array:23 [
  "pii" => "S1578219016302694"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2016.10.002"
  "estado" => "S300"
  "fechaPublicacion" => "2016-11-01"
  "aid" => "1418"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2016;107:797-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 740
    "formatos" => array:3 [
      "EPUB" => 43
      "HTML" => 516
      "PDF" => 181
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S0001731016300825"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2016.04.011"
      "estado" => "S300"
      "fechaPublicacion" => "2016-11-01"
      "aid" => "1418"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2016;107:797-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 717
        "formatos" => array:3 [
          "EPUB" => 76
          "HTML" => 388
          "PDF" => 253
        ]
      ]
      "en" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
        "titulo" => "Father-to-Newborn Transmission of Herpes Simplex Virus Infection&#58; A Sweet but Bitter Kiss"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "797"
            "paginaFinal" => "798"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Herpes neonatal tras contacto con herpes labial paterno&#58; dulce y amargo beso"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1020
                "Ancho" => 950
                "Tamanyo" => 161030
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Groups of vesicles and pustules overlying erythematous skin&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "O&#46; Guergu&#233; Diaz de Cerio, M&#46; Rubio Lombra&#241;a, A&#46; Barrutia Borque, M&#46;R&#46; Gonz&#225;lez Hermosa"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "O&#46;"
                "apellidos" => "Guergu&#233; Diaz de Cerio"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Rubio Lombra&#241;a"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Barrutia Borque"
              ]
              3 => array:2 [
                "nombre" => "M&#46;R&#46;"
                "apellidos" => "Gonz&#225;lez Hermosa"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219016302694"
          "doi" => "10.1016/j.adengl.2016.10.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302694?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016300825?idApp=UINPBA000044"
      "url" => "/00017310/0000010700000009/v1_201611020109/S0001731016300825/v1_201611020109/en/main.assets"
    ]
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219016302682"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.10.001"
    "estado" => "S300"
    "fechaPublicacion" => "2016-11-01"
    "aid" => "1427"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:795-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 562
      "formatos" => array:3 [
        "EPUB" => 39
        "HTML" => 386
        "PDF" => 137
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Leukocytoclastic vasculitis related to cocaine-adulterated levamisole"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "795"
          "paginaFinal" => "797"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Vasculitis leucocitocl&#225;stica relacionada con coca&#237;na adulterada con levamisol"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1245
              "Ancho" => 701
              "Tamanyo" => 169186
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Patches with a necrotic central area and erythematous borders on the right ear&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Imbern&#243;n-Moya, R&#46; Chico, I&#46; de la Hera, M&#46;&#193;&#46; Gallego-Vald&#233;s"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Imbern&#243;n-Moya"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Chico"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "de la Hera"
            ]
            3 => array:2 [
              "nombre" => "M&#46;&#193;&#46;"
              "apellidos" => "Gallego-Vald&#233;s"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302682?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000009/v1_201611010039/S1578219016302682/v1_201611010039/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Father-to-Newborn Transmission of Herpes Simplex Virus Infection&#58; A Sweet but Bitter Kiss"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "797"
        "paginaFinal" => "798"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "O&#46; Guergu&#233; Diaz de Cerio, M&#46; Rubio Lombra&#241;a, A&#46; Barrutia Borque, M&#46;R&#46; Gonz&#225;lez Hermosa"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "O&#46;"
            "apellidos" => "Guergu&#233; Diaz de Cerio"
            "email" => array:2 [
              0 => "olaneguergue06051988&#64;gmail&#46;com"
              1 => "olane&#46;guerguediazdecerio&#64;osakidetza&#46;eus"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Rubio Lombra&#241;a"
          ]
          2 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Barrutia Borque"
          ]
          3 => array:2 [
            "nombre" => "M&#46;R&#46;"
            "apellidos" => "Gonz&#225;lez Hermosa"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a del Hospital Universitario Cruces&#44; Vizcaya&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Herpes neonatal tras contacto con herpes labial paterno&#58; dulce y amargo beso"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1020
            "Ancho" => 951
            "Tamanyo" => 166520
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Groups of vesicles and pustules overlying erythematous skin&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">While rare&#44; neonatal herpes simplex virus &#40;HSV&#41; infection is one of the most severe perinatal infections&#46; Only 10&#37; of cases are acquired after birth&#46; The disease is classified according to clinical presentation as follows&#58; skin&#44; eye&#44; and mouth &#40;SEM&#41; disease &#40;prevalence of &#8776;45&#37;&#41;&#59; central nervous system &#40;CNS&#41; disease &#40;&#8776;30&#37;&#41;&#44; and disseminated disease &#40;&#8776;25&#37;&#41;&#44; which has the worst prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> No deaths have been reported for SEM disease&#44; but 2&#37; of those affected may develop some degree of impairment by the age of 12 years&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a> Early recognition and treatment with high-dose acyclovir &#40;60<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#41; reduces mortality and may improve long-term outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 10-day-old newborn female admitted to the hospital with generalized skin lesions that had appeared 5<span class="elsevierStyleHsp" style=""></span>h previously&#46; The lesions consisted of groups of vesicles and pustules overlying erythematous skin&#44; affecting the trunk and tongue &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The infant did not have fever or neurologic symptoms and was systemically well&#46; There had been no complications during the pregnancy&#44; vaginal delivery&#44; or immediate postpartum period&#46; The mother had had systemic lupus erythematous for the past 6 years&#44; but this was clinically stable&#46; She had had chickenpox during her childhood but had no genital lesions suggestive of herpes infection&#46; The father&#44; however&#44; had active herpes simplex labialis and admitted to having repeatedly kissed his baby while he had active lesions&#46; HSV type 1 was isolated from vesicular lesions in the neonate by real-time polymerase chain reaction &#40;PCR&#41;&#46; The rest of the tests were normal or negative&#44; and included biochemical analysis&#44; blood cell count&#44; coagulation studies&#44; blood culture&#44; PCR for varicella-zoster virus from the newborn&#39;s vesicles&#44; and culture and PCR for HSV&#44; enterovirus&#44; and varicella-zoster virus in cerebrospinal fluid&#46; The fundus of the eye and ultrasound imaging of the brain were also normal&#46; Due to the high suspicion of HSV infection&#44; high-dose intravenous acyclovir was administered empirically while awaiting the PCR test results&#46; Once the diagnosis had been confirmed&#44; acyclovir was continued to complete 14 days of treatment&#46; Contact isolation was also established&#46; The girl&#39;s condition gradually improved over the next few days&#44; and no sequelae were observed in the follow-up period&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">HSV is a common human pathogen&#46; Between 30&#37; and 100&#37; of adults have serologic evidence of the virus&#46; It has been shown that oral HSV excretion is episodic and may occur in the presence or absence of herpes labialis&#46; Importantly and contrary to general belief&#44; reactivation of HSV leads more frequently to asymptomatic viral shedding than to recurrence of mucocutaneous lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">HSV infection in neonates typically presents within the first 4 weeks of life&#46; Skin lesions are an important diagnostic clue&#44; but they are absent in 39&#37; of cases of disseminated disease&#44; 32&#37; of cases of CNS disease&#44; and 17&#37; of cases of SEM disease&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a> The proportion of neonatal infections due to HSV type 1 has increased in the last decade&#44; possibly as a consequence of changing sexual habits among parents&#46; An early diagnosis is mandatory and the method of choice is detection of HSV DNA by PCR or virus culture&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Our findings led to a diagnosis of neonatal HSV type 1 infection &#40;SEM disease&#41;&#46; We believe that the most likely source of transmission was the father&#39;s herpes simplex labialis&#44; although we cannot be entirely certain because virus isolation was not performed&#46; We initiated early empirical treatment about 8<span class="elsevierStyleHsp" style=""></span>h after onset of the lesions&#44; and may&#44; therefore&#44; have prevented progression to CNS involvement&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The aim of this article is to alert dermatologists to the possibility of postnatally acquired HSV infection in newborns&#46; We emphasize the importance of establishing an early diagnosis and initiating empirical treatment upon the first suspicion&#46; Based on our case&#44; we strongly recommend separation of the newborn from any person with active HSV lesions &#40;mothers with herpes labialis should wear a mask&#41;&#46; We also recommend offering anticipatory guidance for parents&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:3 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflict of interests"
        ]
        1 => array:2 [
          "identificador" => "xack249673"
          "titulo" => "Acknowledgments"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1020
            "Ancho" => 951
            "Tamanyo" => 166520
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Groups of vesicles and pustules overlying erythematous skin&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:4 [
            0 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Gantt"
                            1 => "W&#46;J&#46; Muller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2013/369172"
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Dev Immunol"
                        "fecha" => "2013"
                        "volumen" => "2013"
                        "paginaInicial" => "369172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23606868"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural history of neonatal herpes simplex virus infections in the acyclovir era"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;W&#46; Kimberlin"
                            1 => "C&#46;Y&#46; Lin"
                            2 => "R&#46;F&#46; Jacobs"
                            3 => "D&#46;A&#46; Powell"
                            4 => "L&#46;M&#46; Frenkel"
                            5 => "W&#46;C&#46; Gruber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2001"
                        "volumen" => "108"
                        "paginaInicial" => "223"
                        "paginaFinal" => "229"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11483781"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of herpes simplex virus infections in pediatric patients&#58; current status and future needs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;H&#46; James"
                            1 => "R&#46;J&#46; Whitley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/clpt.2010.192"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Pharmacol Ther"
                        "fecha" => "2010"
                        "volumen" => "88"
                        "paginaInicial" => "720"
                        "paginaFinal" => "724"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20881952"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevention and management of neonatal herpes simplex virus infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "U&#46;D&#46; Allen"
                            1 => "J&#46;L&#46; Robinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Paediatr Child Health"
                        "fecha" => "2014"
                        "volumen" => "19"
                        "paginaInicial" => "201"
                        "paginaFinal" => "206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24855418"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack249673"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0040" class="elsevierStylePara elsevierViewall">We thank the patient&#39;s parents for providing the photographs used in this article and for authorizing their publication&#46; We would also like to thank Rabia Sofia Rashid for correcting the manuscript&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010700000009/v1_201611010039/S1578219016302694/v1_201611010039/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000009/v1_201611010039/S1578219016302694/v1_201611010039/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302694?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letter
Father-to-Newborn Transmission of Herpes Simplex Virus Infection: A Sweet but Bitter Kiss
Herpes neonatal tras contacto con herpes labial paterno: dulce y amargo beso
O. Guergué Diaz de Cerio
Autor para correspondencia
, M. Rubio Lombraña, A. Barrutia Borque, M.R. González Hermosa
Servicio de Dermatología del Hospital Universitario Cruces, Vizcaya, Spain
Leído
11051
Veces
se ha leído el artículo
1958
Total PDF
9093
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S1578219016302694"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2016.10.002"
  "estado" => "S300"
  "fechaPublicacion" => "2016-11-01"
  "aid" => "1418"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2016;107:797-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 740
    "formatos" => array:3 [
      "EPUB" => 43
      "HTML" => 516
      "PDF" => 181
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S0001731016300825"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2016.04.011"
      "estado" => "S300"
      "fechaPublicacion" => "2016-11-01"
      "aid" => "1418"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2016;107:797-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 717
        "formatos" => array:3 [
          "EPUB" => 76
          "HTML" => 388
          "PDF" => 253
        ]
      ]
      "en" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
        "titulo" => "Father-to-Newborn Transmission of Herpes Simplex Virus Infection&#58; A Sweet but Bitter Kiss"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "797"
            "paginaFinal" => "798"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Herpes neonatal tras contacto con herpes labial paterno&#58; dulce y amargo beso"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1020
                "Ancho" => 950
                "Tamanyo" => 161030
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Groups of vesicles and pustules overlying erythematous skin&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "O&#46; Guergu&#233; Diaz de Cerio, M&#46; Rubio Lombra&#241;a, A&#46; Barrutia Borque, M&#46;R&#46; Gonz&#225;lez Hermosa"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "O&#46;"
                "apellidos" => "Guergu&#233; Diaz de Cerio"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Rubio Lombra&#241;a"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Barrutia Borque"
              ]
              3 => array:2 [
                "nombre" => "M&#46;R&#46;"
                "apellidos" => "Gonz&#225;lez Hermosa"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219016302694"
          "doi" => "10.1016/j.adengl.2016.10.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302694?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016300825?idApp=UINPBA000044"
      "url" => "/00017310/0000010700000009/v1_201611020109/S0001731016300825/v1_201611020109/en/main.assets"
    ]
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219016302682"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.10.001"
    "estado" => "S300"
    "fechaPublicacion" => "2016-11-01"
    "aid" => "1427"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:795-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 562
      "formatos" => array:3 [
        "EPUB" => 39
        "HTML" => 386
        "PDF" => 137
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Leukocytoclastic vasculitis related to cocaine-adulterated levamisole"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "795"
          "paginaFinal" => "797"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Vasculitis leucocitocl&#225;stica relacionada con coca&#237;na adulterada con levamisol"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1245
              "Ancho" => 701
              "Tamanyo" => 169186
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Patches with a necrotic central area and erythematous borders on the right ear&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Imbern&#243;n-Moya, R&#46; Chico, I&#46; de la Hera, M&#46;&#193;&#46; Gallego-Vald&#233;s"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Imbern&#243;n-Moya"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Chico"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "de la Hera"
            ]
            3 => array:2 [
              "nombre" => "M&#46;&#193;&#46;"
              "apellidos" => "Gallego-Vald&#233;s"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302682?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000009/v1_201611010039/S1578219016302682/v1_201611010039/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Father-to-Newborn Transmission of Herpes Simplex Virus Infection&#58; A Sweet but Bitter Kiss"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "797"
        "paginaFinal" => "798"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "O&#46; Guergu&#233; Diaz de Cerio, M&#46; Rubio Lombra&#241;a, A&#46; Barrutia Borque, M&#46;R&#46; Gonz&#225;lez Hermosa"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "O&#46;"
            "apellidos" => "Guergu&#233; Diaz de Cerio"
            "email" => array:2 [
              0 => "olaneguergue06051988&#64;gmail&#46;com"
              1 => "olane&#46;guerguediazdecerio&#64;osakidetza&#46;eus"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Rubio Lombra&#241;a"
          ]
          2 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Barrutia Borque"
          ]
          3 => array:2 [
            "nombre" => "M&#46;R&#46;"
            "apellidos" => "Gonz&#225;lez Hermosa"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a del Hospital Universitario Cruces&#44; Vizcaya&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Herpes neonatal tras contacto con herpes labial paterno&#58; dulce y amargo beso"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1020
            "Ancho" => 951
            "Tamanyo" => 166520
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Groups of vesicles and pustules overlying erythematous skin&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">While rare&#44; neonatal herpes simplex virus &#40;HSV&#41; infection is one of the most severe perinatal infections&#46; Only 10&#37; of cases are acquired after birth&#46; The disease is classified according to clinical presentation as follows&#58; skin&#44; eye&#44; and mouth &#40;SEM&#41; disease &#40;prevalence of &#8776;45&#37;&#41;&#59; central nervous system &#40;CNS&#41; disease &#40;&#8776;30&#37;&#41;&#44; and disseminated disease &#40;&#8776;25&#37;&#41;&#44; which has the worst prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> No deaths have been reported for SEM disease&#44; but 2&#37; of those affected may develop some degree of impairment by the age of 12 years&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a> Early recognition and treatment with high-dose acyclovir &#40;60<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#41; reduces mortality and may improve long-term outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 10-day-old newborn female admitted to the hospital with generalized skin lesions that had appeared 5<span class="elsevierStyleHsp" style=""></span>h previously&#46; The lesions consisted of groups of vesicles and pustules overlying erythematous skin&#44; affecting the trunk and tongue &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The infant did not have fever or neurologic symptoms and was systemically well&#46; There had been no complications during the pregnancy&#44; vaginal delivery&#44; or immediate postpartum period&#46; The mother had had systemic lupus erythematous for the past 6 years&#44; but this was clinically stable&#46; She had had chickenpox during her childhood but had no genital lesions suggestive of herpes infection&#46; The father&#44; however&#44; had active herpes simplex labialis and admitted to having repeatedly kissed his baby while he had active lesions&#46; HSV type 1 was isolated from vesicular lesions in the neonate by real-time polymerase chain reaction &#40;PCR&#41;&#46; The rest of the tests were normal or negative&#44; and included biochemical analysis&#44; blood cell count&#44; coagulation studies&#44; blood culture&#44; PCR for varicella-zoster virus from the newborn&#39;s vesicles&#44; and culture and PCR for HSV&#44; enterovirus&#44; and varicella-zoster virus in cerebrospinal fluid&#46; The fundus of the eye and ultrasound imaging of the brain were also normal&#46; Due to the high suspicion of HSV infection&#44; high-dose intravenous acyclovir was administered empirically while awaiting the PCR test results&#46; Once the diagnosis had been confirmed&#44; acyclovir was continued to complete 14 days of treatment&#46; Contact isolation was also established&#46; The girl&#39;s condition gradually improved over the next few days&#44; and no sequelae were observed in the follow-up period&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">HSV is a common human pathogen&#46; Between 30&#37; and 100&#37; of adults have serologic evidence of the virus&#46; It has been shown that oral HSV excretion is episodic and may occur in the presence or absence of herpes labialis&#46; Importantly and contrary to general belief&#44; reactivation of HSV leads more frequently to asymptomatic viral shedding than to recurrence of mucocutaneous lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">HSV infection in neonates typically presents within the first 4 weeks of life&#46; Skin lesions are an important diagnostic clue&#44; but they are absent in 39&#37; of cases of disseminated disease&#44; 32&#37; of cases of CNS disease&#44; and 17&#37; of cases of SEM disease&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a> The proportion of neonatal infections due to HSV type 1 has increased in the last decade&#44; possibly as a consequence of changing sexual habits among parents&#46; An early diagnosis is mandatory and the method of choice is detection of HSV DNA by PCR or virus culture&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Our findings led to a diagnosis of neonatal HSV type 1 infection &#40;SEM disease&#41;&#46; We believe that the most likely source of transmission was the father&#39;s herpes simplex labialis&#44; although we cannot be entirely certain because virus isolation was not performed&#46; We initiated early empirical treatment about 8<span class="elsevierStyleHsp" style=""></span>h after onset of the lesions&#44; and may&#44; therefore&#44; have prevented progression to CNS involvement&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The aim of this article is to alert dermatologists to the possibility of postnatally acquired HSV infection in newborns&#46; We emphasize the importance of establishing an early diagnosis and initiating empirical treatment upon the first suspicion&#46; Based on our case&#44; we strongly recommend separation of the newborn from any person with active HSV lesions &#40;mothers with herpes labialis should wear a mask&#41;&#46; We also recommend offering anticipatory guidance for parents&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:3 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflict of interests"
        ]
        1 => array:2 [
          "identificador" => "xack249673"
          "titulo" => "Acknowledgments"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1020
            "Ancho" => 951
            "Tamanyo" => 166520
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Groups of vesicles and pustules overlying erythematous skin&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:4 [
            0 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Gantt"
                            1 => "W&#46;J&#46; Muller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2013/369172"
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Dev Immunol"
                        "fecha" => "2013"
                        "volumen" => "2013"
                        "paginaInicial" => "369172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23606868"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural history of neonatal herpes simplex virus infections in the acyclovir era"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;W&#46; Kimberlin"
                            1 => "C&#46;Y&#46; Lin"
                            2 => "R&#46;F&#46; Jacobs"
                            3 => "D&#46;A&#46; Powell"
                            4 => "L&#46;M&#46; Frenkel"
                            5 => "W&#46;C&#46; Gruber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2001"
                        "volumen" => "108"
                        "paginaInicial" => "223"
                        "paginaFinal" => "229"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11483781"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of herpes simplex virus infections in pediatric patients&#58; current status and future needs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;H&#46; James"
                            1 => "R&#46;J&#46; Whitley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/clpt.2010.192"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Pharmacol Ther"
                        "fecha" => "2010"
                        "volumen" => "88"
                        "paginaInicial" => "720"
                        "paginaFinal" => "724"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20881952"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevention and management of neonatal herpes simplex virus infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "U&#46;D&#46; Allen"
                            1 => "J&#46;L&#46; Robinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Paediatr Child Health"
                        "fecha" => "2014"
                        "volumen" => "19"
                        "paginaInicial" => "201"
                        "paginaFinal" => "206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24855418"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack249673"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0040" class="elsevierStylePara elsevierViewall">We thank the patient&#39;s parents for providing the photographs used in this article and for authorizing their publication&#46; We would also like to thank Rabia Sofia Rashid for correcting the manuscript&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010700000009/v1_201611010039/S1578219016302694/v1_201611010039/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000009/v1_201611010039/S1578219016302694/v1_201611010039/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302694?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 42 16 58
2024 Octubre 242 51 293
2024 Septiembre 248 25 273
2024 Agosto 244 75 319
2024 Julio 276 42 318
2024 Junio 218 26 244
2024 Mayo 225 46 271
2024 Abril 203 25 228
2024 Marzo 231 28 259
2024 Febrero 302 24 326
2024 Enero 297 41 338
2023 Diciembre 298 17 315
2023 Noviembre 237 54 291
2023 Octubre 191 15 206
2023 Septiembre 190 36 226
2023 Agosto 138 32 170
2023 Julio 165 44 209
2023 Junio 197 39 236
2023 Mayo 208 30 238
2023 Abril 171 24 195
2023 Marzo 148 20 168
2023 Febrero 144 17 161
2023 Enero 134 35 169
2022 Diciembre 44 45 89
2022 Noviembre 27 19 46
2022 Octubre 25 22 47
2022 Septiembre 22 29 51
2022 Agosto 18 29 47
2022 Julio 17 30 47
2022 Junio 25 23 48
2022 Mayo 161 39 200
2022 Abril 211 28 239
2022 Marzo 223 46 269
2022 Febrero 251 40 291
2022 Enero 219 59 278
2021 Diciembre 207 44 251
2021 Noviembre 198 37 235
2021 Octubre 195 64 259
2021 Septiembre 186 42 228
2021 Agosto 199 22 221
2021 Julio 167 32 199
2021 Junio 203 25 228
2021 Mayo 181 49 230
2021 Abril 338 45 383
2021 Marzo 177 25 202
2021 Febrero 102 28 130
2021 Enero 71 23 94
2020 Diciembre 59 20 79
2020 Noviembre 45 14 59
2020 Octubre 52 10 62
2020 Septiembre 49 13 62
2020 Agosto 32 24 56
2020 Julio 21 15 36
2020 Junio 29 24 53
2020 Mayo 19 15 34
2020 Abril 27 17 44
2020 Marzo 26 18 44
2020 Febrero 3 0 3
2020 Enero 4 0 4
2019 Diciembre 6 0 6
2019 Noviembre 4 0 4
2019 Agosto 4 0 4
2019 Julio 4 0 4
2019 Junio 4 0 4
2019 Mayo 5 1 6
2019 Abril 2 8 10
2019 Marzo 2 0 2
2019 Febrero 4 0 4
2019 Enero 3 0 3
2018 Diciembre 1 0 1
2018 Noviembre 1 0 1
2018 Octubre 2 0 2
2018 Febrero 23 4 27
2018 Enero 45 6 51
2017 Diciembre 39 9 48
2017 Noviembre 27 7 34
2017 Octubre 49 10 59
2017 Septiembre 24 5 29
2017 Agosto 29 8 37
2017 Julio 36 11 47
2017 Junio 24 11 35
2017 Mayo 27 5 32
2017 Abril 17 6 23
2017 Marzo 10 15 25
2017 Febrero 24 11 35
2017 Enero 12 9 21
2016 Diciembre 26 16 42
2016 Noviembre 57 39 96
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?