Case and Research Letters
Basal Cell Carcinoma With a Cylindromatous Phenotype
Carcinoma de células basales con fenotipo cilindromatoso
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"apellidos" => "Bazzano" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0001731015003725" "doi" => "10.1016/j.ad.2015.04.020" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003725?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016000421?idApp=UINPBA000044" "url" => "/15782190/0000010700000002/v2_201703220318/S1578219016000421/v2_201703220318/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Basal Cell Carcinoma With a Cylindromatous Phenotype" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "165" "paginaFinal" => "167" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F.J. Torres-Gómez, P. Fernández-Machín, J. Neila-Iglesias" "autores" => array:3 [ 0 => array:4 [ "nombre" => "F.J." "apellidos" => "Torres-Gómez" "email" => array:1 [ 0 => "javiertorresgomez@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "P." "apellidos" => "Fernández-Machín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Neila-Iglesias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Anatomía Patológica, Área de Gestión Clínica de Biotecnología, Agencia Pública Sanitaria Bajo Guadalquivir, Seville, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Agencia Pública Sanitaria Bajo Guadalquivir, Seville, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma de células basales con fenotipo cilindromatoso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1321 "Ancho" => 990 "Tamanyo" => 301473 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma with a cylindromatous pattern. Both images show various tumor areas characterized by the presence of amorphous, hyaline material surrounded by basal cells with mild-to-moderate atypia (hematoxylin-eosin, original magnification ×200 and ×400).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Basal cell carcinoma (BCC) is the most common type of skin cancer and is also one of the most common forms of neoplastic disease generally. Although it is not usually very difficult to diagnose BCC, the multiple morphologic variants of the disease can give rise to various—and in some cases compromised—differential diagnoses. One such variant is the cylindromatous pattern or phenotype, which has been described only rarely in the literature and is not mentioned in the main dermatopathology textbooks.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1–3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 91-year-old man with skin phototype <span class="elsevierStyleSmallCaps">II</span> consulted with our dermatology department for an erythematous, nonulcerated papule on the left cheek that had appeared 4 months earlier and had a maximum diameter of 1<span class="elsevierStyleHsp" style=""></span>cm. A clinical diagnosis of BCC was established and the lesion was excised. Histologic examination revealed an extremely thin, monostratified epidermis under focal pressure from numerous geographic basaloid nodules in the dermal layer that reached the depth of the dermal-hypodermal junction (0.5<span class="elsevierStyleHsp" style=""></span>cm) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The surfaces of the proliferating geographic nests were joined to the stratum basale, from which they appeared to originate. The lesional cells showed mild-to-moderate atypia and were arranged in palisades on the periphery of the nodules, which were surrounded by retraction artifact (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Although there were cystic changes in some basaloid nodules, in others a striking cylindromatous pattern was present. The cylindromatous pattern was defined by the presence of an intensely collagenized and hyalinized stroma around the tumor nodules, with the presence of hyaline prolongations extending toward the center of the nodules, forming well-defined terminal cylinders and creating an appearance similar to that of cylindromas (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). With the application of periodic acid–Schiff and Alcian blue staining techniques, the cylindromatous structures were stained magenta while the cystic structures were stained blue, demonstrating their mucinous content. An intense lymphocytic infiltrate was observed in the peritumoral stroma. On the basis of these findings, a diagnosis of nodular BCC with a cylindromatous phenotype was established. The recommended treatment, excision with free margins, was sufficient. The lesions have not recurred after 1 year of follow-up.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The cylindromatous component can be present in addition to any of the classic BCC patterns, which would provide a clue to the correct diagnosis.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4–6</span></a> The cylindromatous component can be predominant in some cases (as in our patient) or can be the only component present. In such cases, it is useful to check for nuclear atypia, which is mild-to-moderate in BCC and absent in common cylindroma, the main histologic differential diagnosis. The presence of peripheral palisading and retraction artifact around the tumor cell nests, although nonspecific, is useful in making a differential diagnosis with adnexal lesions that have a cylindromatous phenotype.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> One such lesion is cylindromatous carcinoma, which, as is common in malignant adnexal neoplasms, exhibits greater cellular pleomorphism, frequent mitotic figures, some atypias, and foci of necrosis—rare findings in BCCs. Immunohistochemical techniques do not appear to play an important role in the diagnosis of neoplasms with a cylindromatous pattern.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1–3</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Torres-Gómez FJ, Fernández-Machín P, Neila-Iglesias J. Carcinoma de células basales con fenotipo cilindromatoso. Actas Dermosifiliogr. 2016;107:165–167.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 812 "Ancho" => 875 "Tamanyo" => 138507 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma with a cylindromatous pattern. Macroscopic and microscopic image showing basaloid cells infiltrating the dermis.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 743 "Ancho" => 990 "Tamanyo" => 267069 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma with a cylindromatous pattern. Detail of a tumor cell nest composed of basaloid cells forming peripheral palisades surrounded by retraction artifact. Abundant amorphous, hyaline, basement-membrane-type material is observed inside the tumor (hematoxylin-eosin, original magnification ×100).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1321 "Ancho" => 990 "Tamanyo" => 301473 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma with a cylindromatous pattern. Both images show various tumor areas characterized by the presence of amorphous, hyaline material surrounded by basal cells with mild-to-moderate atypia (hematoxylin-eosin, original magnification ×200 and ×400).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Cutaneous Adnexal Tumors" "serieFecha" => "2012" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:1 [ "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "Pathology of the Skin with Clinical Correlations" "edicion" => "Third edition" "serieFecha" => "2005" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0045" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:1 [ "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Carcinoma Basocelular" "serieFecha" => "2010" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0050" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cylindromatous basalioma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. 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| 2023 Agosto | 88 | 27 | 115 |
| 2023 Julio | 83 | 36 | 119 |
| 2023 Junio | 73 | 31 | 104 |
| 2023 Mayo | 75 | 30 | 105 |
| 2023 Abril | 56 | 29 | 85 |
| 2023 Marzo | 57 | 30 | 87 |
| 2023 Febrero | 68 | 22 | 90 |
| 2023 Enero | 47 | 36 | 83 |
| 2022 Diciembre | 54 | 39 | 93 |
| 2022 Noviembre | 34 | 26 | 60 |
| 2022 Octubre | 27 | 18 | 45 |
| 2022 Septiembre | 24 | 36 | 60 |
| 2022 Agosto | 19 | 32 | 51 |
| 2022 Julio | 24 | 29 | 53 |
| 2022 Junio | 22 | 25 | 47 |
| 2022 Mayo | 82 | 37 | 119 |
| 2022 Abril | 65 | 36 | 101 |
| 2022 Marzo | 68 | 45 | 113 |
| 2022 Febrero | 78 | 22 | 100 |
| 2022 Enero | 79 | 30 | 109 |
| 2021 Diciembre | 39 | 44 | 83 |
| 2021 Noviembre | 57 | 49 | 106 |
| 2021 Octubre | 58 | 47 | 105 |
| 2021 Septiembre | 52 | 47 | 99 |
| 2021 Agosto | 47 | 28 | 75 |
| 2021 Julio | 68 | 30 | 98 |
| 2021 Junio | 63 | 32 | 95 |
| 2021 Mayo | 57 | 42 | 99 |
| 2021 Abril | 94 | 45 | 139 |
| 2021 Marzo | 117 | 29 | 146 |
| 2021 Febrero | 75 | 32 | 107 |
| 2021 Enero | 52 | 19 | 71 |
| 2020 Diciembre | 42 | 15 | 57 |
| 2020 Noviembre | 30 | 27 | 57 |
| 2020 Octubre | 29 | 9 | 38 |
| 2020 Septiembre | 34 | 10 | 44 |
| 2020 Agosto | 37 | 11 | 48 |
| 2020 Julio | 27 | 11 | 38 |
| 2020 Junio | 28 | 25 | 53 |
| 2020 Mayo | 22 | 20 | 42 |
| 2020 Abril | 42 | 19 | 61 |
| 2020 Marzo | 25 | 20 | 45 |
| 2020 Febrero | 4 | 1 | 5 |
| 2020 Enero | 6 | 0 | 6 |
| 2019 Diciembre | 8 | 0 | 8 |
| 2019 Noviembre | 4 | 0 | 4 |
| 2019 Septiembre | 7 | 0 | 7 |
| 2019 Agosto | 4 | 0 | 4 |
| 2019 Julio | 4 | 0 | 4 |
| 2019 Junio | 4 | 0 | 4 |
| 2019 Mayo | 8 | 0 | 8 |
| 2019 Abril | 2 | 1 | 3 |
| 2019 Marzo | 4 | 5 | 9 |
| 2019 Enero | 2 | 0 | 2 |
| 2018 Diciembre | 3 | 0 | 3 |
| 2018 Octubre | 3 | 0 | 3 |
| 2018 Septiembre | 5 | 0 | 5 |
| 2018 Marzo | 2 | 2 | 4 |
| 2018 Febrero | 52 | 3 | 55 |
| 2018 Enero | 41 | 5 | 46 |
| 2017 Diciembre | 65 | 6 | 71 |
| 2017 Noviembre | 27 | 10 | 37 |
| 2017 Octubre | 19 | 8 | 27 |
| 2017 Septiembre | 16 | 1 | 17 |
| 2017 Agosto | 24 | 6 | 30 |
| 2017 Julio | 14 | 7 | 21 |
| 2017 Junio | 30 | 8 | 38 |
| 2017 Mayo | 28 | 3 | 31 |
| 2017 Abril | 22 | 11 | 33 |
| 2017 Marzo | 14 | 8 | 22 |
| 2017 Febrero | 15 | 4 | 19 |
| 2017 Enero | 14 | 4 | 18 |
| 2016 Diciembre | 15 | 14 | 29 |
| 2016 Noviembre | 15 | 15 | 30 |
| 2016 Octubre | 41 | 24 | 65 |
| 2016 Mayo | 0 | 1 | 1 |
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