Case and Research Letter
Allergic Contact Dermatitis Due to Capryloyl Salicylic Acid
Dermatitis alérgica de contacto por ácido capriloil salicílico
R. González-Pérez
, L. Carnero-González, M.I. Martínez-González
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Servicio de Dermatología, Hospital Universitario Araba, Vitoria-Gasteiz, Araba, Spain
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González-Pérez, L. Carnero-González, M.I. Martínez-González" "autores" => array:3 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "González-Pérez" "email" => array:1 [ 0 => "ricardo.gonzalezperez@osakidetza.eus" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Carnero-González" ] 2 => array:2 [ "nombre" => "M.I." "apellidos" => "Martínez-González" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Araba, Vitoria-Gasteiz, Araba, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatitis alérgica de contacto por ácido capriloil salicílico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 602 "Ancho" => 803 "Tamanyo" => 65070 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Positive allergic reaction to capryloyl salicylic acid.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">When cosmetic allergy is suspected, it is essential to include the personal care products used by the patient in the patch tests as not only will this facilitate a more exact diagnosis, but also it may make it possible to identify new allergens. The collaboration of the pharmaceutical and cosmetics industries is fundamental to this approach, as it is those companies that will have to supply us with the components of the specific products. We present a case of allergic contact dermatitis to capryloyl salicylic acid present in an antiwrinkle cream. A 40-year-old woman consulted for a pruritic erythematous rash that arose on her face 10 days after starting to apply an antiwrinkle cream (Revitalift Laser X3 Day Cream by L’Oreal). The condition resolved after interruption of the use of the cream and a week of treatment with a topical corticosteroid. Patch testing was performed using the standard series of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC), a cosmetics series (Chemotechnique, Sweden), and the specific cream used by the patient, with readings taken at 48 and 96<span class="elsevierStyleHsp" style=""></span>hours, in accordance with the recommendations of the European Society of Contact Dermatitis (ESCD). In the final reading at 96<span class="elsevierStyleHsp" style=""></span>hours, a positive reaction (++) was observed to the specific cream used by the patient and negative reactions to the other allergens in the standard and cosmetics series. We contacted the company that marketed the cream involved and they provided us with the 27 ingredients of the cream, thus enabling us to complete the study. A positive allergic reaction (++) to 1% capryloyl salicylic acid in alcohol was observed in the readings taken at 48 and 96<span class="elsevierStyleHsp" style=""></span>hours (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). This same substance showed no allergic responses after patch testing in 15 healthy controls.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Capryloyl salicylic acid (5-capryloyl salicylic acid, CAS no. 78418-01-6, also known as 2-hydroxy-5-octanoylbenzoic acid) is a lipophilic derivative of salicylic acid that promotes epidermal renewal, stimulates collagen formation, combats chronic actinic photodamage,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> and increases skin resilience to UV radiation. It is attributed comedolytic,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> antiacne,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> antibacterial, and anti-inflammatory<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> properties. This substance is widely used, mainly by the French cosmetics industry, and it can be included in facial emollients, antiaging formulations, products for the treatment of acne, sunscreens, and facial hygiene products.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">De Groot et al.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> recently published the first 2 cases of contact allergy to capryloyl salicylic acid, using 1% capryloyl salicylic acid in alcohol in the patch testing of their patients. According to those authors, the allergenicity of this substance may derive more from the salicylic or benzoic part of the molecule that from the caprylic acid fraction. However, Roberts et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> concluded that 5-capryloyl salicylic acid was probably not the agent responsible for the allergy of the patients described by de Groot et al.; in their opinion, the allergy was due to its 3-capryloyl salicylic acid isomer, a contaminant of 5-capryloyl salicylic acid.</p><p id="par0020" class="elsevierStylePara elsevierViewall">We have described a third case of allergic contact dermatitis to capryloyl salicylic acid, the diagnosis of which was made possible by patch testing the ingredients provided by the company marketing the cream used by the patient, as these substances are not included in other test series. The description of further cases in which capryloyl salicylic acid is implicated will clarify the allergenic potential of this substance.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: González-Pérez R, Carnero-González L, Martínez-González MI. Dermatitis alérgica de contacto por ácido capriloil salicílico. Actas Dermosifiliogr. 2016;107:694–695.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 602 "Ancho" => 803 "Tamanyo" => 65070 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Positive allergic reaction to capryloyl salicylic acid.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. 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Verschoore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1473-2165.2007.00296.x" "Revista" => array:6 [ "tituloSerie" => "J Cosmet Dermatol" "fecha" => "2007" "volumen" => "6" "paginaInicial" => "59" "paginaFinal" => "65" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17348998" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact allergy to capryloyl salicylic acid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. De Groot" 1 => "T. Rustemeyer" 2 => "D. Hissink" 3 => "M. Bakker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cod.12239" "Revista" => array:7 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2014" "volumen" => "71" "paginaInicial" => "185" "paginaFinal" => "187" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25155078" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0302283808002947" "estado" => "S300" "issn" => "03022838" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact allergy to capryloyl salicylic acid: A mechanistic chemistry and structure-activity perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.W. Roberts" 1 => "A.O. Aptula" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cod.12368" "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2015" "volumen" => "72" "paginaInicial" => "347" "paginaFinal" => "351" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25720316" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010700000008/v2_201704100057/S1578219016301603/v2_201704100057/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000008/v2_201704100057/S1578219016301603/v2_201704100057/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016301603?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 13 | 9 | 22 |
| 2024 Octubre | 176 | 47 | 223 |
| 2024 Septiembre | 181 | 24 | 205 |
| 2024 Agosto | 226 | 58 | 284 |
| 2024 Julio | 220 | 32 | 252 |
| 2024 Junio | 184 | 25 | 209 |
| 2024 Mayo | 212 | 37 | 249 |
| 2024 Abril | 208 | 21 | 229 |
| 2024 Marzo | 202 | 27 | 229 |
| 2024 Febrero | 187 | 36 | 223 |
| 2024 Enero | 170 | 32 | 202 |
| 2023 Diciembre | 146 | 28 | 174 |
| 2023 Noviembre | 271 | 63 | 334 |
| 2023 Octubre | 197 | 24 | 221 |
| 2023 Septiembre | 242 | 43 | 285 |
| 2023 Agosto | 236 | 31 | 267 |
| 2023 Julio | 233 | 42 | 275 |
| 2023 Junio | 170 | 40 | 210 |
| 2023 Mayo | 133 | 69 | 202 |
| 2023 Abril | 143 | 25 | 168 |
| 2023 Marzo | 137 | 43 | 180 |
| 2023 Febrero | 110 | 31 | 141 |
| 2023 Enero | 74 | 32 | 106 |
| 2022 Diciembre | 75 | 38 | 113 |
| 2022 Noviembre | 47 | 23 | 70 |
| 2022 Octubre | 51 | 22 | 73 |
| 2022 Septiembre | 24 | 37 | 61 |
| 2022 Agosto | 28 | 34 | 62 |
| 2022 Julio | 33 | 38 | 71 |
| 2022 Junio | 31 | 35 | 66 |
| 2022 Mayo | 78 | 42 | 120 |
| 2022 Abril | 101 | 43 | 144 |
| 2022 Marzo | 99 | 56 | 155 |
| 2022 Febrero | 89 | 31 | 120 |
| 2022 Enero | 123 | 35 | 158 |
| 2021 Diciembre | 84 | 40 | 124 |
| 2021 Noviembre | 94 | 61 | 155 |
| 2021 Octubre | 116 | 57 | 173 |
| 2021 Septiembre | 94 | 46 | 140 |
| 2021 Agosto | 90 | 40 | 130 |
| 2021 Julio | 79 | 29 | 108 |
| 2021 Junio | 99 | 28 | 127 |
| 2021 Mayo | 80 | 38 | 118 |
| 2021 Abril | 181 | 34 | 215 |
| 2021 Marzo | 121 | 29 | 150 |
| 2021 Febrero | 111 | 36 | 147 |
| 2021 Enero | 83 | 19 | 102 |
| 2020 Diciembre | 77 | 16 | 93 |
| 2020 Noviembre | 64 | 20 | 84 |
| 2020 Octubre | 80 | 16 | 96 |
| 2020 Septiembre | 74 | 27 | 101 |
| 2020 Agosto | 56 | 21 | 77 |
| 2020 Julio | 71 | 17 | 88 |
| 2020 Junio | 58 | 33 | 91 |
| 2020 Mayo | 68 | 24 | 92 |
| 2020 Abril | 68 | 21 | 89 |
| 2020 Marzo | 28 | 16 | 44 |
| 2020 Febrero | 5 | 4 | 9 |
| 2020 Enero | 6 | 0 | 6 |
| 2019 Diciembre | 8 | 0 | 8 |
| 2019 Noviembre | 4 | 0 | 4 |
| 2019 Septiembre | 4 | 0 | 4 |
| 2019 Agosto | 6 | 0 | 6 |
| 2019 Julio | 4 | 0 | 4 |
| 2019 Junio | 4 | 0 | 4 |
| 2019 Mayo | 7 | 1 | 8 |
| 2019 Abril | 6 | 6 | 12 |
| 2019 Marzo | 4 | 0 | 4 |
| 2019 Febrero | 1 | 0 | 1 |
| 2019 Enero | 2 | 0 | 2 |
| 2018 Diciembre | 5 | 0 | 5 |
| 2018 Noviembre | 1 | 0 | 1 |
| 2018 Octubre | 3 | 0 | 3 |
| 2018 Septiembre | 2 | 0 | 2 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Febrero | 81 | 3 | 84 |
| 2018 Enero | 65 | 13 | 78 |
| 2017 Diciembre | 78 | 8 | 86 |
| 2017 Noviembre | 68 | 8 | 76 |
| 2017 Octubre | 66 | 9 | 75 |
| 2017 Septiembre | 46 | 8 | 54 |
| 2017 Agosto | 42 | 9 | 51 |
| 2017 Julio | 31 | 6 | 37 |
| 2017 Junio | 34 | 19 | 53 |
| 2017 Mayo | 43 | 16 | 59 |
| 2017 Abril | 49 | 14 | 63 |
| 2017 Marzo | 37 | 17 | 54 |
| 2017 Febrero | 32 | 16 | 48 |
| 2017 Enero | 29 | 13 | 42 |
| 2016 Diciembre | 26 | 26 | 52 |
| 2016 Noviembre | 34 | 25 | 59 |
| 2016 Octubre | 68 | 32 | 100 |
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