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Commentary
Considerations on Subgroup Analyses in Clinical Trials
Consideraciones sobre los análisis de subgrupos en los ensayos clínicos
P. Coto-Segura
Unidad de Psoriasis, Hospital Universitario Central de Asturias Universidad de Oviedo, Oviedo, Asturias, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">As clinicians&#44; we routinely treat patients with drugs whose efficacy is supported by evidence from multicenter clinical trials&#44; some of which include thousands of patients from different parts of the world&#46; When it comes to treating a given patient&#44; however&#44; we need to know whether the beneficial effect described for the average patient will apply to this patient in particular&#46; This can be done by subgroup analysis&#46; Subgroup analysis is a valid tool&#44; but it is not without risk and therefore any conclusions drawn need to be interpreted with caution&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Problems associated with subgroup analyses include loss of statistical power and multiple comparisons&#46; I think that subgroup analyses are justified if they are designed to test a well-formulated hypothesis before the study starts&#46; Inferences made on the basis of a posteriori analyses can be problematic both ethically and methodologically&#46; In this issue&#44; Valenzuela et al&#46; report on the results of a subgroup analysis of the efficacy of ixekizumab in the treatment of psoriasis in the UNCOVER-3 trial in Latin American patients identified by ethnicity&#46; Considering the limited number of patients studied and the difficulty of defining a homogeneous ethnic group for Latin America&#44; their article deserves to be read with care and with consideration of the above-mentioned factors&#46;</p></span>"
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
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