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with foci of degenerated collagen surrounded by histiocytes in the connective tissue septa of the hypodermis&#44; forming granulomas of vaguely sarcoid appearance &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">A diagnosis of sarcoidal necrobiosis lipoidica was made and blood tests were requested&#44; including measurement of blood glucose&#44; thyroid hormones&#44; and antithyroid antibodies&#44; which were normal or negative&#46; Treatment was started with topical corticosteroids&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">This case illustrates the usefulness of high-frequency ultrasound to guide the diagnosis in suspected necrobiosis lipoidica&#46; The technique enables us to locate foci of inflammation in the mid and deep dermis&#44; and to demonstrate the presence of panniculitis with edema and thickening of the septa in the subcutaneous cellular tissue&#46; Dermal inflammation is seen as hypoechoic areas that usually have increased blood flow on color Doppler or power Doppler &#40;slow flow&#41;&#46; The inflammatory findings in the subcutaneous cellular tissue vary depending on whether involvement is predominantly lobular&#44; septal&#44; or mixed&#46; Lobular involvement produces a diffuse increase in echogenicity of the adipose tissue&#59; septal involvement produces a typically hypoechoic noncompressible thickening of the septa&#44; seen as hypoechoic perilobular bands&#46; In mixed panniculitis&#44; the 2 patterns coexist&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> In our patient&#44; we also observed the characteristic loss of sharpness of the dermohypodermal junction&#44; which we believe to be due to the simultaneous inflammatory involvement of the deep reticular dermis and the hypodermis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Dermoscopy in our patient was characteristic&#46; The lesions presented hairpin vessels on a yellowish-orange background with whitish areas&#46; Branching vascular structures are formed of anastomosing vessels of a similar size&#46; The presence of comma vessels has also been described as an early manifestation of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> A pigmented pseudonetwork and a brown-colored background due to melanocyte stimulation are sometimes observed&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The case presented occurred in a nondiabetic patient with a diagnosis of systemic lupus erythematosus and nonspecific colitis&#46; The association of necrobiosis lipoidica and diabetes mellitus is well known&#44; but the proportion of patients who present both diseases varies between the different studies &#40;11&#37; to 65&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;8</span></a> Necrobiosis lipoidica has also been reported in healthy individuals and in patients with other autoimmune and inflammatory diseases&#44; including inflammatory bowel disease&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Finally&#44; the finding on histopathology of sarcoid granulomas in the dermis and in the adipose tissue septa was interesting&#46; These structures&#44; formed of groups of giant and epithelioid cells in areas of degenerated collagen&#44; are an uncommon feature that defines what has been called the sarcoid variant of necrobiosis lipoidica&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9&#44;10</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letter
Sarcoidal Necrobiosis Lipoidica in a Nondiabetic Patient: Usefulness of Skin Ultrasound
Necrobiosis lipoídica sarcoidea en paciente no diabético. Utilidad de la ecografía cutánea
J. García-Gavína,
Autor para correspondencia
, L. Comba Pérez-Péreza, L. Requenab, X. Wortsmanc
a Clínica Pérez & Gavín dermatólogos, Vigo, Pontevedra, Spain
b Departamento de Dermatología, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain
c Departamentos de Radiología y Dermatología, Instituto de Investigación y Diagnóstico por Imágenes en Piel y Tejidos Blandos (IDIEP), Clínica Servet, Facultad de Medicina, Universidad de Chile, Santiago, Región Metropolitana, Chile
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Necrobiosis lipoidica is a granulomatous disease of unknown origin that typically gives rise to multiple lesions on the anterior aspect of both lower legs&#46; The histopathologic abnormalities are mainly observed in the mid and deep dermis&#46; The alterations tend to extend into the subcutaneous cellular tissue along the adipose tissue septa&#44; giving rise to a predominantly septal panniculitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">High-frequency skin ultrasound has been shown to be a useful additional test for the diagnosis and differentiation of inflammatory diseases that affect the dermis and subcutaneous cellular tissue&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Description</span><p id="par0015" class="elsevierStylePara elsevierViewall">Our patient was a 40-year-old woman with a history of systemic lupus erythematosus&#44; with lupus nephritis diagnosed in 1997 &#40;currently asymptomatic and not on treatment&#41; and nonspecific colitis diagnosed in 2010 &#40;on treatment with sulfasalazine&#41;&#46; She was seen for asymptomatic lesions on the lower legs&#46; The alterations had started 2 years earlier as a single lesion on the anterior aspect of left lower leg and had later affected the right lower limb&#46; Dermoscopic study of 1 of the lesions &#40;FotoFinder Medicam 800HD&#44; FotoFinder Systems GmbH&#44; Bad Birnbach&#44; Germany&#41; revealed a dense network of branching anastomosing vessels on a yellow-orange background &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Ultrasound was performed using the LOGIQ E9 XDclear device &#40;General Electric Health Systems&#44; Milwaukee&#44; United States&#41; with 2 linear transducers with maximum frequencies of 15 and 18<span class="elsevierStyleHsp" style=""></span>MHz&#46; Hypoechoic areas were observed in the mid and deep dermis&#44; with evidence of increased blood flow on color power Doppler&#46; Compared with healthy perilesional skin&#44; the dermohypodermal interface was blurred as a result of a diffuse increase in echogenicity of the subcutaneous cellular tissue &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; At greater depth&#44; vertical hypoechoic bands were seen to penetrate deeply into the fat &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Histopathology revealed areas of degenerated collagen surrounded by palisaded histiocytes and a lymphocytic and plasma-cell infiltrate that mainly affected the mid and deep dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#46; The inflammatory changes extended into the subcutaneous cellular tissue&#44; with foci of degenerated collagen surrounded by histiocytes in the connective tissue septa of the hypodermis&#44; forming granulomas of vaguely sarcoid appearance &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">A diagnosis of sarcoidal necrobiosis lipoidica was made and blood tests were requested&#44; including measurement of blood glucose&#44; thyroid hormones&#44; and antithyroid antibodies&#44; which were normal or negative&#46; Treatment was started with topical corticosteroids&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">This case illustrates the usefulness of high-frequency ultrasound to guide the diagnosis in suspected necrobiosis lipoidica&#46; The technique enables us to locate foci of inflammation in the mid and deep dermis&#44; and to demonstrate the presence of panniculitis with edema and thickening of the septa in the subcutaneous cellular tissue&#46; Dermal inflammation is seen as hypoechoic areas that usually have increased blood flow on color Doppler or power Doppler &#40;slow flow&#41;&#46; The inflammatory findings in the subcutaneous cellular tissue vary depending on whether involvement is predominantly lobular&#44; septal&#44; or mixed&#46; Lobular involvement produces a diffuse increase in echogenicity of the adipose tissue&#59; septal involvement produces a typically hypoechoic noncompressible thickening of the septa&#44; seen as hypoechoic perilobular bands&#46; In mixed panniculitis&#44; the 2 patterns coexist&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> In our patient&#44; we also observed the characteristic loss of sharpness of the dermohypodermal junction&#44; which we believe to be due to the simultaneous inflammatory involvement of the deep reticular dermis and the hypodermis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Dermoscopy in our patient was characteristic&#46; The lesions presented hairpin vessels on a yellowish-orange background with whitish areas&#46; Branching vascular structures are formed of anastomosing vessels of a similar size&#46; The presence of comma vessels has also been described as an early manifestation of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> A pigmented pseudonetwork and a brown-colored background due to melanocyte stimulation are sometimes observed&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The case presented occurred in a nondiabetic patient with a diagnosis of systemic lupus erythematosus and nonspecific colitis&#46; The association of necrobiosis lipoidica and diabetes mellitus is well known&#44; but the proportion of patients who present both diseases varies between the different studies &#40;11&#37; to 65&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;8</span></a> Necrobiosis lipoidica has also been reported in healthy individuals and in patients with other autoimmune and inflammatory diseases&#44; including inflammatory bowel disease&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Finally&#44; the finding on histopathology of sarcoid granulomas in the dermis and in the adipose tissue septa was interesting&#46; These structures&#44; formed of groups of giant and epithelioid cells in areas of degenerated collagen&#44; are an uncommon feature that defines what has been called the sarcoid variant of necrobiosis lipoidica&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9&#44;10</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Garc&#237;a-Gav&#237;n J&#44; Comba P&#233;rez-P&#233;rez L&#44; Requena L&#44; Wortsman X&#46; Necrobiosis lipo&#237;dica sarcoidea en paciente no diab&#233;tico&#46; Utilidad de la ecograf&#237;a cut&#225;nea&#46; Actas Dermosifiliogr&#46; 2016&#59;107&#58;525&#8211;527&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Well-defined&#44; round and oval plaques affecting the anterior aspect of both lower legs&#46; B&#44; Detail of an isolated erythematous lesion&#44; with orange&#44; yellowish&#44; brownish&#44; and whitish areas&#59; superficial atrophy and numerous telangiectasias can be observed&#46; C&#44; Dermoscopic image showing a dense network of branching anastomosing vessels on a yellow-orange background with whitish areas&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Power Doppler ultrasound &#40;linear 15<span class="elsevierStyleHsp" style=""></span>MHz transducer&#59; longitudinal axis&#44; left leg&#41;&#58; hypoechoic areas in the mid and deep dermis &#40;arrow&#41;&#44; with blurring of the dermohypodermal junction and a diffusely increased echogenicity of the underlying superficial hypodermal adipose tissue&#46; Power Doppler shows increased dermal and superficial hypodermal flow&#46; The image allows us to compare the affected area &#40;right side of the image&#41; with healthy perilesional skin &#40;left side of the image&#41;&#46; B&#44; Gray-scale ultrasound &#40;linear 18<span class="elsevierStyleHsp" style=""></span>MHz transducer&#59; longitudinal axis&#44; left leg&#41;&#46; The hypoechoic vertical bands correspond to thickened septa &#40;arrows&#41;&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#44; Predominant involvement of the mid and deep dermis&#44; with areas of degenerated collagen surrounded by palisaded histiocytes and a lymphocytic and plasma-cell infiltrate&#46; B&#44; The inflammatory changes extend into the subcutaneous cellular tissue&#44; with foci of degenerated collagen surrounded by histiocytes in the connective tissue septa&#44; forming granulomas of vaguely sarcoid appearance&#46;</p>"
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