Case and Research Letters
Allergic Contact Dermatitis Due to Dittrichia viscosa
Dermatitis alérgica de contacto por Dittrichia viscosa
A. Calderón-Komáromy
, N. Puente-Pablo, S. Córdoba, J. Borbujo
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Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Madrid, Spain
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Cuevas" "apellidos" => "Santos" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003224?idApp=UINPBA000044" "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003224/v2_201704190205/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Allergic Contact Dermatitis Due to <span class="elsevierStyleItalic">Dittrichia viscosa</span>" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "76" "paginaFinal" => "78" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Calderón-Komáromy, N. Puente-Pablo, S. Córdoba, J. Borbujo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Calderón-Komáromy" "email" => array:1 [ 0 => "komaromy20@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Puente-Pablo" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Córdoba" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Borbujo" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatitis alérgica de contacto por <span class="elsevierStyleItalic">Dittrichia viscosa</span>" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1756 "Ancho" => 1800 "Tamanyo" => 281839 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Vesiculobullous lesions with a bloodstained content on the dorsum and palms of the hands, with some areas of erosion and desquamating erythematous plaques on the wrists.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Plant-induced allergic contact dermatitis (ACD) is a common disorder that can arise in numerous situations and places during daily life.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Diagnosis is often challenging due to our lack of experience in its management.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 51-year-old woman with a long-standing history of rheumatoid arthritis on treatment with leflunomide. She consulted for an outbreak of pruritic lesions that had arisen 2 days earlier on her hands. Two weeks earlier she had developed lesions of similar characteristics that had resolved within a few days, after the application of topical corticosteroids. She stated that for the previous 2 months she had been applying an infusion of a plant called yellow fleabane (also known as sticky fleabane or false yellowhead) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) once a week to her hands to control pain. She prepared the infusion at home. Examination revealed multiple vesiculobullous lesions with a blood-stained content on a background of normal skin on the dorsum, palms, and fingers of both hands; in addition, she had desquamating erythematous plaques on both wrists (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Treatment with oral and topical corticosteroids and discontinuation of the application of the infusion led to complete resolution of the lesions and there have been no recurrences. The unknown irritant capacity of the plant led us to perform semi-open patch testing, applying fragments of the plant (stem, leaf, and flower) to the patient's forearm, covering the samples with porous tape and removing them after an hour. At 48<span class="elsevierStyleHsp" style=""></span>hours, 2+ positive reactions were observed in the area of application of the leaf and stalk, with reactivation of the lesions previously present on the hands; these manifestations started to appear 24<span class="elsevierStyleHsp" style=""></span>hours after performing the test. Control tests were performed on 10 healthy patients using the same technique with dry leaves and stalks, with negative results. Patch testing was also performed with the standard series of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC), the Martitor plant series, and the infusion of yellow fleabane in water. A 2+ positive reaction to the infusion of the plant was observed at 48 and 96<span class="elsevierStyleHsp" style=""></span>hours. All patch testing was performed in accordance with the criteria of the International Contact Dermatitis Research Group.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Yellow fleabane—scientific name <span class="elsevierStyleItalic">Dittrichia viscosa</span>, a plant species of the <span class="elsevierStyleItalic">Asteraceae/Compositae</span> family—is an aromatic Mediterranean shrub. This plant is widely used in homeopathy for its medicinal properties as it contains biologically active substances that act as modifiers of the inflammatory response,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> though they also have allergenic potential. These substances are the sesquiterpenic lactones (SL), a group of metabolites found in the oil-resins released from the leaves, flower stalk, and possibly from the polen.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> There are around 1350 identified varieties of SLs and approximately 50% of them have allergenic potential.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> Although the concentration of SLs varies between plant species, small similarities in their molecular structure can give rise to crossreactions.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> Identical SLs from different plant species can be responsible for false crossreactions. This situation, together with the few standardized tests for the study of this pathology, makes it difficult to study plant-induced ACD. Two preparations are available for patch testing. The “SL mix”, which contains 3 forms representative of the 3 main structural groups,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> only enables us to identify 60% of cases of SL sensitization. An alternative preparation for diagnosis is the “Compositae mix”, based on a mixture of multiple plant extracts; this has a considerably higher sensitivity (85%) than can be achieved with SL mix, although specificity is low.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Ten cases of <span class="elsevierStyleItalic">D. viscosa</span>-induced ACD have been published. As in our case, those reports described positive patch testing to fragments of the plant. Additionally, positive reactions to extracts from other plant and to substances included in the perfumes series were observed in some cases, which supports the high probability of crossreactions.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8,9</span></a> Negative patch testing to SLs, as in our case, does not exclude the diagnosis because of the test's low sensitivity.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The study of plant-induced ACD is a significant challenge, mainly because the majority of patients do not identify the specific trigger. This is further complicated by the high probability of crossreactions with substances obtained from other plants and the low specificity of standardized tests. The specific substance to which the patient has been exposed, if it can be identified, must be included in the study, avoiding tests with fresh plants or plant extracts due to the high risk of irritation or sensitization.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> We also draw attention to the importance of studying healthy controls using the same techniques, in order to classify the type of reaction as allergic or irritant.</p><p id="par0030" class="elsevierStylePara elsevierViewall">This case highlights the need for dermatologists to recognize this type of reaction and the difficulties that can arise during its investigation.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Calderón-Komáromy A, Puente-Pablo N, Córdoba S, Borbujo J. Dermatitis alérgica de contacto por <span class="elsevierStyleItalic">Dittrichia viscosa</span>. Actas Dermosifiliogr. 2016;107:77–79.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 508 "Ancho" => 1000 "Tamanyo" => 98660 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Dry yellow fleabane <span class="elsevierStyleItalic">(Dittrichia viscosa)</span> provided by the patient.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1756 "Ancho" => 1800 "Tamanyo" => 281839 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Vesiculobullous lesions with a bloodstained content on the dorsum and palms of the hands, with some areas of erosion and desquamating erythematous plaques on the wrists.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic contact dermatitis to plants: Understanding the chemistry will help our diagnostic approach" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Rozas-Muñoz" 1 => "J.P. Lepoittevin" 2 => "R.M. Pujol" 3 => "A. Giménez-Arnau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2011.07.017" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr." "fecha" => "2012" "volumen" => "103" "paginaInicial" => "456" "paginaFinal" => "477" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22217935" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0055" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sesquiterpenoids lactones: Benefits to plants and people" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Chadwick" 1 => "H. Trewin" 2 => "F. Gawthrop" 3 => "C. Wagstaff" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3390/ijms140612780" "Revista" => array:6 [ "tituloSerie" => "Int J Mol Sci." "fecha" => "2013" "volumen" => "14" "paginaInicial" => "12780" "paginaFinal" => "12805" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23783276" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0060" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sesquiterpene lactones: Adverse health effects and toxicity mechanism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.H. Amorim" 1 => "R.M. Gil da Costa" 2 => "C. Lopes" 3 => "M.M. Bastos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/10408444.2013.813905" "Revista" => array:6 [ "tituloSerie" => "Crit Rev Toxicol." "fecha" => "2013" "volumen" => "43" "paginaInicial" => "559" "paginaFinal" => "579" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23875764" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0065" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Airborne contact dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Mensing" 1 => "W. Kimmig" 2 => "B.M. Hausen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hauzart." "fecha" => "1985" "volumen" => "36" "paginaInicial" => "398" "paginaFinal" => "402" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0070" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quantification of sesquiterpene lactones in Asteraceae plant extracts: Evaluation of their allergenic potential" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Salapovic" 1 => "J. Geier" 2 => "G. Reznicek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3797/scipharm.1306-17" "Revista" => array:6 [ "tituloSerie" => "Sci Pharm." "fecha" => "2013" "volumen" => "81" "paginaInicial" => "807" "paginaFinal" => "818" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24106675" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0075" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patch testing with the sesquiterpene lactone mix: A marker for contact allergy to Compositae and other sesquiterpene-lactone-containing plants. A multicentre study of the EECDRG" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Ducombs" 1 => "C. Benezra" 2 => "P. Talaga" 3 => "K.E. Andersen" 4 => "D. Burrows" 5 => "J.G. Camarasa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis." "fecha" => "1990" "volumen" => "22" "paginaInicial" => "249" "paginaFinal" => "252" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2383982" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0080" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic contact dermatitis in food handlers, with patch test positive with Compositae mix but negative to sesquiterpene lactone mix" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K.W. Shum" 1 => "J.S. English" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis." "fecha" => "1998" "volumen" => "39" "paginaInicial" => "207" "paginaFinal" => "208" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9817239" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0085" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic contact dermatitis from Dittricia viscosa (L.) Greuter" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Gonçalo" 1 => "S. Gonçalo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1991" "volumen" => "24" "paginaInicial" => "40" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2044368" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0090" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic contact dermatitis from Dittrichia viscosa (L.) Greuter" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Estrela" 1 => "C. Tapadinhas" 2 => "F. Pereira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis." "fecha" => "1995" "volumen" => "32" "paginaInicial" => "108" "paginaFinal" => "109" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7758306" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010700000001/v2_201704190205/S1578219015003236/v2_201704190205/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000001/v2_201704190205/S1578219015003236/v2_201704190205/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015003236?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 11 | 7 | 18 |
| 2024 Octubre | 85 | 45 | 130 |
| 2024 Septiembre | 81 | 27 | 108 |
| 2024 Agosto | 110 | 56 | 166 |
| 2024 Julio | 106 | 30 | 136 |
| 2024 Junio | 77 | 25 | 102 |
| 2024 Mayo | 79 | 35 | 114 |
| 2024 Abril | 72 | 21 | 93 |
| 2024 Marzo | 65 | 30 | 95 |
| 2024 Febrero | 64 | 32 | 96 |
| 2024 Enero | 52 | 29 | 81 |
| 2023 Diciembre | 59 | 15 | 74 |
| 2023 Noviembre | 85 | 35 | 120 |
| 2023 Octubre | 84 | 17 | 101 |
| 2023 Septiembre | 72 | 30 | 102 |
| 2023 Agosto | 52 | 17 | 69 |
| 2023 Julio | 61 | 35 | 96 |
| 2023 Junio | 61 | 17 | 78 |
| 2023 Mayo | 51 | 20 | 71 |
| 2023 Abril | 52 | 29 | 81 |
| 2023 Marzo | 68 | 28 | 96 |
| 2023 Febrero | 60 | 24 | 84 |
| 2023 Enero | 30 | 37 | 67 |
| 2022 Diciembre | 49 | 48 | 97 |
| 2022 Noviembre | 42 | 32 | 74 |
| 2022 Octubre | 39 | 32 | 71 |
| 2022 Septiembre | 21 | 29 | 50 |
| 2022 Agosto | 23 | 39 | 62 |
| 2022 Julio | 23 | 36 | 59 |
| 2022 Junio | 31 | 22 | 53 |
| 2022 Mayo | 54 | 36 | 90 |
| 2022 Abril | 55 | 56 | 111 |
| 2022 Marzo | 48 | 49 | 97 |
| 2022 Febrero | 44 | 33 | 77 |
| 2022 Enero | 55 | 42 | 97 |
| 2021 Diciembre | 50 | 43 | 93 |
| 2021 Noviembre | 49 | 39 | 88 |
| 2021 Octubre | 67 | 55 | 122 |
| 2021 Septiembre | 52 | 40 | 92 |
| 2021 Agosto | 58 | 60 | 118 |
| 2021 Julio | 37 | 43 | 80 |
| 2021 Junio | 37 | 24 | 61 |
| 2021 Mayo | 36 | 32 | 68 |
| 2021 Abril | 74 | 40 | 114 |
| 2021 Marzo | 62 | 21 | 83 |
| 2021 Febrero | 62 | 21 | 83 |
| 2021 Enero | 57 | 14 | 71 |
| 2020 Diciembre | 43 | 12 | 55 |
| 2020 Noviembre | 30 | 26 | 56 |
| 2020 Octubre | 21 | 9 | 30 |
| 2020 Septiembre | 37 | 11 | 48 |
| 2020 Agosto | 29 | 18 | 47 |
| 2020 Julio | 31 | 11 | 42 |
| 2020 Junio | 37 | 32 | 69 |
| 2020 Mayo | 33 | 24 | 57 |
| 2020 Abril | 40 | 16 | 56 |
| 2020 Marzo | 46 | 22 | 68 |
| 2020 Febrero | 6 | 5 | 11 |
| 2020 Enero | 6 | 1 | 7 |
| 2019 Diciembre | 8 | 1 | 9 |
| 2019 Noviembre | 4 | 0 | 4 |
| 2019 Octubre | 0 | 3 | 3 |
| 2019 Septiembre | 4 | 0 | 4 |
| 2019 Agosto | 6 | 0 | 6 |
| 2019 Julio | 4 | 0 | 4 |
| 2019 Junio | 4 | 0 | 4 |
| 2019 Mayo | 7 | 2 | 9 |
| 2019 Abril | 3 | 0 | 3 |
| 2019 Marzo | 4 | 3 | 7 |
| 2019 Febrero | 1 | 0 | 1 |
| 2019 Enero | 3 | 0 | 3 |
| 2018 Diciembre | 2 | 0 | 2 |
| 2018 Octubre | 10 | 0 | 10 |
| 2018 Septiembre | 6 | 0 | 6 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 23 | 1 | 24 |
| 2018 Enero | 43 | 7 | 50 |
| 2017 Diciembre | 46 | 8 | 54 |
| 2017 Noviembre | 29 | 3 | 32 |
| 2017 Octubre | 29 | 7 | 36 |
| 2017 Septiembre | 22 | 12 | 34 |
| 2017 Agosto | 36 | 13 | 49 |
| 2017 Julio | 34 | 10 | 44 |
| 2017 Junio | 27 | 20 | 47 |
| 2017 Mayo | 27 | 10 | 37 |
| 2017 Abril | 32 | 14 | 46 |
| 2017 Marzo | 18 | 49 | 67 |
| 2017 Febrero | 17 | 12 | 29 |
| 2017 Enero | 16 | 9 | 25 |
| 2016 Diciembre | 37 | 19 | 56 |
| 2016 Noviembre | 36 | 18 | 54 |
| 2016 Octubre | 28 | 17 | 45 |
| 2016 Septiembre | 0 | 1 | 1 |
| 2016 Agosto | 0 | 1 | 1 |
| 2016 Junio | 0 | 1 | 1 |
| 2016 Mayo | 0 | 1 | 1 |
| 2016 Abril | 0 | 6 | 6 |
| 2016 Marzo | 0 | 1 | 1 |
| 2016 Febrero | 0 | 2 | 2 |
| 2016 Enero | 0 | 1 | 1 |
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