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1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">A biopsy of the lesion revealed a proliferation of uniform&#44; small branching vessels in the dermis&#46; The vessels had a collapsed appearance&#44; with a very small lumen and prominent endothelial cells&#46; No cell atypia or mitotic figures were observed&#46; Immunohistochemistry for herpesvirus<span class="elsevierStyleHsp" style=""></span>8 was negative &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Additional Tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">On dermoscopy the lesion showed diffuse central erythema with desquamation and a delicate peripheral pigment network &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis&#63;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Microvenular hemangioma&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Course and Treatment</span><p id="par0035" class="elsevierStylePara elsevierViewall">The excision biopsy performed at the first visit completely removed the lesion&#46; No further treatment was required&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Comment</span><p id="par0040" class="elsevierStylePara elsevierViewall">Microvenular hemangioma is a slow-growing&#44; acquired benign vascular tumor that usually presents as a single erythematous papule&#44; plaque&#44; or nodule on the trunk or limbs of a young adult&#46; The pathogenesis is unknown&#46; The differential diagnosis includes benign &#40;capillary hemangioma&#44; pyogenic granuloma&#44; and angioblastoma&#41; and malignant &#40;angiosarcoma and Kaposi sarcoma&#41; vascular tumors and other lesions that present as erythematous-violaceous nodules&#44; macules&#44; or plaques that can resemble microvenular hemangioma&#46; When multiple lesions are present&#44; the differential diagnosis should include tumors and inflammatory lesions&#44; such as eruptive dermatofibromas and leiomyomas&#44; pityriasis lichenoides et varioliformis acuta&#44; and drug eruption&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The definitive diagnosis is histological&#44; with the finding of a proliferation of small dermal vessels formed of capillaries and venules&#44; with no atypia&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Recent studies have described the immunohistochemistry of microvenular hemangioma&#44; which is positive for WT1 &#40;and angiogenesis marker&#41; and negative for D2-40 &#40;a marker of lymphatic differentiation&#41;&#44; GLUT-1 &#40;specific to infantile hemangioma&#41;&#44; and HHV-8 &#40;positive in Kaposi sarcoma&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Although dermoscopy can reveal certain peculiarities&#44; there are few published descriptions because of the low frequency of the disease&#46; The first description was provided by Scalvenzi et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> who reported diffuse erythema with multiple red globules of variably small size&#44; and the presence of a fine peripheral pigment network&#46; The red globules are defined as round structures&#44; larger than dots&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Based on the dermoscopic findings&#44; the differential diagnosis should include Kaposi sarcoma&#44; which presents a classic rainbow pattern in its papular and nodular phases&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> However&#44; early lesions can be similar to microvenular hemangioma&#44; with a fine peripheral pigment network and a homogeneous pinkish-red color or a homogeneous structure with reddish-blue areas&#59; globules&#44; characteristic of microvenular hemangioma&#44; have not been reported&#46; In the present case we did not observe globules&#44; further increasing the difficulty of differentiation from Kaposi sarcoma&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The presence of erythema or small vessels&#44; particularly when associated with a multicomponent pattern&#44; increases the possibility of vascular tumors and malignant lesions&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The dermoscopic findings were similar to those of a variant of dermatofibroma&#44; 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Case for Diagnosis
Erythematous Abdominal Papule
Pápula eritematosa abdominal
T. Fernández-Moranoa,
Autor para correspondencia
tfm_84@hotmail.com

Corresponding author.
, I. Fernández-Canedoa, R. Fúnez-Liébanab
a Servicio de Dermatología, Hospital Costa del Sol, Marbella, Málaga, Spain
b Servicio de Anatomía Patológica, Hospital Costa del Sol, Marbella, Málaga, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 35-year-old woman with no past history of interest&#46; She consulted for a skin lesion that had arisen on the abdomen 8 months earlier&#46; The lesion was asymptomatic and had not changed&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">An erythematous papule with a whitish halo&#44; measuring 1<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>0&#46;5<span class="elsevierStyleHsp" style=""></span>cm diameter&#44; was observed on the left side of the abdomen &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">A biopsy of the lesion revealed a proliferation of uniform&#44; small branching vessels in the dermis&#46; The vessels had a collapsed appearance&#44; with a very small lumen and prominent endothelial cells&#46; No cell atypia or mitotic figures were observed&#46; Immunohistochemistry for herpesvirus<span class="elsevierStyleHsp" style=""></span>8 was negative &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Additional Tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">On dermoscopy the lesion showed diffuse central erythema with desquamation and a delicate peripheral pigment network &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis&#63;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Microvenular hemangioma&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Course and Treatment</span><p id="par0035" class="elsevierStylePara elsevierViewall">The excision biopsy performed at the first visit completely removed the lesion&#46; No further treatment was required&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Comment</span><p id="par0040" class="elsevierStylePara elsevierViewall">Microvenular hemangioma is a slow-growing&#44; acquired benign vascular tumor that usually presents as a single erythematous papule&#44; plaque&#44; or nodule on the trunk or limbs of a young adult&#46; The pathogenesis is unknown&#46; The differential diagnosis includes benign &#40;capillary hemangioma&#44; pyogenic granuloma&#44; and angioblastoma&#41; and malignant &#40;angiosarcoma and Kaposi sarcoma&#41; vascular tumors and other lesions that present as erythematous-violaceous nodules&#44; macules&#44; or plaques that can resemble microvenular hemangioma&#46; When multiple lesions are present&#44; the differential diagnosis should include tumors and inflammatory lesions&#44; such as eruptive dermatofibromas and leiomyomas&#44; pityriasis lichenoides et varioliformis acuta&#44; and drug eruption&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The definitive diagnosis is histological&#44; with the finding of a proliferation of small dermal vessels formed of capillaries and venules&#44; with no atypia&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Recent studies have described the immunohistochemistry of microvenular hemangioma&#44; which is positive for WT1 &#40;and angiogenesis marker&#41; and negative for D2-40 &#40;a marker of lymphatic differentiation&#41;&#44; GLUT-1 &#40;specific to infantile hemangioma&#41;&#44; and HHV-8 &#40;positive in Kaposi sarcoma&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Although dermoscopy can reveal certain peculiarities&#44; there are few published descriptions because of the low frequency of the disease&#46; The first description was provided by Scalvenzi et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> who reported diffuse erythema with multiple red globules of variably small size&#44; and the presence of a fine peripheral pigment network&#46; The red globules are defined as round structures&#44; larger than dots&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Based on the dermoscopic findings&#44; the differential diagnosis should include Kaposi sarcoma&#44; which presents a classic rainbow pattern in its papular and nodular phases&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> However&#44; early lesions can be similar to microvenular hemangioma&#44; with a fine peripheral pigment network and a homogeneous pinkish-red color or a homogeneous structure with reddish-blue areas&#59; globules&#44; characteristic of microvenular hemangioma&#44; have not been reported&#46; In the present case we did not observe globules&#44; further increasing the difficulty of differentiation from Kaposi sarcoma&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The presence of erythema or small vessels&#44; particularly when associated with a multicomponent pattern&#44; increases the possibility of vascular tumors and malignant lesions&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The dermoscopic findings were similar to those of a variant of dermatofibroma&#44; with a peripheral network and a homogeneously erythematous central area&#46; To date there have been no descriptions of cases of microvenular hemangioma that mimic dermatofibroma on dermoscopy&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">We have presented a case of microvenular hemangioma&#44; a rare vascular tumor with dermoscopic features that can mimic other tumors and that must be included in the differential diagnosis of vascular tumors and of nonmelanocytic lesions with a pigment network&#46;</p></span></span>"
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