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acral regions&#44; and areas around the joints on all 4 limbs&#44; especially on extensor surfaces &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The development of the boy was normal for his age&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histologic examination revealed hyperkeratosis with focal parakeratosis&#44; hypergranulosis&#44; and acanthosis with elongated rete ridges &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Progressive symmetric erythrokeratoderma &#40;PSEK&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">Topical treatment was started with 20&#37; urea cream and systemic treatment was started with oral acitretin at a dose of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46; Patient tolerance was good&#46; Over several months&#44; the lesions clearly involuted until they were limited to the acral regions of the limbs and the flexures&#44; with a minimal effective dose of 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46; Periodic blood tests were carried out at follow-up visits&#44; and no abnormalities caused by the treatment were observed&#46; Adherence to treatment has been erratic over several years of follow-up at our dermatology clinic&#59; periods of evident exacerbation have coincided with the voluntary withdrawal of the medication&#46; The patient&#44; now 14 years old&#44; continues to receive treatment with acitretin at a minimum effective dose of 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Erythrokeratodermas are a clinically and genetically heterogeneous group of skin diseases characterized by well-defined erythematous-keratotic plaques&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> There are various subtypes&#44; the most important of which are PSEK and erythrokeratoderma variabilis&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#8211;6</span></a> PSEK is a rare genodermatosis that has been associated with a mutation in the loricrin gene on chromosome 1q21&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4&#44;5</span></a> although it is genetically heterogeneous&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In most cases&#44; PSEK is hereditary&#44; with autosomal dominant inheritance&#44; incomplete penetrance&#44; and variable expressivity&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a> although sporadic cases<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;6</span></a> and cases with a recessive inheritance pattern<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> have also been reported&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Clinically&#44; PSEK is characterized by the appearance of large&#44; erythematous&#44; orange-colored&#44; well-defined&#44; symmetrical plaques that in some cases can have a keratotic or verrucous appearance&#44; usually located on the buttocks&#44; cheeks&#44; and limbs&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;6</span></a> Palmoplantar involvement has been reported in up to 50&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;6</span></a> The lesions usually appear in the first years of life and spread slowly or remain stable during the following years&#59; spontaneous improvement sometimes occurs&#44; usually during puberty&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Histologic findings are nonspecific&#44; with foci of parakeratosis and marked acanthosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a> Perinuclear vacuolization can be observed in the granular cell layer&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">PSEK is treated symptomatically&#46; Topical treatments&#8212;including emollients and keratolytic agents&#8212;are reserved for the mildest cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a> For severe cases&#44; 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Case for Diagnosis
Can You Identify the Genodermatosis?
¿Qué genodermatosis es?
R. Santesteban Muruzábal
Autor para correspondencia
raquel.santesteban@hotmail.com

Corresponding author.
, M. Hervella Garcés, C. Ros Martín
Servicio de Dermatología, Hospital de Navarra, Complejo Hospitalario de Navarra, Pamplona, Navarre, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Patient History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 5-year-old boy from Colombia with no known family history of skin disease presented with asymptomatic lesions on the limbs&#44; predominantly in acral regions and areas around the joints&#46; His family reported slow&#44; peripheral growth of the lesions over the past few months but were unable to specify exactly when the clinical signs first appeared&#46; No other associated symptoms were present at any level&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination revealed keratotic&#44; lichenoid plaques with mild peripheral erythema affecting the hips&#44; acral regions&#44; and areas around the joints on all 4 limbs&#44; especially on extensor surfaces &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The development of the boy was normal for his age&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histologic examination revealed hyperkeratosis with focal parakeratosis&#44; hypergranulosis&#44; and acanthosis with elongated rete ridges &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Progressive symmetric erythrokeratoderma &#40;PSEK&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">Topical treatment was started with 20&#37; urea cream and systemic treatment was started with oral acitretin at a dose of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46; Patient tolerance was good&#46; Over several months&#44; the lesions clearly involuted until they were limited to the acral regions of the limbs and the flexures&#44; with a minimal effective dose of 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46; Periodic blood tests were carried out at follow-up visits&#44; and no abnormalities caused by the treatment were observed&#46; Adherence to treatment has been erratic over several years of follow-up at our dermatology clinic&#59; periods of evident exacerbation have coincided with the voluntary withdrawal of the medication&#46; The patient&#44; now 14 years old&#44; continues to receive treatment with acitretin at a minimum effective dose of 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Erythrokeratodermas are a clinically and genetically heterogeneous group of skin diseases characterized by well-defined erythematous-keratotic plaques&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> There are various subtypes&#44; the most important of which are PSEK and erythrokeratoderma variabilis&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#8211;6</span></a> PSEK is a rare genodermatosis that has been associated with a mutation in the loricrin gene on chromosome 1q21&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4&#44;5</span></a> although it is genetically heterogeneous&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In most cases&#44; PSEK is hereditary&#44; with autosomal dominant inheritance&#44; incomplete penetrance&#44; and variable expressivity&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a> although sporadic cases<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;6</span></a> and cases with a recessive inheritance pattern<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> have also been reported&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Clinically&#44; PSEK is characterized by the appearance of large&#44; erythematous&#44; orange-colored&#44; well-defined&#44; symmetrical plaques that in some cases can have a keratotic or verrucous appearance&#44; usually located on the buttocks&#44; cheeks&#44; and limbs&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;6</span></a> Palmoplantar involvement has been reported in up to 50&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;6</span></a> The lesions usually appear in the first years of life and spread slowly or remain stable during the following years&#59; spontaneous improvement sometimes occurs&#44; usually during puberty&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Histologic findings are nonspecific&#44; with foci of parakeratosis and marked acanthosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a> Perinuclear vacuolization can be observed in the granular cell layer&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">PSEK is treated symptomatically&#46; Topical treatments&#8212;including emollients and keratolytic agents&#8212;are reserved for the mildest cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a> For severe cases&#44; systemic treatment&#8212;oral retinoids&#44; such as acitretin at a dose of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#8212;is usually added&#46; Psoralen-UV-A phototherapy has also been used&#44; with variable clinical responses&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">We have presented a new case of PSEK&#44; a rare entity&#46; The case is unusual because it is sporadic&#44; autosomal dominant inheritance being more common in this disease&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
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