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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Mycosis fungoides &#40;MF&#41; is the most common primary T-cell cutaneous lymphoma and it mainly affects adults in the fifth decade of life&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> Clinically&#44; it has 3 classic stages &#40;macule&#44; plaque&#44; and tumor&#41; that can overlap&#46; Patients typically have exclusive cutaneous involvement that follows an indolent course for years or even decades&#46; Characteristic histopathologic findings include an epidermotropic tumor infiltrate and proliferation of atypical T cells with a cerebriform appearance&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Primary cutaneous lymphomas are rare in childhood&#46; MF is also rare&#44; but&#44; as with adults&#44; it is the most common type of primary cutaneous lymphoma in this population&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">2</span></a> The first descriptions of MF in children date back to 1984&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> Several cases have been reported since and the most common clinical presentation in most cases has been hypopigmented MF&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#44;4&#8211;11</span></a> Histopathologic findings are similar to those seen in adults&#44; but immunohistochemical studies show a predominant CD8<span class="elsevierStyleSup">&#43;</span> T-cell infiltrate&#44; which would correlate with the hypopigmented clinical lesions&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The aim of this study was to describe the epidemiological&#44; clinical&#44; histopathologic&#44; and immunophenotypic characteristics of MF in pediatric patients and report on T-cell receptor &#40;TCR&#41; gene rearrangement test results&#44; treatments&#44; and disease course&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">We conducted a retrospective&#44; observational&#44; descriptive&#44; cross-sectional study of patients with a clinical and histopathologic diagnosis of MF seen at Hospital de Pediatr&#237;a S&#46;A&#46;M&#46;<span class="elsevierStyleSmallCaps">I</span>&#46;C&#46; &#171;Prof&#46; Dr&#46; Juan P&#46; Garrahan&#187; in Buenos Aires&#44; Argentina between August 1988 and July 2004&#46; This hospital is a referral hospital for children in our country and Latin America&#46; The following variables were analyzed&#58; sex&#44; age&#44; initial diagnosis&#44; time from onset to diagnosis&#44; clinical manifestations&#44; location&#44; stage at diagnosis&#44; histopathologic findings&#44; immunophenotype&#44; TCR gene rearrangement&#44; treatments received&#44; disease course&#44; and follow-up duration&#46; We reviewed clinical charts and pathology reports and applied the diagnostic criteria of the World Health Organization&#47;European Organisation for Research and Treatment of Cancer &#40;2005&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> and the staging criteria of the International Society for Cutaneous Lymphomas&#47;European Organisation for Research and Treatment of Cancer &#40;2007&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0025" class="elsevierStylePara elsevierViewall">Fourteen patients with clinical and histologic features of MF were included in the study&#46; The male to female ratio was 1&#58;1&#46;33&#46; Mean age at diagnosis was 11&#46;23 years &#40;range&#44; 8-15 years&#41; and mean time from onset to diagnosis was 3 years and 6 months &#40;range&#44; 4 months to 7 years&#41;&#46; Information on demographic&#44; clinical&#44; histopathologic&#44; and immunohistochemical characteristics&#44; TCR gene rearrangement&#44; disease stage&#44; treatments&#44; disease course&#44; follow-up&#44; and disease-free months is summarized in <a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">MF was the initial diagnosis in just 8 patients &#40;57&#37;&#41;&#46; The initial diagnoses in the other 6 patients were pityriasis lichenoides chronica &#40;2 patients&#41;&#44; lymphomatoid papulosis &#40;1 patient&#41;&#44; hypopigmented pityriasis versicolor &#40;1 patient&#41;&#44; vitiligo &#40;1 patient&#41;&#44; and atopic dermatitis &#40;1 patient&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">All patients had hypopigmented macules &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Six patients &#40;42&#46;8&#37;&#41; developed concomitant or subsequent classic MF lesions&#46; These took the form of macules &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; in 2 patients&#44; plaques &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41; in 6&#44; and a tumor &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41; in 1&#46; One patient &#40;&#35;9&#41; had clinical manifestations of pityriasis lichenoides chronica but a histopathologic diagnosis of MF&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Two patients &#40;&#35;11 and &#35;12&#41; with a clinical and histopathologic diagnosis of pityriasis lichenoides chronica developed MF after a period of 7 years&#44; and another &#40;&#35;5&#41; experienced progression of lymphomatoid papulosis to MF after a period of 5 years&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">All the patients had histopathologic findings consistent with MF &#40;epidermotropic atypical lymphocytic infiltrate&#41; and half of them had Pautrier microabscesses &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41;&#46; One of these &#40;patient &#35;8&#41; had a folliculotropic histopathologic variant&#44; but there was no correlation with clinical findings&#46; In the immunohistochemical studies&#44; 7 patients &#40;50&#37;&#41; had a CD8<span class="elsevierStyleSup">&#43;</span><span class="elsevierStyleHsp" style=""></span>CD4<span class="elsevierStyleSup">&#8211;</span> immunophenotype&#44; 5 had a CD8<span class="elsevierStyleSup">&#43;</span> CD4<span class="elsevierStyleSup">&#43;</span> immunophenotype&#44; and just 2 had a CD8<span class="elsevierStyleSup">&#8211;</span> CD4<span class="elsevierStyleSup">&#43;</span> immunophenotype &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">TCR gene rearrangement tests were performed in just 6 patients&#46; The results were positive in patient &#35;1 &#40;Vb22 CD4&#44; variable region of beta chain&#41;&#44; patient &#35;4 &#40;gamma&#41;&#44; and patient &#35;14 &#40;beta&#41; and negative in patients &#35;3&#44; &#35;8&#44; and &#35;9&#46; The studies were performed using skin samples in all cases&#46; Blood samples were also tested in 1 patient&#44; and the result was positive for TCR delta &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">At the time of MF diagnosis&#44; 11 patients &#40;78&#46;5&#37;&#41; had stage IB disease&#44; 2 had stage IA disease&#44; and 1 had stage IVA2 disease &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; The patient with stage IV disease had extracutaneous involvement of the axillary and inguinal lymph nodes&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Lactate dehydrogenase &#40;LDH&#41; levels and eosinophil counts were available for 11 of the 14 patients&#46; None had elevated LDH levels and just 1 &#40;&#35;4&#41; had hypereosinophilia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>700&#47;mm<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a>&#41;&#46; Although this patient had chronic bronchitis episodes&#44; it is noteworthy that he did not have hypereosinophilia during his time free of MF&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The treatments reported are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#44; and it is important to note that some treatments were administered concurrently or sequentially in different patients&#46; The initial treatment of choice was phototherapy in 12 patients &#40;85&#46;7&#37;&#41; due to the extension of their lesions&#46; Six received psoralen plus UV-A &#40;PUVA&#41; therapy&#44; 2 received narrowband UV-B therapy&#44; and 3 received these treatments consecutively&#46; Finally&#44; 1 patient was treated with UV-A1 phototherapy&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Additional concomitant and&#47;or consecutive treatments in 9 patients were high-potency topical corticosteroids &#40;clobetasol&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41;&#44; topical bexarotene &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41;&#44; and a combination of oral retinoids &#40;acitretin&#41;&#44; psoralens&#44; and heliotherapy &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#46; The patient with stage IV disease was treated with CHOP chemotherapy &#40;cyclophosphamide 750<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#47;d&#44; doxorubicin 50<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#47;d&#44; intravenous vincristine 1&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#47;d&#44; and methylprednisone 60<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#47;d for 5 days&#41; and with electron beam radiotherapy&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Eight patients are currently receiving treatment&#44; 4 are free of disease&#44; 1 &#40;patient &#35;1&#41; was referred to an adult hospital after a disease-free period of 4 years&#44; and another &#40;&#35;2&#41; was lost to follow up&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Four of the 14 patients &#40;&#35;1&#44; &#35;3&#44; &#35;4&#44; and &#35;5&#41; had at least 1 recurrence&#44; 3 experienced extension of cutaneous involvement&#44; and 1 showed partial response with persistence of MF&#46; There were no deaths over a median follow-up period of 3 years &#40;range&#44; 2 months to 9 years&#41;&#46; The median disease-free period was 3 months &#40;range&#44; 1-48 months&#41;&#46; These wide ranges can be explained by the fact that 9 of 14 patients were added to the series in the last 18 months&#46; Six of them had been followed for less than 1 year and most were on their first treatment&#44; preventing us from evaluating overall treatment effectiveness&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">Children account for between 5&#37; and 16&#37; of all MF patients&#44; although rates vary greatly from study to study&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">6&#8211;9&#44;11&#44;13</span></a> The incidence of MF before the age of 20 years is approximately 0&#46;05 cases per 100&#160;000 inhabitants per year<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> and MF is the most common primary cutaneous T-cell lymphoma in children&#46; Although a predilection for the male sex has been reported&#44;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">13&#44;14</span></a> there was a slight female predominance in our series&#46; The mean age at diagnosis &#40;11&#46;23 years&#41; and the mean time from onset to diagnosis &#40;3 years and 6 months&#41; are similar to those reported in other publications&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;6&#8211;10&#44;13&#44;15</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">MF is difficult to diagnosis on purely clinical grounds in children due to the rarity of the disease in this population&#44; the low index of suspicion among physicians&#44; and the broad differential diagnosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;9</span></a> This diagnostic difficulty is reflected in our study by the time it took to establish a diagnosis &#40;3 years and 6 months&#41; and the low level of clinical suspicion at the first visit&#44; where just 57&#37; of children were diagnosed with MF&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Hypopigmented MF is the most common clinical variant of MF in children&#44; and is particularly frequent in patients with Fitzpatrick skin types <span class="elsevierStyleSmallCaps">iii</span> or <span class="elsevierStyleSmallCaps">iv</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;5&#44;7&#44;8&#44;10&#44;11&#44;13&#44;16&#44;17</span></a> Forty percent of our patients had hypopigmented lesions coexisting with classic MF lesions&#44; supporting previous reports&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">6&#44;8&#44;10</span></a> It should be highlighted that 1 patient in our series had a clinical diagnosis of pityriasis lichenoides chronica but histopathologic findings consistent with MF&#46; Another 2 patients&#44; one with a diagnosis of pityriasis lichenoides chronica and the other with a diagnosis of lymphomatoid papulosis developed MF after several years&#46; These situations have been described infrequently in the literature&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Classic MF typically has a CD3<span class="elsevierStyleSup">&#43;</span>&#44; CD4&#44; CD5<span class="elsevierStyleSup">&#43;</span>&#44; and CD8<span class="elsevierStyleSup">&#8722;</span> immunophenotype&#44; with loss of CD7 expression&#46; CD8<span class="elsevierStyleSup">&#43;</span> predominance is common in hypopigmented MF<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;7&#44;9</span></a> and was observed in 12 of our patients&#46; It should be noted that 5 patients &#40;35&#37;&#41; had a CD4<span class="elsevierStyleSup">&#43;</span> and CD8<span class="elsevierStyleSup">&#43;</span> immunophenotype&#44; which is a rare variant&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">18&#44;19</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">It is difficult to assess treatment response in our series due to the retrospective nature of our study and the fact that a majority of the children are still undergoing treatment&#46; Sixty-four percent of patients were included in the last 18 months and almost half have been monitored for less than a year&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Treatments for MF vary according to disease stage&#46; Because most patients have generalized cutaneous lesions&#44; without systemic involvement&#44; the treatment of choice is phototherapy&#46; Topical corticosteroids are used in cases of localized disease&#46; Phototherapy was also the treatment of choice in most of our patients&#46; PUVA was more effective than narrowband UV-B therapy&#44; and no adverse effects have been observed to date&#46; Young patients with MF&#44; however&#44; require multiple treatments over a lifetime due to the high recurrence rates&#46; Accordingly&#44; prolonged maintenance phototherapy is recommended to prevent early relapse&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;13&#44;14&#44;17</span></a> However&#44; while these treatment regimens prolong periods of remission&#44; they can result in high cumulative doses of UV-A and long-term monitoring is therefore necessary due to the risk of early carcinogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a> Over half of the patients in our series were treated with high-potency topical corticosteroids and&#47;or topical bexarotene&#46; Response was moderate or short-lasting&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Coinciding with reports in the literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#44;4&#44;6&#44;8&#8211;11&#44;13&#44;15&#44;16</span></a> all but 1 patient in our series had stage IA or IB disease&#59; 78&#37; had stage IB disease&#44; which has an excellent prognosis and a life expectancy comparable to that of the general population&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1&#44;20</span></a> Most of the patients progressed very favorably&#46; There were no deaths and only 20&#37; experienced disease progression&#46; Progression&#44; however&#44; was marked by an extension in cutaneous involvement and none of the patients developed systemic disease&#46; The only patient with skin tumors and lymph node involvement was free of disease after 7 years&#8217; follow-up&#46; Other series of childhood MF have reported similar progression-free results&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;13&#44;15</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Our study has limitations inherent to its retrospective design&#46; We used empirical definitions to assess treatment response as there are no standardized criteria for the pediatric population as such&#44; these definitions mainly depend on the assest of the attending specialist&#46; Another limitation is the short follow-up period&#44; as this made it difficult to draw conclusions on long-term outcomes&#44; although the literature reports low rates of disease progression and excellent survival&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;9&#44;11&#44;13&#44;14</span></a> Nonetheless&#44; in a study of patients under 30 years old with MF who were followed for 10 years Ai et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> detected an increased risk of a second cancer &#40;standard incidence ratio of 3&#46;49&#41;&#44; in particular lymphoma and melanoma&#46; Overall survival&#44; however&#44; was between 88&#46;9&#37; and 94&#46;3&#37; and the differences were not statistically significant</p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion&#44; MF is uncommon in children and difficult to diagnose due to the broad differential diagnosis&#46; The hypopigmented variant is the most common form of MF in this age group&#46; Although MF in childhood has a good prognosis&#44; it has high recurrence rates and therefore requires long-term follow-up&#46; Monitoring of children with MF over time will provide more insights into disease course and progression&#44; long-term treatment effects&#44; and onset of second cancers&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Protection of humans and animals</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare that no tests were carried out in humans or animals for the purpose of this study&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Confidentiality of data</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors declare that they have followed their hospital&#39;s protocol on the publication of data concerning patients&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Right to privacy and informed consent</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data appear in this article&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicts of Interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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            0 => "Micosis fungoide"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mycosis fungoides &#40;MF&#41;&#44; the most common primary cutaneous T-cell lymphoma&#44; is unusual in children&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We aimed to describe the epidemiologic&#44; clinical&#44; histopathologic&#44; and immunophenotypic characteristics of MF as well as treatments and course of disease in a pediatric case series&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Data for all patients admitted to our pediatric hospital &#40;Hospital Dr&#46; J&#46; P&#46; Garrahan&#41; in Argentina with a clinical and histopathologic diagnosis of MF between August 1988 and July 2014 were included&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A total of 14 patients were diagnosed with MF&#46; The ratio of boys to girls was 1&#58;1&#46;33&#46; The mean age at diagnosis was 11&#46;23 years &#40;range&#44; 8&#8211;15 years&#41;&#46; The mean time between onset and diagnosis was 3&#46;5 years &#40;range&#44; 4 months&#8211;7 years&#41;&#46; All patients had hypopigmented MF and 42&#37; also presented the features of classic MF&#46; Seven &#40;50&#37;&#41; had the CD8<span class="elsevierStyleSup">&#43;</span> immunophenotype exclusively&#46; Seventy-eight percent were in stage IB at presentation&#46; Phototherapy was the treatment of choice&#46; Four patients relapsed at least once and skin lesions progressed in 3 patients&#46; All patients improved&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">MF is unusual in children&#46; The hypopigmented form is the most common&#46; Diagnosis is delayed because the condition is similar to other hypopigmented diseases seen more often in childhood&#46; Although prognosis is good&#44; the rate of recurrence is high&#44; so long-term follow-up is necessary&#46;</p></span>"
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            "titulo" => "Background"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objectives"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material and methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusions"
          ]
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La micosis fungoide &#40;MF&#41; es el linfoma cut&#225;neo primario de c&#233;lulas T m&#225;s frecuente&#46; Su aparici&#243;n en la infancia es excepcional&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Describir las caracter&#237;sticas epidemiol&#243;gicas&#44; cl&#237;nicas&#44; histopatol&#243;gicas e inmunofenot&#237;picas de los pacientes con MF&#46; Describir los tratamientos utilizados y la evoluci&#243;n&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material y m&#233;todo</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron todos los pacientes admitidos en el Hospital de Pediatr&#237;a Dr&#46; J&#46; P&#46; Garrahan &#40;Argentina&#41; en el per&#237;odo comprendido entre agosto de 1988 y julio de 2014 con diagn&#243;stico cl&#237;nico e histopatol&#243;gico de MF&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se diagnosticaron 14 pacientes con MF&#46; La distribuci&#243;n por sexo fue M&#47;F&#58; 1&#58;1&#44;33&#46; La edad media al diagn&#243;stico fue de 11&#44;23 a&#241;os &#40;rango&#58; 8 a 15 a&#241;os&#41;&#46; El tiempo promedio de evoluci&#243;n hasta el momento del diagn&#243;stico fue de 3 a&#241;os y 6 meses &#40;rango&#58; 4 meses a 7 a&#241;os&#41;&#46; Todos los pacientes presentaron la forma cl&#237;nica hipopigmentada y en el 42&#37; se asoci&#243; la forma cl&#225;sica&#46; El 50&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#41; exhibi&#243; un inmunofenotipo CD8 positivo de forma exclusiva&#46; El 78&#37; present&#243; estadio IB&#46; La fototerapia fue el tratamiento de elecci&#243;n&#46; Cuatro pacientes tuvieron por lo menos una reca&#237;da y 3 demostraron progresi&#243;n de su enfermedad a nivel cut&#225;neo&#46; La evoluci&#243;n fue favorable en todos los casos&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La MF es una entidad infrecuente en la infancia&#44; siendo la forma hipopigmentada la m&#225;s frecuente&#46; Su diagn&#243;stico es tard&#237;o debido a la similitud con otras enfermedades hipopigmentadas frecuentes en la ni&#241;ez&#46; A pesar de tener un buen pron&#243;stico&#44; presenta alta tasa de recidivas y requiere un seguimiento a largo plazo&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objetivos"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Material y m&#233;todo"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Cervini AB&#44; Torres-Huamani AN&#44; Sanchez-La-Rosa C&#44; Galluzzo L&#44; Solernou V&#44; Digiorge J&#44; et al&#46; Micosis fungoide&#46; Experiencia en un hospital pedi&#225;trico&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;564&#8211;570&#46;</p>"
      ]
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Patient &#35;10&#46; Hypopigmented macules&#46;</p>"
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Patient &#35;1&#46; Achromic macules&#44; plaques&#44; and ulcerated tumor&#46;</p>"
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; CMF&#44; classic mycosis fungoides&#59; F&#44; female&#59; HMF&#44; hypopigmented mycosis fungoides&#59; M&#44; male&#59; TOD&#44; time from onset to diagnosis&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&#47;Age&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">TOD&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical Manifestations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Initial Clinical Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques and tumors<br>HMF and CMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Disseminated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques<br>HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk<br>Upper extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Atopic dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#47;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques<br>HMF and CMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Abdomen<br>Lower extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk and extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lymphomatoid papulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk<br>Abdomen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pityriasis versicolor with achromic lesions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Upper extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#47;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Vitiligo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">W&#47;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques<br>HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Abdomen<br>Extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pityriasis lichenoides&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques<br>HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk<br>Extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques<br>HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk<br>Extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#47;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Disseminated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pityriasis lichenoides&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Disseminated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#47;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Disseminated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1450851.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Clinical Data&#46;</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; CHOP&#44;cyclophosphamide&#44; doxorubicin&#44; vincristine&#44; and prednisone&#59; CS&#44; corticosteroids&#59; HT&#44; heliotherapy&#59; DF&#44; disease-free&#59; IHC&#44; immunohistochemical&#59; MF&#44; micosis fungoides&#59; ND&#44; not done&#59; QT&#44; chemotherapy&#59; TCR&#44; T-cell receptor gene rearrangement&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HP and IHC Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">TCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">TNM&#47;Stage<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Disease Course&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">DF Period&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; Vb22 &#40;94&#37;&#41;<br>CD4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T3 N3 M0&#47;IVA2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CHOP QT and electron beam radiotherapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DF and recurrence &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;51 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2b N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lost to follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2b N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>UV-B<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DF after recurrence &#40;n&#160;&#61;&#160;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;5 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#43;</span> CD8<span class="elsevierStyleSup">-</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; gamma &#40;skin&#41; and delta &#40;blood&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2b N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>Topical bexarotene&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Under treatment after recurrence &#40;n&#61;1&#41; and progression&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#43;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND<br>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>UV-B<br>Topical bexarotene&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Under treatment after recurrence &#40;n&#61;2&#41; and progression&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#43;</span> CD8<span class="elsevierStyleSup">-</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Under treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#43;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T1a N0 M0&#47;IA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>Folliclular<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T1a N0 M0&#47;IA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">UV-B<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">UV-B<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>psoralen<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>retinoids &#43; HT<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Progression<br>Under treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">UV-B<br>PUVA<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Under treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#43;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">UV-A-1<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Under treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Under treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 mo&nbsp;\t\t\t\t\t\t\n
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              "identificador" => "bib0105"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "WHO-EORTC classification for cutaneous lymphomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Willemze"
                            1 => "E&#46;S&#46; Jaffe"
                            2 => "G&#46; Burg"
                            3 => "L&#46; Cerroni"
                            4 => "E&#46; Berti"
                            5 => "S&#46;H&#46; Swerdlow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2004-09-3502"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2005"
                        "volumen" => "105"
                        "paginaInicial" => "3768"
                        "paginaFinal" => "3785"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15692063"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The spectrum of cutaneous lymphomas in patients less than 20 years of age"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Fink-Puches"
                            1 => "A&#46; Chott"
                            2 => "M&#46; Ardig&#243;"
                            3 => "I&#46; Simonitsch"
                            4 => "G&#46; Ferrara"
                            5 => "H&#46; Kerl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0736-8046.2004.21500.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2004"
                        "volumen" => "21"
                        "paginaInicial" => "525"
                        "paginaFinal" => "533"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15461755"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary cutaneous T-cell lymphoma in a child"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Paller"
                            1 => "N&#46;B&#46; Esterly"
                            2 => "E&#46;S&#46; Baum"
                            3 => "F&#46; Gonzalez-Crussi"
                            4 => "W&#46;A&#46; Caro"
                            5 => "D&#46; Variakojis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "1984"
                        "volumen" => "2"
                        "paginaInicial" => "131"
                        "paginaFinal" => "135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6334849"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pediatric mycosis fungoides in Singapore&#58; A series of 46 children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y&#46;K&#46; Heng"
                            1 => "M&#46;J&#46; Koh"
                            2 => "Y&#46;C&#46; Giam"
                            3 => "M&#46;B&#46; Tang"
                            4 => "W&#46;S&#46; Chong"
                            5 => "S&#46;H&#46; Tan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/pde.12352"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2014"
                        "volumen" => "31"
                        "paginaInicial" => "477"
                        "paginaFinal" => "482"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24890628"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypopigmented mycosis fungoides in childhood and adolescence&#58; A long-term retrospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Castano"
                            1 => "S&#46; Glick"
                            2 => "L&#46; Wolgast"
                            3 => "R&#46; Naeem"
                            4 => "J&#46; Sunkara"
                            5 => "D&#46; Elston"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cutan Pathol"
                        "fecha" => "2013"
                        "volumen" => "40"
                        "paginaInicial" => "924"
                        "paginaFinal" => "934"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Childhood mycosis fungoides&#58; A report of 20 cases from Turkey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;D&#46; Yazganoglu"
                            1 => "Z&#46; Topkarci"
                            2 => "N&#46; Buyukbabani"
                            3 => "C&#46; Baykal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2011.04383.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2013"
                        "volumen" => "27"
                        "paginaInicial" => "295"
                        "paginaFinal" => "300"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22176010"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
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              "identificador" => "bib0135"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mycosis fungoides in children and adolescents&#58; A report of six cases with predominantly hypopigmentation&#44; along with a literature review"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;A&#46; Rizzo"
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                            2 => "L&#46; Pantale&#227;o"
                            3 => "E&#46;C&#46; Fonseca"
                            4 => "P&#46;F&#46; Magrin"
                            5 => "M&#46; Henrique-Xavier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2012"
                        "volumen" => "18"
                        "paginaInicial" => "5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23286795"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mycosis fungoides in Arab children and adolescents&#58; A report of 36 patients from Kuwait"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Nanda"
                            1 => "Q&#46;A&#46; AlSaleh"
                            2 => "H&#46; Al-Ajmi"
                            3 => "H&#46; Al-Sabah"
                            4 => "M&#46; Elkashlan"
                            5 => "S&#46; Al-Shemmari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1470.2010.01129.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2010"
                        "volumen" => "27"
                        "paginaInicial" => "607"
                        "paginaFinal" => "613"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21138468"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Outcome in 34 patients with juvenile-onset mycosis fungoides&#58; A clinical&#44; immunophenotypic&#44; and molecular study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46;M&#46; Wain"
                            1 => "G&#46;E&#46; Orchard"
                            2 => "S&#46;J&#46; Whittaker"
                            3 => "M&#46; Spittle"
                            4 => "M&#46;F&#46; Sc"
                            5 => "R&#46; Russell-Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.11780"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "2003"
                        "volumen" => "98"
                        "paginaInicial" => "2282"
                        "paginaFinal" => "2290"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14601100"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Juvenile mycosis fungoides diagnosed before 18 years of age"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Ben-Amitai"
                            1 => "D&#46; Michael"
                            2 => "M&#46; Feinmesser"
                            3 => "E&#46; Hodak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "2003"
                        "volumen" => "83"
                        "paginaInicial" => "451"
                        "paginaFinal" => "456"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14690342"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mycosis fungoides in patients under 20 years of age&#58; Report of 7 cases&#44; review of the literature and study of the clinical course"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Quaglino"
                            1 => "A&#46; Zaccagna"
                            2 => "A&#46; Verrone"
                            3 => "F&#46; Dardano"
                            4 => "M&#46;G&#46; Bernengo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "18196"
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                        "tituloSerie" => "Dermatology"
                        "fecha" => "1999"
                        "volumen" => "199"
                        "paginaInicial" => "8"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10449950"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Revisions to the staging and classification of mycosis fungoides and Sezary syndrome&#58; A proposal of the International Society for Cutaneous Lymphomas &#40;ISCL&#41; and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer &#40;EORTC&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Olsen"
                            1 => "E&#46; Vonderheid"
                            2 => "N&#46; Pimpinelli"
                            3 => "R&#46; Willemze"
                            4 => "Y&#46; Kim"
                            5 => "R&#46; Knobler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2007-03-055749"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2007"
                        "volumen" => "110"
                        "paginaInicial" => "1713"
                        "paginaFinal" => "1722"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17540844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Profile and outcome of childhood mycosis fungoides in Singapore"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Tan"
                            1 => "Y&#46;K&#46; Tay"
                            2 => "Y&#46;C&#46; Giam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2000"
                        "volumen" => "17"
                        "paginaInicial" => "352"
                        "paginaFinal" => "356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11085660"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Outcomes after diagnosis of mycosis fungoides and S&#233;zary syndrome before 30 years of age&#58; A population-based study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "T&#46;H&#46; Keegan"
                            2 => "D&#46;J&#46; Press"
                            3 => "J&#46; Yang"
                            4 => "L&#46;B&#46; Pincus"
                            5 => "Y&#46;H&#46; Kim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2013.7747"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2014"
                        "volumen" => "150"
                        "paginaInicial" => "709"
                        "paginaFinal" => "715"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24718769"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0175"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinicopathological features and T-cell receptor gene rearrangement findings of mycosis fungoides in patients younger than age 20 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;T&#46; Kim"
                            1 => "H&#46;J&#46; Sim"
                            2 => "Y&#46;S&#46; Jeon"
                            3 => "J&#46;W&#46; Lee"
                            4 => "H&#46;J&#46; Roh"
                            5 => "S&#46;Y&#46; Choi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1346-8138.2009.00665.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol"
                        "fecha" => "2009"
                        "volumen" => "36"
                        "paginaInicial" => "392"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19583687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Childhood mycosis fungoides&#58; Experience of 28 patients and response to phototherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            1 => "N&#46;H&#46; Shear"
                            2 => "E&#46; Pope"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/pde.12338"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2014"
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Original Article
Mycosis Fungoides: Experience in a Pediatric Hospital
Micosis fungoide. Experiencia en un hospital pediátrico
A.B. Cervinia, A.N. Torres-Huamania,
Autor para correspondencia
torresnat@yahoo.com.ar

Corresponding author.
, C. Sanchez-La-Rosab, L. Galluzzoc, V. Solernouc, J. Digiorged, P. Rubiod
a Servicio de Dermatología, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina
b Servicio de Hemato-Oncología, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina
c Servicio de Anatomía Patológica, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina
d Servicio de Biología Molecular, Hospital de Pediatría Dr. Garrahan, Buenos Aires, Argentina
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    "titulo" => "Mycosis Fungoides&#58; Experience in a Pediatric Hospital"
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        "titulo" => "Micosis fungoide&#46; Experiencia en un hospital pedi&#225;trico"
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          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Patient &#35;1&#46; Achromic macules&#44; plaques&#44; and ulcerated tumor&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Mycosis fungoides &#40;MF&#41; is the most common primary T-cell cutaneous lymphoma and it mainly affects adults in the fifth decade of life&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> Clinically&#44; it has 3 classic stages &#40;macule&#44; plaque&#44; and tumor&#41; that can overlap&#46; Patients typically have exclusive cutaneous involvement that follows an indolent course for years or even decades&#46; Characteristic histopathologic findings include an epidermotropic tumor infiltrate and proliferation of atypical T cells with a cerebriform appearance&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Primary cutaneous lymphomas are rare in childhood&#46; MF is also rare&#44; but&#44; as with adults&#44; it is the most common type of primary cutaneous lymphoma in this population&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">2</span></a> The first descriptions of MF in children date back to 1984&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> Several cases have been reported since and the most common clinical presentation in most cases has been hypopigmented MF&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#44;4&#8211;11</span></a> Histopathologic findings are similar to those seen in adults&#44; but immunohistochemical studies show a predominant CD8<span class="elsevierStyleSup">&#43;</span> T-cell infiltrate&#44; which would correlate with the hypopigmented clinical lesions&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The aim of this study was to describe the epidemiological&#44; clinical&#44; histopathologic&#44; and immunophenotypic characteristics of MF in pediatric patients and report on T-cell receptor &#40;TCR&#41; gene rearrangement test results&#44; treatments&#44; and disease course&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">We conducted a retrospective&#44; observational&#44; descriptive&#44; cross-sectional study of patients with a clinical and histopathologic diagnosis of MF seen at Hospital de Pediatr&#237;a S&#46;A&#46;M&#46;<span class="elsevierStyleSmallCaps">I</span>&#46;C&#46; &#171;Prof&#46; Dr&#46; Juan P&#46; Garrahan&#187; in Buenos Aires&#44; Argentina between August 1988 and July 2004&#46; This hospital is a referral hospital for children in our country and Latin America&#46; The following variables were analyzed&#58; sex&#44; age&#44; initial diagnosis&#44; time from onset to diagnosis&#44; clinical manifestations&#44; location&#44; stage at diagnosis&#44; histopathologic findings&#44; immunophenotype&#44; TCR gene rearrangement&#44; treatments received&#44; disease course&#44; and follow-up duration&#46; We reviewed clinical charts and pathology reports and applied the diagnostic criteria of the World Health Organization&#47;European Organisation for Research and Treatment of Cancer &#40;2005&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> and the staging criteria of the International Society for Cutaneous Lymphomas&#47;European Organisation for Research and Treatment of Cancer &#40;2007&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0025" class="elsevierStylePara elsevierViewall">Fourteen patients with clinical and histologic features of MF were included in the study&#46; The male to female ratio was 1&#58;1&#46;33&#46; Mean age at diagnosis was 11&#46;23 years &#40;range&#44; 8-15 years&#41; and mean time from onset to diagnosis was 3 years and 6 months &#40;range&#44; 4 months to 7 years&#41;&#46; Information on demographic&#44; clinical&#44; histopathologic&#44; and immunohistochemical characteristics&#44; TCR gene rearrangement&#44; disease stage&#44; treatments&#44; disease course&#44; follow-up&#44; and disease-free months is summarized in <a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">MF was the initial diagnosis in just 8 patients &#40;57&#37;&#41;&#46; The initial diagnoses in the other 6 patients were pityriasis lichenoides chronica &#40;2 patients&#41;&#44; lymphomatoid papulosis &#40;1 patient&#41;&#44; hypopigmented pityriasis versicolor &#40;1 patient&#41;&#44; vitiligo &#40;1 patient&#41;&#44; and atopic dermatitis &#40;1 patient&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">All patients had hypopigmented macules &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Six patients &#40;42&#46;8&#37;&#41; developed concomitant or subsequent classic MF lesions&#46; These took the form of macules &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; in 2 patients&#44; plaques &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41; in 6&#44; and a tumor &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41; in 1&#46; One patient &#40;&#35;9&#41; had clinical manifestations of pityriasis lichenoides chronica but a histopathologic diagnosis of MF&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Two patients &#40;&#35;11 and &#35;12&#41; with a clinical and histopathologic diagnosis of pityriasis lichenoides chronica developed MF after a period of 7 years&#44; and another &#40;&#35;5&#41; experienced progression of lymphomatoid papulosis to MF after a period of 5 years&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">All the patients had histopathologic findings consistent with MF &#40;epidermotropic atypical lymphocytic infiltrate&#41; and half of them had Pautrier microabscesses &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41;&#46; One of these &#40;patient &#35;8&#41; had a folliculotropic histopathologic variant&#44; but there was no correlation with clinical findings&#46; In the immunohistochemical studies&#44; 7 patients &#40;50&#37;&#41; had a CD8<span class="elsevierStyleSup">&#43;</span><span class="elsevierStyleHsp" style=""></span>CD4<span class="elsevierStyleSup">&#8211;</span> immunophenotype&#44; 5 had a CD8<span class="elsevierStyleSup">&#43;</span> CD4<span class="elsevierStyleSup">&#43;</span> immunophenotype&#44; and just 2 had a CD8<span class="elsevierStyleSup">&#8211;</span> CD4<span class="elsevierStyleSup">&#43;</span> immunophenotype &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">TCR gene rearrangement tests were performed in just 6 patients&#46; The results were positive in patient &#35;1 &#40;Vb22 CD4&#44; variable region of beta chain&#41;&#44; patient &#35;4 &#40;gamma&#41;&#44; and patient &#35;14 &#40;beta&#41; and negative in patients &#35;3&#44; &#35;8&#44; and &#35;9&#46; The studies were performed using skin samples in all cases&#46; Blood samples were also tested in 1 patient&#44; and the result was positive for TCR delta &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">At the time of MF diagnosis&#44; 11 patients &#40;78&#46;5&#37;&#41; had stage IB disease&#44; 2 had stage IA disease&#44; and 1 had stage IVA2 disease &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; The patient with stage IV disease had extracutaneous involvement of the axillary and inguinal lymph nodes&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Lactate dehydrogenase &#40;LDH&#41; levels and eosinophil counts were available for 11 of the 14 patients&#46; None had elevated LDH levels and just 1 &#40;&#35;4&#41; had hypereosinophilia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>700&#47;mm<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a>&#41;&#46; Although this patient had chronic bronchitis episodes&#44; it is noteworthy that he did not have hypereosinophilia during his time free of MF&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The treatments reported are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#44; and it is important to note that some treatments were administered concurrently or sequentially in different patients&#46; The initial treatment of choice was phototherapy in 12 patients &#40;85&#46;7&#37;&#41; due to the extension of their lesions&#46; Six received psoralen plus UV-A &#40;PUVA&#41; therapy&#44; 2 received narrowband UV-B therapy&#44; and 3 received these treatments consecutively&#46; Finally&#44; 1 patient was treated with UV-A1 phototherapy&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Additional concomitant and&#47;or consecutive treatments in 9 patients were high-potency topical corticosteroids &#40;clobetasol&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41;&#44; topical bexarotene &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41;&#44; and a combination of oral retinoids &#40;acitretin&#41;&#44; psoralens&#44; and heliotherapy &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#46; The patient with stage IV disease was treated with CHOP chemotherapy &#40;cyclophosphamide 750<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#47;d&#44; doxorubicin 50<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#47;d&#44; intravenous vincristine 1&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#47;d&#44; and methylprednisone 60<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#47;d for 5 days&#41; and with electron beam radiotherapy&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Eight patients are currently receiving treatment&#44; 4 are free of disease&#44; 1 &#40;patient &#35;1&#41; was referred to an adult hospital after a disease-free period of 4 years&#44; and another &#40;&#35;2&#41; was lost to follow up&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Four of the 14 patients &#40;&#35;1&#44; &#35;3&#44; &#35;4&#44; and &#35;5&#41; had at least 1 recurrence&#44; 3 experienced extension of cutaneous involvement&#44; and 1 showed partial response with persistence of MF&#46; There were no deaths over a median follow-up period of 3 years &#40;range&#44; 2 months to 9 years&#41;&#46; The median disease-free period was 3 months &#40;range&#44; 1-48 months&#41;&#46; These wide ranges can be explained by the fact that 9 of 14 patients were added to the series in the last 18 months&#46; Six of them had been followed for less than 1 year and most were on their first treatment&#44; preventing us from evaluating overall treatment effectiveness&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">Children account for between 5&#37; and 16&#37; of all MF patients&#44; although rates vary greatly from study to study&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">6&#8211;9&#44;11&#44;13</span></a> The incidence of MF before the age of 20 years is approximately 0&#46;05 cases per 100&#160;000 inhabitants per year<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> and MF is the most common primary cutaneous T-cell lymphoma in children&#46; Although a predilection for the male sex has been reported&#44;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">13&#44;14</span></a> there was a slight female predominance in our series&#46; The mean age at diagnosis &#40;11&#46;23 years&#41; and the mean time from onset to diagnosis &#40;3 years and 6 months&#41; are similar to those reported in other publications&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;6&#8211;10&#44;13&#44;15</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">MF is difficult to diagnosis on purely clinical grounds in children due to the rarity of the disease in this population&#44; the low index of suspicion among physicians&#44; and the broad differential diagnosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;9</span></a> This diagnostic difficulty is reflected in our study by the time it took to establish a diagnosis &#40;3 years and 6 months&#41; and the low level of clinical suspicion at the first visit&#44; where just 57&#37; of children were diagnosed with MF&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Hypopigmented MF is the most common clinical variant of MF in children&#44; and is particularly frequent in patients with Fitzpatrick skin types <span class="elsevierStyleSmallCaps">iii</span> or <span class="elsevierStyleSmallCaps">iv</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;5&#44;7&#44;8&#44;10&#44;11&#44;13&#44;16&#44;17</span></a> Forty percent of our patients had hypopigmented lesions coexisting with classic MF lesions&#44; supporting previous reports&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">6&#44;8&#44;10</span></a> It should be highlighted that 1 patient in our series had a clinical diagnosis of pityriasis lichenoides chronica but histopathologic findings consistent with MF&#46; Another 2 patients&#44; one with a diagnosis of pityriasis lichenoides chronica and the other with a diagnosis of lymphomatoid papulosis developed MF after several years&#46; These situations have been described infrequently in the literature&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Classic MF typically has a CD3<span class="elsevierStyleSup">&#43;</span>&#44; CD4&#44; CD5<span class="elsevierStyleSup">&#43;</span>&#44; and CD8<span class="elsevierStyleSup">&#8722;</span> immunophenotype&#44; with loss of CD7 expression&#46; CD8<span class="elsevierStyleSup">&#43;</span> predominance is common in hypopigmented MF<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;7&#44;9</span></a> and was observed in 12 of our patients&#46; It should be noted that 5 patients &#40;35&#37;&#41; had a CD4<span class="elsevierStyleSup">&#43;</span> and CD8<span class="elsevierStyleSup">&#43;</span> immunophenotype&#44; which is a rare variant&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">18&#44;19</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">It is difficult to assess treatment response in our series due to the retrospective nature of our study and the fact that a majority of the children are still undergoing treatment&#46; Sixty-four percent of patients were included in the last 18 months and almost half have been monitored for less than a year&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Treatments for MF vary according to disease stage&#46; Because most patients have generalized cutaneous lesions&#44; without systemic involvement&#44; the treatment of choice is phototherapy&#46; Topical corticosteroids are used in cases of localized disease&#46; Phototherapy was also the treatment of choice in most of our patients&#46; PUVA was more effective than narrowband UV-B therapy&#44; and no adverse effects have been observed to date&#46; Young patients with MF&#44; however&#44; require multiple treatments over a lifetime due to the high recurrence rates&#46; Accordingly&#44; prolonged maintenance phototherapy is recommended to prevent early relapse&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;13&#44;14&#44;17</span></a> However&#44; while these treatment regimens prolong periods of remission&#44; they can result in high cumulative doses of UV-A and long-term monitoring is therefore necessary due to the risk of early carcinogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a> Over half of the patients in our series were treated with high-potency topical corticosteroids and&#47;or topical bexarotene&#46; Response was moderate or short-lasting&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Coinciding with reports in the literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#44;4&#44;6&#44;8&#8211;11&#44;13&#44;15&#44;16</span></a> all but 1 patient in our series had stage IA or IB disease&#59; 78&#37; had stage IB disease&#44; which has an excellent prognosis and a life expectancy comparable to that of the general population&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1&#44;20</span></a> Most of the patients progressed very favorably&#46; There were no deaths and only 20&#37; experienced disease progression&#46; Progression&#44; however&#44; was marked by an extension in cutaneous involvement and none of the patients developed systemic disease&#46; The only patient with skin tumors and lymph node involvement was free of disease after 7 years&#8217; follow-up&#46; Other series of childhood MF have reported similar progression-free results&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;13&#44;15</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Our study has limitations inherent to its retrospective design&#46; We used empirical definitions to assess treatment response as there are no standardized criteria for the pediatric population as such&#44; these definitions mainly depend on the assest of the attending specialist&#46; Another limitation is the short follow-up period&#44; as this made it difficult to draw conclusions on long-term outcomes&#44; although the literature reports low rates of disease progression and excellent survival&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;9&#44;11&#44;13&#44;14</span></a> Nonetheless&#44; in a study of patients under 30 years old with MF who were followed for 10 years Ai et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> detected an increased risk of a second cancer &#40;standard incidence ratio of 3&#46;49&#41;&#44; in particular lymphoma and melanoma&#46; Overall survival&#44; however&#44; was between 88&#46;9&#37; and 94&#46;3&#37; and the differences were not statistically significant</p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion&#44; MF is uncommon in children and difficult to diagnose due to the broad differential diagnosis&#46; The hypopigmented variant is the most common form of MF in this age group&#46; Although MF in childhood has a good prognosis&#44; it has high recurrence rates and therefore requires long-term follow-up&#46; Monitoring of children with MF over time will provide more insights into disease course and progression&#44; long-term treatment effects&#44; and onset of second cancers&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Protection of humans and animals</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare that no tests were carried out in humans or animals for the purpose of this study&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Confidentiality of data</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors declare that they have followed their hospital&#39;s protocol on the publication of data concerning patients&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Right to privacy and informed consent</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare that no private patient data appear in this article&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicts of Interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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              "titulo" => "Confidentiality of data"
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          "clase" => "keyword"
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            0 => "Mycosis fungoides"
            1 => "Children"
            2 => "Lymphoma"
            3 => "Primary cutaneous"
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          "palabras" => array:3 [
            0 => "Micosis fungoide"
            1 => "Ni&#241;os"
            2 => "Linfoma cut&#225;neo primario"
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    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mycosis fungoides &#40;MF&#41;&#44; the most common primary cutaneous T-cell lymphoma&#44; is unusual in children&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We aimed to describe the epidemiologic&#44; clinical&#44; histopathologic&#44; and immunophenotypic characteristics of MF as well as treatments and course of disease in a pediatric case series&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Data for all patients admitted to our pediatric hospital &#40;Hospital Dr&#46; J&#46; P&#46; Garrahan&#41; in Argentina with a clinical and histopathologic diagnosis of MF between August 1988 and July 2014 were included&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A total of 14 patients were diagnosed with MF&#46; The ratio of boys to girls was 1&#58;1&#46;33&#46; The mean age at diagnosis was 11&#46;23 years &#40;range&#44; 8&#8211;15 years&#41;&#46; The mean time between onset and diagnosis was 3&#46;5 years &#40;range&#44; 4 months&#8211;7 years&#41;&#46; All patients had hypopigmented MF and 42&#37; also presented the features of classic MF&#46; Seven &#40;50&#37;&#41; had the CD8<span class="elsevierStyleSup">&#43;</span> immunophenotype exclusively&#46; Seventy-eight percent were in stage IB at presentation&#46; Phototherapy was the treatment of choice&#46; Four patients relapsed at least once and skin lesions progressed in 3 patients&#46; All patients improved&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">MF is unusual in children&#46; The hypopigmented form is the most common&#46; Diagnosis is delayed because the condition is similar to other hypopigmented diseases seen more often in childhood&#46; Although prognosis is good&#44; the rate of recurrence is high&#44; so long-term follow-up is necessary&#46;</p></span>"
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        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La micosis fungoide &#40;MF&#41; es el linfoma cut&#225;neo primario de c&#233;lulas T m&#225;s frecuente&#46; Su aparici&#243;n en la infancia es excepcional&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Describir las caracter&#237;sticas epidemiol&#243;gicas&#44; cl&#237;nicas&#44; histopatol&#243;gicas e inmunofenot&#237;picas de los pacientes con MF&#46; Describir los tratamientos utilizados y la evoluci&#243;n&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material y m&#233;todo</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron todos los pacientes admitidos en el Hospital de Pediatr&#237;a Dr&#46; J&#46; P&#46; Garrahan &#40;Argentina&#41; en el per&#237;odo comprendido entre agosto de 1988 y julio de 2014 con diagn&#243;stico cl&#237;nico e histopatol&#243;gico de MF&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se diagnosticaron 14 pacientes con MF&#46; La distribuci&#243;n por sexo fue M&#47;F&#58; 1&#58;1&#44;33&#46; La edad media al diagn&#243;stico fue de 11&#44;23 a&#241;os &#40;rango&#58; 8 a 15 a&#241;os&#41;&#46; El tiempo promedio de evoluci&#243;n hasta el momento del diagn&#243;stico fue de 3 a&#241;os y 6 meses &#40;rango&#58; 4 meses a 7 a&#241;os&#41;&#46; Todos los pacientes presentaron la forma cl&#237;nica hipopigmentada y en el 42&#37; se asoci&#243; la forma cl&#225;sica&#46; El 50&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#41; exhibi&#243; un inmunofenotipo CD8 positivo de forma exclusiva&#46; El 78&#37; present&#243; estadio IB&#46; La fototerapia fue el tratamiento de elecci&#243;n&#46; Cuatro pacientes tuvieron por lo menos una reca&#237;da y 3 demostraron progresi&#243;n de su enfermedad a nivel cut&#225;neo&#46; La evoluci&#243;n fue favorable en todos los casos&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La MF es una entidad infrecuente en la infancia&#44; siendo la forma hipopigmentada la m&#225;s frecuente&#46; Su diagn&#243;stico es tard&#237;o debido a la similitud con otras enfermedades hipopigmentadas frecuentes en la ni&#241;ez&#46; A pesar de tener un buen pron&#243;stico&#44; presenta alta tasa de recidivas y requiere un seguimiento a largo plazo&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Cervini AB&#44; Torres-Huamani AN&#44; Sanchez-La-Rosa C&#44; Galluzzo L&#44; Solernou V&#44; Digiorge J&#44; et al&#46; Micosis fungoide&#46; Experiencia en un hospital pedi&#225;trico&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;564&#8211;570&#46;</p>"
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; CMF&#44; classic mycosis fungoides&#59; F&#44; female&#59; HMF&#44; hypopigmented mycosis fungoides&#59; M&#44; male&#59; TOD&#44; time from onset to diagnosis&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&#47;Age&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">TOD&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical Manifestations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Initial Clinical Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques and tumors<br>HMF and CMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Disseminated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques<br>HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk<br>Upper extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Atopic dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#47;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques<br>HMF and CMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Abdomen<br>Lower extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk and extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lymphomatoid papulosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk<br>Abdomen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pityriasis versicolor with achromic lesions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Upper extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#47;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Vitiligo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">W&#47;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques<br>HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Abdomen<br>Extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pityriasis lichenoides&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques<br>HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk<br>Extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Plaques<br>HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trunk<br>Extremities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#47;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Disseminated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pityriasis lichenoides&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&#47;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Disseminated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#47;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HMF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Disseminated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1450851.png"
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          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Clinical Data&#46;</p>"
        ]
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        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; CHOP&#44;cyclophosphamide&#44; doxorubicin&#44; vincristine&#44; and prednisone&#59; CS&#44; corticosteroids&#59; HT&#44; heliotherapy&#59; DF&#44; disease-free&#59; IHC&#44; immunohistochemical&#59; MF&#44; micosis fungoides&#59; ND&#44; not done&#59; QT&#44; chemotherapy&#59; TCR&#44; T-cell receptor gene rearrangement&#46;</p>"
          "tablatextoimagen" => array:1 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HP and IHC Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">TCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">TNM&#47;Stage<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Disease Course&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">DF Period&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; Vb22 &#40;94&#37;&#41;<br>CD4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T3 N3 M0&#47;IVA2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CHOP QT and electron beam radiotherapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DF and recurrence &#40;n&#61;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;51 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2b N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lost to follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2b N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>UV-B<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DF after recurrence &#40;n&#160;&#61;&#160;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;5 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#43;</span> CD8<span class="elsevierStyleSup">-</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; gamma &#40;skin&#41; and delta &#40;blood&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2b N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>Topical bexarotene&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Under treatment after recurrence &#40;n&#61;1&#41; and progression&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#43;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND<br>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>UV-B<br>Topical bexarotene&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Under treatment after recurrence &#40;n&#61;2&#41; and progression&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#43;</span> CD8<span class="elsevierStyleSup">-</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Under treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#43;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T1a N0 M0&#47;IA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PUVA<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>Folliclular<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T1a N0 M0&#47;IA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">UV-B<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MF<br>CD4<span class="elsevierStyleSup">&#8722;</span> CD8<span class="elsevierStyleSup">&#43;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T2a N0 M0&#47;IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">UV-B<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>psoralen<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>retinoids &#43; HT<br>Topical CS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Progression<br>Under treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 mo&nbsp;\t\t\t\t\t\t\n
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "WHO-EORTC classification for cutaneous lymphomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Willemze"
                            1 => "E&#46;S&#46; Jaffe"
                            2 => "G&#46; Burg"
                            3 => "L&#46; Cerroni"
                            4 => "E&#46; Berti"
                            5 => "S&#46;H&#46; Swerdlow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2004-09-3502"
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                        "tituloSerie" => "Blood"
                        "fecha" => "2005"
                        "volumen" => "105"
                        "paginaInicial" => "3768"
                        "paginaFinal" => "3785"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15692063"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The spectrum of cutaneous lymphomas in patients less than 20 years of age"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Fink-Puches"
                            1 => "A&#46; Chott"
                            2 => "M&#46; Ardig&#243;"
                            3 => "I&#46; Simonitsch"
                            4 => "G&#46; Ferrara"
                            5 => "H&#46; Kerl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0736-8046.2004.21500.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2004"
                        "volumen" => "21"
                        "paginaInicial" => "525"
                        "paginaFinal" => "533"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15461755"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary cutaneous T-cell lymphoma in a child"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Paller"
                            1 => "N&#46;B&#46; Esterly"
                            2 => "E&#46;S&#46; Baum"
                            3 => "F&#46; Gonzalez-Crussi"
                            4 => "W&#46;A&#46; Caro"
                            5 => "D&#46; Variakojis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "1984"
                        "volumen" => "2"
                        "paginaInicial" => "131"
                        "paginaFinal" => "135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6334849"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0120"
              "etiqueta" => "4"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Pediatric mycosis fungoides in Singapore&#58; A series of 46 children"
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                          "autores" => array:6 [
                            0 => "Y&#46;K&#46; Heng"
                            1 => "M&#46;J&#46; Koh"
                            2 => "Y&#46;C&#46; Giam"
                            3 => "M&#46;B&#46; Tang"
                            4 => "W&#46;S&#46; Chong"
                            5 => "S&#46;H&#46; Tan"
                          ]
                        ]
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/pde.12352"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2014"
                        "volumen" => "31"
                        "paginaInicial" => "477"
                        "paginaFinal" => "482"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24890628"
                            "web" => "Medline"
                          ]
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            4 => array:3 [
              "identificador" => "bib0125"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypopigmented mycosis fungoides in childhood and adolescence&#58; A long-term retrospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "L&#46; Wolgast"
                            3 => "R&#46; Naeem"
                            4 => "J&#46; Sunkara"
                            5 => "D&#46; Elston"
                          ]
                        ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cutan Pathol"
                        "fecha" => "2013"
                        "volumen" => "40"
                        "paginaInicial" => "924"
                        "paginaFinal" => "934"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0130"
              "etiqueta" => "6"
              "referencia" => array:1 [
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                    0 => array:2 [
                      "titulo" => "Childhood mycosis fungoides&#58; A report of 20 cases from Turkey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;D&#46; Yazganoglu"
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                            2 => "N&#46; Buyukbabani"
                            3 => "C&#46; Baykal"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2011.04383.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2013"
                        "volumen" => "27"
                        "paginaInicial" => "295"
                        "paginaFinal" => "300"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22176010"
                            "web" => "Medline"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            3 => "E&#46;C&#46; Fonseca"
                            4 => "P&#46;F&#46; Magrin"
                            5 => "M&#46; Henrique-Xavier"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2012"
                        "volumen" => "18"
                        "paginaInicial" => "5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23286795"
                            "web" => "Medline"
                          ]
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                  ]
                ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Mycosis fungoides in Arab children and adolescents&#58; A report of 36 patients from Kuwait"
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                          "autores" => array:6 [
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                            2 => "H&#46; Al-Ajmi"
                            3 => "H&#46; Al-Sabah"
                            4 => "M&#46; Elkashlan"
                            5 => "S&#46; Al-Shemmari"
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                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1470.2010.01129.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2010"
                        "volumen" => "27"
                        "paginaInicial" => "607"
                        "paginaFinal" => "613"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21138468"
                            "web" => "Medline"
                          ]
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                    ]
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                    0 => array:2 [
                      "titulo" => "Outcome in 34 patients with juvenile-onset mycosis fungoides&#58; A clinical&#44; immunophenotypic&#44; and molecular study"
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                            2 => "S&#46;J&#46; Whittaker"
                            3 => "M&#46; Spittle"
                            4 => "M&#46;F&#46; Sc"
                            5 => "R&#46; Russell-Jones"
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Cancer"
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                        "volumen" => "98"
                        "paginaInicial" => "2282"
                        "paginaFinal" => "2290"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14601100"
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                    0 => array:2 [
                      "titulo" => "Juvenile mycosis fungoides diagnosed before 18 years of age"
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
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                        "paginaInicial" => "451"
                        "paginaFinal" => "456"
                        "link" => array:1 [
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                      "titulo" => "Revisions to the staging and classification of mycosis fungoides and Sezary syndrome&#58; A proposal of the International Society for Cutaneous Lymphomas &#40;ISCL&#41; and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer &#40;EORTC&#41;"
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                            3 => "R&#46; Willemze"
                            4 => "Y&#46; Kim"
                            5 => "R&#46; Knobler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2007-03-055749"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2007"
                        "volumen" => "110"
                        "paginaInicial" => "1713"
                        "paginaFinal" => "1722"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17540844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Profile and outcome of childhood mycosis fungoides in Singapore"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Tan"
                            1 => "Y&#46;K&#46; Tay"
                            2 => "Y&#46;C&#46; Giam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2000"
                        "volumen" => "17"
                        "paginaInicial" => "352"
                        "paginaFinal" => "356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11085660"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "14"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Outcomes after diagnosis of mycosis fungoides and S&#233;zary syndrome before 30 years of age&#58; A population-based study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;Z&#46; Ai"
                            1 => "T&#46;H&#46; Keegan"
                            2 => "D&#46;J&#46; Press"
                            3 => "J&#46; Yang"
                            4 => "L&#46;B&#46; Pincus"
                            5 => "Y&#46;H&#46; Kim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2013.7747"
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                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2014"
                        "volumen" => "150"
                        "paginaInicial" => "709"
                        "paginaFinal" => "715"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24718769"
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                  ]
                ]
              ]
            ]
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              "etiqueta" => "15"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Clinicopathological features and T-cell receptor gene rearrangement findings of mycosis fungoides in patients younger than age 20 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;T&#46; Kim"
                            1 => "H&#46;J&#46; Sim"
                            2 => "Y&#46;S&#46; Jeon"
                            3 => "J&#46;W&#46; Lee"
                            4 => "H&#46;J&#46; Roh"
                            5 => "S&#46;Y&#46; Choi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1346-8138.2009.00665.x"
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                        "tituloSerie" => "J Dermatol"
                        "fecha" => "2009"
                        "volumen" => "36"
                        "paginaInicial" => "392"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19583687"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "Childhood mycosis fungoides&#58; Experience of 28 patients and response to phototherapy"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "E&#46; Pope"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/pde.12338"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2014"
                        "volumen" => "31"
                        "paginaInicial" => "459"
                        "paginaFinal" => "464"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24916067"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Narrow-band ultraviolet B phototherapy for mycosis fungoides in children"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;J&#46; Koh"
                            1 => "W&#46;S&#46; Chong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.12364"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2014"
                        "volumen" => "39"
                        "paginaInicial" => "474"
                        "paginaFinal" => "478"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24825139"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "18"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CD4&#47;CD8 dual-positive mycosis fungoides&#58; a previously unrecognized variant"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;F&#46; Knapp"
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                            2 => "J&#46;L&#46; Messina"
                            3 => "M&#46;H&#46; Lien"
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                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1097/DAD.0b013e31823e25bb"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2012"
                        "volumen" => "34"
                        "paginaInicial" => "e37"
                        "paginaFinal" => "e39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22356917"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Double-positive CD4&#47;CD8 mycosis fungoides&#58; A rarely reported immunohistochemical profile"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "M&#46; Thomas"
                            3 => "N&#46; Meyer"
                            4 => "R&#46; Viraben"
                            5 => "P&#46; Brousset"
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                      ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "J Cutan Pathol"
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                        "volumen" => "41"
                        "paginaInicial" => "58"
                        "paginaFinal" => "62"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24134789"
                            "web" => "Medline"
                          ]
                        ]
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                    ]
                  ]
                ]
              ]
            ]
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                0 => array:3 [
                  "comentario" => "1-99&#46;28"
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                      "titulo" => "Skin malignancies"
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;M&#46; Pierini"
                            1 => "A&#46;B&#46; Cervini"
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                    ]
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