se ha leído el artículo
array:24 [ "pii" => "S1578219015003273" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.11.018" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "aid" => "1232" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2015" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2016;107:86-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1075 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 812 "PDF" => 225 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731015003361" "issn" => "00017310" "doi" => "10.1016/j.ad.2015.04.018" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "aid" => "1232" "copyright" => "Elsevier España, S.L.U. y AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2016;107:86-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 448 "formatos" => array:3 [ "EPUB" => 2 "HTML" => 192 "PDF" => 254 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => "Linfoma cutáneo primario T CD4+ de célula pequeña/mediana, granulomatoso" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "86" "paginaFinal" => "88" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Primary cutaneous small-to-medium-sized CD4+ T-cell lymphoma with a granulomatous component" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1350 "Ancho" => 1800 "Tamanyo" => 989181 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En el estudio inmunohistoquímico destaca la positividad para CD3 y CD4 en las imágenes superiores y la negatividad para CD8 y CD30 en las imágenes inferiores. El escaso marcaje de CD 8 corresponde a celularidad acompañante y no a la celularidad tumoral.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.R. García de la Fuente, F. Vilardell-Villellas, R.M. Martí-Laborda, J.M. Casanova-Seuma" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M.R." "apellidos" => "García de la Fuente" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Vilardell-Villellas" ] 2 => array:2 [ "nombre" => "R.M." "apellidos" => "Martí-Laborda" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Casanova-Seuma" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219015003273" "doi" => "10.1016/j.adengl.2015.11.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003273?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003361?idApp=UINPBA000044" "url" => "/00017310/0000010700000001/v1_201512300105/S0001731015003361/v1_201512300105/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219015003480" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.05.023" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "aid" => "1236" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2016;107:88-90" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 621 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 425 "PDF" => 153 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Intradermal Lipoblastoma-Like Tumor of the Lip in an Adult Woman" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "88" "paginaFinal" => "90" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lipoblastoma intradérmico tumor tipo en el labio de una mujer adulta" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1415 "Ancho" => 1050 "Tamanyo" => 364001 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multivacuolated and univacuolated lipoblasts constitute most of the dermal fat tissue. Mature adipocytes are scant (hematoxylin and eosin, original magnification ×200).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.F. Val-Bernal, S. Hermana, R. Sánchez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J.F." "apellidos" => "Val-Bernal" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Hermana" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Sánchez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0001731015003403" "doi" => "10.1016/j.ad.2015.05.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003403?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003480?idApp=UINPBA000044" "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003480/v2_201704190205/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219015003261" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.11.017" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "aid" => "1231" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2016;107:83-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 991 "formatos" => array:3 [ "EPUB" => 52 "HTML" => 606 "PDF" => 333 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Cutaneous metastases on the head and neck from a papillary thyroid carcinoma, follicular variant" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "83" "paginaFinal" => "85" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Metástasis cutáneas craneocervicales de un carcinoma papilar de tiroides variedad folicular" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1100 "Ancho" => 1443 "Tamanyo" => 534529 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Histologic lesion of the scalp. Epithelial nodules surrounded by fibrosis and lymphatic invasion of tumor cells (hematoxylin-eosin [H-E], ×40). B, Follicular structures lined by round cells with clear cytoplasm and pleomorphic nuclei (H-E, ×100). C, TTF-1 positive (immunohistochemical staining). D, Galectine-3 positive (immunohistochemical staining).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Márquez García, L. Ferrándiz Pulido, J.J. Ríos-Martín, F.M. Camacho Martínez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Márquez García" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Ferrándiz Pulido" ] 2 => array:2 [ "nombre" => "J.J." "apellidos" => "Ríos-Martín" ] 3 => array:2 [ "nombre" => "F.M." "apellidos" => "Camacho Martínez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S000173101500335X" "doi" => "10.1016/j.ad.2015.06.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101500335X?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003261?idApp=UINPBA000044" "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003261/v2_201704190205/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Primary cutaneous small-to-medium-sized CD4+ T-cell lymphoma with a granulomatous component" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "86" "paginaFinal" => "88" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.R. García de la Fuente, F. Vilardell-Villellas, R.M. Martí-Laborda, J.M. Casanova-Seuma" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M.R." "apellidos" => "García de la Fuente" "email" => array:1 [ 0 => "mrgarcia_dlf@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "F." "apellidos" => "Vilardell-Villellas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "R.M." "apellidos" => "Martí-Laborda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "J.M." "apellidos" => "Casanova-Seuma" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Arnau de Vilanova, Lérida, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario Arnau de Vilanova, Lérida, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Linfoma cutáneo primario T CD4+ de célula pequeña/mediana, granulomatoso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1350 "Ancho" => 1800 "Tamanyo" => 704953 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical images of the lesion. A, At the first visit. B, 2 months later, with self-resolution. Histological appearance of the biopsies corresponding to the clinical images immediately above, with partial reduction of the tumor infiltrate in the second of them. C, Hematoxylin-eosin (H-E), x40. D, H-E, x400.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We describe a patient with primary cutaneous small-to-medium–sized CD4+ T-cell lymphoma, according to the most recent World Health Organization (WHO) classification of cutaneous lymphomas.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">This lymphoma, previously known as primary cutaneous small-to-medium-sized pleomorphic CD4+ T-cell lymphoma,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> has a low incidence and good prognosis. The interest in the case presented in this report derives from a substantial granulomatous component in the clinical-pathological study and the self-healing nature of the lesion. We discuss the possibility of a relationship between these 2 characteristics.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 32-year-old woman with no clinical history of relevance who attended the clinic in December, 2012, due to a cutaneous lesion on the right breast related to an insect bite 3 months earlier. The lesion consisted of an itchy erythematous nodule measuring 2<span class="elsevierStyleHsp" style=""></span>cm in diameter with a smooth surface (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Biopsy showed a dense and diffuse infiltrate that occupied the entire thickness of the dermis, composed of small and medium sized cells alongside some eosinophils (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Epidermotropism was scarce. Abundant histiocytes and multinucleated giant cells were also observed, forming granulomatous aggregates (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>), interspersed with lymphoid proliferation. Immunohistochemistry showed CD3+ and CD4+ cells that were however negative for CD8 and CD30 (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Molecular study of the λ chain of the T-cell receptor showed monoclonal rearrangement, and so the patient was diagnosed with primary cutaneous granulomatous small-to-medium sized CD4+ T-cell lymphoma. An extension study was conducted, including study with lymphoid subpopulations, LDH, β2-microglobulin, and positron emission tomography-computed tomography, with normal results. Surgical resection was proposed. On the day of surgery, 2 months later, the nodule had disappeared to leave a residual erythematous macule (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Excision biopsy of the lesion showed a considerable reduction in lymphoid infiltrate, but this remained positive for CD20, CD3, and CD68, with predominance of CD4 over CD8; the infiltrate was negative for CD30. The same monoclonal pattern persisted.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The patient is still in follow-up in our department and is disease free after 2 years.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Primary cutaneous small-to-medium-sized CD4+ T-cell lymphoma is a rare T-cell lymphoid proliferation that usually presents as a single lesion on the head or trunk and whose histology findings coincide with the case described.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3</span></a> Prognosis is good, with 5-year survival of 80%, with good response to chemotherapy or surgery. In aggressive cases, with multiple lesions, polychemotherapy such as CHOP is used.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The association of cutaneous lymphoma and granuloma is rare although well known. The presence of lymphoma and granuloma in biopsy can lead to erroneous diagnosis and enable the disease to progress undetected for months.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In the literature review, this phenomenon occurs most frequently in mycosis fungoides and its clinical variant granulomatous slack skin,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> but there have also been isolated reports in Sézary syndrome,<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6,7</span></a> anaplastic CD30+ lymphoma,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> panniculitis-type T lymphoma,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> follicle center lymphoma,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> and in 4 cases of primary cutaneous small-to-medium–sized CD4+ T-cell lymphoma.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> A lymphoma is considered granulomatous when the granulomas occupy at least 25% of the infiltrate.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> This finding occurs in 1.8% of all cutaneous lymphomas.</p><p id="par0040" class="elsevierStylePara elsevierViewall">It is not known whether the granuloma occurs as an immune response of the host to tumor cells or is a result of cytokine release, contributing to better prognosis. Beltraminelli et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> went as far as to suggest that small granulomas could be secondary to destruction of skin appendages.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The extent to which this immune reaction could influence the prognosis of lymphoma has also not been established. Granulomatous cutaneous lymphomas normally have a slowly progressive course, although around 50% develop nodal lymphomas with a fatal outcome.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The incongruence between histological findings (pleomorphism, appendage destruction, T-cell monoclonality) and the favorable clinical outcome with a high percentage of remissions seems paradoxic. Histology and immunohistochemistry are, for the time being, not helpful in this case. The monoclonality found in the infiltrate is suggestive of a malign lymphoproliferative process but this finding is not exclusive as reactive inflammatory processes and other processes of unknown significance can also be monoclonal.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> The pattern of PD-1 immuno expression, which we could not determine in our case, may have helped in the diagnosis of primary cutaneous small-to-medium-sized CD4+ T-cell lymphoma.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Patients with solitary lesions usually have an indolent course. Aggressive treatments should be avoided and these patients should be managed differently to those with multiple cutaneous lesions, in whom prognosis may not be favorable.</p><p id="par0060" class="elsevierStylePara elsevierViewall">In summary, we describe a case of granulomatous primary cutaneous small-to-medium–sized CD4+ T-cell lymphoma with partial self-resolution. The lymphoma has remained in complete remission after surgical excision. Although the presence of granulomas in the histology may hinder diagnosis of the primary tumor,<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> and enable its progression, in other cases it may be a true host-versus-tumor reaction and favor self-resolution.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: García de la Fuente MR, Vilardell-Villellas F, Martí-Laborda RM, Casanova-Seuma JM. Linfoma cutáneo primario T CD4+ de célula pequeña/mediana, granulomatoso. Actas Dermosifiliogr. 2016;107:89–91.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1350 "Ancho" => 1800 "Tamanyo" => 704953 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical images of the lesion. A, At the first visit. B, 2 months later, with self-resolution. Histological appearance of the biopsies corresponding to the clinical images immediately above, with partial reduction of the tumor infiltrate in the second of them. C, Hematoxylin-eosin (H-E), x40. D, H-E, x400.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 750 "Ancho" => 1000 "Tamanyo" => 303499 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histological appearance. Of note is the presence of numerous multinucleated gigant cells (H-E, x200).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1350 "Ancho" => 1800 "Tamanyo" => 1012122 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In the immunohistochemical study, of note was positivity for CD3 and CD4 in the upper images and negativity for CD8 and CD30 in the lower ones. The limited staining for CD8 corresponds to accompanying cellularity and not tumoral cellularity.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous lymphomas: From morphology to chip technology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Cerroni" 1 => "T. Wiesner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2009" "volumen" => "100" "numero" => "Supl. 1" "paginaInicial" => "3" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20096193" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous CD 4+ small/medium sized pleomorphic T-cell lymphoma: A cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance? A study of 136 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H. Beltraminelli" 1 => "B. Leinweber" 2 => "H. Kerl" 3 => "L. Cerroni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0b013e31819f19bb" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2009" "volumen" => "31" "paginaInicial" => "317" "paginaFinal" => "322" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19461234" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous CD4+ small to medium sized pleomorphic T-cell lymphoma: Report of a case with spontaneous resolution" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Messeguer" 1 => "E. Gimeno" 2 => "A. Agusti-Mejias" 3 => "J. San Juan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2010.10.023" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr." "fecha" => "2011" "volumen" => "102" "paginaInicial" => "636" "paginaFinal" => "638" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21605848" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dual diagnosis of sarcoidosis and lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Brady" 1 => "D. Kamel" 2 => "J. Kiely" 3 => "B. Hennessy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11845-012-0854-1" "Revista" => array:6 [ "tituloSerie" => "Ir J Med Sci." "fecha" => "2013" "volumen" => "182" "paginaInicial" => "283" "paginaFinal" => "286" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22983882" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Granulomatous slack skin disease: A review, in comparison with mycosis fungoides" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Shah" 1 => "A. Safaya" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2012.04513.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2012" "volumen" => "26" "paginaInicial" => "1472" "paginaFinal" => "1478" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22435618" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The frequency of dual TCR-PCR clonality in granulomatous disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Dabiri" 1 => "A. Morales" 2 => "L. Ma" 3 => "U. Sundram" 4 => "Y.H. Kim" 5 => "D.A. Arber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0560.2011.01727.x" "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol." "fecha" => "2011" "volumen" => "38" "paginaInicial" => "704" "paginaFinal" => "709" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21645036" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of Sézary's syndrome associated with granulomatous lesions, myelodysplastic syndrome and transformation into CD30-positive large-cell pleomorphic lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.M. Carrozza" 1 => "W. Kempf" 2 => "D.V. Kazakov" 3 => "R. Dummer" 4 => "G. Burg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2002" "volumen" => "147" "paginaInicial" => "582" "paginaFinal" => "586" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12207606" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous lymphomas showing prominent granulomatous component: Clinico-pathological features in a series of 16 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Gallardo" 1 => "M.P. García-Muret" 2 => "O. Servitje" 3 => "T. Estrach" 4 => "I. Bielsa" 5 => "A. Salar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2008.03020.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2009" "volumen" => "23" "paginaInicial" => "639" "paginaFinal" => "647" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19207677" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous lymphomas with prominent granulomatous reaction: A potential pitfall in the histopathologic diagnosis of cutaneous T- and B-cell lymphomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Scarabello" 1 => "B. Leinweber" 2 => "M. Ardigó" 3 => "A. Rütten" 4 => "A.C. Feller" 5 => "H. Kerl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol." "fecha" => "2002" "volumen" => "26" "paginaInicial" => "1259" "paginaFinal" => "1268" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12360040" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of programmed death-1 in primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous T-cell lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Cetinözman" 1 => "P.M. Jansen" 2 => "R. Willemze" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/PAS.0b013e318230df87" "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2012" "volumen" => "36" "paginaInicial" => "109" "paginaFinal" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21989349" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003273/v2_201704190205/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000001/v2_201704190205/S1578219015003273/v2_201704190205/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003273?idApp=UINPBA000044" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 9 | 4 | 13 |
2024 Octubre | 71 | 38 | 109 |
2024 Septiembre | 91 | 22 | 113 |
2024 Agosto | 114 | 50 | 164 |
2024 Julio | 101 | 32 | 133 |
2024 Junio | 98 | 50 | 148 |
2024 Mayo | 71 | 44 | 115 |
2024 Abril | 79 | 24 | 103 |
2024 Marzo | 76 | 32 | 108 |
2024 Febrero | 56 | 37 | 93 |
2024 Enero | 47 | 27 | 74 |
2023 Diciembre | 73 | 27 | 100 |
2023 Noviembre | 67 | 28 | 95 |
2023 Octubre | 84 | 33 | 117 |
2023 Septiembre | 81 | 37 | 118 |
2023 Agosto | 69 | 14 | 83 |
2023 Julio | 83 | 24 | 107 |
2023 Junio | 70 | 25 | 95 |
2023 Mayo | 96 | 27 | 123 |
2023 Abril | 92 | 18 | 110 |
2023 Marzo | 74 | 29 | 103 |
2023 Febrero | 75 | 21 | 96 |
2023 Enero | 61 | 25 | 86 |
2022 Diciembre | 77 | 43 | 120 |
2022 Noviembre | 52 | 29 | 81 |
2022 Octubre | 34 | 19 | 53 |
2022 Septiembre | 61 | 36 | 97 |
2022 Agosto | 71 | 39 | 110 |
2022 Julio | 58 | 26 | 84 |
2022 Junio | 44 | 25 | 69 |
2022 Mayo | 125 | 58 | 183 |
2022 Abril | 128 | 49 | 177 |
2022 Marzo | 183 | 55 | 238 |
2022 Febrero | 135 | 31 | 166 |
2022 Enero | 182 | 45 | 227 |
2021 Diciembre | 122 | 59 | 181 |
2021 Noviembre | 84 | 46 | 130 |
2021 Octubre | 86 | 50 | 136 |
2021 Septiembre | 80 | 43 | 123 |
2021 Agosto | 74 | 26 | 100 |
2021 Julio | 64 | 28 | 92 |
2021 Junio | 47 | 34 | 81 |
2021 Mayo | 39 | 28 | 67 |
2021 Abril | 132 | 36 | 168 |
2021 Marzo | 96 | 26 | 122 |
2021 Febrero | 78 | 27 | 105 |
2021 Enero | 61 | 15 | 76 |
2020 Diciembre | 44 | 14 | 58 |
2020 Noviembre | 37 | 23 | 60 |
2020 Octubre | 47 | 5 | 52 |
2020 Septiembre | 40 | 16 | 56 |
2020 Agosto | 28 | 15 | 43 |
2020 Julio | 27 | 15 | 42 |
2020 Junio | 45 | 28 | 73 |
2020 Mayo | 27 | 23 | 50 |
2020 Abril | 36 | 14 | 50 |
2020 Marzo | 28 | 15 | 43 |
2020 Febrero | 5 | 1 | 6 |
2020 Enero | 0 | 1 | 1 |
2019 Diciembre | 4 | 0 | 4 |
2019 Octubre | 1 | 3 | 4 |
2019 Septiembre | 8 | 0 | 8 |
2019 Junio | 4 | 0 | 4 |
2019 Mayo | 2 | 1 | 3 |
2019 Abril | 2 | 4 | 6 |
2019 Marzo | 2 | 6 | 8 |
2019 Enero | 4 | 1 | 5 |
2018 Diciembre | 2 | 0 | 2 |
2018 Noviembre | 2 | 0 | 2 |
2018 Octubre | 8 | 0 | 8 |
2018 Septiembre | 13 | 0 | 13 |
2018 Mayo | 0 | 1 | 1 |
2018 Marzo | 0 | 2 | 2 |
2018 Febrero | 124 | 1 | 125 |
2018 Enero | 64 | 7 | 71 |
2017 Diciembre | 117 | 6 | 123 |
2017 Noviembre | 52 | 10 | 62 |
2017 Octubre | 47 | 8 | 55 |
2017 Septiembre | 39 | 3 | 42 |
2017 Agosto | 28 | 25 | 53 |
2017 Julio | 36 | 9 | 45 |
2017 Junio | 35 | 8 | 43 |
2017 Mayo | 43 | 12 | 55 |
2017 Abril | 21 | 14 | 35 |
2017 Marzo | 13 | 14 | 27 |
2017 Febrero | 29 | 9 | 38 |
2017 Enero | 17 | 5 | 22 |
2016 Diciembre | 30 | 18 | 48 |
2016 Noviembre | 34 | 20 | 54 |
2016 Octubre | 29 | 18 | 47 |
2016 Septiembre | 0 | 1 | 1 |
2016 Julio | 0 | 1 | 1 |
2016 Junio | 0 | 1 | 1 |
2016 Mayo | 0 | 1 | 1 |
2016 Abril | 0 | 2 | 2 |
2016 Febrero | 0 | 11 | 11 |
2016 Enero | 0 | 2 | 2 |