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1</a>&#41;&#46; No other cutaneous lesions were observed and there were no palpable lymph nodes or organomegaly&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">An incisional biopsy revealed a dense&#44; diffuse lymphocytic infiltrate in the dermis&#46; The lymphocyte population was formed of small-sized lymphocytes associated with another population of medium-sized lymphocytes&#44; both populations showing pleomorphism&#46; No discernible germinal centers were found&#46; Epidermotropism was minimal and there was slight infiltration of the follicular epithelium&#46; Immunohistochemistry revealed a lymphocyte population formed predominantly of T cells that expressed CD3 and CD5&#46; The CD4&#47;CD8 ratio was greater than 2 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Analysis of T-cell receptor rearrangement revealed a monoclonal T-cell population&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Blood tests including complete blood count&#44; routine biochemistry&#44; and lactate dehydrogenase were normal&#44; as was cervical-thoracic-abdominal computed tomography&#44; excluding the involvement of other organs&#46; Based on these findings we made a diagnosis of PCSM-TCL&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Since the first follow-up visit&#44; 10 days after the biopsy&#44; the lesion was seen to regress and it had completely disappeared after 3 months &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; In view of the good clinical course&#44; we decided to maintain a wait-and-see approach with frequent follow-up visits&#46; After a year the patient remained asymptomatic and no new lesions had appeared&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">PCSM-TCL is included as a provisional entity in the group of primary cutaneous T-cell lymphomas&#44; both in the 2005 WHO&#47;EORTC classification of cutaneous lymphomas and in the latest &#40;2008&#41; 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one as an aggressive tumor and the other as multiple lesions with abundant eosinophils observed in the skin biopsy&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> The histology of the lesions contrasts with the benign course of PCSM-TCL&#46; Dense&#44; nodular or diffuse infiltrates of atypical&#44; pleomorphic small- and medium-sized lymphocytes are found in the superficial and deep dermis and tend to infiltrate the subcutaneous cellular tissue&#46; Although large pleomorphic cells may be observed&#44; by definition these make up less than 30&#37; of the infiltrate&#46; An inflammatory infiltrate of reactive CD8&#43; T cells is usually present&#44; as well as a variable number of B cells&#44; plasma cells&#44; macrophages&#44; and eosinophils&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> It is not uncommon to find focal areas of epidermotropism and invasion of adnexal structures&#46; The atypical cells show the following immunohistochemical profile&#58; CD3&#43;&#44; CD4&#43;&#44; CD8&#8211;&#44; and CD30&#8211;&#46; The proliferation index is less than 30&#37;&#44; and molecular analysis reveals monoclonal rearrangement of the T-cell receptor gene&#44; either of the gamma chain or of the beta chain&#44; in 60&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;3</span></a> In the differential diagnosis&#44; there are no clear criteria to differentiate PCSM-TCL from benign lymphoid diseases&#44; and the nuclear pleomorphism&#44; immunohistochemistry&#44; and detection of clonality are therefore used to orient the diagnosis to PCSM-TCL&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Five-year survival is over 90&#37; when presentation is with a single lesion with typical characteristics&#46; This prognosis worsens when presentation is multifocal&#44; and overall 5-year survival is of 60&#37; to 80&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;3</span></a> Poor prognostic factors include CD2&#8211;&#44; rapidly growing tumors over 5<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; the presence of a limited number of accompanying CD8&#43; T<span class="elsevierStyleHsp" style=""></span>cells and a high ki-67 index&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;7</span></a> To date&#44; 3 other cases of spontaneous regression after biopsy have been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#8211;9</span></a> The therapeutic options described in the consensus statement on the treatment of cutaneous lymphomas<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> suggest non-aggressive management for patients with primary or recurrent&#44; single or multiple localized nodular forms&#44; varying from follow-up of the patient to topical or intralesional corticosteroids or even surgery or radiation therapy&#46; Treatment for aggressive forms must be individualized according to the characteristics of the patient&#46;</p></span>"
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Case and Research Letters
Primary Cutaneous CD4+ Small/Medium-Sized T-Cell Lymphoma With Spontaneous Regression After Biopsy
Linfoma primario cutáneo T CD4 positivo de linfocitos de pequeño y mediano tamaño con regresión espontánea tras la biopsia
D. González Fernándeza,
Autor para correspondencia
danigf81@gmail.com

Corresponding author.
, F. Valdés Pinedaa, S. Gómez Díeza, B. Vivanco Allendeb
a Servicio de Dermatología, Hospital Universitario Central de Asturias, Oviedo, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, Spain
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1</a>&#41;&#46; No other cutaneous lesions were observed and there were no palpable lymph nodes or organomegaly&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">An incisional biopsy revealed a dense&#44; diffuse lymphocytic infiltrate in the dermis&#46; The lymphocyte population was formed of small-sized lymphocytes associated with another population of medium-sized lymphocytes&#44; both populations showing pleomorphism&#46; No discernible germinal centers were found&#46; Epidermotropism was minimal and there was slight infiltration of the follicular epithelium&#46; Immunohistochemistry revealed a lymphocyte population formed predominantly of T cells that expressed CD3 and CD5&#46; The CD4&#47;CD8 ratio was greater than 2 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Analysis of T-cell receptor rearrangement revealed a monoclonal T-cell population&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Blood tests including complete blood count&#44; routine biochemistry&#44; and lactate dehydrogenase were normal&#44; as was cervical-thoracic-abdominal computed tomography&#44; excluding the involvement of other organs&#46; Based on these findings we made a diagnosis of PCSM-TCL&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Since the first follow-up visit&#44; 10 days after the biopsy&#44; the lesion was seen to regress and it had completely disappeared after 3 months &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; In view of the good clinical course&#44; we decided to maintain a wait-and-see approach with frequent follow-up visits&#46; After a year the patient remained asymptomatic and no new lesions had appeared&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">PCSM-TCL is included as a provisional entity in the group of primary cutaneous T-cell lymphomas&#44; both in the 2005 WHO&#47;EORTC classification of cutaneous lymphomas and in the latest &#40;2008&#41; classification of tumors of hematopoietic and lymphoid tissue&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> It is a rare disease that accounts for approximately 2&#37; to 3&#37; of primary cutaneous lymphomas&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> It affects men and women equally&#44; and the mean age at the time of diagnosis is 50-60 years&#44; though it can arise at any age&#8212;published cases range from 3 to 90 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Clinical presentation is usually as a solitary&#44; asymptomatic&#44; rapidly growing plaque or mass of up to 3<span class="elsevierStyleHsp" style=""></span>cm diameter&#59; lesions most commonly arise on the face or neck&#44; or on the upper part of the trunk&#46; The surface is typically smooth and may have an erythematous or violaceous appearance&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> There are 2 other forms of presentation with a poorer prognosis&#44; one as an aggressive tumor and the other as multiple lesions with abundant eosinophils observed in the skin biopsy&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> The histology of the lesions contrasts with the benign course of PCSM-TCL&#46; Dense&#44; nodular or diffuse infiltrates of atypical&#44; pleomorphic small- and medium-sized lymphocytes are found in the superficial and deep dermis and tend to infiltrate the subcutaneous cellular tissue&#46; Although large pleomorphic cells may be observed&#44; by definition these make up less than 30&#37; of the infiltrate&#46; An inflammatory infiltrate of reactive CD8&#43; T cells is usually present&#44; as well as a variable number of B cells&#44; plasma cells&#44; macrophages&#44; and eosinophils&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> It is not uncommon to find focal areas of epidermotropism and invasion of adnexal structures&#46; The atypical cells show the following immunohistochemical profile&#58; CD3&#43;&#44; CD4&#43;&#44; CD8&#8211;&#44; and CD30&#8211;&#46; The proliferation index is less than 30&#37;&#44; and molecular analysis reveals monoclonal rearrangement of the T-cell receptor gene&#44; either of the gamma chain or of the beta chain&#44; in 60&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;3</span></a> In the differential diagnosis&#44; there are no clear criteria to differentiate PCSM-TCL from benign lymphoid diseases&#44; and the nuclear pleomorphism&#44; immunohistochemistry&#44; and detection of clonality are therefore used to orient the diagnosis to PCSM-TCL&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Five-year survival is over 90&#37; when presentation is with a single lesion with typical characteristics&#46; This prognosis worsens when presentation is multifocal&#44; and overall 5-year survival is of 60&#37; to 80&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;3</span></a> Poor prognostic factors include CD2&#8211;&#44; rapidly growing tumors over 5<span class="elsevierStyleHsp" style=""></span>cm in diameter&#44; the presence of a limited number of accompanying CD8&#43; T<span class="elsevierStyleHsp" style=""></span>cells and a high ki-67 index&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;7</span></a> To date&#44; 3 other cases of spontaneous regression after biopsy have been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#8211;9</span></a> The therapeutic options described in the consensus statement on the treatment of cutaneous lymphomas<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> suggest non-aggressive management for patients with primary or recurrent&#44; single or multiple localized nodular forms&#44; varying from follow-up of the patient to topical or intralesional corticosteroids or even surgery or radiation therapy&#46; Treatment for aggressive forms must be individualized according to the characteristics of the patient&#46;</p></span>"
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