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Parte 1: síndromes urticariformes, síndromes pustulosos y síndromes con ulceraciones cutáneo-mucosas" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1020 "Ancho" => 975 "Tamanyo" => 237937 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">DITRA (deficiency of the IL-36 receptor antagonist). Generalized pustular eruption with polycyclic contours on an erythematous base, similar to an outbreak of generalized pustular psoriasis.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Hernández-Ostiz, L. Prieto-Torres, G. Xirotagaros, L. 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"apellidos" => "del Rio" "email" => array:1 [ 0 => "dermalar@clinicadermalar.com" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Clínica Dermalar, Santiago de Compostela, A Coruña, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Otras caras de la enfermedad de Darier" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Darier disease</span>—or, more appropriately, <span class="elsevierStyleItalic">Darier-White disease</span>—will perhaps be one of the few eponymous disease names that will survive in the dermatology of the future. The eponym's survival will surely be assisted by the clear inappropriateness of the alternative names that have been proposed: <span class="elsevierStyleItalic">keratosis follicularis</span> and, more recently, <span class="elsevierStyleItalic">dyskeratosis follicularis</span>.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The last 2 decades have yielded key molecular and genetic knowledge. The relationship between Darier disease and the <span class="elsevierStyleItalic">ATP2A2</span> gene and its chromosomal locus was clearly established, and the aura of mystery surrounding this genodermatosis seemed to vanish. But nothing could be further from reality: the wealth of expression and the clinical and therapeutic unpredictability of Darier disease continue to fascinate us.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The cases reported in this issue by Flores-Terry et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> provide a lovely example of the diversity of Darier disease. They show that, in parallel to—and even in spite of—advances in basic research, clinical practice continues to attract and captivate us on a daily basis. In fact, suspicion of Darier disease based on those peculiar hemorrhagic blisters at acral sites is a good example of the old maxim, “If you don’t think of it, you won’t diagnose it,” and it shows us the way to clinical excellence in dermatology.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: del Rio E. Otras caras de la enfermedad de Darier. Actas Dermosifiliogr. 2017;108:608.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Reference" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:1 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enfermedad de Darier acral hemorrágica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.A. Flores-Terry" 1 => "M. García-Arpa" 2 => "M. Llamas-Velasco" 3 => "C. Mendoza-Chaparro" 4 => "C. Ramos-Rodríguez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2017.02.012" "Revista" => array:2 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2017" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010800000007/v2_201708291348/S1578219017301877/v2_201708291348/en/main.assets" "Apartado" => array:4 [ "identificador" => "66476" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Commentaries" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010800000007/v2_201708291348/S1578219017301877/v2_201708291348/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017301877?idApp=UINPBA000044" ]
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