array:24 [
  "pii" => "S1578219015003480"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.05.023"
  "estado" => "S300"
  "fechaPublicacion" => "2016-01-01"
  "aid" => "1236"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2016;107:88-90"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 621
    "formatos" => array:3 [
      "EPUB" => 43
      "HTML" => 425
      "PDF" => 153
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S0001731015003403"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2015.05.013"
      "estado" => "S300"
      "fechaPublicacion" => "2016-01-01"
      "aid" => "1236"
      "copyright" => "Elsevier España, S.L.U. and AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2016;107:88-90"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 605
        "formatos" => array:3 [
          "EPUB" => 43
          "HTML" => 232
          "PDF" => 330
        ]
      ]
      "en" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
        "titulo" => "Intradermal Lipoblastoma-Like Tumor of the Lip in an Adult Woman"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "88"
            "paginaFinal" => "90"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Lipoblastoma intrad&#233;rmico tumor tipo en el labio de una mujer adulta"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1415
                "Ancho" => 1050
                "Tamanyo" => 488116
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Partial view of epidermal acanthosis&#44; papillomatosis&#44; and basal hyperpigmentation&#46; Scattered aggregates of immature fat cells are seen in the submucosa &#40;hematoxylin and eosin&#44; original magnification &#215;100&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46;F&#46; Val-Bernal, S&#46; Hermana, R&#46; S&#225;nchez"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "J&#46;F&#46;"
                "apellidos" => "Val-Bernal"
              ]
              1 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Hermana"
              ]
              2 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "S&#225;nchez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015003480"
          "doi" => "10.1016/j.adengl.2015.05.023"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003480?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003403?idApp=UINPBA000044"
      "url" => "/00017310/0000010700000001/v1_201512300105/S0001731015003403/v1_201512300105/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015003492"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.04.021"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-01"
    "aid" => "1237"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:91-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 425
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 286
        "PDF" => 98
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Granulomatous Variant of Pigmented Purpura"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "91"
          "paginaFinal" => "92"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Variante granulomatosa de p&#250;rpura pigmentada"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 964
              "Ancho" => 1300
              "Tamanyo" => 196035
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Clinical features of purpuric lesions on the right and left shin&#46; &#40;B&#41; Close-up view&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "H&#46; Hakenoshita, T&#46; Yamamoto"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "H&#46;"
              "apellidos" => "Hakenoshita"
            ]
            1 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Yamamoto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0001731015003415"
        "doi" => "10.1016/j.ad.2015.04.019"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003415?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003492?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003492/v2_201704190205/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015003273"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.11.018"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-01"
    "aid" => "1232"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:86-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1075
      "formatos" => array:3 [
        "EPUB" => 38
        "HTML" => 812
        "PDF" => 225
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Primary cutaneous small-to-medium-sized CD4&#43; T-cell lymphoma with a granulomatous component"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "86"
          "paginaFinal" => "88"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Linfoma cut&#225;neo primario T CD4&#43; de c&#233;lula peque&#241;a&#47;mediana&#44; granulomatoso"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1350
              "Ancho" => 1800
              "Tamanyo" => 704953
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical images of the lesion&#46; A&#44; At the first visit&#46; B&#44; 2 months later&#44; with self-resolution&#46; Histological appearance of the biopsies corresponding to the clinical images immediately above&#44; with partial reduction of the tumor infiltrate in the second of them&#46; C&#44; Hematoxylin-eosin &#40;H-E&#41;&#44; x40&#46; D&#44; H-E&#44; x400&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;R&#46; Garc&#237;a de la Fuente, F&#46; Vilardell-Villellas, R&#46;M&#46; Mart&#237;-Laborda, J&#46;M&#46; Casanova-Seuma"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;R&#46;"
              "apellidos" => "Garc&#237;a de la Fuente"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Vilardell-Villellas"
            ]
            2 => array:2 [
              "nombre" => "R&#46;M&#46;"
              "apellidos" => "Mart&#237;-Laborda"
            ]
            3 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Casanova-Seuma"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015003361"
        "doi" => "10.1016/j.ad.2015.04.018"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003361?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003273?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003273/v2_201704190205/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Intradermal Lipoblastoma-Like Tumor of the Lip in an Adult Woman"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "88"
        "paginaFinal" => "90"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46;F&#46; Val-Bernal, S&#46; Hermana, R&#46; S&#225;nchez"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "J&#46;F&#46;"
            "apellidos" => "Val-Bernal"
            "email" => array:1 [
              0 => "apavbj&#64;humv&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "S&#46;"
            "apellidos" => "Hermana"
          ]
          2 => array:2 [
            "nombre" => "R&#46;"
            "apellidos" => "S&#225;nchez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Department of Anatomical Pathology&#44; Marqu&#233;s de Valdecilla University Hospital&#44; Medical Faculty&#44; University of Cantabria and IDIVAL&#44; Santander&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Lipoblastoma intrad&#233;rmico tumor tipo en el labio de una mujer adulta"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1415
            "Ancho" => 1050
            "Tamanyo" => 364001
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multivacuolated and univacuolated lipoblasts constitute most of the dermal fat tissue&#46; Mature adipocytes are scant &#40;hematoxylin and eosin&#44; original magnification &#215;200&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lipoblastoma is a benign adipocytic tumor consisting of lobulated&#44; immature white fat cells with a prominent capillary pattern and&#44; frequently&#44; a focal myxoid matrix&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The tumor can be localized or diffuse&#44; occurs predominantly in infancy and early childhood&#44; and affects patients aged 5 years or younger in 84&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Nevertheless&#44; rare cases have been reported in adolescents and adults&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> Most lipoblastomas are subcutaneous lesions affecting the arms and legs&#44; and they are more common in male patients&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a distinctive mesenchymal neoplasm of the lip showing adipocytic differentiation in an adult woman&#46; We consider that this tumor is akin to infantile lipoblastoma&#46; As far as we are aware&#44; only 1 such lesion has been previously reported&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A 36-year-old woman presented with a history of a small asymptomatic&#44; pigmented&#44; raised nodule on the vermilion border of the lower lip that had been present for about 9 months&#46; The patient had not undergone lip piercing&#44; filler injection for lip augmentation&#44; or any other interventions&#46; Her past medical history was not significant for systemic disease&#46; Physical examination revealed a soft&#44; brown-colored&#44; sessile nodule measuring 0&#46;8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>0&#46;4<span class="elsevierStyleHsp" style=""></span>cm on the right half of the lower lip&#46; The clinical diagnosis was melanocytic nevus&#46; The lesion was completely removed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The microscopic study showed a poorly demarcated lesion&#44; with epidermal acanthosis&#44; irregular papillomatosis&#44; and hyperpigmentation of the basal layer&#46; Scattered aggregates of immature fat cells replaced much of the submucosa &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; with a preferential perivascular location&#46; These cells showed variation in size and were multivacuolated lipoblasts&#44; which indented the nuclei and were interspersed with univacuolated lipoblasts that displaced the nuclei and looked like signet-ring fat cells&#46; Mature adipocytes were scant &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Hibernoma-like cells were not seen&#46; All the nuclei were small and monomorphic without atypia&#46; Mitotic figures were absent&#46; No giant cells&#44; lymphocytes&#44; mucin deposits&#44; or plexiform vascularization were observed&#46; Dermal aggregates were surrounded by numerous small vessels&#44; and were incompletely separated by the thick collagenous bundles of dermis&#46; In the depth of the lesion&#44; lipoblast aggregates were seen to form part of the adventitia of small veins or to infiltrate between the fascicles of the orbicularis muscle &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; No birefringence was observed in the adipocytic cells&#46; Alcian blue &#40;pH 2&#46;5&#41; did not show any acid mucin in the fat cell groups or in the dermal connective tissue&#46; The cells stained positively for vimentin and retinoblastoma antibody and negatively for AE1&#47;AE3 cytokeratin&#44; CD34&#44; CD31&#44; CD68&#44; and estrogen receptor&#46; Immature adipocytes showed moderate amounts of cytoplasmic mitochondria around fat vacuoles that were visible with the antimitochondrial antibody&#46; The amount of mitochondria was not comparable to that observed in the brown adipose tissue cells&#46; The neoplasm involved the surgical margins&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">There has been no local recurrence or metastasis in the 9 months since surgery&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The tumor in the case reported here shared histological features with lipoblastoma&#44; namely prominent lobulation&#44; immature fat cells consisting of multivacuolated and univacuolated lipoblasts admixed with mature fat cells&#44; conspicuous capillaries&#44; variably developed collagenous septae&#44; and diffuse borders&#46; The clinical manifestations suggested a diagnosis of melanocytic nevus due to the concomitant pigmented epidermal lesion&#46; We interpret the epidermal lesion as a reactive hyperplasia that may accompany lesions of this kind&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Lipoblastoma occurs primarily in infancy and early childhood&#44; but it can be observed in adolescents and young adults&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Lae et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> described 2 cases in women aged 23 and 38 years&#44; and Silverman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> reported a recurring lipoblastoma in a 48-year-old man&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">To our knowledge&#44; the present case is the second report of a lipoblastoma-like tumor of the lip&#46; Jeong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> reported a similar intradermal lesion involving the lower lip of a 61-year-old woman&#46; The dermal tumor was erythematous&#44; slightly elevated&#44; and measured 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>cm&#46; The clinical differential diagnosis included Fordyce spot&#44; nevus lipomatosus superficialis&#44; and foreign body granuloma&#46; The excised specimen showed abundant dermal lobules composed of lipoblasts and mature cells&#46; The epidermis above the dermal tumor showed acanthosis and irregular papillomatosis&#44; which is a change similar to that observed in the case we are reporting&#46; Neither local recurrence nor metastasis was observed 1 year after surgery&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Lipoblastoma is a benign tumor&#44; but it can return in 9&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Recurrence may occur in the form of a mature lipomatous tumor&#46; The differential diagnosis includes other dermal tumors with lipoblasts such as atypical lipomatous tumor&#47;well-differentiated liposarcoma&#44; spindle cell&#47;pleomorphic lipoma&#44; and myxoid liposarcoma&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The nature of lipoblastoma remains to be explained&#46; The structure of the lesion is reminiscent of the development of white adipose tissue&#46; White embryonal&#47;fetal fat is characterized by a very close association between adipocyte development and angiogenesis&#46; Both small univacuolated and multivacuolated adipocytes form lobules with abundant delicate branching capillaries&#46; It has been proposed that the white adipocyte precursor is derived from undifferentiated mesenchymal cells that reside in the mural cell compartment of the adipose vasculature&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The embryonal&#47;fetal structure of the lipoblastoma and its occurrence primarily in the very young suggests a hamartomatous lesion&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1415
            "Ancho" => 1050
            "Tamanyo" => 488116
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Partial view of epidermal acanthosis&#44; papillomatosis&#44; and basal hyperpigmentation&#46; Scattered aggregates of immature fat cells are seen in the submucosa &#40;hematoxylin and eosin&#44; original magnification &#215;100&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1415
            "Ancho" => 1050
            "Tamanyo" => 364001
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multivacuolated and univacuolated lipoblasts constitute most of the dermal fat tissue&#46; Mature adipocytes are scant &#40;hematoxylin and eosin&#44; original magnification &#215;200&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1415
            "Ancho" => 1050
            "Tamanyo" => 345218
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Immature adipocytes can be seen infiltrating between the fascicles of the orbicularis muscle &#40;hematoxylin and eosin&#44; original magnification &#215;100&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumors of the soft tissues&#46; AFIP Atlas of Tumor Pathology&#44; series 4&#44; fascicle 20"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Miettinen"
                            1 => "J&#46;F&#46; Fetsch"
                            2 => "C&#46;R&#46; Antonescu"
                            3 => "A&#46;L&#46; Folpe"
                            4 => "P&#46;E&#46; Wakely"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2014"
                        "editorial" => "American Registry of Pathology"
                        "editorialLocalizacion" => "Silver Spring&#44; Maryland"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipoblastoma&#47;lipoblastomatosis&#58; a clinicopathologic study of 25 tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;H&#46; Collins"
                            1 => "J&#46; Chatten"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg Pathol"
                        "fecha" => "1997"
                        "volumen" => "21"
                        "paginaInicial" => "1131"
                        "paginaFinal" => "1137"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9331284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipoblastoma-like tumour of the vulva&#58; report of three cases of a distinctive mesenchymal neoplasm of adipocytic differentiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;E&#46; Lae"
                            1 => "P&#46;F&#46; Pereira"
                            2 => "G&#46;L&#46; Keeney"
                            3 => "A&#46;G&#46; Nascimento"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Histopathology"
                        "fecha" => "2002"
                        "volumen" => "40"
                        "paginaInicial" => "505"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12047760"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipoblastoma in adolescents and young adults&#58; report of six cases with FISH analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; de Saint Aubain Somerhausen"
                            1 => "J&#46;M&#46; Coindre"
                            2 => "M&#46; Debiec-Rychter"
                            3 => "J&#46; Delplace"
                            4 => "R&#46; Sciot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2559.2007.02954.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Histopathology"
                        "fecha" => "2008"
                        "volumen" => "52"
                        "paginaInicial" => "294"
                        "paginaFinal" => "298"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18269579"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109700008044"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipoblastoma-like tumour of the lip in an adult woman"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;J&#46; Jeong"
                            1 => "Y&#46;J&#46; Oh"
                            2 => "J&#46;J&#46; Ahn"
                            3 => "M&#46;K&#46; Shin"
                            4 => "N&#46;I&#46; Kim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2340/00015555-0904"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "2010"
                        "volumen" => "90"
                        "paginaInicial" => "537"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20814641"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Benign recurring lipoblastoma in an adult versus well differentiated subcutaneous myxoid liposarcoma&#58; clinicopathologic&#44; immunohistochemical and molecular analysis of a unique case"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;S&#46; Silverman"
                            1 => "J&#46; Hamilton"
                            2 => "A&#46; Tamsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0344-0338(99)80122-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pathol Res Pract"
                        "fecha" => "1999"
                        "volumen" => "195"
                        "paginaInicial" => "787"
                        "paginaFinal" => "792"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10605700"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary liposarcoma of the skin&#58; a rare neoplasm with unusual high grade features"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;P&#46; Dei Tos"
                            1 => "T&#46; Mentzel"
                            2 => "C&#46;D&#46;M&#46; Fletcher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1998"
                        "volumen" => "20"
                        "paginaInicial" => "332"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9700369"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "White fat progenitor cells reside in the adipose vasculature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46; Tang"
                            1 => "D&#46; Zeve"
                            2 => "J&#46;M&#46; Suh"
                            3 => "D&#46; Bosnakovski"
                            4 => "M&#46; Kyba"
                            5 => "R&#46;E&#46; Hammer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.1156232"
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "2008"
                        "volumen" => "322"
                        "paginaInicial" => "583"
                        "paginaFinal" => "586"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18801968"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Before they were fat&#58; adipocyte progenitors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;W&#46; Park"
                            1 => "D&#46;S&#46; Halperin"
                            2 => "P&#46; Tontonoz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cmet.2008.11.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell Metab"
                        "fecha" => "2008"
                        "volumen" => "8"
                        "paginaInicial" => "454"
                        "paginaFinal" => "457"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19041761"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A text and atlas with correlated cell and molecular biology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;H&#46; Ross"
                            1 => "W&#46; Pawlina"
                            2 => "Histology"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "6th ed&#46;"
                        "fecha" => "2010"
                        "editorial" => "Lippincott Williams and Wilkins&#44; Wolters Kluwer"
                        "editorialLocalizacion" => "Philadelphia&#44; PA"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003480/v2_201704190205/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000001/v2_201704190205/S1578219015003480/v2_201704190205/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003480?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letter
Intradermal Lipoblastoma-Like Tumor of the Lip in an Adult Woman
Lipoblastoma intradérmico tumor tipo en el labio de una mujer adulta
J.F. Val-Bernal
Autor para correspondencia
apavbj@humv.es

Corresponding author.
, S. Hermana, R. Sánchez
Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria and IDIVAL, Santander, Spain
Leído
5060
Veces
se ha leído el artículo
1818
Total PDF
3242
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S1578219015003480"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.05.023"
  "estado" => "S300"
  "fechaPublicacion" => "2016-01-01"
  "aid" => "1236"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2016;107:88-90"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 621
    "formatos" => array:3 [
      "EPUB" => 43
      "HTML" => 425
      "PDF" => 153
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S0001731015003403"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2015.05.013"
      "estado" => "S300"
      "fechaPublicacion" => "2016-01-01"
      "aid" => "1236"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2016;107:88-90"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 605
        "formatos" => array:3 [
          "EPUB" => 43
          "HTML" => 232
          "PDF" => 330
        ]
      ]
      "en" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
        "titulo" => "Intradermal Lipoblastoma-Like Tumor of the Lip in an Adult Woman"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "88"
            "paginaFinal" => "90"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Lipoblastoma intrad&#233;rmico tumor tipo en el labio de una mujer adulta"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1415
                "Ancho" => 1050
                "Tamanyo" => 488116
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Partial view of epidermal acanthosis&#44; papillomatosis&#44; and basal hyperpigmentation&#46; Scattered aggregates of immature fat cells are seen in the submucosa &#40;hematoxylin and eosin&#44; original magnification &#215;100&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46;F&#46; Val-Bernal, S&#46; Hermana, R&#46; S&#225;nchez"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "J&#46;F&#46;"
                "apellidos" => "Val-Bernal"
              ]
              1 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Hermana"
              ]
              2 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "S&#225;nchez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015003480"
          "doi" => "10.1016/j.adengl.2015.05.023"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003480?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003403?idApp=UINPBA000044"
      "url" => "/00017310/0000010700000001/v1_201512300105/S0001731015003403/v1_201512300105/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015003492"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.04.021"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-01"
    "aid" => "1237"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:91-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 425
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 286
        "PDF" => 98
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Granulomatous Variant of Pigmented Purpura"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "91"
          "paginaFinal" => "92"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Variante granulomatosa de p&#250;rpura pigmentada"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 964
              "Ancho" => 1300
              "Tamanyo" => 196035
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Clinical features of purpuric lesions on the right and left shin&#46; &#40;B&#41; Close-up view&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "H&#46; Hakenoshita, T&#46; Yamamoto"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "H&#46;"
              "apellidos" => "Hakenoshita"
            ]
            1 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Yamamoto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0001731015003415"
        "doi" => "10.1016/j.ad.2015.04.019"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003415?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003492?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003492/v2_201704190205/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015003273"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.11.018"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-01"
    "aid" => "1232"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:86-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1075
      "formatos" => array:3 [
        "EPUB" => 38
        "HTML" => 812
        "PDF" => 225
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Primary cutaneous small-to-medium-sized CD4&#43; T-cell lymphoma with a granulomatous component"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "86"
          "paginaFinal" => "88"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Linfoma cut&#225;neo primario T CD4&#43; de c&#233;lula peque&#241;a&#47;mediana&#44; granulomatoso"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1350
              "Ancho" => 1800
              "Tamanyo" => 704953
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical images of the lesion&#46; A&#44; At the first visit&#46; B&#44; 2 months later&#44; with self-resolution&#46; Histological appearance of the biopsies corresponding to the clinical images immediately above&#44; with partial reduction of the tumor infiltrate in the second of them&#46; C&#44; Hematoxylin-eosin &#40;H-E&#41;&#44; x40&#46; D&#44; H-E&#44; x400&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;R&#46; Garc&#237;a de la Fuente, F&#46; Vilardell-Villellas, R&#46;M&#46; Mart&#237;-Laborda, J&#46;M&#46; Casanova-Seuma"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;R&#46;"
              "apellidos" => "Garc&#237;a de la Fuente"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Vilardell-Villellas"
            ]
            2 => array:2 [
              "nombre" => "R&#46;M&#46;"
              "apellidos" => "Mart&#237;-Laborda"
            ]
            3 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Casanova-Seuma"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015003361"
        "doi" => "10.1016/j.ad.2015.04.018"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003361?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003273?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003273/v2_201704190205/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Intradermal Lipoblastoma-Like Tumor of the Lip in an Adult Woman"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "88"
        "paginaFinal" => "90"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46;F&#46; Val-Bernal, S&#46; Hermana, R&#46; S&#225;nchez"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "J&#46;F&#46;"
            "apellidos" => "Val-Bernal"
            "email" => array:1 [
              0 => "apavbj&#64;humv&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "S&#46;"
            "apellidos" => "Hermana"
          ]
          2 => array:2 [
            "nombre" => "R&#46;"
            "apellidos" => "S&#225;nchez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Department of Anatomical Pathology&#44; Marqu&#233;s de Valdecilla University Hospital&#44; Medical Faculty&#44; University of Cantabria and IDIVAL&#44; Santander&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Lipoblastoma intrad&#233;rmico tumor tipo en el labio de una mujer adulta"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1415
            "Ancho" => 1050
            "Tamanyo" => 364001
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multivacuolated and univacuolated lipoblasts constitute most of the dermal fat tissue&#46; Mature adipocytes are scant &#40;hematoxylin and eosin&#44; original magnification &#215;200&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lipoblastoma is a benign adipocytic tumor consisting of lobulated&#44; immature white fat cells with a prominent capillary pattern and&#44; frequently&#44; a focal myxoid matrix&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The tumor can be localized or diffuse&#44; occurs predominantly in infancy and early childhood&#44; and affects patients aged 5 years or younger in 84&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Nevertheless&#44; rare cases have been reported in adolescents and adults&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> Most lipoblastomas are subcutaneous lesions affecting the arms and legs&#44; and they are more common in male patients&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a distinctive mesenchymal neoplasm of the lip showing adipocytic differentiation in an adult woman&#46; We consider that this tumor is akin to infantile lipoblastoma&#46; As far as we are aware&#44; only 1 such lesion has been previously reported&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A 36-year-old woman presented with a history of a small asymptomatic&#44; pigmented&#44; raised nodule on the vermilion border of the lower lip that had been present for about 9 months&#46; The patient had not undergone lip piercing&#44; filler injection for lip augmentation&#44; or any other interventions&#46; Her past medical history was not significant for systemic disease&#46; Physical examination revealed a soft&#44; brown-colored&#44; sessile nodule measuring 0&#46;8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>0&#46;4<span class="elsevierStyleHsp" style=""></span>cm on the right half of the lower lip&#46; The clinical diagnosis was melanocytic nevus&#46; The lesion was completely removed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The microscopic study showed a poorly demarcated lesion&#44; with epidermal acanthosis&#44; irregular papillomatosis&#44; and hyperpigmentation of the basal layer&#46; Scattered aggregates of immature fat cells replaced much of the submucosa &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; with a preferential perivascular location&#46; These cells showed variation in size and were multivacuolated lipoblasts&#44; which indented the nuclei and were interspersed with univacuolated lipoblasts that displaced the nuclei and looked like signet-ring fat cells&#46; Mature adipocytes were scant &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Hibernoma-like cells were not seen&#46; All the nuclei were small and monomorphic without atypia&#46; Mitotic figures were absent&#46; No giant cells&#44; lymphocytes&#44; mucin deposits&#44; or plexiform vascularization were observed&#46; Dermal aggregates were surrounded by numerous small vessels&#44; and were incompletely separated by the thick collagenous bundles of dermis&#46; In the depth of the lesion&#44; lipoblast aggregates were seen to form part of the adventitia of small veins or to infiltrate between the fascicles of the orbicularis muscle &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; No birefringence was observed in the adipocytic cells&#46; Alcian blue &#40;pH 2&#46;5&#41; did not show any acid mucin in the fat cell groups or in the dermal connective tissue&#46; The cells stained positively for vimentin and retinoblastoma antibody and negatively for AE1&#47;AE3 cytokeratin&#44; CD34&#44; CD31&#44; CD68&#44; and estrogen receptor&#46; Immature adipocytes showed moderate amounts of cytoplasmic mitochondria around fat vacuoles that were visible with the antimitochondrial antibody&#46; The amount of mitochondria was not comparable to that observed in the brown adipose tissue cells&#46; The neoplasm involved the surgical margins&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">There has been no local recurrence or metastasis in the 9 months since surgery&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The tumor in the case reported here shared histological features with lipoblastoma&#44; namely prominent lobulation&#44; immature fat cells consisting of multivacuolated and univacuolated lipoblasts admixed with mature fat cells&#44; conspicuous capillaries&#44; variably developed collagenous septae&#44; and diffuse borders&#46; The clinical manifestations suggested a diagnosis of melanocytic nevus due to the concomitant pigmented epidermal lesion&#46; We interpret the epidermal lesion as a reactive hyperplasia that may accompany lesions of this kind&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Lipoblastoma occurs primarily in infancy and early childhood&#44; but it can be observed in adolescents and young adults&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Lae et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> described 2 cases in women aged 23 and 38 years&#44; and Silverman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> reported a recurring lipoblastoma in a 48-year-old man&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">To our knowledge&#44; the present case is the second report of a lipoblastoma-like tumor of the lip&#46; Jeong et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> reported a similar intradermal lesion involving the lower lip of a 61-year-old woman&#46; The dermal tumor was erythematous&#44; slightly elevated&#44; and measured 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>cm&#46; The clinical differential diagnosis included Fordyce spot&#44; nevus lipomatosus superficialis&#44; and foreign body granuloma&#46; The excised specimen showed abundant dermal lobules composed of lipoblasts and mature cells&#46; The epidermis above the dermal tumor showed acanthosis and irregular papillomatosis&#44; which is a change similar to that observed in the case we are reporting&#46; Neither local recurrence nor metastasis was observed 1 year after surgery&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Lipoblastoma is a benign tumor&#44; but it can return in 9&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Recurrence may occur in the form of a mature lipomatous tumor&#46; The differential diagnosis includes other dermal tumors with lipoblasts such as atypical lipomatous tumor&#47;well-differentiated liposarcoma&#44; spindle cell&#47;pleomorphic lipoma&#44; and myxoid liposarcoma&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The nature of lipoblastoma remains to be explained&#46; The structure of the lesion is reminiscent of the development of white adipose tissue&#46; White embryonal&#47;fetal fat is characterized by a very close association between adipocyte development and angiogenesis&#46; Both small univacuolated and multivacuolated adipocytes form lobules with abundant delicate branching capillaries&#46; It has been proposed that the white adipocyte precursor is derived from undifferentiated mesenchymal cells that reside in the mural cell compartment of the adipose vasculature&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The embryonal&#47;fetal structure of the lipoblastoma and its occurrence primarily in the very young suggests a hamartomatous lesion&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1415
            "Ancho" => 1050
            "Tamanyo" => 488116
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Partial view of epidermal acanthosis&#44; papillomatosis&#44; and basal hyperpigmentation&#46; Scattered aggregates of immature fat cells are seen in the submucosa &#40;hematoxylin and eosin&#44; original magnification &#215;100&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1415
            "Ancho" => 1050
            "Tamanyo" => 364001
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multivacuolated and univacuolated lipoblasts constitute most of the dermal fat tissue&#46; Mature adipocytes are scant &#40;hematoxylin and eosin&#44; original magnification &#215;200&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1415
            "Ancho" => 1050
            "Tamanyo" => 345218
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Immature adipocytes can be seen infiltrating between the fascicles of the orbicularis muscle &#40;hematoxylin and eosin&#44; original magnification &#215;100&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumors of the soft tissues&#46; AFIP Atlas of Tumor Pathology&#44; series 4&#44; fascicle 20"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Miettinen"
                            1 => "J&#46;F&#46; Fetsch"
                            2 => "C&#46;R&#46; Antonescu"
                            3 => "A&#46;L&#46; Folpe"
                            4 => "P&#46;E&#46; Wakely"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2014"
                        "editorial" => "American Registry of Pathology"
                        "editorialLocalizacion" => "Silver Spring&#44; Maryland"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipoblastoma&#47;lipoblastomatosis&#58; a clinicopathologic study of 25 tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;H&#46; Collins"
                            1 => "J&#46; Chatten"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg Pathol"
                        "fecha" => "1997"
                        "volumen" => "21"
                        "paginaInicial" => "1131"
                        "paginaFinal" => "1137"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9331284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipoblastoma-like tumour of the vulva&#58; report of three cases of a distinctive mesenchymal neoplasm of adipocytic differentiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;E&#46; Lae"
                            1 => "P&#46;F&#46; Pereira"
                            2 => "G&#46;L&#46; Keeney"
                            3 => "A&#46;G&#46; Nascimento"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Histopathology"
                        "fecha" => "2002"
                        "volumen" => "40"
                        "paginaInicial" => "505"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12047760"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipoblastoma in adolescents and young adults&#58; report of six cases with FISH analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; de Saint Aubain Somerhausen"
                            1 => "J&#46;M&#46; Coindre"
                            2 => "M&#46; Debiec-Rychter"
                            3 => "J&#46; Delplace"
                            4 => "R&#46; Sciot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2559.2007.02954.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Histopathology"
                        "fecha" => "2008"
                        "volumen" => "52"
                        "paginaInicial" => "294"
                        "paginaFinal" => "298"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18269579"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109700008044"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lipoblastoma-like tumour of the lip in an adult woman"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;J&#46; Jeong"
                            1 => "Y&#46;J&#46; Oh"
                            2 => "J&#46;J&#46; Ahn"
                            3 => "M&#46;K&#46; Shin"
                            4 => "N&#46;I&#46; Kim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2340/00015555-0904"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "2010"
                        "volumen" => "90"
                        "paginaInicial" => "537"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20814641"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Benign recurring lipoblastoma in an adult versus well differentiated subcutaneous myxoid liposarcoma&#58; clinicopathologic&#44; immunohistochemical and molecular analysis of a unique case"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;S&#46; Silverman"
                            1 => "J&#46; Hamilton"
                            2 => "A&#46; Tamsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0344-0338(99)80122-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pathol Res Pract"
                        "fecha" => "1999"
                        "volumen" => "195"
                        "paginaInicial" => "787"
                        "paginaFinal" => "792"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10605700"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary liposarcoma of the skin&#58; a rare neoplasm with unusual high grade features"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;P&#46; Dei Tos"
                            1 => "T&#46; Mentzel"
                            2 => "C&#46;D&#46;M&#46; Fletcher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1998"
                        "volumen" => "20"
                        "paginaInicial" => "332"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9700369"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "White fat progenitor cells reside in the adipose vasculature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46; Tang"
                            1 => "D&#46; Zeve"
                            2 => "J&#46;M&#46; Suh"
                            3 => "D&#46; Bosnakovski"
                            4 => "M&#46; Kyba"
                            5 => "R&#46;E&#46; Hammer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.1156232"
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "2008"
                        "volumen" => "322"
                        "paginaInicial" => "583"
                        "paginaFinal" => "586"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18801968"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Before they were fat&#58; adipocyte progenitors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;W&#46; Park"
                            1 => "D&#46;S&#46; Halperin"
                            2 => "P&#46; Tontonoz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cmet.2008.11.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell Metab"
                        "fecha" => "2008"
                        "volumen" => "8"
                        "paginaInicial" => "454"
                        "paginaFinal" => "457"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19041761"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A text and atlas with correlated cell and molecular biology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;H&#46; Ross"
                            1 => "W&#46; Pawlina"
                            2 => "Histology"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "6th ed&#46;"
                        "fecha" => "2010"
                        "editorial" => "Lippincott Williams and Wilkins&#44; Wolters Kluwer"
                        "editorialLocalizacion" => "Philadelphia&#44; PA"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003480/v2_201704190205/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000001/v2_201704190205/S1578219015003480/v2_201704190205/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003480?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 6 7 13
2024 Octubre 65 39 104
2024 Septiembre 76 25 101
2024 Agosto 96 59 155
2024 Julio 73 47 120
2024 Junio 70 32 102
2024 Mayo 64 34 98
2024 Abril 71 25 96
2024 Marzo 77 30 107
2024 Febrero 67 35 102
2024 Enero 45 38 83
2023 Diciembre 59 19 78
2023 Noviembre 65 41 106
2023 Octubre 70 25 95
2023 Septiembre 67 25 92
2023 Agosto 44 21 65
2023 Julio 74 30 104
2023 Junio 65 23 88
2023 Mayo 59 25 84
2023 Abril 57 22 79
2023 Marzo 65 24 89
2023 Febrero 56 26 82
2023 Enero 40 56 96
2022 Diciembre 44 38 82
2022 Noviembre 33 28 61
2022 Octubre 24 24 48
2022 Septiembre 24 30 54
2022 Agosto 30 46 76
2022 Julio 17 36 53
2022 Junio 20 30 50
2022 Mayo 50 37 87
2022 Abril 59 33 92
2022 Marzo 54 45 99
2022 Febrero 39 29 68
2022 Enero 63 42 105
2021 Diciembre 54 29 83
2021 Noviembre 42 52 94
2021 Octubre 51 45 96
2021 Septiembre 54 43 97
2021 Agosto 69 22 91
2021 Julio 69 33 102
2021 Junio 57 24 81
2021 Mayo 36 34 70
2021 Abril 91 30 121
2021 Marzo 48 22 70
2021 Febrero 77 25 102
2021 Enero 39 15 54
2020 Diciembre 28 8 36
2020 Noviembre 29 20 49
2020 Octubre 22 18 40
2020 Septiembre 32 10 42
2020 Agosto 31 14 45
2020 Julio 17 15 32
2020 Junio 22 24 46
2020 Mayo 15 19 34
2020 Abril 26 18 44
2020 Marzo 17 19 36
2020 Febrero 4 0 4
2020 Enero 4 1 5
2019 Diciembre 4 0 4
2019 Noviembre 4 0 4
2019 Octubre 0 3 3
2019 Agosto 4 0 4
2019 Julio 4 0 4
2019 Junio 4 0 4
2019 Mayo 5 2 7
2019 Abril 3 0 3
2019 Marzo 2 5 7
2019 Febrero 5 0 5
2019 Enero 3 0 3
2018 Noviembre 17 0 17
2018 Octubre 10 0 10
2018 Septiembre 6 0 6
2018 Marzo 2 1 3
2018 Febrero 24 2 26
2018 Enero 33 5 38
2017 Diciembre 32 3 35
2017 Noviembre 12 7 19
2017 Octubre 23 4 27
2017 Septiembre 10 5 15
2017 Agosto 21 7 28
2017 Julio 22 9 31
2017 Junio 26 10 36
2017 Mayo 25 3 28
2017 Abril 30 8 38
2017 Marzo 5 5 10
2017 Febrero 13 4 17
2017 Enero 19 7 26
2016 Diciembre 14 11 25
2016 Noviembre 25 10 35
2016 Octubre 13 11 24
2016 Septiembre 0 3 3
2016 Agosto 0 3 3
2016 Junio 0 4 4
2016 Mayo 0 6 6
2016 Abril 0 1 1
2016 Marzo 0 7 7
2016 Febrero 0 4 4
2016 Enero 0 2 2
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?