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as well as in cosmetic dermatology&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5&#8211;11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We report 3 cases of KS in which skin lesions were evaluated using B-mode and color Doppler ultrasound&#46; Here&#44; we aim to establish a correlation between ultrasound findings and the clinical and histologic characteristics of KS skin lesions and to describe the usefulness of both types of ultrasound in this disease&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Descriptions</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Patient 1</span><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was an 80-year-old woman who consulted for an asymptomatic nodule that recently appeared on her right ankle&#46; She had developed a similar lesion on the same leg 5 years previously&#46; The lesion was confirmed both clinically and histologically as CKS&#44; and the result of the extension study was negative&#46; The lesion was treated with surgery&#46; The physical examination revealed a reddish-violaceous nodular lesion on the internal surface of the right ankle &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; B-mode ultrasound revealed a solid hypoechoic&#44; homogeneous&#44; solid oval lesion with regular&#44; well-defined edges&#46; The lesion affected the papillary and reticular dermis&#46; Color Doppler revealed intense intralesional vascularization that was more marked on the inferior pole&#46; Spectral analysis showed biphasic arterial flow &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; KS was confirmed by histology&#44; and the lesion was removed&#46; The result of a second extension study was negative&#46; The patient continues to be followed&#44; with no signs of new lesions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Patient 2</span><p id="par0025" class="elsevierStylePara elsevierViewall">The patient was a 42-year-old man diagnosed with pulmonary fibrosis who had received a lung transplant 5 years previously followed by immunosuppressive treatment&#46; He consulted for 2 localized asymptomatic plaques that had appeared on his left leg 2 months earlier&#46; Physical examination revealed 2 reddish-violaceous plaques on the anterior surface of the thigh and left knee &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; The B-mode ultrasound examination revealed a solid&#44; hypoechoic&#44; and heterogeneous lesion with irregular&#44; acicular edges that reached the papillary dermis&#46; Color Doppler ultrasound did not reveal intralesional vascularization &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46; The skin biopsy confirmed the diagnosis of IKS&#44; and the results of serology testing were positive for HHV-8 and cytomegalovirus&#46; The results of the extension study were negative&#46; The lesions improved when immunosuppressive treatment was modified&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Patient 3</span><p id="par0030" class="elsevierStylePara elsevierViewall">The patient was a 67-year-old man who had received a heart transplant 7 years earlier&#46; Surgery was followed by immunosuppressive treatment&#46; He consulted for asymptomatic nodules and papulae that had appeared 3 months previously on his legs&#44; hands&#44; and palate&#46; The physical examination revealed a reddish papule on the hard palate&#44; a reddish-violaceous nodule on the dorsum of the right hand&#44; and multiple reddish-violaceous papules grouped in plaques on the anterior surface of the legs &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; A and B&#41;&#46; B-mode ultrasound of 1 of the plaques on the legs revealed a solid hypoechoic&#44; heterogeneous lesion with irregular acicular edges affecting the papillary dermis&#46; Examination of the nodule on the hand using the same technique revealed a solid&#44; hypoechoic&#44; homogeneous oval or round lesion with irregular&#44; well-defined edges affecting the papillary and reticular dermis&#46; Color Doppler revealed no intralesional vascularization in the plaque-like lesion&#44; although in the case of the nodule&#44; slight vascularization was visible at the inferior pole &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; C and D&#41;&#46; Skin biopsy confirmed the diagnosis of IKS&#46; The results of the extension study were negative&#44; and the lesions improved when immunosuppressive therapy was modified&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">In the cases of KS we report&#44; the pattern revealed by B-mode ultrasound was solid and hypoechoic&#44; and the lesions were located in the dermis&#46; Nodules were more homogeneous&#44; with regular&#44; well-defined outlines&#44; whereas plaques were less homogeneous with irregular edges&#44; acicular morphology&#44; and less well-defined outlines&#46; A review of the literature reveals few studies that use cutaneous ultrasound to describe the structural characteristics of KS skin lesions&#59; in addition&#44; the results of these studies are contradictory&#46; In 1993&#44; Bogner et al&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> described KS skin lesions as hypoechoic&#44; with a homogeneous structure and well-defined outlines&#46; In contrast&#44; Cammarota<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> reported the KS ultrasound pattern to consist of a solid&#44; nonhomogeneous nodule with a poorly defined outline&#46; More recently&#44; in 2011&#44; Solivetti et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> who used higher-frequency probes&#44; analyzed the ultrasound characteristics of KS skin lesions &#40;confirmed by histology&#41; in 24 patients&#44; from each of whom a single skin lesion &#40;both plaques and nodules&#41; was selected according to its size &#40;0&#46;4<span class="elsevierStyleHsp" style=""></span>cm-2<span class="elsevierStyleHsp" style=""></span>cm&#41;&#46; Their ultrasound pattern corresponded to hypoechoic lesions with well-defined &#40;and frequently multilobulated&#41; outlines located between the epidermis and dermis and&#44; in some cases&#44; in the subcutaneous layer&#46; Most of the lesions had a homogeneous structure&#44; which was more homogeneous in CKS lesions than in AIDS-KS lesions&#46; However&#44; the authors admit that this finding could be attributed to the small size of the lesions studied &#40;all &#60;2<span class="elsevierStyleHsp" style=""></span>cm&#41; and the possibility that the largest lesions could have a more heterogeneous structure owing to intratumoral degeneration&#44; necrosis&#44; and&#47;or fibrosis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">As for color Doppler&#44; we observed intralesional vascularization that was more marked at the lower pole in lesions clinically defined as nodules and markedly diminished or absent vascularization in lesions that were clinically defined as plaques&#46; Only 1 study in the literature used color Doppler to describe the vascular characteristics of KS skin lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> The authors found that the skin lesions of CKS and those of AIDS-KS differed and that intralesional vascularization was absent in most cases of CKS and often present in those of AIDS-KS&#46; They postulated that the intralesional vascularization found in the latter could be associated with the formation of new vessels induced by the human immunodeficiency virus<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a>&#59; however&#44; in CKS with intralesional vascularization&#44; this ultrasound finding could be associated with a more aggressive clinical picture or higher HHV-8 load&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; cutaneous ultrasound &#40;B-mode and color Doppler&#41; could be useful as a complementary test in the study of skin lesions in KS&#46; The technique could provide us with more information on the structural and vascular characteristics of the lesions&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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            0 => "Kaposi sarcoma"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The use of ultrasound imaging has recently been increasing in numerous dermatologic diseases&#46; This noninvasive technique provides additional details on the structure and vascularization of skin lesions&#46; Kaposi sarcoma is a vascular tumor that typically arises in the skin and mucosas&#46; It can spread to lymph nodes and internal organs&#46; We performed B-mode and color Doppler ultrasound studies in 3 patients with a clinical diagnosis of Kaposi sarcoma confirmed by histological examination&#46; We found differences in the ultrasound pattern between nodular and plaque lesions&#44; in both B-mode and color Doppler&#46; We believe that skin ultrasound imaging could be a useful technique for studying cutaneous Kaposi sarcoma&#44; providing additional information on the structural and vascular characteristics of the lesion&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Recientemente ha aumentado el uso de la ecograf&#237;a cut&#225;nea en m&#250;ltiples enfermedades dermatol&#243;gicas&#46; Se trata de una t&#233;cnica no invasiva&#44; que nos proporciona m&#225;s detalles acerca de la estructura y vascularizaci&#243;n de las lesiones cut&#225;neas&#46; El sarcoma de Kaposi es un tumor vascular&#44; que se localiza principalmente en la piel y las mucosas&#44; pudiendo afectar los ganglios linf&#225;ticos y los &#243;rganos internos&#46; Presentamos 3 pacientes con diagn&#243;stico de sarcoma de Kaposi&#44; sospechado cl&#237;nicamente&#44; y confirmado histol&#243;gicamente&#44; a los cuales realizamos exploraci&#243;n ecogr&#225;fica en modo B y modo Doppler color&#46; Encontramos diferencias en el patr&#243;n ecogr&#225;fico&#44; tanto en modo B como en modo Doppler color&#44; entre las lesiones que cl&#237;nicamente correspond&#237;an a n&#243;dulos frente a las que eran placas&#46; Consideramos que la ecograf&#237;a cut&#225;nea podr&#237;a ser &#250;til como prueba complementaria&#44; en el estudio de las lesiones cut&#225;neas del sarcoma de Kaposi&#44; proporcion&#225;ndonos m&#225;s informaci&#243;n acerca de sus caracter&#237;sticas estructurales y vasculares&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Carrascosa R&#44; Alfageme F&#44; Roust&#225;n G&#44; Suarez MD&#46; Ecograf&#237;a cut&#225;nea en el sarcoma de Kaposi&#46; Actas Dermosifiliogr&#46; 2016&#59;107&#58;e19&#8211;e22&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A&#44; Reddish-violaceous plaque on the anterior surface of the left thigh&#46; B&#44; The ultrasound examination revealed a solid&#44; hypoechoic&#44; heterogeneous lesion with irregular&#44; acicular edges in the papillary dermis&#46; Color Doppler did not reveal intralesional vascularization&#46;</p>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A&#44; Reddish-violaceous nodule on the dorsum of the right hand&#46; B&#44; Multiple reddish-violaceous papules coalescing to form plaques on the anterior surface of the legs&#46; C&#44; Ultrasound of the nodule revealed a solid&#44; hypoechoic&#44; homogeneous oval lesion with well-defined and regular edges in the papillary and reticular dermis&#46; Color Doppler revealed mild intralesional vascularization in the inferior pole&#46; D&#44; Ultrasound examination of the plaque revealed a solid&#44; hypoechoic&#44; heterogeneous lesion with irregular&#44; acicular edges in the papillary dermis&#46; No intralesional vascularization was observed in color Doppler&#46;</p>"
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E-Case Report
Skin Ultrasound in Kaposi Sarcoma
Ecografía cutánea en el sarcoma de Kaposi
R. Carrascosaa,
Autor para correspondencia
rachel170786@gmail.com

Corresponding author.
, F. Alfagemeb, G. Roustánb, M.D. Suarezc
a Servicio de Dermatología, Hospital Universitario La Princesa, Madrid, Spain
b Servicio de Dermatología, Hospital Universitario Puerta de Hierro , Majadahonda, Madrid, Spain
c Servicio de Anatomía Patológica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A&#44; Reddish-violaceous nodule on the dorsum of the right hand&#46; B&#44; Multiple reddish-violaceous papules coalescing to form plaques on the anterior surface of the legs&#46; C&#44; Ultrasound of the nodule revealed a solid&#44; hypoechoic&#44; homogeneous oval lesion with well-defined and regular edges in the papillary and reticular dermis&#46; Color Doppler revealed mild intralesional vascularization in the inferior pole&#46; D&#44; Ultrasound examination of the plaque revealed a solid&#44; hypoechoic&#44; heterogeneous lesion with irregular&#44; acicular edges in the papillary dermis&#46; No intralesional vascularization was observed in color Doppler&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Kaposi sarcoma &#40;KS&#41; is a tumor that arises in the vascular endothelium and mainly affects the skin and mucosae&#44; although it can spread to the lymph nodes and even to internal organs&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;2</span></a> Human herpesvirus 8 &#40;HHV-8&#41; is considered the etiologic agent of KS&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> The 4 clinical variants of KS are classic KS &#40;CKS&#41;&#44; iatrogenic KS &#40;IKS&#41;&#44; endemic &#40;African&#41; KS&#44; and KS associated with AIDS &#40;AIDS-KS&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a> The suspected diagnosis is based on the presence of macules&#44; plaques&#44; and&#47;or nodules&#44; which may be violaceous or reddish and asymptomatic&#44; although up to 10 different clinical forms have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> The lesions have a characteristic distribution on the lower leg&#44; except in the case of AIDS-KS&#44; in which the lesions mainly affect the face and trunk&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> Diagnosis is confirmed by skin biopsy&#44; which typically reveals proliferation of irregular cleft-shaped vessels and spindle-shaped cells&#44; with no significant histologic differences between the clinical variants&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Use of ultrasound was recently implemented in several skin diseases&#44; such as inflammatory dermatoses and benign and malignant tumors&#44; as well as in cosmetic dermatology&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5&#8211;11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We report 3 cases of KS in which skin lesions were evaluated using B-mode and color Doppler ultrasound&#46; Here&#44; we aim to establish a correlation between ultrasound findings and the clinical and histologic characteristics of KS skin lesions and to describe the usefulness of both types of ultrasound in this disease&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Descriptions</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Patient 1</span><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was an 80-year-old woman who consulted for an asymptomatic nodule that recently appeared on her right ankle&#46; She had developed a similar lesion on the same leg 5 years previously&#46; The lesion was confirmed both clinically and histologically as CKS&#44; and the result of the extension study was negative&#46; The lesion was treated with surgery&#46; The physical examination revealed a reddish-violaceous nodular lesion on the internal surface of the right ankle &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; B-mode ultrasound revealed a solid hypoechoic&#44; homogeneous&#44; solid oval lesion with regular&#44; well-defined edges&#46; The lesion affected the papillary and reticular dermis&#46; Color Doppler revealed intense intralesional vascularization that was more marked on the inferior pole&#46; Spectral analysis showed biphasic arterial flow &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; KS was confirmed by histology&#44; and the lesion was removed&#46; The result of a second extension study was negative&#46; The patient continues to be followed&#44; with no signs of new lesions&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Patient 2</span><p id="par0025" class="elsevierStylePara elsevierViewall">The patient was a 42-year-old man diagnosed with pulmonary fibrosis who had received a lung transplant 5 years previously followed by immunosuppressive treatment&#46; He consulted for 2 localized asymptomatic plaques that had appeared on his left leg 2 months earlier&#46; Physical examination revealed 2 reddish-violaceous plaques on the anterior surface of the thigh and left knee &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; The B-mode ultrasound examination revealed a solid&#44; hypoechoic&#44; and heterogeneous lesion with irregular&#44; acicular edges that reached the papillary dermis&#46; Color Doppler ultrasound did not reveal intralesional vascularization &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46; The skin biopsy confirmed the diagnosis of IKS&#44; and the results of serology testing were positive for HHV-8 and cytomegalovirus&#46; The results of the extension study were negative&#46; The lesions improved when immunosuppressive treatment was modified&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Patient 3</span><p id="par0030" class="elsevierStylePara elsevierViewall">The patient was a 67-year-old man who had received a heart transplant 7 years earlier&#46; Surgery was followed by immunosuppressive treatment&#46; He consulted for asymptomatic nodules and papulae that had appeared 3 months previously on his legs&#44; hands&#44; and palate&#46; The physical examination revealed a reddish papule on the hard palate&#44; a reddish-violaceous nodule on the dorsum of the right hand&#44; and multiple reddish-violaceous papules grouped in plaques on the anterior surface of the legs &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; A and B&#41;&#46; B-mode ultrasound of 1 of the plaques on the legs revealed a solid hypoechoic&#44; heterogeneous lesion with irregular acicular edges affecting the papillary dermis&#46; Examination of the nodule on the hand using the same technique revealed a solid&#44; hypoechoic&#44; homogeneous oval or round lesion with irregular&#44; well-defined edges affecting the papillary and reticular dermis&#46; Color Doppler revealed no intralesional vascularization in the plaque-like lesion&#44; although in the case of the nodule&#44; slight vascularization was visible at the inferior pole &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; C and D&#41;&#46; Skin biopsy confirmed the diagnosis of IKS&#46; The results of the extension study were negative&#44; and the lesions improved when immunosuppressive therapy was modified&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">In the cases of KS we report&#44; the pattern revealed by B-mode ultrasound was solid and hypoechoic&#44; and the lesions were located in the dermis&#46; Nodules were more homogeneous&#44; with regular&#44; well-defined outlines&#44; whereas plaques were less homogeneous with irregular edges&#44; acicular morphology&#44; and less well-defined outlines&#46; A review of the literature reveals few studies that use cutaneous ultrasound to describe the structural characteristics of KS skin lesions&#59; in addition&#44; the results of these studies are contradictory&#46; In 1993&#44; Bogner et al&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> described KS skin lesions as hypoechoic&#44; with a homogeneous structure and well-defined outlines&#46; In contrast&#44; Cammarota<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> reported the KS ultrasound pattern to consist of a solid&#44; nonhomogeneous nodule with a poorly defined outline&#46; More recently&#44; in 2011&#44; Solivetti et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> who used higher-frequency probes&#44; analyzed the ultrasound characteristics of KS skin lesions &#40;confirmed by histology&#41; in 24 patients&#44; from each of whom a single skin lesion &#40;both plaques and nodules&#41; was selected according to its size &#40;0&#46;4<span class="elsevierStyleHsp" style=""></span>cm-2<span class="elsevierStyleHsp" style=""></span>cm&#41;&#46; Their ultrasound pattern corresponded to hypoechoic lesions with well-defined &#40;and frequently multilobulated&#41; outlines located between the epidermis and dermis and&#44; in some cases&#44; in the subcutaneous layer&#46; Most of the lesions had a homogeneous structure&#44; which was more homogeneous in CKS lesions than in AIDS-KS lesions&#46; However&#44; the authors admit that this finding could be attributed to the small size of the lesions studied &#40;all &#60;2<span class="elsevierStyleHsp" style=""></span>cm&#41; and the possibility that the largest lesions could have a more heterogeneous structure owing to intratumoral degeneration&#44; necrosis&#44; and&#47;or fibrosis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">As for color Doppler&#44; we observed intralesional vascularization that was more marked at the lower pole in lesions clinically defined as nodules and markedly diminished or absent vascularization in lesions that were clinically defined as plaques&#46; Only 1 study in the literature used color Doppler to describe the vascular characteristics of KS skin lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> The authors found that the skin lesions of CKS and those of AIDS-KS differed and that intralesional vascularization was absent in most cases of CKS and often present in those of AIDS-KS&#46; They postulated that the intralesional vascularization found in the latter could be associated with the formation of new vessels induced by the human immunodeficiency virus<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a>&#59; however&#44; in CKS with intralesional vascularization&#44; this ultrasound finding could be associated with a more aggressive clinical picture or higher HHV-8 load&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; cutaneous ultrasound &#40;B-mode and color Doppler&#41; could be useful as a complementary test in the study of skin lesions in KS&#46; The technique could provide us with more information on the structural and vascular characteristics of the lesions&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The use of ultrasound imaging has recently been increasing in numerous dermatologic diseases&#46; This noninvasive technique provides additional details on the structure and vascularization of skin lesions&#46; Kaposi sarcoma is a vascular tumor that typically arises in the skin and mucosas&#46; It can spread to lymph nodes and internal organs&#46; We performed B-mode and color Doppler ultrasound studies in 3 patients with a clinical diagnosis of Kaposi sarcoma confirmed by histological examination&#46; We found differences in the ultrasound pattern between nodular and plaque lesions&#44; in both B-mode and color Doppler&#46; We believe that skin ultrasound imaging could be a useful technique for studying cutaneous Kaposi sarcoma&#44; providing additional information on the structural and vascular characteristics of the lesion&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Recientemente ha aumentado el uso de la ecograf&#237;a cut&#225;nea en m&#250;ltiples enfermedades dermatol&#243;gicas&#46; Se trata de una t&#233;cnica no invasiva&#44; que nos proporciona m&#225;s detalles acerca de la estructura y vascularizaci&#243;n de las lesiones cut&#225;neas&#46; El sarcoma de Kaposi es un tumor vascular&#44; que se localiza principalmente en la piel y las mucosas&#44; pudiendo afectar los ganglios linf&#225;ticos y los &#243;rganos internos&#46; Presentamos 3 pacientes con diagn&#243;stico de sarcoma de Kaposi&#44; sospechado cl&#237;nicamente&#44; y confirmado histol&#243;gicamente&#44; a los cuales realizamos exploraci&#243;n ecogr&#225;fica en modo B y modo Doppler color&#46; Encontramos diferencias en el patr&#243;n ecogr&#225;fico&#44; tanto en modo B como en modo Doppler color&#44; entre las lesiones que cl&#237;nicamente correspond&#237;an a n&#243;dulos frente a las que eran placas&#46; Consideramos que la ecograf&#237;a cut&#225;nea podr&#237;a ser &#250;til como prueba complementaria&#44; en el estudio de las lesiones cut&#225;neas del sarcoma de Kaposi&#44; proporcion&#225;ndonos m&#225;s informaci&#243;n acerca de sus caracter&#237;sticas estructurales y vasculares&#46;</p></span>"
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