Case and Research Letters
Erythema Multiforme Contact Dermatitis After Accidental Exposure to Acrylate-based Printing Inks
Eritema multiforme de contacto tras exposición accidental a acrilatos en tintas de impresión
S. Córdoba
, N. Puente, A. Calderón, J.M. Borbujo
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Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Madrid, Spain
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Córdoba, N. Puente, A. Calderón, J.M. Borbujo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "Córdoba" "email" => array:1 [ 0 => "scordoba.hflr@salud.madrid.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Puente" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Calderón" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Borbujo" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eritema multiforme de contacto tras exposición accidental a acrilatos en tintas de impresión" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 472 "Ancho" => 1300 "Tamanyo" => 114379 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A and B, Similar lesions on both thighs and the trunk (areas not exposed to direct contact with ink).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Acrylates are well recognized as allergens. People working in the graphic arts field are exposed to acrylate-based printing inks and are therefore at high risk for occupational allergic contact dermatitis to acrylates.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> The most commonly used acrylic monomers in the printing process are 2-hydroxyethyl acrylate, 2-hydroxypropyl acrylate, 2-hydroxypropyl methacrylate, 2-hydroxyethyl methacrylate, and 2-ethyl acrylate.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 26-year-old printing worker whose forearms came into contact with waste ink that spilled from a container. He was not exposed to sunlight or UV light and washed the affected area after the spill. Three days later, he began to experience intense pruritus, and vesicles began to appear on the wrists and forearms. The intensity of the lesions increased during the following days, with the appearance of multiple targetoid erythematous-edematous macules in the neighboring areas of the forearms and arms (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and on the face, trunk, and extremities at some distance from the ink splashes (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The patient had no history of skin disease, infection, or ingestion of medication during the previous months.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Analysis of a biopsy specimen revealed vacuolar degeneration of the basement membrane, necrotic keratinocytes in the epidermis, exocytosis, and a predominantly perivascular, lymphocytic inflammatory dermal infiltrate with no spongiosis.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The suspected diagnosis was erythema multiforme contact dermatitis. Oral prednisone was prescribed, and the lesions improved gradually until they had completely resolved 2 weeks later leaving only scaling. A few hours after returning to work, he experienced a new outbreak, albeit of lesser intensity. The patient remains asymptomatic 7 months after being moved from his job.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Patch tests were performed using the standard series of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) and the Marti Tor meth(acrylate) series. Positive reactions were recorded for 2-hydroxyethyl methacrylate 1% petrolatum (pet), 2-hydroxyethyl acrylate 0.1% pet, 2-hydroxypropyl methacrylate 2% pet, ethyl acrylate 0.1% pet, and tetrahydrofurfuryl methacrylate 2% pet. No further positive reactions were recorded (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Although we did not have access to the ink that caused the initial reaction (SR238, Sartomer), the technical specifications of the product showed that it contained hexamethylene diacrylate. Therefore, diagnosis was confirmed as erythema multiforme contact dermatitis, probably caused by sensitization to hexamethylene diacrylate, with cross-reaction to other acrylates.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Erythema multiforme contact dermatitis is an uncommon condition that is caused by contact with vegetable allergens, metals, tropical woods, cosmetics, and chemicals.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> It is the most common noneczematous clinical presentation of allergic contact dermatitis. The initial lesions are eczematous in appearance and are found in the area of direct contact with the allergen. During the following days, targetoid, erythematous-vesicular, or urticarial lesions appear on the periphery of and at a distance from the area of the original contact. Histopathology findings are nonspecific. Spongiosis and exocytosis are common findings, although vacuolar degeneration of the basement membrane or epidermal necrolysis is more unusual.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Acrylate-induced allergic contact dermatitis usually manifests as eczematous dermatitis on the hands or fingertip dermatitis in patients who handle acrylates in the workplace.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4–6</span></a> To date, only 1 case of acrylate-induced erythema multiforme contact dermatitis has been reported. The patient developed large blisters with skin detachment indicative of progress to toxic epidermal necrolysis.</p><p id="par0040" class="elsevierStylePara elsevierViewall">We present a case of acrylate-induced allergic contact dermatitis after accidental workplace exposure to printing ink. The case is interesting because of the curious nature of the presentation. We wish to highlight the importance of protective measures in industries where workers are required to handle acrylates. Workers should be aware that they are handling potent sensitizers that can lead to occupational disability.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as: Córdoba S, Puente N, Calderón A, Borbujo JM. Eritema multiforme de contacto tras exposición accidental a acrilatos en tintas de impresión. Actas Dermosifiliogr. 2015;106:684–685.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 631 "Ancho" => 975 "Tamanyo" => 102884 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Targetoid erythematous macules on the forearm.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 472 "Ancho" => 1300 "Tamanyo" => 114379 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A and B, Similar lesions on both thighs and the trunk (areas not exposed to direct contact with ink).</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviation: Pet, petrolatum.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">48 h \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">96 h \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">GEIDAC</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleItalic">standard series</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">MartiTor (meth)acrylate series \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2-hydroxyethyl methacrylate 1% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2-hydroxyethyl acrylate 0.1% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">++ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">++ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2-hydroxypropyl methacrylate 2% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">++ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Bisphenol A methacrylate 2% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Butyl acrylate 0.1% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ethylene glycol dimethacrylate 2% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Methyl methacrylate 2% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Triethylene glycol dimethacrylate 2% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ethyl acrylate 0.1% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">++ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ethyl cyanoacrylate 10% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ethyl methacrylate 2% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tetrahydrofurfuryl methacrylate 2% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab908837.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Spanish Contact Dermatitis and Skin Allergy Research Group.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara 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Rycroft" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Textbook of contact dermat." "paginaInicial" => "343" "paginaFinal" => "400" "edicion" => "2nd edn." "serieFecha" => "1999" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "1,6-hexanediol diacrylate: A rapid and potent sensitizer in the printing industry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V.A. Morgan" 1 => "J.M. Fewings" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Australas J Dermatol" "fecha" => "2000" "volumen" => "41" "paginaInicial" => "190" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10954995" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0045" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toxic epidermal necrolysis following allergic contact dermatitis caused by occupational exposure to ultraviolet-cured inks" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Ido" 1 => "T. Kiyohara" 2 => "H. Takahashi" 3 => "Y. Yamaguchi" 4 => "D. Tani" 5 => "M. Kumakiri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555-1255" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2012" "volumen" => "92" "paginaInicial" => "313" "paginaFinal" => "315" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22101957" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0050" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatitis de contacto a acrilatos en una industria de fabricación de ascensores. A propósito de 8 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.L. Pérez-Formoso" 1 => "J. de Anca-Fernández" 2 => "R. Maraví-Cecilia" 3 => "J.M. Díaz-Torrez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2010" "volumen" => "10" "paginaInicial" => "336" "paginaFinal" => "340" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatitis de contacto profesional por Threebond®. Cuatro casos en la misma empresa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Romaguera" 1 => "J. Vilaplana" 2 => "M. Llagostera" 3 => "R. Grimalt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2010.09.013" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2011" "volumen" => "102" "paginaInicial" => "468" "paginaFinal" => "469" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21429470" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sensibilización a acrilatos por uñas artificiales. Revisión de 15 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Roche" 1 => "J. de la Cuadra" 2 => "V. Alegre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "788" "paginaFinal" => "794" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19091218" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002048/v1_201510011018/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000008/v1_201510011018/S1578219015002048/v1_201510011018/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002048?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 10 | 9 | 19 |
| 2024 Octubre | 121 | 51 | 172 |
| 2024 Septiembre | 101 | 34 | 135 |
| 2024 Agosto | 220 | 62 | 282 |
| 2024 Julio | 202 | 38 | 240 |
| 2024 Junio | 132 | 44 | 176 |
| 2024 Mayo | 82 | 37 | 119 |
| 2024 Abril | 81 | 25 | 106 |
| 2024 Marzo | 85 | 32 | 117 |
| 2024 Febrero | 72 | 33 | 105 |
| 2024 Enero | 67 | 28 | 95 |
| 2023 Diciembre | 59 | 31 | 90 |
| 2023 Noviembre | 94 | 41 | 135 |
| 2023 Octubre | 59 | 22 | 81 |
| 2023 Septiembre | 77 | 42 | 119 |
| 2023 Agosto | 77 | 18 | 95 |
| 2023 Julio | 103 | 38 | 141 |
| 2023 Junio | 86 | 24 | 110 |
| 2023 Mayo | 109 | 37 | 146 |
| 2023 Abril | 60 | 22 | 82 |
| 2023 Marzo | 65 | 29 | 94 |
| 2023 Febrero | 52 | 26 | 78 |
| 2023 Enero | 57 | 21 | 78 |
| 2022 Diciembre | 74 | 57 | 131 |
| 2022 Noviembre | 58 | 39 | 97 |
| 2022 Octubre | 54 | 18 | 72 |
| 2022 Septiembre | 53 | 44 | 97 |
| 2022 Agosto | 39 | 38 | 77 |
| 2022 Julio | 62 | 49 | 111 |
| 2022 Junio | 48 | 44 | 92 |
| 2022 Mayo | 92 | 65 | 157 |
| 2022 Abril | 84 | 50 | 134 |
| 2022 Marzo | 82 | 49 | 131 |
| 2022 Febrero | 84 | 24 | 108 |
| 2022 Enero | 92 | 33 | 125 |
| 2021 Diciembre | 71 | 34 | 105 |
| 2021 Noviembre | 51 | 48 | 99 |
| 2021 Octubre | 68 | 49 | 117 |
| 2021 Septiembre | 56 | 28 | 84 |
| 2021 Agosto | 58 | 40 | 98 |
| 2021 Julio | 58 | 34 | 92 |
| 2021 Junio | 66 | 38 | 104 |
| 2021 Mayo | 33 | 25 | 58 |
| 2021 Abril | 64 | 93 | 157 |
| 2021 Marzo | 75 | 34 | 109 |
| 2021 Febrero | 70 | 22 | 92 |
| 2021 Enero | 65 | 32 | 97 |
| 2020 Diciembre | 35 | 24 | 59 |
| 2020 Noviembre | 34 | 19 | 53 |
| 2020 Octubre | 31 | 17 | 48 |
| 2020 Septiembre | 37 | 18 | 55 |
| 2020 Agosto | 34 | 20 | 54 |
| 2020 Julio | 34 | 16 | 50 |
| 2020 Junio | 46 | 26 | 72 |
| 2020 Mayo | 26 | 12 | 38 |
| 2020 Abril | 38 | 18 | 56 |
| 2020 Marzo | 27 | 14 | 41 |
| 2020 Febrero | 3 | 4 | 7 |
| 2019 Diciembre | 4 | 2 | 6 |
| 2019 Octubre | 0 | 2 | 2 |
| 2019 Septiembre | 4 | 0 | 4 |
| 2019 Agosto | 0 | 1 | 1 |
| 2019 Julio | 0 | 2 | 2 |
| 2019 Junio | 0 | 1 | 1 |
| 2019 Mayo | 3 | 15 | 18 |
| 2019 Abril | 0 | 1 | 1 |
| 2019 Marzo | 2 | 3 | 5 |
| 2019 Febrero | 1 | 0 | 1 |
| 2019 Enero | 2 | 0 | 2 |
| 2018 Diciembre | 3 | 0 | 3 |
| 2018 Octubre | 6 | 0 | 6 |
| 2018 Septiembre | 3 | 0 | 3 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 4 | 0 | 4 |
| 2018 Febrero | 28 | 5 | 33 |
| 2018 Enero | 22 | 2 | 24 |
| 2017 Diciembre | 33 | 11 | 44 |
| 2017 Noviembre | 17 | 5 | 22 |
| 2017 Octubre | 19 | 5 | 24 |
| 2017 Septiembre | 17 | 4 | 21 |
| 2017 Agosto | 25 | 7 | 32 |
| 2017 Julio | 18 | 14 | 32 |
| 2017 Junio | 26 | 11 | 37 |
| 2017 Mayo | 20 | 11 | 31 |
| 2017 Abril | 24 | 11 | 35 |
| 2017 Marzo | 8 | 6 | 14 |
| 2017 Febrero | 16 | 11 | 27 |
| 2017 Enero | 13 | 5 | 18 |
| 2016 Diciembre | 20 | 11 | 31 |
| 2016 Noviembre | 33 | 23 | 56 |
| 2016 Octubre | 14 | 18 | 32 |
| 2016 Septiembre | 0 | 16 | 16 |
| 2016 Agosto | 0 | 1 | 1 |
| 2016 Julio | 1 | 2 | 3 |
| 2016 Junio | 4 | 2 | 6 |
| 2016 Mayo | 0 | 10 | 10 |
| 2016 Abril | 0 | 5 | 5 |
| 2016 Marzo | 0 | 8 | 8 |
| 2016 Febrero | 0 | 1 | 1 |
| 2015 Noviembre | 0 | 1 | 1 |
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