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Commentaries
Antimicrobial Photodynamic Therapy: An Unexplored New Field
Terapia fotodinámica antimicrobiana: un mundo por explorar
J. Romaní
Autor para correspondencia
jromani@tauli.cat

Corresponding author.
Servicio de Dermatología, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí I3PT, Barcelona, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">For several years&#44; photodynamic therapy &#40;PDT&#41; has been a treatment option for skin conditions such as nonmelanoma skin cancer&#46; Recently&#44; this technique has been studied for skin infections&#44; particularly those in which biofilms have formed&#46; The antibacterial&#44; immunoregulatory&#44; and regenerative effect of PDT may enable healing of antibiotic-resistant infections and infections at sites with limited antibiotic penetration&#46; The technique may also be useful in patients for whom a local treatment is sought free of the side effects of systemic antibiotic therapies&#46; The group who published this article has extensive experience in the use of PDT for the treatment of onychomycosis and other infections&#44; such as sporotrichosis&#44; <span class="elsevierStyleItalic">Scytalidium&#44; Demodex</span> or <span class="elsevierStyleItalic">Candida</span>&#44; and for biofilm-mediated processes such as suppurative hidradenitis&#46; The authors report an open-label series in which several superinfected ulcers achieved healing with PDT using methylene blue and visible light&#46; Methylene blue is a photoactivated phenothiazine that is suited to inducing cytotoxicity at the bacterial membrane thanks to its cationic nature&#46; It is cheap and its incubation time is relatively short&#44; thus facilitating its use in daily clinical practice&#46; The success reported by these authors should encourage controlled&#44; randomized studies to provide stronger evidence for PDT in this context&#46;</p></span>"
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
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