheumatologist promptly.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">2,3</span></a> In recent years, dermatologists who work with psoriatic patients have become increasingly aware of the need to screen for joint symptoms because of the high suspicion of arthritis in these patients. Likewise, greater involvement on both sides has facilitated collaboration between dermatologists and rheumatologists in joint units or consultations. However, while those of us who work closely with rheumatologists are very aware of the need for early detection of arthritis in patients with psoriasis, several studies have reported that specialist dermatologists in general have a low capacity for detecting arthritis,<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">4,5</span></a> a task that requires close collaboration between the two specialties to ensure prompt diagnosis of joint disease in a patient with psoriasis.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Furthermore, the questionnaires developed to detect psoriatic arthritis in patients with psoriasis (PASE, TOPAs, PEST, EARP) have now been shown not be as effective as expected,<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">6</span></a> and their use has now been relegated to a second-line position, making close collaboration between the two specialties even more essential.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Another incentive for rheumatologists and dermatologists to work together is the need to identify and agree on the best treatment for patients who have both psoriasis and arthritis and whose disease is uncontrolled in some area.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The first dermatology-rheumatology units were created in the USA based on a very different model from the one later used in Spain. According to Vélez et al, the goal of those units was to ensure the diagnosis and follow-up of patients with psoriatic arthritis and to deal with all aspects of their disease. As a result, they included clinicians from all of the relevant specialty areas, and not just dermatologists and rheumatologists. These pioneering initiatives were conceived of as multidisciplinary units for the management of a specific disease: psoriatic arthritis.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Although there is no descriptive study of a representative sample of hospitals in Spain that can provide sufficient data to support conclusions about the current situation of dermatology-rheumatology units in this country, articles have been published on some of the units set up in recent years.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">8–10</span></a> The first clinics were based on a high-efficiency model, with a high number of first visits compared to follow-up visits; in one or very few consultations the problem was resolved and the patient was referred back to the referring consultant (dermatologist or rheumatologist). These units are particularly useful for the early diagnosis of joint disease in patients with psoriasis, for confirming a diagnosis of psoriasis in a patient with arthritis, and also for starting the patient on the most appropriate treatment. However, they are not a good model for the care of complex cases or patients with a poor response to several different types of treatment.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Consequently, these units have evolved naturally towards the management of complex cases, irrespective of whether the complexity is related to the course of the psoriasis or of the joint disease. These include cases that fail to respond to conventional treatments, either because of the nature of the disease or due to comorbidities. Such cases require management by experts in both specialties to bring the disease under control and this may take several visits.</p><p id="par0045" class="elsevierStylePara elsevierViewall">In many cases, the complexity arises from the severity of the psoriasis or the joint disease and involves patients who respond only partially to the treatment prescribed for one or the other disease. They require a therapeutic approach designed through close collaboration between the two specialists, who can tailor the regimen to control both the skin and joint disease at the same time for the longest period possible.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The management and follow-up of complex cases highlights the clear correlation between the complexity of the case and the severity of the comorbidities. Patients with psoriasis, and particularly those with moderate to severe forms of the disease, tend to have comorbidities, in particular cardiovascular conditions.<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">11–14</span></a> It is well known that patients with psoriasis and psoriatic arthritis have a higher risk of cardiovascular disease and metabolic syndrome. As their doctors and as the people responsible for coordinating the overall management of their condition, we must refer them to the appropriate specialist in each case. Also well-known is the influence of obesity and metabolic syndrome on psoriasis and psoriatic arthritis and, even more important, the poorer response to conventional systemic and biologic treatments observed in patients with those conditions.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">15</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">As psoriasis is an independent cardiovascular risk factor, our multidisciplinary clinics should perhaps also incorporate physicians from other specialties, such as internal medicine, endocrinology, and cardiology. Likewise, we should establish closer communication with the primary care team working with our hospital. Dermatologists are well positioned to improve the care of psoriasis, and we also have the opportunity of detecting unhealthy blood lipid levels, persistently high glycemic values, and elevated waist circumference measurements, all of which are factors that exponentially increase the cardiovascular risk associated with psoriasis. In view of the high prevalence of psoriasis and psoriatic arthritis, collaboration between dermatologists and rheumatologists could significantly reduce cardiovascular risk in Spain.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Another medical specialty closely related to rheumatology and dermatology is hepatology because many of our patients have liver comorbidities, due mainly to fatty liver disease.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">16</span></a> Therefore, a digestive specialist is required to monitor and control their liver disease.</p><p id="par0065" class="elsevierStylePara elsevierViewall">The involvement of a digestive specialist is also warranted for patients who have inflammatory bowel disease (IBD) in addition to psoriasis and psoriatic arthritis.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">17</span></a> In such cases, all 3 specialist areas must be involved. Since the disease is often more severe and the range of treatments more limited in patients with IBD, coordination between the 3 specialists is needed to ensure that the therapeutic options available to these patients are not exhausted. Furthermore, paradoxical reactions, and particularly psoriasis-like skin reactions, occur relatively often patients with IBD in response to the biologic drugs indicated for the treatment of their intestinal disease.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">18</span></a> While these skin reactions are generally mild and self-limiting, in some cases treatment with an additional systemic drug or a switch to another biologic agent is necessary to control the paradoxical reaction—which often takes the form of generalized pustular psoriasis. In such cases, better results are achieved when the different specialists work together, bearing in mind the need to avoid exhausting available treatments unnecessarily.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Today, our improved knowledge of the physiopathogenesis of psoriatic arthritis and its comorbidities underscores the need to create real multidisciplinary units, possibly coordinated by the existing dermatology-rheumatology units, and to involve other specialists depending on the needs of each hospital.</p><p id="par0075" class="elsevierStylePara elsevierViewall">We currently have no evidence related to the collaboration between dermatologists and rheumatologists in Spain because the data available comes from a very small number of hospitals. Moreover, that study included initiatives in which the two specialists did not conduct joint consultations and which cannot, therefore, be classified as true dermatology-rheumatology units.</p><p id="par0080" class="elsevierStylePara elsevierViewall">This is not to say that the dermatology-rheumatology unit is the only possible model of collaboration between the two specialist areas. In small hospitals, where only a small number of patients are treated for complex psoriatic arthritis, consultations between these specialists can take place in other more simple ways, such as parallel consultations or a rapid pathway for such patients to access the other consultant. In all these cases, protocols developed jointly by the two specialists are needed to define the process and the pathways patients must follow between the two specialist areas until they have been diagnosed and are in treatment.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Another important consideration that must be discussed in relation to joint dermatology-rheumatology units is the cost arising from the participation of two specialists in a single consultation. As yet, there are no studies that allow us to quantify the economic viability of this option. It would, therefore, be of interest to assess the results obtained in such joint consultations.</p><p id="par0090" class="elsevierStylePara elsevierViewall">In view of the above, we believe that it is essential to obtain a more realistic overview of the current status of dermatology-rheumatology units in Spain as a whole, including the largest number of hospitals possible. This would open the way for the creation of standardized protocols and joint patient registries, two measures that would make it possible to draw much more evidence from our work with patients in daily practice.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0095" class="elsevierStylePara elsevierViewall">Dr. Anna López-Ferrer has received fees as a consultant and speaker from Abbvie, Janssen, MSD, UCB, Pfizer, Lilly, and Celgene.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Dr. Ana Láiz-Alonso has received fees as a consultant and speaker from Abbvie, Janssen, MSD, and UCB.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interests" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: López-Ferrer A, Láiz-Alonso A. Unidades psoriasis-artritis: 3 años después. Actas Dermosifiliogr. 2018;109:101–103.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0095" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification criteria for psoriatic arthritis: Development of new criteria from a large international study" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "CASPA Study Group" "etal" => false "autores" => array:6 [ 0 => "W. Taylor" 1 => "D. Gladman" 2 => "P. Helliwell" 3 => "A. Marchesoni" 4 => "P. Mease" 5 => "H. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 6 | 7 | 13 |
| 2024 Octubre | 71 | 43 | 114 |
| 2024 Septiembre | 65 | 26 | 91 |
| 2024 Agosto | 97 | 59 | 156 |
| 2024 Julio | 61 | 26 | 87 |
| 2024 Junio | 58 | 41 | 99 |
| 2024 Mayo | 47 | 36 | 83 |
| 2024 Abril | 64 | 25 | 89 |
| 2024 Marzo | 58 | 24 | 82 |
| 2024 Febrero | 65 | 27 | 92 |
| 2024 Enero | 45 | 34 | 79 |
| 2023 Diciembre | 53 | 15 | 68 |
| 2023 Noviembre | 66 | 20 | 86 |
| 2023 Octubre | 76 | 14 | 90 |
| 2023 Septiembre | 51 | 35 | 86 |
| 2023 Agosto | 49 | 5 | 54 |
| 2023 Julio | 56 | 31 | 87 |
| 2023 Junio | 78 | 20 | 98 |
| 2023 Mayo | 54 | 24 | 78 |
| 2023 Abril | 52 | 18 | 70 |
| 2023 Marzo | 62 | 23 | 85 |
| 2023 Febrero | 51 | 26 | 77 |
| 2023 Enero | 47 | 33 | 80 |
| 2022 Diciembre | 49 | 32 | 81 |
| 2022 Noviembre | 38 | 29 | 67 |
| 2022 Octubre | 20 | 26 | 46 |
| 2022 Septiembre | 16 | 39 | 55 |
| 2022 Agosto | 22 | 32 | 54 |
| 2022 Julio | 21 | 34 | 55 |
| 2022 Junio | 23 | 27 | 50 |
| 2022 Mayo | 34 | 51 | 85 |
| 2022 Abril | 42 | 45 | 87 |
| 2022 Marzo | 69 | 56 | 125 |
| 2022 Febrero | 43 | 26 | 69 |
| 2022 Enero | 37 | 44 | 81 |
| 2021 Diciembre | 30 | 54 | 84 |
| 2021 Noviembre | 36 | 54 | 90 |
| 2021 Octubre | 47 | 58 | 105 |
| 2021 Septiembre | 34 | 51 | 85 |
| 2021 Agosto | 26 | 35 | 61 |
| 2021 Julio | 24 | 37 | 61 |
| 2021 Junio | 43 | 42 | 85 |
| 2021 Mayo | 47 | 55 | 102 |
| 2021 Abril | 58 | 82 | 140 |
| 2021 Marzo | 86 | 55 | 141 |
| 2021 Febrero | 79 | 41 | 120 |
| 2021 Enero | 50 | 50 | 100 |
| 2020 Diciembre | 58 | 42 | 100 |
| 2020 Noviembre | 40 | 40 | 80 |
| 2020 Octubre | 30 | 23 | 53 |
| 2020 Septiembre | 29 | 22 | 51 |
| 2020 Agosto | 46 | 37 | 83 |
| 2020 Julio | 37 | 41 | 78 |
| 2020 Junio | 31 | 35 | 66 |
| 2020 Mayo | 14 | 11 | 25 |
| 2020 Abril | 40 | 17 | 57 |
| 2020 Marzo | 17 | 11 | 28 |
| 2020 Febrero | 6 | 0 | 6 |
| 2020 Enero | 4 | 0 | 4 |
| 2019 Diciembre | 8 | 0 | 8 |
| 2019 Noviembre | 4 | 0 | 4 |
| 2019 Septiembre | 14 | 0 | 14 |
| 2019 Agosto | 4 | 0 | 4 |
| 2019 Julio | 4 | 0 | 4 |
| 2019 Junio | 4 | 0 | 4 |
| 2019 Mayo | 6 | 0 | 6 |
| 2019 Abril | 2 | 0 | 2 |
| 2019 Marzo | 2 | 0 | 2 |
| 2019 Febrero | 2 | 0 | 2 |
| 2018 Diciembre | 5 | 0 | 5 |
| 2018 Noviembre | 2 | 0 | 2 |
| 2018 Octubre | 2 | 0 | 2 |
| 2018 Septiembre | 3 | 0 | 3 |
| 2018 Marzo | 1 | 1 | 2 |
| 2018 Febrero | 1 | 7 | 8 |
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