se ha leído el artículo
array:24 [ "pii" => "S1578219017300483" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.02.019" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1590" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2017;108:365-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 617 "formatos" => array:3 [ "EPUB" => 51 "HTML" => 414 "PDF" => 152 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731017300467" "issn" => "00017310" "doi" => "10.1016/j.ad.2016.12.008" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1590" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2017;108:365-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 229 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 200 "PDF" => 26 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Foro de Residentes</span>" "titulo" => "FR-¿Son los nuevos agentes antivirales de acción directa un tratamiento eficaz para las manifestaciones cutáneas de la hepatitis <span class="elsevierStyleSmallCaps">C</span>?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "365" "paginaFinal" => "366" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "RF -Are the New Direct-Acting Antiviral Agents Effective for Treating the Cutaneous Manifestations of Hepatitis C?" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Morgado-Carrasco, X. Fustà-Novell, S. Podlipnik, P. Giavedoni" "autores" => array:4 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Morgado-Carrasco" ] 1 => array:2 [ "nombre" => "X." "apellidos" => "Fustà-Novell" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Podlipnik" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Giavedoni" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219017300483" "doi" => "10.1016/j.adengl.2017.02.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300483?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017300467?idApp=UINPBA000044" "url" => "/00017310/0000010800000004/v2_201705020105/S0001731017300467/v2_201705020105/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219017300537" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.03.003" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1447" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2017;108:367" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 931 "formatos" => array:3 [ "EPUB" => 61 "HTML" => 761 "PDF" => 109 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>" "titulo" => "What Lies Beneath: Acropachy Hiding Subungual Osteochondroma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "367" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lo que la acropaquia esconde: osteocondroma subungueal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 732 "Ancho" => 1667 "Tamanyo" => 291028 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Galán-Gutierrez, F. Ramos Pleguezuelos, R. Ruiz-Villaverde" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Galán-Gutierrez" ] 1 => array:2 [ "nombre" => "F. Ramos" "apellidos" => "Pleguezuelos" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Ruiz-Villaverde" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016301739" "doi" => "10.1016/j.ad.2016.03.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016301739?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300537?idApp=UINPBA000044" "url" => "/15782190/0000010800000004/v1_201704280927/S1578219017300537/v1_201704280927/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219017300495" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.02.020" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1452" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:363-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 634 "formatos" => array:3 [ "EPUB" => 52 "HTML" => 478 "PDF" => 104 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>" "titulo" => "Nodular Peristomal Lesions" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "363" "paginaFinal" => "364" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lesiones nodulares periestomales" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1227 "Ancho" => 1650 "Tamanyo" => 802660 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin-eosin, original magnification ×<span class="elsevierStyleHsp" style=""></span>10.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Latour-Álvarez, E. García-Peris, M.M. Pestana-Eliche, M. García-Bustínduy" "autores" => array:4 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Latour-Álvarez" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "García-Peris" ] 2 => array:2 [ "nombre" => "M.M." "apellidos" => "Pestana-Eliche" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "García-Bustínduy" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016301788" "doi" => "10.1016/j.ad.2016.02.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016301788?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300495?idApp=UINPBA000044" "url" => "/15782190/0000010800000004/v1_201704280927/S1578219017300495/v1_201704280927/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Residents Forum</span>" "titulo" => "RF- Are the New Direct-Acting Antiviral Agents Effective for Treating the Cutaneous Manifestations of Hepatitis C?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "365" "paginaFinal" => "366" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "D. Morgado-Carrasco, X. Fustà-Novell, S. Podlipnik, P. Giavedoni" "autores" => array:4 [ 0 => array:4 [ "nombre" => "D." "apellidos" => "Morgado-Carrasco" "email" => array:1 [ 0 => "danielmorgado@yahoo.com.ar" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "X." "apellidos" => "Fustà-Novell" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Podlipnik" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Giavedoni" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Dermatology Department, Hospital Clínic, Barcelona, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "FR-¿Son los nuevos agentes antivirales de acción directa un tratamiento eficaz para las manifestaciones cutáneas de la hepatitis <span class="elsevierStyleSmallCaps">C</span>?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The hepatitis C virus (HCV) is one of the most common causes of chronic liver disease worldwide. The virus increases the risk of liver cirrhosis and hepatocellular carcinoma. HCV is associated with numerous extrahepatic manifestations, such as type 2 diabetes mellitus, chronic kidney disease, cardiovascular disease, non-Hodgkin lymphomas, and various skin diseases (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Patients infected with HCV may have symptomatic mixed cryoglobulinemia (cryoglobulinemic vasculitis), which has an estimated prevalence of 4.9%, as well as porphyria cutanea tarda and lichen planus, with a relative risk 2 and 8 times that of the general population, respectively.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Other skin disorders possibly associated with HCV are psoriasis, alopecia, pruritus, polyarteritis nodosa, sarcoidosis, and necrolytic migratory erythema. Urticaria, Behçet disease, erythema nodosum, and erythema multiforme have also been reported, although the association is less clear.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The recent introduction of the latest generation of direct acting antivirals (DAAs)—including sofosbuvir, ledipasvir, daclatasvir, asunaprevir, and others—has revolutionized the treatment of chronic HCV infection due to the very high effectiveness, excellent safety profile, and tolerability of these drugs.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Current clinical guidelines (September 2016) suggest initiating treatment in all patients with chronic HCV infection except those with limited life expectancy.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Recently there have been reports of improvement in skin diseases associated with HCV after successful treatment with DAAs. A prospective study in Spain of 64 patients with mixed cryoglobulinemia secondary to HCV infection, 35 of whom had manifestations of cryoglobulinemic vasculitis—including purpura (65%, 23 of 35 patients), joint or muscle pain (51%), and neurologic or renal involvement (70%)—found that complete clinical response was achieved in 71% of symptomatic patients after therapy with various combinations of DAAs. In the patients who had purpura, cutaneous involvement remitted after sustained virological response (SVR) in nearly all cases (21 of 23 patients).<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Nagao et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> presented a series of 7 patients with HCV and oral lichen planus—4 with erosive lichen planus (3 of whom were previously treated with topical corticosteroids)—who received daclatasvir-asunaprevir combination therapy with SVR; complete resolution of oral disease was achieved in 4 patients and partial improvement was achieved in 3. Finally, Tong et al.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> described 3 individuals diagnosed with porphyria cutanea tarda and HCV infection who were successfully treated with ledipasvir-sofosbuvir combination therapy. Remission of cutaneous symptoms was achieved in 2 patients, and a marked decrease in the number of erosive lesions was achieved in the third patient between 1 and 3 months after completion of antiviral therapy.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In conclusion, DAAs are highly effective and safe for the treatment of HCV infection. Some reports suggest that DAAs could also achieve improvement in some skin diseases associated with HCV and that these drugs could perhaps be a therapeutic option for patients with aggressive skin disorders or who do not respond to conventional treatments. Given that the use of these drugs is expected to increase, we will be able to see whether these effects occur in a larger number of patients and if the effects persist over time.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec830195" "palabras" => array:6 [ 0 => "Hepatitis C virus" 1 => "Direct-acting antiviral" 2 => "Antiviral therapy" 3 => "Skin manifestations" 4 => "Mixed cryoglobulinemia" 5 => "Lichen planus" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Morgado-Carrasco D, Fustà-Novell X, Podlipnik S, Giavedoni P. FR-¿Son los nuevos agentes antivirales de acción directa un tratamiento eficaz para las manifestaciones cutáneas de la hepatitis <span class="elsevierStyleSmallCaps">C</span>?. Actas Dermosifiliogr. 2017;108:365–366.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Source: Younossi et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Well-established association</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Porphyria cutanea tarda \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lichen planus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Symptomatic cryoglobulinemia (cryoglobulinemic vasculitis) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Possible association</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Psoriasis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Alopecia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Polyarteritis nodosa \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sarcoidosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Necrolytic migratory erythema \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Uncertain association</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Urticaria \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Erythema multiforme \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Erythema nodosum \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Behçet disease \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1406716.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Skin Disorders Associated With Hepatitis C Virus Infection.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extrahepatic manifestations of hepatitis C: A meta-analysis of prevalence, quality of life, and economic burden" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Z. Younossi" 1 => "H. Park" 2 => "L. Henry" 3 => "A. Adeyemi" 4 => "M. Stepanova" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.gastro.2016.02.039" "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "2016" "volumen" => "150" "paginaInicial" => "1599" "paginaFinal" => "1608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26924097" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "pii: S1542-3565(16)30878-3" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Virologic, clinical, and immune response outcomes of patients with hepatitis C virus-associated cryoglobulinemia treated with direct-acting antivirals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Bonacci" 1 => "S. Lens" 2 => "M.C. Londoño" 3 => "Z. Mariño" 4 => "M.C. Cid" 5 => "M. Ramos-Casals" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Clin Gastroenterol Hepatol" "fecha" => "2016" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "AASLD-IDSA. Recommendations for testing, managing, and treating hepatitis C. <a href="http://www.hcvguidelines.org/">http://www.hcvguidelines.org</a>. Accessed October 23, 2016." ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of hepatitis C virus-associated oral lichen planus by interferon-free therapy with direct-acting antivirals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y. Nagao" 1 => "K. Kimura" 2 => "Y. Kawahigashi" 3 => "M. Sata" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ctg.2016.37" "Revista" => array:5 [ "tituloSerie" => "Clin Transl Gastroenterol" "fecha" => "2016" "volumen" => "7" "paginaInicial" => "e179" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27388424" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resolution of porphyria cutanea tarda in patients with hepatitis C following ledipasvir-sofosbuvir combination therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y. Tong" 1 => "Y.K. Song" 2 => "S. Tyring" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2016.3036" "Revista" => array:6 [ "tituloSerie" => "JAMA Dermatol" "fecha" => "2016" "volumen" => "152" "paginaInicial" => "1393" "paginaFinal" => "1395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27732687" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010800000004/v1_201704280927/S1578219017300483/v1_201704280927/en/main.assets" "Apartado" => array:4 [ "identificador" => "34945" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Resident's Forum" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010800000004/v1_201704280927/S1578219017300483/v1_201704280927/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300483?idApp=UINPBA000044" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 10 | 9 | 19 |
2024 Octubre | 77 | 33 | 110 |
2024 Septiembre | 77 | 27 | 104 |
2024 Agosto | 108 | 50 | 158 |
2024 Julio | 84 | 23 | 107 |
2024 Junio | 71 | 34 | 105 |
2024 Mayo | 51 | 31 | 82 |
2024 Abril | 67 | 26 | 93 |
2024 Marzo | 67 | 37 | 104 |
2024 Febrero | 65 | 29 | 94 |
2024 Enero | 60 | 33 | 93 |
2023 Diciembre | 59 | 14 | 73 |
2023 Noviembre | 80 | 29 | 109 |
2023 Octubre | 57 | 20 | 77 |
2023 Septiembre | 48 | 35 | 83 |
2023 Agosto | 44 | 17 | 61 |
2023 Julio | 43 | 31 | 74 |
2023 Junio | 41 | 22 | 63 |
2023 Mayo | 34 | 25 | 59 |
2023 Abril | 36 | 21 | 57 |
2023 Marzo | 34 | 17 | 51 |
2023 Febrero | 35 | 22 | 57 |
2023 Enero | 43 | 31 | 74 |
2022 Diciembre | 44 | 38 | 82 |
2022 Noviembre | 29 | 35 | 64 |
2022 Octubre | 32 | 16 | 48 |
2022 Septiembre | 27 | 33 | 60 |
2022 Agosto | 22 | 30 | 52 |
2022 Julio | 21 | 36 | 57 |
2022 Junio | 39 | 17 | 56 |
2022 Mayo | 22 | 35 | 57 |
2022 Abril | 32 | 32 | 64 |
2022 Marzo | 46 | 47 | 93 |
2022 Febrero | 28 | 34 | 62 |
2022 Enero | 37 | 29 | 66 |
2021 Diciembre | 23 | 42 | 65 |
2021 Noviembre | 26 | 39 | 65 |
2021 Octubre | 38 | 53 | 91 |
2021 Septiembre | 22 | 35 | 57 |
2021 Agosto | 27 | 40 | 67 |
2021 Julio | 19 | 28 | 47 |
2021 Junio | 23 | 23 | 46 |
2021 Mayo | 40 | 33 | 73 |
2021 Abril | 49 | 47 | 96 |
2021 Marzo | 52 | 21 | 73 |
2021 Febrero | 40 | 29 | 69 |
2021 Enero | 22 | 10 | 32 |
2020 Diciembre | 26 | 16 | 42 |
2020 Noviembre | 31 | 22 | 53 |
2020 Octubre | 27 | 15 | 42 |
2020 Septiembre | 35 | 14 | 49 |
2020 Agosto | 31 | 13 | 44 |
2020 Julio | 25 | 11 | 36 |
2020 Junio | 32 | 31 | 63 |
2020 Mayo | 13 | 15 | 28 |
2020 Abril | 29 | 17 | 46 |
2020 Marzo | 16 | 15 | 31 |
2020 Febrero | 3 | 0 | 3 |
2020 Enero | 8 | 0 | 8 |
2019 Diciembre | 4 | 0 | 4 |
2019 Noviembre | 4 | 0 | 4 |
2019 Octubre | 6 | 0 | 6 |
2019 Septiembre | 5 | 0 | 5 |
2019 Agosto | 6 | 0 | 6 |
2019 Julio | 8 | 0 | 8 |
2019 Junio | 4 | 0 | 4 |
2019 Mayo | 6 | 2 | 8 |
2019 Abril | 2 | 3 | 5 |
2019 Febrero | 7 | 0 | 7 |
2018 Diciembre | 5 | 0 | 5 |
2018 Noviembre | 4 | 0 | 4 |
2018 Octubre | 5 | 1 | 6 |
2018 Septiembre | 6 | 0 | 6 |
2018 Febrero | 23 | 4 | 27 |
2018 Enero | 29 | 6 | 35 |
2017 Diciembre | 30 | 6 | 36 |
2017 Noviembre | 23 | 12 | 35 |
2017 Octubre | 37 | 6 | 43 |
2017 Septiembre | 23 | 19 | 42 |
2017 Agosto | 26 | 29 | 55 |
2017 Julio | 28 | 9 | 37 |
2017 Junio | 41 | 11 | 52 |
2017 Mayo | 59 | 26 | 85 |
2017 Abril | 13 | 13 | 26 |
2017 Marzo | 1 | 5 | 6 |