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Physical examination revealed the presence of numerous&#44; small &#40;2-4<span class="elsevierStyleHsp" style=""></span>mm&#41;&#44; well-defined papules of whitish color and with a verrucous surface lying on a background of mild erythema &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; A and B&#41;&#46; Histology of one of the lesions showed an acanthotic epidermis with intense orthokeratotic hyperkeratosis with hypergranulosis and papillomatosis&#46; Abundant large keratohyalin granules were observed in the stratum granulosum&#44; associated with vacuolar cell degeneration and edema&#44; giving rise to focal separation in the upper third of the epidermis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; C and D&#41;&#46; No histopathological changes suggestive of human papillomavirus &#40;HPV&#41; infection were present&#44; and immunohistochemistry with anti-HPV antibodies was negative&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Treatment with 0&#46;1&#37; pimecrolimus cream was prescribed for the pruritus&#44; and the lesions were then treated using cryotherapy&#44; causing increased discomfort&#46; A slight improvement was observed at the following visit&#44; with reduced erythema and pruritus&#44; and the lesions treated with cryotherapy had resolved&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">EA is a benign and usually asymptomatic tumor that typically presents in adult individuals&#46; It has been described as a solitary lesion&#44; though occasionally it can present with multiple lesions that may be localized or widespread&#46; The solitary forms can arise at any site&#44; whereas multiple or widespread lesions appear to preferentially affect the genitocrural region&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinically&#44; multiple genital EA lesions present as numerous&#44; flat or verrucous&#44; skin-colored or whitish papules on the scrotum&#44; vulva&#44; perineum&#44; or occasionally perianal region&#46; The lesions can be asymptomatic or produce a variable degree of pruritus&#44; causing scratching and persistence of the condition&#46; The differential diagnosis includes other diseases more prevalent in the genital region&#44; such as condyloma acuminatum&#44; bowenoid papulosis&#44; and molluscum contagiosum&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Histologically there is a compact hyperkeratosis&#46; Vacuolar degeneration of keratinocytes is observed in the granular layer and stratum spinosum of the epidermis&#44; together with the presence of cytoplasmic amphophilic material and numerous basophilic bodies similar to keratohyalin and amorphous eosinophilic bodies of the trichohyalin type&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The etiopathogenesis of EA is unknown&#46; Some potential triggers have been identified&#44; including viral infections&#44; UV exposure&#44; immunosuppression&#44; and recurrent trauma &#40;scratching&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#8211;7</span></a> Mutations in the keratin K1 and K10 genes have been reported in isolated cases&#44; and there has been no evidence of the presence or participation of HPV in the majority of cases studied&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Multiple asymptomatic EA does not require treatment&#46; However&#44; certain topical keratolytic treatments &#40;lactic&#44; salicylic&#44; or glycolic acid&#41; have been found to be effective in some cases&#44; as have more aggressive treatments&#44; such as curettage&#44; cryotherapy&#44; and carbon dioxide laser&#46; Low-potency topical corticosteroids can be useful in cases with pruritus&#44; and the use of calcineurin inhibitors has also recently been described&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Multiple anogenital EA is a clinical variant of EA that can present with persistent genital pruritus and must be included in the differential diagnosis of multiple papular genital lesions&#46; The characteristic histological findings of EA make skin biopsy useful to confirm the diagnosis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letters
Multiple Epidermolytic Acanthomas on the Scrotum: What Genital Pruritus Can Reveal
Acantomas epidermolíticos múltiples del escroto: Lo que el prurito genital puede esconder
P. García-Martínez
Autor para correspondencia
pablogmh@gmail.com

Corresponding author.
, L. Curto-Barredo, R. Rovira-López, R.M. Pujol
Servicio Dermatología, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain
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    "titulo" => "Multiple Epidermolytic Acanthomas on the Scrotum&#58; What Genital Pruritus Can Reveal"
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Physical examination revealed the presence of numerous&#44; small &#40;2-4<span class="elsevierStyleHsp" style=""></span>mm&#41;&#44; well-defined papules of whitish color and with a verrucous surface lying on a background of mild erythema &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; A and B&#41;&#46; Histology of one of the lesions showed an acanthotic epidermis with intense orthokeratotic hyperkeratosis with hypergranulosis and papillomatosis&#46; Abundant large keratohyalin granules were observed in the stratum granulosum&#44; associated with vacuolar cell degeneration and edema&#44; giving rise to focal separation in the upper third of the epidermis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; C and D&#41;&#46; No histopathological changes suggestive of human papillomavirus &#40;HPV&#41; infection were present&#44; and immunohistochemistry with anti-HPV antibodies was negative&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Treatment with 0&#46;1&#37; pimecrolimus cream was prescribed for the pruritus&#44; and the lesions were then treated using cryotherapy&#44; causing increased discomfort&#46; A slight improvement was observed at the following visit&#44; with reduced erythema and pruritus&#44; and the lesions treated with cryotherapy had resolved&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">EA is a benign and usually asymptomatic tumor that typically presents in adult individuals&#46; It has been described as a solitary lesion&#44; though occasionally it can present with multiple lesions that may be localized or widespread&#46; The solitary forms can arise at any site&#44; whereas multiple or widespread lesions appear to preferentially affect the genitocrural region&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinically&#44; multiple genital EA lesions present as numerous&#44; flat or verrucous&#44; skin-colored or whitish papules on the scrotum&#44; vulva&#44; perineum&#44; or occasionally perianal region&#46; The lesions can be asymptomatic or produce a variable degree of pruritus&#44; causing scratching and persistence of the condition&#46; The differential diagnosis includes other diseases more prevalent in the genital region&#44; such as condyloma acuminatum&#44; bowenoid papulosis&#44; and molluscum contagiosum&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Histologically there is a compact hyperkeratosis&#46; Vacuolar degeneration of keratinocytes is observed in the granular layer and stratum spinosum of the epidermis&#44; together with the presence of cytoplasmic amphophilic material and numerous basophilic bodies similar to keratohyalin and amorphous eosinophilic bodies of the trichohyalin type&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The etiopathogenesis of EA is unknown&#46; Some potential triggers have been identified&#44; including viral infections&#44; UV exposure&#44; immunosuppression&#44; and recurrent trauma &#40;scratching&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#8211;7</span></a> Mutations in the keratin K1 and K10 genes have been reported in isolated cases&#44; and there has been no evidence of the presence or participation of HPV in the majority of cases studied&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Multiple asymptomatic EA does not require treatment&#46; However&#44; certain topical keratolytic treatments &#40;lactic&#44; salicylic&#44; or glycolic acid&#41; have been found to be effective in some cases&#44; as have more aggressive treatments&#44; such as curettage&#44; cryotherapy&#44; and carbon dioxide laser&#46; Low-potency topical corticosteroids can be useful in cases with pruritus&#44; and the use of calcineurin inhibitors has also recently been described&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Multiple anogenital EA is a clinical variant of EA that can present with persistent genital pruritus and must be included in the differential diagnosis of multiple papular genital lesions&#46; The characteristic histological findings of EA make skin biopsy useful to confirm the diagnosis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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