array:24 [
  "pii" => "S1578219016300750"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2016.05.005"
  "estado" => "S300"
  "fechaPublicacion" => "2016-07-01"
  "aid" => "1315"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2016;107:521-2"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 815
    "formatos" => array:3 [
      "EPUB" => 51
      "HTML" => 594
      "PDF" => 170
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015005165"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2015.07.019"
      "estado" => "S300"
      "fechaPublicacion" => "2016-07-01"
      "aid" => "1315"
      "copyright" => "AEDV"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2016;107:521-2"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 309
        "formatos" => array:3 [
          "EPUB" => 4
          "HTML" => 221
          "PDF" => 84
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Foro de Residentes</span>"
        "titulo" => "FR-&#191;D&#243;nde posicionamos la combinaci&#243;n de antipal&#250;dicos en el manejo del lupus eritematoso cut&#225;neo refractario&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "521"
            "paginaFinal" => "522"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Where Should We Position Antimalarial Drug Combinations in the Management of Refractory Cutaneous Lupus Erythematosus&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "I&#46; P&#233;rez-L&#243;pez, A&#46; Mart&#237;nez-L&#243;pez, J&#46; Tercedor-S&#225;nchez, R&#46; Ruiz-Villaverde"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "P&#233;rez-L&#243;pez"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Mart&#237;nez-L&#243;pez"
              ]
              2 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Tercedor-S&#225;nchez"
              ]
              3 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Ruiz-Villaverde"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219016300750"
          "doi" => "10.1016/j.adengl.2016.05.005"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300750?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015005165?idApp=UINPBA000044"
      "url" => "/00017310/0000010700000006/v1_201606280028/S0001731015005165/v1_201606280028/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219016300762"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.05.006"
    "estado" => "S300"
    "fechaPublicacion" => "2016-07-01"
    "aid" => "1324"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2016;107:523"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 952
      "formatos" => array:3 [
        "EPUB" => 59
        "HTML" => 766
        "PDF" => 127
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>"
      "titulo" => "Bednar Tumor Mimicking Congenital Melanocytic Nevus"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "523"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tumor de Bednar simulando nevus melanoc&#237;tico cong&#233;nito"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 746
              "Ancho" => 995
              "Tamanyo" => 277445
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Bern&#225;rdez, A&#46;M&#46; Molina-Ruiz, L&#46; Requena"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Bern&#225;rdez"
            ]
            1 => array:2 [
              "nombre" => "A&#46;M&#46;"
              "apellidos" => "Molina-Ruiz"
            ]
            2 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Requena"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015005633"
        "doi" => "10.1016/j.ad.2015.04.027"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015005633?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300762?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000006/v2_201704050141/S1578219016300762/v2_201704050141/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219016300981"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.04.025"
    "estado" => "S300"
    "fechaPublicacion" => "2016-07-01"
    "aid" => "131400"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:519-20"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1177
      "formatos" => array:3 [
        "EPUB" => 69
        "HTML" => 938
        "PDF" => 170
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>"
      "titulo" => "Follicular Papules and Erythematous Plaques on the Back"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "519"
          "paginaFinal" => "520"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "P&#225;pulas foliculares y placas eritematosas en espalda"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 401
              "Ancho" => 505
              "Tamanyo" => 149965
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin and eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>x4&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Ruiz-Villaverde, I&#46; P&#233;rez-L&#243;pez, J&#46; Aneiros-Fern&#225;ndez"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz-Villaverde"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "P&#233;rez-L&#243;pez"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Aneiros-Fern&#225;ndez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015005153"
        "doi" => "10.1016/j.ad.2015.04.025"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015005153?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300981?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000006/v2_201704050141/S1578219016300981/v2_201704050141/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Resident&#39;s Forum</span>"
    "titulo" => "Where Should We Position Antimalarial Drug Combinations in the Management of Refractory Cutaneous Lupus Erythematosus&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "521"
        "paginaFinal" => "522"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "I&#46; P&#233;rez-L&#243;pez, A&#46; Mart&#237;nez-L&#243;pez, J&#46; Tercedor-S&#225;nchez, R&#46; Ruiz-Villaverde"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "I&#46;"
            "apellidos" => "P&#233;rez-L&#243;pez"
            "email" => array:1 [
              0 => "ipl&#95;elmadrono&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Mart&#237;nez-L&#243;pez"
          ]
          2 => array:2 [
            "nombre" => "J&#46;"
            "apellidos" => "Tercedor-S&#225;nchez"
          ]
          3 => array:2 [
            "nombre" => "R&#46;"
            "apellidos" => "Ruiz-Villaverde"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Unidad de Gesti&#243;n Cl&#237;nica de Dermatolog&#237;a M&#233;dico Quir&#250;rgica y Venereolog&#237;a&#44; Hospital Universitario Virgen de las Nieves&#46; Granada&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "FR-&#191;D&#243;nde posicionamos la combinaci&#243;n de antipal&#250;dicos en el manejo del lupus eritematoso cut&#225;neo refractario&#63;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Topical therapy with high-potency corticosteroids or calcineurin inhibitors combined with synthetic antimalarial drugs achieves satisfactory disease control in the majority of patients with cutaneous lupus erythematosus&#46; However&#44; the management of refractory cases is a real challenge in daily clinical practice&#46; Very few case series and clinical trials have been published&#44; and it was only with the development and validation of the Cutaneous Lupus Erythematosus Disease Area and Severity Index &#40;CLASI&#41; in 2007 that it became possible to objectively assess the severity of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The therapies most commonly used in refractory cases include particularly methotrexate&#44; acitretin &#40;with the highest level of evidence&#41;&#44; mycophenolate mofetil&#44; and dapsone&#46; However&#44; the combination of conventional antimalarial drugs &#40;chloroquine &#91;CQ&#93; and hydroxychloroquine &#91;HDQ&#93;&#41; with quinacrine &#40;QN&#41; is an option not always considered despite its good therapeutic results&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">QN&#44; which is seldom used as it has to be requested for use as a foreign medication&#44; is effective both in monotherapy and in combination with other antimalarials&#46; In 2010&#44; Gonz&#225;lez-Sixto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> presented a retrospective series of 8 cases with excellent results after using QN in combined therapies to treat different forms of cutaneous lupus erythematosus&#46; CQ and HDQ have similar therapeutic and ocular toxicity profiles&#44; and their combined use is not therefore recommended&#46; However&#44; a therapeutic advantage of QN is its absence of retinal toxicity&#46; In contrast&#44; its side effects do include a risk of severe and potentially fatal aplastic anemia&#46; Periodic &#40;3-monthly&#41; complete blood counts must therefore be performed to detect this anemia in its hypocellular phase&#44; which resolves on withdrawal of the drug&#59; this phase is occasionally preceded by nonspecific lichenoid eruptions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A number of case series in the literature have described the combined use of synthetic antimalarial drugs&#44; but the regimen typically used is the one proposed by McCune and Gonz&#225;lez-Rivera<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> in 2001&#58; HDQ &#40;at a dose not higher than 6&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#41; combined&#44; when necessary&#44; with QN &#40;100<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#46; If no adequate therapeutic response is observed after 6 to 8 weeks of combined therapy&#44; HDQ is substituted by CQ &#40;at a dose below 3&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#41; while continuing with QN&#46; Recently&#44; in a review by Rodr&#237;guez-Caruncho and Bielsa&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> we were reminded of the realities of this association&#59; those authors drew attention to a series of unresolved issues&#44; including whether there is a time limit for the use of this combination&#44; whether drug holidays can be used&#44; why the cardioprotective effect of QN has still not been studied in sufficient detail&#44; possible additional risks of the combination&#44; and whether QN can potentiate other side effects of HDQ&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In view of these considerations and on the basis of our own experience&#44; we believe that&#44; in the management of cutaneous lupus erythematosus refractory to conventional treatments&#44; it is necessary to reposition the combination of antimalarial drugs as a therapeutic option to be used prior to employing other immunosuppressive agents or systemic retinoids&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec821301"
          "palabras" => array:4 [
            0 => "Cutaneous lupus"
            1 => "Treatment"
            2 => "Antimalarials"
            3 => "Quinacrine"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; P&#233;rez-L&#243;pez I&#44; Mart&#237;nez-L&#243;pez A&#44; Tercedor-S&#225;nchez J&#44; Ruiz-Villaverde R&#46; FR-&#191;D&#243;nde posicionamos la combinaci&#243;n de antipal&#250;dicos en el manejo del lupus eritematoso cut&#225;neo refractario&#63;&#46; Actas Dermosifiliogr&#46; 2016&#59;107&#58;521&#8211;522&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The CLASI &#40;Cutaneous Lupus Erythematosus Disease Area and Severity Index&#41;&#58; An outcome instrument for cutaneous lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Albrecht"
                            1 => "L&#46; Taylor"
                            2 => "J&#46;A&#46; Berlin"
                            3 => "S&#46; Dulay"
                            4 => "G&#46; Ang"
                            5 => "S&#46; Fakharzadeh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0022-202X.2005.23889.x"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2005"
                        "volumen" => "125"
                        "paginaInicial" => "889"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16297185"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quinacrine in the treatment of cutaneous lupus erythematosus&#58; Practical aspects and a case series &#91;Article in Spanish&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Gonz&#225;lez-Sixto"
                            1 => "I&#46; Garc&#237;a-Doval"
                            2 => "R&#46; Oliveira"
                            3 => "C&#46; Posada"
                            4 => "M&#46;A&#46; Garc&#237;a-Cruz"
                            5 => "M&#46; Cruces"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2010"
                        "volumen" => "101"
                        "paginaInicial" => "54"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20109393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Should very low doses of hydroxychloroquine and quinacrine be employed in combination for long-term maintenance of remission in systemic lupus to reduce the risk of ocular toxicity&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;J&#46; McCune"
                            1 => "T&#46; Gonz&#225;lez-Rivera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/BOR.0000000000000173"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Rheumatol"
                        "fecha" => "2015"
                        "volumen" => "27"
                        "paginaInicial" => "213"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25784384"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antipal&#250;dicos en dermatolog&#237;a&#58; mecanismo de acci&#243;n&#44; indicaciones y efectos secundarios"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Rodr&#237;guez-Caruncho"
                            1 => "I&#46; Bielsa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.adengl.2012.10.021"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2014"
                        "volumen" => "105"
                        "paginaInicial" => "243"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24656224"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coloraci&#243;n amarillenta inducida por quinacrina en una paciente con lupus eritematoso cut&#225;neo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Vidal"
                            1 => "J&#46; Alt&#233;s"
                            2 => "J&#46;A&#46; Smandia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2011.12.025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2013"
                        "volumen" => "104"
                        "paginaInicial" => "89"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22831783"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010700000006/v2_201704050141/S1578219016300750/v2_201704050141/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "34945"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Resident&#39;s Forum"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000006/v2_201704050141/S1578219016300750/v2_201704050141/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300750?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Resident's Forum
Where Should We Position Antimalarial Drug Combinations in the Management of Refractory Cutaneous Lupus Erythematosus?
FR-¿Dónde posicionamos la combinación de antipalúdicos en el manejo del lupus eritematoso cutáneo refractario?
I. Pérez-López
Autor para correspondencia
ipl_elmadrono@hotmail.com

Corresponding author.
, A. Martínez-López, J. Tercedor-Sánchez, R. Ruiz-Villaverde
Unidad de Gestión Clínica de Dermatología Médico Quirúrgica y Venereología, Hospital Universitario Virgen de las Nieves. Granada, Spain
Leído
4611
Veces
se ha leído el artículo
1767
Total PDF
2844
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S1578219016300750"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2016.05.005"
  "estado" => "S300"
  "fechaPublicacion" => "2016-07-01"
  "aid" => "1315"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2016;107:521-2"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 815
    "formatos" => array:3 [
      "EPUB" => 51
      "HTML" => 594
      "PDF" => 170
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015005165"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2015.07.019"
      "estado" => "S300"
      "fechaPublicacion" => "2016-07-01"
      "aid" => "1315"
      "copyright" => "AEDV"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2016;107:521-2"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 309
        "formatos" => array:3 [
          "EPUB" => 4
          "HTML" => 221
          "PDF" => 84
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Foro de Residentes</span>"
        "titulo" => "FR-&#191;D&#243;nde posicionamos la combinaci&#243;n de antipal&#250;dicos en el manejo del lupus eritematoso cut&#225;neo refractario&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "521"
            "paginaFinal" => "522"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Where Should We Position Antimalarial Drug Combinations in the Management of Refractory Cutaneous Lupus Erythematosus&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "I&#46; P&#233;rez-L&#243;pez, A&#46; Mart&#237;nez-L&#243;pez, J&#46; Tercedor-S&#225;nchez, R&#46; Ruiz-Villaverde"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "P&#233;rez-L&#243;pez"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Mart&#237;nez-L&#243;pez"
              ]
              2 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Tercedor-S&#225;nchez"
              ]
              3 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Ruiz-Villaverde"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219016300750"
          "doi" => "10.1016/j.adengl.2016.05.005"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300750?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015005165?idApp=UINPBA000044"
      "url" => "/00017310/0000010700000006/v1_201606280028/S0001731015005165/v1_201606280028/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219016300762"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.05.006"
    "estado" => "S300"
    "fechaPublicacion" => "2016-07-01"
    "aid" => "1324"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2016;107:523"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 952
      "formatos" => array:3 [
        "EPUB" => 59
        "HTML" => 766
        "PDF" => 127
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>"
      "titulo" => "Bednar Tumor Mimicking Congenital Melanocytic Nevus"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "523"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tumor de Bednar simulando nevus melanoc&#237;tico cong&#233;nito"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 746
              "Ancho" => 995
              "Tamanyo" => 277445
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Bern&#225;rdez, A&#46;M&#46; Molina-Ruiz, L&#46; Requena"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Bern&#225;rdez"
            ]
            1 => array:2 [
              "nombre" => "A&#46;M&#46;"
              "apellidos" => "Molina-Ruiz"
            ]
            2 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Requena"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015005633"
        "doi" => "10.1016/j.ad.2015.04.027"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015005633?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300762?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000006/v2_201704050141/S1578219016300762/v2_201704050141/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219016300981"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.04.025"
    "estado" => "S300"
    "fechaPublicacion" => "2016-07-01"
    "aid" => "131400"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:519-20"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1177
      "formatos" => array:3 [
        "EPUB" => 69
        "HTML" => 938
        "PDF" => 170
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>"
      "titulo" => "Follicular Papules and Erythematous Plaques on the Back"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "519"
          "paginaFinal" => "520"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "P&#225;pulas foliculares y placas eritematosas en espalda"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 401
              "Ancho" => 505
              "Tamanyo" => 149965
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin and eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>x4&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Ruiz-Villaverde, I&#46; P&#233;rez-L&#243;pez, J&#46; Aneiros-Fern&#225;ndez"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz-Villaverde"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "P&#233;rez-L&#243;pez"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Aneiros-Fern&#225;ndez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015005153"
        "doi" => "10.1016/j.ad.2015.04.025"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015005153?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300981?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000006/v2_201704050141/S1578219016300981/v2_201704050141/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Resident&#39;s Forum</span>"
    "titulo" => "Where Should We Position Antimalarial Drug Combinations in the Management of Refractory Cutaneous Lupus Erythematosus&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "521"
        "paginaFinal" => "522"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "I&#46; P&#233;rez-L&#243;pez, A&#46; Mart&#237;nez-L&#243;pez, J&#46; Tercedor-S&#225;nchez, R&#46; Ruiz-Villaverde"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "I&#46;"
            "apellidos" => "P&#233;rez-L&#243;pez"
            "email" => array:1 [
              0 => "ipl&#95;elmadrono&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Mart&#237;nez-L&#243;pez"
          ]
          2 => array:2 [
            "nombre" => "J&#46;"
            "apellidos" => "Tercedor-S&#225;nchez"
          ]
          3 => array:2 [
            "nombre" => "R&#46;"
            "apellidos" => "Ruiz-Villaverde"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Unidad de Gesti&#243;n Cl&#237;nica de Dermatolog&#237;a M&#233;dico Quir&#250;rgica y Venereolog&#237;a&#44; Hospital Universitario Virgen de las Nieves&#46; Granada&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "FR-&#191;D&#243;nde posicionamos la combinaci&#243;n de antipal&#250;dicos en el manejo del lupus eritematoso cut&#225;neo refractario&#63;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Topical therapy with high-potency corticosteroids or calcineurin inhibitors combined with synthetic antimalarial drugs achieves satisfactory disease control in the majority of patients with cutaneous lupus erythematosus&#46; However&#44; the management of refractory cases is a real challenge in daily clinical practice&#46; Very few case series and clinical trials have been published&#44; and it was only with the development and validation of the Cutaneous Lupus Erythematosus Disease Area and Severity Index &#40;CLASI&#41; in 2007 that it became possible to objectively assess the severity of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The therapies most commonly used in refractory cases include particularly methotrexate&#44; acitretin &#40;with the highest level of evidence&#41;&#44; mycophenolate mofetil&#44; and dapsone&#46; However&#44; the combination of conventional antimalarial drugs &#40;chloroquine &#91;CQ&#93; and hydroxychloroquine &#91;HDQ&#93;&#41; with quinacrine &#40;QN&#41; is an option not always considered despite its good therapeutic results&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">QN&#44; which is seldom used as it has to be requested for use as a foreign medication&#44; is effective both in monotherapy and in combination with other antimalarials&#46; In 2010&#44; Gonz&#225;lez-Sixto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> presented a retrospective series of 8 cases with excellent results after using QN in combined therapies to treat different forms of cutaneous lupus erythematosus&#46; CQ and HDQ have similar therapeutic and ocular toxicity profiles&#44; and their combined use is not therefore recommended&#46; However&#44; a therapeutic advantage of QN is its absence of retinal toxicity&#46; In contrast&#44; its side effects do include a risk of severe and potentially fatal aplastic anemia&#46; Periodic &#40;3-monthly&#41; complete blood counts must therefore be performed to detect this anemia in its hypocellular phase&#44; which resolves on withdrawal of the drug&#59; this phase is occasionally preceded by nonspecific lichenoid eruptions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A number of case series in the literature have described the combined use of synthetic antimalarial drugs&#44; but the regimen typically used is the one proposed by McCune and Gonz&#225;lez-Rivera<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> in 2001&#58; HDQ &#40;at a dose not higher than 6&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#41; combined&#44; when necessary&#44; with QN &#40;100<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#46; If no adequate therapeutic response is observed after 6 to 8 weeks of combined therapy&#44; HDQ is substituted by CQ &#40;at a dose below 3&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#41; while continuing with QN&#46; Recently&#44; in a review by Rodr&#237;guez-Caruncho and Bielsa&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> we were reminded of the realities of this association&#59; those authors drew attention to a series of unresolved issues&#44; including whether there is a time limit for the use of this combination&#44; whether drug holidays can be used&#44; why the cardioprotective effect of QN has still not been studied in sufficient detail&#44; possible additional risks of the combination&#44; and whether QN can potentiate other side effects of HDQ&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In view of these considerations and on the basis of our own experience&#44; we believe that&#44; in the management of cutaneous lupus erythematosus refractory to conventional treatments&#44; it is necessary to reposition the combination of antimalarial drugs as a therapeutic option to be used prior to employing other immunosuppressive agents or systemic retinoids&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec821301"
          "palabras" => array:4 [
            0 => "Cutaneous lupus"
            1 => "Treatment"
            2 => "Antimalarials"
            3 => "Quinacrine"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; P&#233;rez-L&#243;pez I&#44; Mart&#237;nez-L&#243;pez A&#44; Tercedor-S&#225;nchez J&#44; Ruiz-Villaverde R&#46; FR-&#191;D&#243;nde posicionamos la combinaci&#243;n de antipal&#250;dicos en el manejo del lupus eritematoso cut&#225;neo refractario&#63;&#46; Actas Dermosifiliogr&#46; 2016&#59;107&#58;521&#8211;522&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The CLASI &#40;Cutaneous Lupus Erythematosus Disease Area and Severity Index&#41;&#58; An outcome instrument for cutaneous lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Albrecht"
                            1 => "L&#46; Taylor"
                            2 => "J&#46;A&#46; Berlin"
                            3 => "S&#46; Dulay"
                            4 => "G&#46; Ang"
                            5 => "S&#46; Fakharzadeh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0022-202X.2005.23889.x"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2005"
                        "volumen" => "125"
                        "paginaInicial" => "889"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16297185"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quinacrine in the treatment of cutaneous lupus erythematosus&#58; Practical aspects and a case series &#91;Article in Spanish&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Gonz&#225;lez-Sixto"
                            1 => "I&#46; Garc&#237;a-Doval"
                            2 => "R&#46; Oliveira"
                            3 => "C&#46; Posada"
                            4 => "M&#46;A&#46; Garc&#237;a-Cruz"
                            5 => "M&#46; Cruces"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2010"
                        "volumen" => "101"
                        "paginaInicial" => "54"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20109393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Should very low doses of hydroxychloroquine and quinacrine be employed in combination for long-term maintenance of remission in systemic lupus to reduce the risk of ocular toxicity&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;J&#46; McCune"
                            1 => "T&#46; Gonz&#225;lez-Rivera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/BOR.0000000000000173"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Rheumatol"
                        "fecha" => "2015"
                        "volumen" => "27"
                        "paginaInicial" => "213"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25784384"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antipal&#250;dicos en dermatolog&#237;a&#58; mecanismo de acci&#243;n&#44; indicaciones y efectos secundarios"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Rodr&#237;guez-Caruncho"
                            1 => "I&#46; Bielsa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.adengl.2012.10.021"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2014"
                        "volumen" => "105"
                        "paginaInicial" => "243"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24656224"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coloraci&#243;n amarillenta inducida por quinacrina en una paciente con lupus eritematoso cut&#225;neo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Vidal"
                            1 => "J&#46; Alt&#233;s"
                            2 => "J&#46;A&#46; Smandia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2011.12.025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2013"
                        "volumen" => "104"
                        "paginaInicial" => "89"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22831783"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010700000006/v2_201704050141/S1578219016300750/v2_201704050141/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "34945"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Resident&#39;s Forum"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000006/v2_201704050141/S1578219016300750/v2_201704050141/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300750?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 6 8 14
2024 Octubre 68 41 109
2024 Septiembre 62 20 82
2024 Agosto 79 52 131
2024 Julio 64 25 89
2024 Junio 67 32 99
2024 Mayo 61 25 86
2024 Abril 69 27 96
2024 Marzo 53 32 85
2024 Febrero 41 27 68
2024 Enero 48 28 76
2023 Diciembre 49 12 61
2023 Noviembre 66 26 92
2023 Octubre 57 18 75
2023 Septiembre 64 32 96
2023 Agosto 36 11 47
2023 Julio 45 27 72
2023 Junio 42 18 60
2023 Mayo 45 25 70
2023 Abril 26 21 47
2023 Marzo 32 17 49
2023 Febrero 36 23 59
2023 Enero 28 26 54
2022 Diciembre 49 46 95
2022 Noviembre 32 29 61
2022 Octubre 24 17 41
2022 Septiembre 32 35 67
2022 Agosto 16 31 47
2022 Julio 25 38 63
2022 Junio 15 16 31
2022 Mayo 24 37 61
2022 Abril 49 28 77
2022 Marzo 42 47 89
2022 Febrero 24 28 52
2022 Enero 38 31 69
2021 Diciembre 33 38 71
2021 Noviembre 33 49 82
2021 Octubre 35 50 85
2021 Septiembre 25 48 73
2021 Agosto 20 33 53
2021 Julio 21 35 56
2021 Junio 21 24 45
2021 Mayo 37 45 82
2021 Abril 63 68 131
2021 Marzo 56 19 75
2021 Febrero 57 26 83
2021 Enero 34 22 56
2020 Diciembre 34 32 66
2020 Noviembre 31 19 50
2020 Octubre 26 12 38
2020 Septiembre 31 12 43
2020 Agosto 24 21 45
2020 Julio 38 14 52
2020 Junio 38 28 66
2020 Mayo 25 9 34
2020 Abril 28 16 44
2020 Marzo 24 20 44
2020 Febrero 7 1 8
2019 Diciembre 10 0 10
2019 Noviembre 4 0 4
2019 Septiembre 8 0 8
2019 Agosto 4 0 4
2019 Julio 6 0 6
2019 Junio 6 0 6
2019 Mayo 4 0 4
2019 Abril 3 1 4
2019 Marzo 2 3 5
2019 Febrero 2 0 2
2019 Enero 1 0 1
2018 Diciembre 6 0 6
2018 Noviembre 1 0 1
2018 Octubre 11 0 11
2018 Septiembre 7 0 7
2018 Febrero 30 3 33
2018 Enero 36 6 42
2017 Diciembre 59 11 70
2017 Noviembre 22 7 29
2017 Octubre 28 6 34
2017 Septiembre 26 5 31
2017 Agosto 31 6 37
2017 Julio 24 4 28
2017 Junio 34 9 43
2017 Mayo 31 8 39
2017 Abril 34 9 43
2017 Marzo 18 11 29
2017 Febrero 22 12 34
2017 Enero 25 5 30
2016 Diciembre 41 17 58
2016 Noviembre 29 22 51
2016 Octubre 21 19 40
2016 Julio 3 6 9
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?