Commentaries
Eosinophils as a Warning Sign
El eosinófilo como alerta
E. Rodríguez-Díaz
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Servicio de Dermatología, Hospital Universitario de Cabueñes, Gijón, Asturias, España
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Rodríguez-Díaz" "autores" => array:1 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Rodríguez-Díaz" "email" => array:1 [ 0 => "eloy1@telecable.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Cabueñes, Gijón, Asturias, España" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El eosinófilo como alerta" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Eosinophils are effector cells of the innate immune system that play a key role in the body's defense against parasites and tumors. Their main function is to eliminate biological targets, such as helminths, protozoa, bacteria, and tumor cells. The pathological circumstances that trigger an increase in the number of eosinophils in tissues or peripheral blood are very varied. The literature includes very few review articles dealing specifically with eosinophilic dermatoses, and attempts to draw up a preliminary classification are even rarer.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In 2001, Byrd et al.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> coined the term <span class="elsevierStyleItalic">eosinophilic dermatosis of myeloproliferative disease</span>, for which they proposed the following clinical and pathological diagnostic criteria: a pruritic papular or vesiculobullous eruption refractory to standard treatment; a concurrent diagnosis of blood dyscrasia or hematologic malignancy; an eosinophil-rich lymphohistiocytic infiltrate in the superficial and deep dermis; and the exclusion of other causes of tissue eosinophilia. This description corresponds to the dermatosis originally described in 1965 by Weed<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> as a <span class="elsevierStyleItalic">mosquito bite-like reaction</span>. More recently, a new nomenclature has been proposed: <span class="elsevierStyleItalic">eosinophilic dermatosis of hematologic malignancy</span>.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> It is a reactive process without specific hematologic cell infiltration. The etiology and pathogenesis is poorly understood, but it is thought to be associated with the immune dysregulation found in conditions such as chronic lymphocytic leukemia.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Our journal has already published a small case series of this skin condition.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> In this issue of <span class="elsevierStyleSmallCaps">Actas Dermosifiliográficas,</span> Lucas-Truyols et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> review 4 new typical examples and, for the first time, 1 case associated with mycosis fungoides. The great interest of this condition, and all skin disorders linked to systemic diseases, is that its prompt recognition may have diagnostic and, in some cases, prognostic value with regard to the underlying hematologic disease.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Rodríguez E. El eosinófilo como alerta. Actas Dermosifiliogr. 2017;108:499–500.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatosis eosinofílicas (y II)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Rodríguez-Díaz" 1 => "C. Álvarez-Cuesta" 2 => "S. Blanco Barrios" 3 => "C. Galache Osuna" 4 => "C. Requena Caballero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2003" "volumen" => "94" "paginaInicial" => "131" "paginaFinal" => "143" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eosinophilic dermatosis of myeloproliferative disease: Characterization of a unique eruption in patients with hematologic disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.A. Byrd" 1 => "L. Scherschun" 2 => "M.L. Chaffins" 3 => "D.P. 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Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0560.2012.01906.x" "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "2012" "volumen" => "39" "paginaInicial" => "690" "paginaFinal" => "695" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22612903" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatosis eosinofílica asociada a leucemia linfática crónica: estudio clínico, microscópico e inmunohistoquímico de 5 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Mangas" 1 => "I. Bielsa" 2 => "J.L. Mate" 3 => "M<span class="elsevierStyleSup">a</span>.T. Fernández-Figueras" 4 => "M. Ribera" 5 => "C. Ferrándiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2004" "volumen" => "95" "paginaInicial" => "165" "paginaFinal" => "170" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Lucas-Truyols S, Rodrigo-Nicolás B, Lloret-Ruiz C, Quecedo-Estébanez E. Cuatro nuevos casos de dermatosis eosinofílicas asociadas a procesos hematológicos. Actas Dermosifiliogr. 2017. Doi: <a href="http://dx.doi.org/10.1016/j.ad.2016.10.021">http://dx.doi.org/10.1016/j.ad.2016.10.021</a>" ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010800000006/v1_201706300050/S1578219017301592/v1_201706300050/en/main.assets" "Apartado" => array:4 [ "identificador" => "66476" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Commentaries" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010800000006/v1_201706300050/S1578219017301592/v1_201706300050/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017301592?idApp=UINPBA000044" ]
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