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Noguera-Morel, I. Andrés-Ramos, A. Hernández-Martín, A. Torrelo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "L." "apellidos" => "Noguera-Morel" "email" => array:1 [ 0 => "luceronoguera@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Andrés-Ramos" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Hernández-Martín" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Torrelo" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Infantil Universitario Niño Jesús, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Bebé Michelin asociado a anomalías faciales" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 648 "Ancho" => 975 "Tamanyo" => 90894 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Abundant circumferential skin folds of soft but solid consistency around the limbs and neck.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The term Michelin tire baby (MTB) was first used in 1969 by Ross<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> to refer to the case of a baby with multiple, widespread skin folds associated with hemihypertrophy and a broad bridge of the nose. We report the case of a girl with MTB and mild associated dysmorphic alterations.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 3-month-old girl of Romanian origin, born at 34 weeks, with no history of consanguinity, was seen for excessive skin folds. She had no personal or family history of interest. Physical examination revealed abundant circumferential folds of skin of soft but solid consistency around the limbs and neck (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). In addition, we observed microcephaly with frontotemporal flattening and hypotelorism, small, low-set ears, and teletelia. Skin biopsy showed an excessive accumulation of adipose tissue in the superficial dermis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Cardiology study and transfontanellar ultrasound were normal. Ophthalmologic examination revealed convergent strabismus, microphthalmos, and blepharophimosis. The karyotype was normal, 46 XX.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A proposal has been made to replace the original term Michelin tire baby by the term circumferential skin folds syndrome or phenotype when the condition is associated with extracutaneous alterations.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> These associated manifestations, detected in up to 74% of MTB patients, include facial abnormalities, neurologic disturbances (mental retardation, delayed psychomotor development, hypotonia, convulsions), ocular and cardiac alterations, genital hypoplasia or malformation, scoliosis, and pectus excavatum (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2–5</span></a> Our patient presented teletelia, not previously reported in association with MTB. To date, no consistent pattern of inheritance has been identified.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Histology in MTB can reveal signs of smooth muscle hamartoma, lipomatous nevus, degenerated collagen, scarring, or even normal skin, although biopsy was not performed in 59% of reported cases.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">This new case of MTB with lipomatous nevus associated with facial dysmorphism, ocular alterations, and teletelia, highlights the need to perform complete clinical evaluation in these children, including neurologic and ophthalmologic examination. When associated malformations are present, the term circumferential skin folds syndrome should be used.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Please cite this article as: Noguera-Morel L, Andrés-Ramos I, Hernández-Martín A, Torrelo A. Bebé Michelin asociado a anomalías faciales. Actas Dermosifiliogr. 2016;107:530–531.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 648 "Ancho" => 975 "Tamanyo" => 90894 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Abundant circumferential skin folds of soft but solid consistency around the limbs and neck.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 731 "Ancho" => 975 "Tamanyo" => 207192 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Skin biopsy showed an excessive accumulation of adipose tissue in the superficial dermis.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Description \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Percentage \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">All cases \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">100 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lipomatous nevus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Smooth muscle hamartoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Facial abnormalities<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">60 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neurological alterations<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">44 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Eye alterations<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1386718.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Most frequent facial abnormalities, reported in 3 or more patients: malformations of the auricles of the ear, broad or sunken bridge of the nose, epicanthic folds, hypertelorism, cleft palate, microphthalmos, micrognathia, and central facial flattening.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Most frequent neurologic abnormalities, reported in 3 or more patients: delayed psychomotor development, mental retardation, dilatation of the ventricles, hypotonia, convulsions, and microcephaly.</p>" ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Most frequent eye abnormalities, reported in 3 or more patients: blepharophimosis and strabismus or esotropia.</p> <p class="elsevierStyleNotepara" id="npar0020">Source: Adapted and updated from Rothman<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> 2014.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Summary of the Number and Percentage of Cases of Circumferential Skin Folds Syndrome Reported in the Literature up to the Time of Writing This Review Article, Including Our Case.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Generalized folded skin with an underlying lipomatous nevus. «The Michelin Tire baby»" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.M. 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año/Mes | Html | Total | |
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2024 Noviembre | 11 | 9 | 20 |
2024 Octubre | 110 | 55 | 165 |
2024 Septiembre | 113 | 39 | 152 |
2024 Agosto | 147 | 60 | 207 |
2024 Julio | 126 | 38 | 164 |
2024 Junio | 117 | 36 | 153 |
2024 Mayo | 129 | 38 | 167 |
2024 Abril | 81 | 43 | 124 |
2024 Marzo | 122 | 30 | 152 |
2024 Febrero | 119 | 31 | 150 |
2024 Enero | 132 | 43 | 175 |
2023 Diciembre | 186 | 23 | 209 |
2023 Noviembre | 233 | 28 | 261 |
2023 Octubre | 170 | 24 | 194 |
2023 Septiembre | 182 | 33 | 215 |
2023 Agosto | 136 | 26 | 162 |
2023 Julio | 144 | 33 | 177 |
2023 Junio | 97 | 30 | 127 |
2023 Mayo | 128 | 20 | 148 |
2023 Abril | 113 | 25 | 138 |
2023 Marzo | 95 | 20 | 115 |
2023 Febrero | 100 | 22 | 122 |
2023 Enero | 109 | 28 | 137 |
2022 Diciembre | 110 | 32 | 142 |
2022 Noviembre | 87 | 30 | 117 |
2022 Octubre | 78 | 23 | 101 |
2022 Septiembre | 95 | 33 | 128 |
2022 Agosto | 79 | 21 | 100 |
2022 Julio | 100 | 30 | 130 |
2022 Junio | 104 | 18 | 122 |
2022 Mayo | 141 | 25 | 166 |
2022 Abril | 144 | 40 | 184 |
2022 Marzo | 149 | 40 | 189 |
2022 Febrero | 123 | 26 | 149 |
2022 Enero | 211 | 33 | 244 |
2021 Diciembre | 124 | 39 | 163 |
2021 Noviembre | 96 | 39 | 135 |
2021 Octubre | 125 | 48 | 173 |
2021 Septiembre | 145 | 54 | 199 |
2021 Agosto | 85 | 17 | 102 |
2021 Julio | 100 | 20 | 120 |
2021 Junio | 122 | 23 | 145 |
2021 Mayo | 96 | 41 | 137 |
2021 Abril | 370 | 52 | 422 |
2021 Marzo | 200 | 21 | 221 |
2021 Febrero | 152 | 34 | 186 |
2021 Enero | 77 | 11 | 88 |
2020 Diciembre | 75 | 10 | 85 |
2020 Noviembre | 70 | 20 | 90 |
2020 Octubre | 41 | 18 | 59 |
2020 Septiembre | 79 | 9 | 88 |
2020 Agosto | 20 | 20 | 40 |
2020 Julio | 26 | 13 | 39 |
2020 Junio | 34 | 24 | 58 |
2020 Mayo | 29 | 16 | 45 |
2020 Abril | 28 | 17 | 45 |
2020 Marzo | 32 | 12 | 44 |
2020 Febrero | 2 | 0 | 2 |
2020 Enero | 6 | 0 | 6 |
2019 Diciembre | 4 | 0 | 4 |
2019 Noviembre | 4 | 0 | 4 |
2019 Octubre | 1 | 0 | 1 |
2019 Agosto | 4 | 0 | 4 |
2019 Julio | 4 | 0 | 4 |
2019 Junio | 4 | 0 | 4 |
2019 Mayo | 5 | 1 | 6 |
2019 Abril | 2 | 1 | 3 |
2019 Marzo | 2 | 3 | 5 |
2019 Febrero | 1 | 0 | 1 |
2019 Enero | 3 | 0 | 3 |
2018 Diciembre | 2 | 0 | 2 |
2018 Noviembre | 2 | 0 | 2 |
2018 Octubre | 4 | 0 | 4 |
2018 Septiembre | 5 | 0 | 5 |
2018 Julio | 1 | 0 | 1 |
2018 Febrero | 38 | 1 | 39 |
2018 Enero | 65 | 8 | 73 |
2017 Diciembre | 61 | 5 | 66 |
2017 Noviembre | 49 | 10 | 59 |
2017 Octubre | 57 | 6 | 63 |
2017 Septiembre | 37 | 8 | 45 |
2017 Agosto | 43 | 7 | 50 |
2017 Julio | 48 | 8 | 56 |
2017 Junio | 31 | 7 | 38 |
2017 Mayo | 32 | 12 | 44 |
2017 Abril | 24 | 9 | 33 |
2017 Marzo | 17 | 4 | 21 |
2017 Febrero | 18 | 5 | 23 |
2017 Enero | 12 | 5 | 17 |
2016 Diciembre | 27 | 17 | 44 |
2016 Noviembre | 26 | 18 | 44 |
2016 Octubre | 28 | 20 | 48 |
2016 Julio | 2 | 2 | 4 |