Case and Research Letter
Primary Mucinous Carcinoma of the Skin: A Case Report
Carcinoma mucinoso primario cutáneo: presentación de un caso
Leído
7015
Vecesse ha leído el artículo
2024
Total PDF
4991
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S1578219017302640" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.08.008" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "1705" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2017" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:884-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 496 "formatos" => array:3 [ "EPUB" => 25 "HTML" => 372 "PDF" => 99 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731017302739" "issn" => "00017310" "doi" => "10.1016/j.ad.2017.03.013" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "1705" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:884-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 178 "formatos" => array:3 [ "EPUB" => 1 "HTML" => 147 "PDF" => 30 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => "Carcinoma mucinoso primario cutáneo: presentación de un caso" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "884" "paginaFinal" => "886" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Primary Mucinous Carcinoma of the Skin: A Case Report" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1005 "Ancho" => 2000 "Tamanyo" => 289602 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Muestra de piel, desprovista de epidermis. Se observan anejos cutáneos normales en relación con tumor mucinoso (flecha) (H&E, ×2); B) Detalle del tumor con lagos de mucina que contienen nidos tumorales, en áreas de aspecto cordonal y cribiforme (H&E, ×10); C) Tinción de PAS positiva en los lagos de mucina (×10); D) positividad intensa y difusa para CK7 en las células neoplásicas (×10); E) Negatividad para CK20 (×10); F) Dos microfotografías que muestran el detalle de la positividad nuclear para p63 en aisladas células dentro de los nidos tumorales, que corresponden a un componente mioepitelial detectable en el tumor, favoreciendo origen cutáneo del mismo (×20).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Areán-Cuns, A. Córdoba-Iturriagagoitia, B. Aguiar-Losada, I. Yanguas-Bayona" "autores" => array:4 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Areán-Cuns" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Córdoba-Iturriagagoitia" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Aguiar-Losada" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Yanguas-Bayona" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219017302640" "doi" => "10.1016/j.adengl.2017.08.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017302640?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017302739?idApp=UINPBA000044" "url" => "/00017310/0000010800000009/v1_201711021011/S0001731017302739/v1_201711021011/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219017302743" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.04.007" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "1702" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2017;108:887" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 281 "formatos" => array:3 [ "EPUB" => 19 "HTML" => 168 "PDF" => 94 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Clinical Features of Merkel Cell Carcinoma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "887" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Características clínicas del carcinoma de células de Merkel" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Marcoval, J.R. Ferreres" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Marcoval" ] 1 => array:2 [ "nombre" => "J.R." "apellidos" => "Ferreres" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731017302703" "doi" => "10.1016/j.ad.2017.04.020" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017302703?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017302743?idApp=UINPBA000044" "url" => "/15782190/0000010800000009/v1_201711021004/S1578219017302743/v1_201711021004/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219017302652" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.08.009" "estado" => "S300" "fechaPublicacion" => "2017-11-01" "aid" => "1707" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:882-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 266 "formatos" => array:3 [ "EPUB" => 21 "HTML" => 154 "PDF" => 91 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Lichen Striatus in Childhood: Is It Associated With Atopic Dermatitis?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "882" "paginaFinal" => "884" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Liquen estriado en la infancia. ¿Una entidad relacionada con la dermatitis atópica?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1905 "Ancho" => 1500 "Tamanyo" => 885049 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical photograph of a patient with lichen striatus.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.I. García-Briz, S. Santos-Alarcón, M.D. Fuertes-Prosper, A. Mateu-Puchades" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M.I." "apellidos" => "García-Briz" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Santos-Alarcón" ] 2 => array:2 [ "nombre" => "M.D." "apellidos" => "Fuertes-Prosper" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Mateu-Puchades" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017302652?idApp=UINPBA000044" "url" => "/15782190/0000010800000009/v1_201711021004/S1578219017302652/v1_201711021004/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Primary Mucinous Carcinoma of the Skin: A Case Report" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "884" "paginaFinal" => "886" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Areán-Cuns, A. Córdoba-Iturriagagoitia, B. Aguiar-Losada, I. Yanguas-Bayona" "autores" => array:4 [ 0 => array:4 [ "nombre" => "C." "apellidos" => "Areán-Cuns" "email" => array:1 [ 0 => "carolina.arean.cuns@navarra.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Córdoba-Iturriagagoitia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "B." "apellidos" => "Aguiar-Losada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Yanguas-Bayona" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma mucinoso primario cutáneo: presentación de un caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1005 "Ancho" => 2000 "Tamanyo" => 289602 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Skin sample after removal of the epidermis. Normal skin adnexa may be observed in the mucinous tumor (arrow). Hematoxylin and eosin (H&E), original magnification<span class="elsevierStyleHsp" style=""></span>×2. B, Detail of the tumor with lakes of mucin that contain tumor nests, with a cord-like and cribriform appearance in some areas. H&E, original magnification<span class="elsevierStyleHsp" style=""></span>×10. C, Positive staining with period acid Schiff (PAS) in the lakes of mucin. PAS, original magnification<span class="elsevierStyleHsp" style=""></span>×10. D, Diffuse, intense positivity for CK7 in the neoplastic cells. Original magnification<span class="elsevierStyleHsp" style=""></span>×10. E, Negative stain for CK20. Original magnification<span class="elsevierStyleHsp" style=""></span>×10. F, Two photomicrographs showing details of nuclear positivity for p63 in isolated cells within the tumor nests; these cells correspond to a detectable myoepithelial component in the tumor, supporting the cutaneous origin of the tumor. Original magnification<span class="elsevierStyleHsp" style=""></span>×20.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Primary cutaneous mucinous carcinoma (PCMC) is a rare neoplasm of the adnexa of the skin, with around 150 cases published in the literature.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,2</span></a> Clinically, it usually presents in adults as a solitary, asymptomatic, erythematous nodule, papule, or cyst of variable size, typically occurring on the face or scalp or in the axilla.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> It had been thought to arise from the eccrine sweat glands,<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2,3</span></a> but apocrine differentiation has recently been shown in some cases.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> In general, PCMCs are slow-growing tumors and have an indolent behavior.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> However, late recurrence and metastases have been reported, probably related to incomplete excision of the tumor.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Histologically, it is indistinguishable from metastatic mucinous adenocarcinomas from other organs,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> particularly from the breast, which can make diagnosis difficult. We present a case of this rare entity and review the literature, discussing the main recommendations and the immunohistochemical reactions useful to reach a correct diagnosis.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Description</span><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 68-year-old man with no past history of interest. He was seen for a mobile nodular lesion that had been present for 2 years in the left axilla. The lesion was not adherent to deeper planes and measured 1.5<span class="elsevierStyleHsp" style=""></span>cm in diameter. The clinical diagnosis was epidermal cyst. Macroscopically, the sample consisted of a number of reddish fragments of soft tissue, including areas with a gelatinous appearance, with an overall diameter of 3<span class="elsevierStyleHsp" style=""></span>cm. Histologically, there were fragments of skin with abundant eccrine and apocrine glands that were diffusely infiltrated by lakes of mucin (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). These lakes contained cords and solid nests of cuboidal and round epithelial cells that, in some areas, formed glandular structures, with scattered cribriform lumina (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). The cells presented cytologic atypia and occasional mitotic figures. Periodic acid Schiff stain revealed an abundant quantity of mucin (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C). Immunohistochemistry was positive for CK7 (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D), CK19, epithelial membrane antigen, GATA3, estrogen receptors (ER), progesterone receptors (PR), and p63 (in isolated small cells) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>F); the study was negative for CK20 (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>E), CK5/6, CD15, and mammaglobin. The pathologic diagnosis based on these findings was mucinous carcinoma. Subsequently the patient underwent complete clinical evaluation, including positron emission tomography (PET) in which no increased uptake was observed in other organs. In cases such as ours, it cannot be ruled out that the tumor may have arisen in a focus of ectopic breast tissue in the axilla; however, as no remnant of healthy breast tissue was observed in the surgical sample, we made a definitive diagnosis of PCMC.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">PCMC is a rare entity that was first described in 1952 by Lenox et al.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> It usually shows an indolent clinical course and is typically present for several years before diagnosis; it is often misdiagnosed clinically as an epidermal cyst, sebaceous carcinoma, cystic basal cell carcinoma, squamous cell carcinoma, neuroma, or pilomatrixoma.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Late recurrence and metastases due to incomplete excision of the tumor<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> and lymphovascular invasion have been reported.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Apparently, such recurrences have not responded well to treatment with radiotherapy or chemotherapy.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Morphologically, it is not possible to differentiate PCMC from metastatic mucinous adenocarcinomas of noncutaneous organs.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Immunohistochemistry can exclude metastatic mucinous adenocarcinomas from the colon, as these tumors are usually positive for CK20<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> and CDX2, whereas PCMC is negative for these markers. However, immunohistochemistry is not particularly useful in distinguishing PCMC from mucinous adenocarcinoma of the breast, as both tumors can express CK7,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> GATA3,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> mammaglobin, REs, and<span class="elsevierStyleHsp" style=""></span>PRs.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">It has recently been suggested in the literature that detection of a myoepithelial component in the tumor (confirmed by positivity for p63, CK5/6, or calponin, in isolated peripheral cells) supports or suggests PCMC, but unfortunately this is not a common finding.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,2</span></a> In our case, we did detect the presence of this remnant of myoepithelial cells with immune stain for p63 (Fig.<span class="elsevierStyleHsp" style=""></span>1F); however, CK5/6 was negative.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In view of this situation, it is strictly necessary to perform a metastatic workup (computed tomography and/or PET), which must be negative in order to confirm that the lesion is not a metastasis from another primary site and to make a definitive diagnosis of PCMC.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion, despite the low incidence of PCMC, it must be included in the differential diagnosis of a mucosecretory adenocarcinoma in the skin. Using immunohistochemistry techniques, it is now possible to differentiate PCMC from metastatic mucinous adenocarcinomas from a primary in the colon, as these colonic tumors are positive for CK20 and CDX2. However, no immunohistochemistry panel has yet been identified that will consistently differentiate PCMC from metastatic mucinous adenocarcinomas of the breast, though detection of a residual myoepithelial component (confirmed by positivity for p63, CK5/6, or calponin in isolated peripheral cells) suggests a primary cutaneous origin.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Finally, it is essential to establish an adequate clinical correlation and make the diagnosis of PCMC as a diagnosis of exclusion, after ruling out the presence of a primary tumor in other organs.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,2</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case Description" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Discussion" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of Interest" ] 3 => array:2 [ "identificador" => "xack315545" "titulo" => "Acknowledgments" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Areán-Cuns C, Córdoba-Iturriagagoitia A, Aguiar-Losada B, Yanguas-Bayona I. Carcinoma mucinoso primario cutáneo: presentación de un caso. Actas Dermosifiliogr. 2017;108:884–886.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1005 "Ancho" => 2000 "Tamanyo" => 289602 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Skin sample after removal of the epidermis. Normal skin adnexa may be observed in the mucinous tumor (arrow). Hematoxylin and eosin (H&E), original magnification<span class="elsevierStyleHsp" style=""></span>×2. B, Detail of the tumor with lakes of mucin that contain tumor nests, with a cord-like and cribriform appearance in some areas. H&E, original magnification<span class="elsevierStyleHsp" style=""></span>×10. C, Positive staining with period acid Schiff (PAS) in the lakes of mucin. PAS, original magnification<span class="elsevierStyleHsp" style=""></span>×10. D, Diffuse, intense positivity for CK7 in the neoplastic cells. Original magnification<span class="elsevierStyleHsp" style=""></span>×10. E, Negative stain for CK20. Original magnification<span class="elsevierStyleHsp" style=""></span>×10. F, Two photomicrographs showing details of nuclear positivity for p63 in isolated cells within the tumor nests; these cells correspond to a detectable myoepithelial component in the tumor, supporting the cutaneous origin of the tumor. Original magnification<span class="elsevierStyleHsp" style=""></span>×20.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemical techniques to compare primary vs metastatic mucinous carcinoma of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Levy" 1 => "A. Finkelstein" 2 => "J. McNiff" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0560.2009.01436.x" "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "2010" "volumen" => "37" "paginaInicial" => "411" "paginaFinal" => "415" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19788442" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Adefusika" 1 => "J. Pimentel" 2 => "R. Chavan" 3 => "J. Brewer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DSS.0000000000000198" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2015" "volumen" => "41" "paginaInicial" => "201" "paginaFinal" => "208" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25627628" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0045" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous mucinous carcinoma a systematic review and meta-analysis of outcomes after surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Kamalpour" 1 => "R. Brindise" 2 => "M. Nodzenski" 3 => "D. Bach" 4 => "E. Veledar" 5 => "M. Alam" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2013.6006" "Revista" => array:6 [ "tituloSerie" => "JAMA Dermatol" "fecha" => "2014" "volumen" => "150" "paginaInicial" => "380" "paginaFinal" => "384" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24452370" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0050" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary mucinous carcinoma of the skin: usefulness of p63 in excluding metastasis and first report of psammoma bodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Kalebi" 1 => "M. Hale" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2008" "volumen" => "30" "paginaInicial" => "511" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary mucinous adenocarcinoma of the scalp: a case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O. Beteddini" 1 => "S. Sheikh" 2 => "F. Shareefi" 3 => "R. Shahab" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijscr.2015.02.006" "Revista" => array:6 [ "tituloSerie" => "Int J Surg Case Rep" "fecha" => "2015" "volumen" => "10" "paginaInicial" => "241" "paginaFinal" => "244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25708135" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "GATA3 expression in normal skin and in benign and malignant epidermal and cutaneous adnexal neoplasms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Mertens" 1 => "M. De Peralta-Venturina" 2 => "B. Balzer" 3 => "D. Frishberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0000000000000306" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2015" "volumen" => "37" "paginaInicial" => "885" "paginaFinal" => "891" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26595821" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack315545" "titulo" => "Acknowledgments" "texto" => "<p id="par0045" class="elsevierStylePara elsevierViewall">The authors would like to thank the Dermatology Department and the technicians of the Pathology Department of Complejo Hospitalario de Navarra.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010800000009/v1_201711021004/S1578219017302640/v1_201711021004/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010800000009/v1_201711021004/S1578219017302640/v1_201711021004/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017302640?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 15 | 12 | 27 |
| 2024 Octubre | 162 | 46 | 208 |
| 2024 Septiembre | 165 | 40 | 205 |
| 2024 Agosto | 185 | 87 | 272 |
| 2024 Julio | 167 | 41 | 208 |
| 2024 Junio | 154 | 67 | 221 |
| 2024 Mayo | 117 | 41 | 158 |
| 2024 Abril | 97 | 36 | 133 |
| 2024 Marzo | 117 | 36 | 153 |
| 2024 Febrero | 123 | 39 | 162 |
| 2024 Enero | 103 | 43 | 146 |
| 2023 Diciembre | 106 | 30 | 136 |
| 2023 Noviembre | 118 | 25 | 143 |
| 2023 Octubre | 97 | 37 | 134 |
| 2023 Septiembre | 94 | 39 | 133 |
| 2023 Agosto | 108 | 30 | 138 |
| 2023 Julio | 114 | 34 | 148 |
| 2023 Junio | 97 | 29 | 126 |
| 2023 Mayo | 106 | 30 | 136 |
| 2023 Abril | 87 | 31 | 118 |
| 2023 Marzo | 100 | 28 | 128 |
| 2023 Febrero | 98 | 22 | 120 |
| 2023 Enero | 78 | 40 | 118 |
| 2022 Diciembre | 63 | 39 | 102 |
| 2022 Noviembre | 35 | 26 | 61 |
| 2022 Octubre | 32 | 22 | 54 |
| 2022 Septiembre | 24 | 37 | 61 |
| 2022 Agosto | 29 | 32 | 61 |
| 2022 Julio | 26 | 43 | 69 |
| 2022 Junio | 23 | 30 | 53 |
| 2022 Mayo | 84 | 48 | 132 |
| 2022 Abril | 67 | 41 | 108 |
| 2022 Marzo | 125 | 52 | 177 |
| 2022 Febrero | 93 | 30 | 123 |
| 2022 Enero | 117 | 28 | 145 |
| 2021 Diciembre | 60 | 34 | 94 |
| 2021 Noviembre | 128 | 47 | 175 |
| 2021 Octubre | 93 | 49 | 142 |
| 2021 Septiembre | 80 | 39 | 119 |
| 2021 Agosto | 64 | 27 | 91 |
| 2021 Julio | 59 | 28 | 87 |
| 2021 Junio | 61 | 34 | 95 |
| 2021 Mayo | 48 | 50 | 98 |
| 2021 Abril | 140 | 75 | 215 |
| 2021 Marzo | 99 | 26 | 125 |
| 2021 Febrero | 67 | 21 | 88 |
| 2021 Enero | 60 | 29 | 89 |
| 2020 Diciembre | 48 | 15 | 63 |
| 2020 Noviembre | 42 | 15 | 57 |
| 2020 Octubre | 39 | 24 | 63 |
| 2020 Septiembre | 38 | 14 | 52 |
| 2020 Agosto | 38 | 21 | 59 |
| 2020 Julio | 36 | 17 | 53 |
| 2020 Junio | 31 | 26 | 57 |
| 2020 Mayo | 15 | 12 | 27 |
| 2020 Abril | 23 | 16 | 39 |
| 2020 Marzo | 21 | 15 | 36 |
| 2020 Febrero | 5 | 0 | 5 |
| 2019 Diciembre | 4 | 0 | 4 |
| 2019 Septiembre | 10 | 0 | 10 |
| 2019 Mayo | 4 | 1 | 5 |
| 2019 Abril | 1 | 0 | 1 |
| 2019 Febrero | 2 | 0 | 2 |
| 2019 Enero | 2 | 0 | 2 |
| 2018 Diciembre | 2 | 0 | 2 |
| 2018 Noviembre | 1 | 0 | 1 |
| 2018 Octubre | 3 | 0 | 3 |
| 2018 Septiembre | 3 | 0 | 3 |
| 2018 Febrero | 34 | 5 | 39 |
| 2018 Enero | 57 | 11 | 68 |
| 2017 Diciembre | 53 | 15 | 68 |
| 2017 Noviembre | 154 | 38 | 192 |
| 2017 Octubre | 37 | 18 | 55 |
| 2017 Septiembre | 3 | 11 | 14 |
Mostrar todo
