Letter to the Editor
Comment on “Distant Cutaneous Metastases of Prostate Cancer: A Report of 2 Cases”
Comentario a «Metástasis cutáneas a distancia de cáncer de próstata: 2 casos»
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array:23 [ "pii" => "S1578219016303584" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.12.017" "estado" => "S300" "fechaPublicacion" => "2017-03-01" "aid" => "1544" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2016" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2017;108:174-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 522 "formatos" => array:3 [ "EPUB" => 50 "HTML" => 332 "PDF" => 140 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S000173101630360X" "issn" => "00017310" "doi" => "10.1016/j.ad.2016.10.008" "estado" => "S300" "fechaPublicacion" => "2017-03-01" "aid" => "1544" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2017;108:174-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 252 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 144 "PDF" => 103 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>" "titulo" => "Comentario a «Metástasis cutáneas a distancia de cáncer de próstata: 2 casos»" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "174" "paginaFinal" => "175" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Comment on «Distant Cutaneous Metastases of Prostate Cancer: A Report of 2 Cases»" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 659 "Ancho" => 990 "Tamanyo" => 218689 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Nódulo subcutáneo en espalda paravertebral derecha (ERG ×200, tinción nuclear).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Santos-Juanes, I. Fernández-Vega, B. Vivanco" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Santos-Juanes" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Fernández-Vega" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Vivanco" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219016303584" "doi" => "10.1016/j.adengl.2016.12.017" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016303584?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101630360X?idApp=UINPBA000044" "url" => "/00017310/0000010800000002/v1_201702250114/S000173101630360X/v1_201702250114/es/main.assets" ] ] "itemAnterior" => array:19 [ "pii" => "S157821901730015X" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.10.005" "estado" => "S300" "fechaPublicacion" => "2017-03-01" "aid" => "1548" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2017;108:174" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 402 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 263 "PDF" => 95 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Response to Professor Wiwanitkit's Comment on “Zika Virus Disease: Should We Be Worried?”" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "174" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Respuesta al comentario del profesor Wiwanitkit sobre “Enfermedad por el virus de Zika ¿debe preocuparnos?”" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.P. Alonso" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J.P." "apellidos" => "Alonso" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0001731016303647" "doi" => "10.1016/j.ad.2016.10.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016303647?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901730015X?idApp=UINPBA000044" "url" => "/15782190/0000010800000002/v1_201702250104/S157821901730015X/v1_201702250104/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Comment on “Distant Cutaneous Metastases of Prostate Cancer: A Report of 2 Cases”" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "174" "paginaFinal" => "175" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Santos-Juanes, I. Fernández-Vega, B. Vivanco" "autores" => array:3 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Santos-Juanes" "email" => array:1 [ 0 => "jorgesantosjuanes@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "Fernández-Vega" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "B." "apellidos" => "Vivanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología II, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Comentario a «Metástasis cutáneas a distancia de cáncer de próstata: 2 casos»" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 659 "Ancho" => 990 "Tamanyo" => 220609 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Subcutaneous nodule in right paravertebral back (ERG<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>200, nuclear staining).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with interest the article entitled “Distant cutaneous metastases of prostate cancer: a report of 2 cases”<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> in which an exhaustive immunohistochemical study left no doubt about the diagnosis. These cases remind us of usefulness of avian erythroblastosis virus E26 oncogene homolog (ERG) in the cutaneous diagnosis of prostate cancer metastasis.</p><p id="par0010" class="elsevierStylePara elsevierViewall">ERG is a member of the erythroblast transformation-specific family of transcription factors. It is expressed in normal and neoplastic endothelial cells of blood and lymph vessels and is a highly specific marker of vascular endothelium. ERG is very useful in the diagnosis of angiosarcomas, hemangioendotheliomas, and Kaposi's sarcoma. However, it is also positive in the following cell types: 1) neoplastic epithelial cells of 50% of primary and metastatic prostate carcinomas (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>), but not in normal prostate tissue; 2) immature myeloid cells in bone marrow; 3) chronic myeloid leukemia cells; and 4) Ewing sarcoma cells.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a> The fact that it is positive in prostate carcinoma but negative in almost all other carcinomas makes ERG a very valuable in immunohistochemical panels used to investigate cutaneous metastases of unknown origin.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Santos-Juanes J, Fernández-Vega I, Vivanco B. Comentario a «Metástasis cutáneas a distancia de cáncer de próstata: 2 casos». Actas Dermosifiliogr. 2017;108:174–175.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 659 "Ancho" => 990 "Tamanyo" => 220609 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Subcutaneous nodule in right paravertebral back (ERG<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>200, nuclear staining).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástasis cutáneas a distancia de cáncer de próstata: 2 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Rodríguez-Lojo" 1 => "I. Castiñeiras" 2 => "J.L. Rey-Sanjurjo" 3 => "M.L. Fernández-Díaz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2015.09.021" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2016" "volumen" => "107" "paginaInicial" => "e52" "paginaFinal" => "e56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27085465" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Miettinen" 1 => "Z.F. Wang" 2 => "A. Paetau" 3 => "S.H. Tan" 4 => "A. Dobi" 5 => "S. Srivastava" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/PAS.0b013e318206b67b" "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2011" "volumen" => "35" "paginaInicial" => "432" "paginaFinal" => "441" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21317715" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inmunohistoquímica en dermatopatología: revisión de los anticuerpos utilizados con mayor frecuencia (parte I)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Fuertes" 1 => "C. Santonja" 2 => "H. Kutzner" 3 => "L. Requena" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2012.02.015" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2013" "volumen" => "104" "paginaInicial" => "99" "paginaFinal" => "127" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23062957" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010800000002/v1_201702250104/S1578219016303584/v1_201702250104/en/main.assets" "Apartado" => array:4 [ "identificador" => "6208" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010800000002/v1_201702250104/S1578219016303584/v1_201702250104/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016303584?idApp=UINPBA000044" ]
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