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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Primary cutaneous lymphomas have a low incidence in the general population&#46; The clinical presentation is very variable&#44; often making the diagnosis unexpected for the dermatologist&#46; Although the diagnosis of these lesions always requires histopathologic confirmation&#44; skin ultrasound is an additional tool that can be helpful for the initial diagnosis of malignancy&#46; We present a case of primary cutaneous CD4&#43; small&#47;medium T-cell lymphoproliferative disorder &#40;PCSM-TCLD&#41; and its ultrasound findings&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 55-year-old woman with a past history of hypothyroidism and dyslipidemia came to the emergency department for a pruritic lesion in the right scapular region&#59; the lesion had grown rapidly in the previous 2 months&#46; She reported no fever&#44; asthenia&#44; or weight loss&#44; and she denied any previous lesions or trauma&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed a solid&#44; tender erythematous-violaceous nodule of 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;5<span class="elsevierStyleHsp" style=""></span>cm in the right scapular region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The nodule was not adherent to deeper planes&#46; A surgical drainage-aspiration procedure performed in the emergency department excluded the presence of fluid collections&#46; There were no palpable lymph nodes or hepatosplenomegaly&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Skin ultrasound of the lesion was performed in dermatology outpatient clinic&#46; Examination in B mode &#40;18<span class="elsevierStyleHsp" style=""></span>MHz probe&#44; MyLab 25 Gold&#44; Esaote&#44; Italy&#41; revealed a dermal nodule of 20<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>11<span class="elsevierStyleHsp" style=""></span>mm&#44; with deep extension into the subcutaneous cellular tissue&#46; The nodule had a heterogeneous content&#44; was not encapsulated&#44; and had poorly defined borders &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; The superficial or dermal plane of the lesion and its deeper or hypodermal plane were noticeably more hypoechoic than the intermediate plane that separated them&#44; and contained hypoechoic tubular tracts&#46; Color Doppler examination revealed the presence of extensive neovascularization&#44; with large vessels within the tumor &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">These ultrasound findings supported the clinical suspicion of malignancy&#44; and a 4<span class="elsevierStyleHsp" style=""></span>mm punch biopsy was therefore performed for histopathology study&#46; Analysis of the sample showed a dense perivascular and periadnexal interstitial lymphocytic infiltrate that extended into the hypodermis and did not affect the epidermis&#59; the infiltrate was formed of small&#47;medium-sized lymphocytes with mild-to-moderate pleomorphism &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; A and B&#41;&#46; Immunohistochemistry was positive for CD2&#44; CD3&#44; CD4&#44; CD5&#44; and BF1 and negative for CD8&#44; CD30&#44; granzyme&#44; perforin&#44; CD56&#44; CD57&#44; CD20&#44; and CD79&#46; Molecular analysis detected a monoclonal rearrangement of the T-cell receptor gene that&#44; together with the previous findings&#44; was consistent with a diagnosis of PCSM-TCLD&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">No significant alterations were detected in the metastatic work-up with cervico-thoraco-abdominopelvic computed tomography and a blood test including lymphocyte subpopulations&#44; lactate dehydrogenase&#44; and &#946;2-microglobulin&#46; The patient was offered radiotherapy&#44; which achieved a good response&#44; and there has been no recurrence of the disease&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Primary cutaneous CD4&#43; small&#47;medium T-cell lymphoma was a provisional entity in the 2008 World Health Organization classification of hematologic tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> Because of its uncertain malignant potential&#44; the term lymphoproliferative disorder has been recommended instead of lymphoma in the more recent 2016 classification&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> The disease typically presents clinically as an erythematous-violaceous plaque or nodule of firm consistency&#44; usually localized on the trunk or face&#46; It is characterized histologically by a diffuse or nodular dermal infiltrate of atypical CD4&#43; small- and medium-sized lymphocytes&#44; as in the case described&#46; Although the prognosis of these lesions is usually excellent&#44;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;4</span></a> aggressive forms have very rarely been described&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The widespread incorporation of skin ultrasound into dermatology outpatient clinics has led to the recent development of numerous applications&#44; from the study of inflammatory diseases to definition of the ultrasound characteristics of a number of malignant tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a> However&#44; little has been published on the ultrasound findings in cutaneous lymphoma&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Taking into account the clinical and histopathologic variability of PCSM-TCLD&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> certain diversity is to be expected in the ultrasound findings&#46; Using studies performed on soft-tissue lymphomas as reference&#44;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">8&#8211;11</span></a> it can be seen that a diffuse infiltration of atypical lymphocytes usually produces an ultrasound image with hypoechoic and heterogeneous areas with poorly defined borders&#44; as was observed in our patient&#46; The presence of an intense neoangiogenesis on color Doppler appears to be a characteristic finding in soft-tissue lymphomas&#44; and is typically more prominent than in other malignant tumors&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The sonographic differentiation between skin metastases and other tumors can be complicated&#44; but carries important prognostic implications for the patient&#46; Such lesions often present clinical and ultrasound features similar to those described&#44; and this must be taken into account&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In summary&#44; we have presented a case of PCSM-TCLD and its ultrasound findings&#46; These findings helped to orient the initial suspicion of malignancy in a clinically nonspecific lesion&#46; We hope that progressive advances in cutaneous ultrasonography will enable us to better define the diagnosis of this type of tumors&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letter
Ultrasound features of Primary Cutaneous CD4+ Small/Medium-Sized T-Cell Lymphoproliferative Disorder
Ecografía del síndrome linfoproliferativo primario cutáneo T CD4+ de célula pequeña/mediana
E. Rodríguez-Lomba
Autor para correspondencia
enriquerlomba@outlook.com

Corresponding author.
, I. Molina-López, A. Pulido-Pérez, C. Ciudad-Blanco
Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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    "titulo" => "Ultrasound features of Primary Cutaneous CD4&#43; Small&#47;Medium-Sized T-Cell Lymphoproliferative Disorder"
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        "titulo" => "Ecograf&#237;a del s&#237;ndrome linfoproliferativo primario cut&#225;neo T CD4&#43; de c&#233;lula peque&#241;a&#47;mediana"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous-violaceous subcutaneous nodule of 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;5<span class="elsevierStyleHsp" style=""></span>cm in the right scapular region&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Primary cutaneous lymphomas have a low incidence in the general population&#46; The clinical presentation is very variable&#44; often making the diagnosis unexpected for the dermatologist&#46; Although the diagnosis of these lesions always requires histopathologic confirmation&#44; skin ultrasound is an additional tool that can be helpful for the initial diagnosis of malignancy&#46; We present a case of primary cutaneous CD4&#43; small&#47;medium T-cell lymphoproliferative disorder &#40;PCSM-TCLD&#41; and its ultrasound findings&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 55-year-old woman with a past history of hypothyroidism and dyslipidemia came to the emergency department for a pruritic lesion in the right scapular region&#59; the lesion had grown rapidly in the previous 2 months&#46; She reported no fever&#44; asthenia&#44; or weight loss&#44; and she denied any previous lesions or trauma&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed a solid&#44; tender erythematous-violaceous nodule of 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;5<span class="elsevierStyleHsp" style=""></span>cm in the right scapular region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The nodule was not adherent to deeper planes&#46; A surgical drainage-aspiration procedure performed in the emergency department excluded the presence of fluid collections&#46; There were no palpable lymph nodes or hepatosplenomegaly&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Skin ultrasound of the lesion was performed in dermatology outpatient clinic&#46; Examination in B mode &#40;18<span class="elsevierStyleHsp" style=""></span>MHz probe&#44; MyLab 25 Gold&#44; Esaote&#44; Italy&#41; revealed a dermal nodule of 20<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>11<span class="elsevierStyleHsp" style=""></span>mm&#44; with deep extension into the subcutaneous cellular tissue&#46; The nodule had a heterogeneous content&#44; was not encapsulated&#44; and had poorly defined borders &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; The superficial or dermal plane of the lesion and its deeper or hypodermal plane were noticeably more hypoechoic than the intermediate plane that separated them&#44; and contained hypoechoic tubular tracts&#46; Color Doppler examination revealed the presence of extensive neovascularization&#44; with large vessels within the tumor &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">These ultrasound findings supported the clinical suspicion of malignancy&#44; and a 4<span class="elsevierStyleHsp" style=""></span>mm punch biopsy was therefore performed for histopathology study&#46; Analysis of the sample showed a dense perivascular and periadnexal interstitial lymphocytic infiltrate that extended into the hypodermis and did not affect the epidermis&#59; the infiltrate was formed of small&#47;medium-sized lymphocytes with mild-to-moderate pleomorphism &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; A and B&#41;&#46; Immunohistochemistry was positive for CD2&#44; CD3&#44; CD4&#44; CD5&#44; and BF1 and negative for CD8&#44; CD30&#44; granzyme&#44; perforin&#44; CD56&#44; CD57&#44; CD20&#44; and CD79&#46; Molecular analysis detected a monoclonal rearrangement of the T-cell receptor gene that&#44; together with the previous findings&#44; was consistent with a diagnosis of PCSM-TCLD&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">No significant alterations were detected in the metastatic work-up with cervico-thoraco-abdominopelvic computed tomography and a blood test including lymphocyte subpopulations&#44; lactate dehydrogenase&#44; and &#946;2-microglobulin&#46; The patient was offered radiotherapy&#44; which achieved a good response&#44; and there has been no recurrence of the disease&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Primary cutaneous CD4&#43; small&#47;medium T-cell lymphoma was a provisional entity in the 2008 World Health Organization classification of hematologic tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> Because of its uncertain malignant potential&#44; the term lymphoproliferative disorder has been recommended instead of lymphoma in the more recent 2016 classification&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> The disease typically presents clinically as an erythematous-violaceous plaque or nodule of firm consistency&#44; usually localized on the trunk or face&#46; It is characterized histologically by a diffuse or nodular dermal infiltrate of atypical CD4&#43; small- and medium-sized lymphocytes&#44; as in the case described&#46; Although the prognosis of these lesions is usually excellent&#44;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;4</span></a> aggressive forms have very rarely been described&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The widespread incorporation of skin ultrasound into dermatology outpatient clinics has led to the recent development of numerous applications&#44; from the study of inflammatory diseases to definition of the ultrasound characteristics of a number of malignant tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a> However&#44; little has been published on the ultrasound findings in cutaneous lymphoma&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Taking into account the clinical and histopathologic variability of PCSM-TCLD&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> certain diversity is to be expected in the ultrasound findings&#46; Using studies performed on soft-tissue lymphomas as reference&#44;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">8&#8211;11</span></a> it can be seen that a diffuse infiltration of atypical lymphocytes usually produces an ultrasound image with hypoechoic and heterogeneous areas with poorly defined borders&#44; as was observed in our patient&#46; The presence of an intense neoangiogenesis on color Doppler appears to be a characteristic finding in soft-tissue lymphomas&#44; and is typically more prominent than in other malignant tumors&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The sonographic differentiation between skin metastases and other tumors can be complicated&#44; but carries important prognostic implications for the patient&#46; Such lesions often present clinical and ultrasound features similar to those described&#44; and this must be taken into account&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In summary&#44; we have presented a case of PCSM-TCLD and its ultrasound findings&#46; These findings helped to orient the initial suspicion of malignancy in a clinically nonspecific lesion&#46; We hope that progressive advances in cutaneous ultrasonography will enable us to better define the diagnosis of this type of tumors&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Rodr&#237;guez-Lomba E&#44; Molina-L&#243;pez I&#44; Pulido-P&#233;rez A&#44; Ciudad-Blanco C&#46; Ecograf&#237;a del s&#237;ndrome linfoproliferativo primario cut&#225;neo T CD4&#43; de c&#233;lula peque&#241;a&#47;mediana&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;792&#8211;794&#46;</p>"
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