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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pediatric anogenital condyloma acuminata &#40;CA&#41; is not infrequent&#44; as increasing reports of its prevalence have demonstrated in recent years&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> However&#44; periurethral CA is an unusual location for this virally transmitted disease and is exceptionally reported in medical literature&#46; Human papilloma viruses &#40;HPV&#41; are the etiological causes for all types of warts&#44; and variable modes of transmission both sexual and non-sexual&#44; have been described in the pediatric population&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Current treatments for anogenital CA in children prove challenging due to their young age&#44; anatomic location and the high recurrence rates&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;3</span></a> Multiple therapeutic approaches range from topical treatments to more aggressive procedures&#44; including surgery&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present an otherwise healthy&#44; 2-year-old girl referred to our Department of Dermatology&#44; with progressively increasing asymptomatic lesions in the diaper area of 2 months in duration&#46; Physical examination showed multiple flesh-colored and brownish papules of 1&#8211;2<span class="elsevierStyleHsp" style=""></span>mm in diameter located in the vestibular and vulvar region in a symmetric V-shaped distribution as well as in the perianal region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#40;A&#41;&#41; Additionally&#44; careful periurethral examination revealed an exophytic&#44; reddish and papillomatous lesion of 1&#46;2<span class="elsevierStyleHsp" style=""></span>cm in diameter &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#40;A&#41;&#41; observing rich vascularity with dermoscopy&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A clinical diagnosis of CA stage IV was established due to the extension of the lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> PCR testing was performed for the vulvar&#44; perianal and the periurethral lesions confirming the diagnosis of CA for HPV subtype 6&#46; Subsequently&#44; the patient was screened for other sexually transmitted diseases and reported to social services for possible child abuse investigations&#46; The father presented genital warts&#44; however&#44; PCR testing results were not conclusive for the detection and typification of the HPV&#46; No further information was retrieved from the mother&#46; The exact source of infection could not be determined&#44; but most importantly&#44; no signs of sexual abuse were identified&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">CO<span class="elsevierStyleInf">2</span> laser surgery was proposed as a prompt solution for lack of sphincter control and the giant periurethral CA&#46; The procedure was carried out in an in-patient regimen under general anesthesia and prophylactic systemic antibiotic with cefazolin&#46; Under gynecological examination&#44; urethral catheterization was performed&#46; The operators were required to use a mask to prevent HPV in the vapor plume emitted by the CO<span class="elsevierStyleInf">2</span> laser&#46; Vaporization with CO<span class="elsevierStyleInf">2</span> laser was performed with the following parameters&#58; 5 Watts&#44; continuous mode and repeated pulse in two consecutive passes&#46; After vaporization and using the same CO<span class="elsevierStyleInf">2</span> laser parameters&#44; the periurethral wart was coagulated from the base and sent for histopathological analysis&#46; The treated area was covered with mupirocin ointment and a non-adherent dressing&#44; both of which were changed on a daily basis until complete healing was achieved&#46; The laser surgery lasted approximately 30<span class="elsevierStyleHsp" style=""></span>min with no intra or postoperative complications&#46; The histopathological study revealed acanthosis and parakeratosis with elongation of rete ridges and the presence of koilocytes&#44; features consistent with CA&#46; Complete epithelialization was achieved within 9 days and only one session was required to achieve clearance&#46; The giant periurethral and anogenital CA did not recur&#46; A 13-month follow-up shows complete remission and no signs of scarring &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Fig&#46; 1&#40;B&#41; and 2&#40;B&#41;</a>&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Anogenital CA in the pediatric population is not rare in daily practice as one may suppose&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> However&#44; giant periurethral condyloma occurs exceptionally in association with extensive dissemination of CA&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> Most importantly&#44; anogenital HPV infection in this particular age group poses a therapeutic challenge&#46; Among several treatment recommendations for CA are podophyllin or imiquimod&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> trichloroacetic acid&#44; 5-fluorouracil&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> cryotherapy&#44; CO<span class="elsevierStyleInf">2</span> laser&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> electrocautery and surgery&#44;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5-7</span></a> all of which present variable cure and recurrence rates&#46; The multiple approaches and varying responses suggest that there is no gold standard for the treatment of CA in children<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6-8</span></a> and while topical treatments are indicated as a first line approach&#44; there is no consensus regarding pediatric management&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7-9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In our case&#44; topical therapy was not a treatment option owing to the clinical presentation of the periurethral CA&#46; Another important factor taken into account&#44; was the infant that required diapers&#44; for the occlusion and constant diaper changes would have interfered with the topical treatments&#44; leading to possible lack of therapeutic effectiveness and adherence&#46; However&#44; the greatest concern was the periurethral wart&#44; which due to size and location required a surgical procedure&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">CO<span class="elsevierStyleInf">2</span> laser surgery is an effective technique&#44; demonstrating rapid healing and lower recurrence rates as the main advantages&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4</span></a> In our patient&#39;s case&#44; after 9 days and only one session&#44; complete epithelialization was achieved and no recurrence was observed in the 13-month follow-up &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#40;B&#41;&#41;&#46; To our knowledge&#44; this is the first pediatric case presenting a periurethral CA successfully treated with CO<span class="elsevierStyleInf">2</span> laser reported in medical literature&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In summary&#44; we report the outstanding results achieved with the CO<span class="elsevierStyleInf">2</span> laser for the treatment of a periurethral and disseminated CA in a pediatric patient&#46; We therefore recommend this surgical procedure in cases where large CA in association with extensive disseminated infection are observed&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letter
Giant periurethral condyloma acuminata in a 2-year-old girl: Successful treatment with carbon dioxide laser
Condiloma acuminado periuretral gigante en niña de 2 años: tratamiento exitoso con láser de dióxido de carbono
X. Calderón-Castrat
Autor para correspondencia
xime_777@hotmail.com

Corresponding author.
, S. Blanco, J.C. Santos-Durán, M. Roncero-Riesco
Department of Dermatology, University Hospital of Salamanca, Spain
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Giant periurethral condyloma acuminata&#46; &#40;B&#41; 13-month follow-up post-CO<span class="elsevierStyleInf">2</span> laser surgery for the giant periurethral condyloma acuminata&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pediatric anogenital condyloma acuminata &#40;CA&#41; is not infrequent&#44; as increasing reports of its prevalence have demonstrated in recent years&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> However&#44; periurethral CA is an unusual location for this virally transmitted disease and is exceptionally reported in medical literature&#46; Human papilloma viruses &#40;HPV&#41; are the etiological causes for all types of warts&#44; and variable modes of transmission both sexual and non-sexual&#44; have been described in the pediatric population&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Current treatments for anogenital CA in children prove challenging due to their young age&#44; anatomic location and the high recurrence rates&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;3</span></a> Multiple therapeutic approaches range from topical treatments to more aggressive procedures&#44; including surgery&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present an otherwise healthy&#44; 2-year-old girl referred to our Department of Dermatology&#44; with progressively increasing asymptomatic lesions in the diaper area of 2 months in duration&#46; Physical examination showed multiple flesh-colored and brownish papules of 1&#8211;2<span class="elsevierStyleHsp" style=""></span>mm in diameter located in the vestibular and vulvar region in a symmetric V-shaped distribution as well as in the perianal region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#40;A&#41;&#41; Additionally&#44; careful periurethral examination revealed an exophytic&#44; reddish and papillomatous lesion of 1&#46;2<span class="elsevierStyleHsp" style=""></span>cm in diameter &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#40;A&#41;&#41; observing rich vascularity with dermoscopy&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A clinical diagnosis of CA stage IV was established due to the extension of the lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> PCR testing was performed for the vulvar&#44; perianal and the periurethral lesions confirming the diagnosis of CA for HPV subtype 6&#46; Subsequently&#44; the patient was screened for other sexually transmitted diseases and reported to social services for possible child abuse investigations&#46; The father presented genital warts&#44; however&#44; PCR testing results were not conclusive for the detection and typification of the HPV&#46; No further information was retrieved from the mother&#46; The exact source of infection could not be determined&#44; but most importantly&#44; no signs of sexual abuse were identified&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">CO<span class="elsevierStyleInf">2</span> laser surgery was proposed as a prompt solution for lack of sphincter control and the giant periurethral CA&#46; The procedure was carried out in an in-patient regimen under general anesthesia and prophylactic systemic antibiotic with cefazolin&#46; Under gynecological examination&#44; urethral catheterization was performed&#46; The operators were required to use a mask to prevent HPV in the vapor plume emitted by the CO<span class="elsevierStyleInf">2</span> laser&#46; Vaporization with CO<span class="elsevierStyleInf">2</span> laser was performed with the following parameters&#58; 5 Watts&#44; continuous mode and repeated pulse in two consecutive passes&#46; After vaporization and using the same CO<span class="elsevierStyleInf">2</span> laser parameters&#44; the periurethral wart was coagulated from the base and sent for histopathological analysis&#46; The treated area was covered with mupirocin ointment and a non-adherent dressing&#44; both of which were changed on a daily basis until complete healing was achieved&#46; The laser surgery lasted approximately 30<span class="elsevierStyleHsp" style=""></span>min with no intra or postoperative complications&#46; The histopathological study revealed acanthosis and parakeratosis with elongation of rete ridges and the presence of koilocytes&#44; features consistent with CA&#46; Complete epithelialization was achieved within 9 days and only one session was required to achieve clearance&#46; The giant periurethral and anogenital CA did not recur&#46; A 13-month follow-up shows complete remission and no signs of scarring &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Fig&#46; 1&#40;B&#41; and 2&#40;B&#41;</a>&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Anogenital CA in the pediatric population is not rare in daily practice as one may suppose&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> However&#44; giant periurethral condyloma occurs exceptionally in association with extensive dissemination of CA&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> Most importantly&#44; anogenital HPV infection in this particular age group poses a therapeutic challenge&#46; Among several treatment recommendations for CA are podophyllin or imiquimod&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> trichloroacetic acid&#44; 5-fluorouracil&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> cryotherapy&#44; CO<span class="elsevierStyleInf">2</span> laser&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> electrocautery and surgery&#44;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5-7</span></a> all of which present variable cure and recurrence rates&#46; The multiple approaches and varying responses suggest that there is no gold standard for the treatment of CA in children<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6-8</span></a> and while topical treatments are indicated as a first line approach&#44; there is no consensus regarding pediatric management&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7-9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In our case&#44; topical therapy was not a treatment option owing to the clinical presentation of the periurethral CA&#46; Another important factor taken into account&#44; was the infant that required diapers&#44; for the occlusion and constant diaper changes would have interfered with the topical treatments&#44; leading to possible lack of therapeutic effectiveness and adherence&#46; However&#44; the greatest concern was the periurethral wart&#44; which due to size and location required a surgical procedure&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">CO<span class="elsevierStyleInf">2</span> laser surgery is an effective technique&#44; demonstrating rapid healing and lower recurrence rates as the main advantages&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4</span></a> In our patient&#39;s case&#44; after 9 days and only one session&#44; complete epithelialization was achieved and no recurrence was observed in the 13-month follow-up &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#40;B&#41;&#41;&#46; To our knowledge&#44; this is the first pediatric case presenting a periurethral CA successfully treated with CO<span class="elsevierStyleInf">2</span> laser reported in medical literature&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In summary&#44; we report the outstanding results achieved with the CO<span class="elsevierStyleInf">2</span> laser for the treatment of a periurethral and disseminated CA in a pediatric patient&#46; We therefore recommend this surgical procedure in cases where large CA in association with extensive disseminated infection are observed&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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