Estadísticas

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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The term <span class="elsevierStyleItalic">inherited epidermolysis bullosa</span> &#40;EB&#41; describes a group of genetic disorders in which a protein defect causes skin fragility and subsequent blistering&#46; It is a rare disease&#44; with a prevalence of just 8 cases per million population&#46; It can affect deeper layers&#44; and patients may also develop complications in other organs&#44; caused not by the genetic defect itself but by its consequences&#46; One such complication is dilated cardiomyopathy&#44; which needs to be contemplated in patients with EB&#44; not so much because of its frequency &#40;which is low&#41;&#44; but because of its severity and the important role of early diagnosis and treatment in prognosis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The pathogenesis of dilated cardiomyopathy in patients with EB is unknown&#46; It has been associated with numerous factors&#44; such as deficiencies in certain micronutrients &#40;iron&#44; thiamine&#44; selenium&#44; carnitine&#41; and iron overload&#44; and it may be multifactorial&#46; Very few case series of dilated cardiomyopathy in EB have been reported&#46; In this issue of <span class="elsevierStyleItalic">Actas Dermo-Sifiliogr&#225;ficas</span>&#44; Batalla et al&#46; present an interesting article that reports on the prevalence of this serious complication in a series of patients with EB seen at a referral hospital over a period of 30 years&#46; The condition was most common&#44; with a prevalence of 15&#37;&#44; in patients with recessive dystrophic EB&#44; and this greater frequency has also been reported in other series&#46; The authors point to possible causes of dilated cardiomyopathy in EB and also outline a follow-up plan aimed at early detection and treatment&#46; Considering the low prevalence of both EB and dilated cardiomyopathy&#44; more prospective&#44; multicenter studies are needed to further define this association&#46;</p></span>"
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