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Case and Research Letter
Michelin Baby Associated With Facial Abnormalities
Bebé Michelin asociado a anomalías faciales
L. Noguera-Morel
Autor para correspondencia
luceronoguera@gmail.com

Corresponding author.
, I. Andrés-Ramos, A. Hernández-Martín, A. Torrelo
Servicio de Dermatología, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
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    "titulo" => "Michelin Baby Associated With Facial Abnormalities"
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      "es" => array:1 [
        "titulo" => "Beb&#233; Michelin asociado a anomal&#237;as faciales"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Abundant circumferential skin folds of soft but solid consistency around the limbs and neck&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The term Michelin tire baby &#40;MTB&#41; was first used in 1969 by Ross<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> to refer to the case of a baby with multiple&#44; widespread skin folds associated with hemihypertrophy and a broad bridge of the nose&#46; We report the case of a girl with MTB and mild associated dysmorphic alterations&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 3-month-old girl of Romanian origin&#44; born at 34 weeks&#44; with no history of consanguinity&#44; was seen for excessive skin folds&#46; She had no personal or family history of interest&#46; Physical examination revealed abundant circumferential folds of skin of soft but solid consistency around the limbs and neck &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In addition&#44; we observed microcephaly with frontotemporal flattening and hypotelorism&#44; small&#44; low-set ears&#44; and teletelia&#46; Skin biopsy showed an excessive accumulation of adipose tissue in the superficial dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Cardiology study and transfontanellar ultrasound were normal&#46; Ophthalmologic examination revealed convergent strabismus&#44; microphthalmos&#44; and blepharophimosis&#46; The karyotype was normal&#44; 46 XX&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A proposal has been made to replace the original term Michelin tire baby by the term circumferential skin folds syndrome or phenotype when the condition is associated with extracutaneous alterations&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> These associated manifestations&#44; detected in up to 74&#37; of MTB patients&#44; include facial abnormalities&#44; neurologic disturbances &#40;mental retardation&#44; delayed psychomotor development&#44; hypotonia&#44; convulsions&#41;&#44; ocular and cardiac alterations&#44; genital hypoplasia or malformation&#44; scoliosis&#44; and pectus excavatum &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#8211;5</span></a> Our patient presented teletelia&#44; not previously reported in association with MTB&#46; To date&#44; no consistent pattern of inheritance has been identified&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Histology in MTB can reveal signs of smooth muscle hamartoma&#44; lipomatous nevus&#44; degenerated collagen&#44; scarring&#44; or even normal skin&#44; although biopsy was not performed in 59&#37; of reported cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">This new case of MTB with lipomatous nevus associated with facial dysmorphism&#44; ocular alterations&#44; and teletelia&#44; highlights the need to perform complete clinical evaluation in these children&#44; including neurologic and ophthalmologic examination&#46; When associated malformations are present&#44; the term circumferential skin folds syndrome should be used&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Description&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number&nbsp;\t\t\t\t\t\t\n
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
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