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        "titulo" => "Descripci&#243;n de los pacientes intervenidos mediante cirug&#237;a de Mohs en Espa&#241;a&#46; Datos basales del registro espa&#241;ol de cirug&#237;a de Mohs &#40;REGESMOHS&#41;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Mohs micrographic surgery &#40;MMS&#41; is a technique for skin cancer treatment that is available at many Spanish health care facilities&#44; both public and private&#46; Most experiences with MMS described in the literature&#8212;including large case series with long-term follow-up data&#8212;are from the United States and Australia&#44; although a few reports from European and Latin American hospitals have recently started to appear&#46; In an October 2012 report&#44; the American Academy of Dermatology attempted to unify therapeutic criteria by rating the use of MMS as &#8220;appropriate&#44;&#8221; &#8220;uncertain&#44;&#8221; or &#8220;inappropriate&#8221; for 270 scenarios in which this type of surgery is often considered on the basis of tumor type and patient characteristics&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> However&#44; because there are fewer restrictions on the use of MMS in the United States than in Europe&#44; American studies and results can have limited applicability in Spain&#44; where the tumors treated with this technique are often larger or more complex&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A few teams of dermatologists have reported their experiences with MMS in Spain&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#8211;4</span></a> However&#44; because the findings of these studies correspond to individual hospitals&#44; they may not be representative of the use of MMS at the national level&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The Spanish Registry of Mohs Surgery &#40;REGESMOHS&#41; was created in July 2013 and now has 15 participating hospitals&#46; Its main objective is to describe the use of MMS in Spain and the factors that influence the outcomes achieved&#46; In this initial report&#44; we describe the characteristics of the patients and tumors treated with MMS in Spain&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">REGESMOHS is a prospective cohort study&#46; The 15 participating centers are public and private Spanish hospitals where MMS is performed at least once each week&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Before launching the registry&#44; we identified the hospitals that regularly performed MMS and invited them to participate in the study&#46; Fifteen of the 22 hospitals contacted are currently participating in REGESMOHS &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; and the registry is open to the addition of new hospitals&#46; All patients considered for MMS at the participating hospitals&#8212;except those who have been declared legally incompetent&#8212;are enrolled consecutively in the study&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">For each entry added to the registry&#44; we record patient and surgery characteristics&#44; as well as the short-term outcome &#40;at a postoperative appointment&#41; and long-term outcome&#46; Patients are followed up at least once a year so that their long-term outcomes can be described&#46; In patients with several successive tumors&#44; all tumors are described in the registry but follow-up data are only recorded for the first tumor&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">REGESMOHS was designed so that its objectives could be achieved within 6 years if patient enrollment targets were met&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The study was approved by the research ethics committee of Navarre&#44; the Spanish Agency of Medicines and Medical Devices &#40;AEMPS&#41;&#44; and all participating hospitals&#46; It was conducted in accordance with the Declaration of Helsinki and current legislation&#46; Written informed consent was obtained from all participating patients&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Following an established protocol&#44; data were collected using an online data collection system &#40;OpenClinica open source software&#44; version 3&#46;1&#41; that belongs to the research unit of the Foundation of the Spanish Academy of Dermatology and Venereology&#46; The statistical analysis was carried out using the Stata software package &#40;version 13&#46;1&#44; Statacorp&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">A total of 655 patients were included in REGESMOHS between July 2013&#44; when the registry opened&#44; and October 2014&#46; The mean age at the time of the surgery was 68&#46;4 &#40;13&#46;6&#41; years&#46; The 341 men who received MMS accounted for slightly more than half &#40;52&#46;06&#37;&#41; of the patients&#44; while the 314 women accounted for 47&#46;94&#37;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Patients lived in the catchment area of the hospital where the surgery was performed in 496 cases &#40;75&#46;73&#37;&#41; and lived elsewhere in 158 cases &#40;24&#46;12&#37;&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Immunosuppression was present in 27 patients &#40;4&#46;13&#37;&#41;&#44; diabetes mellitus in 80 &#40;12&#46;21&#37;&#41;&#44; and a diagnosis of some sort of multiple tumor syndrome in 28 &#40;4&#46;27&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">The most common type of skin tumor was basal cell carcinoma &#40;BCC&#41;&#44; which was present in 589 patients &#40;89&#46;93&#37;&#41;&#44; and the most common histologic subtype was infiltrative BCC&#44; which was present in 256 patients &#40;39&#46;08&#37;&#41;&#46; The second most common tumor type was squamous cell carcinoma &#40;SCC&#41;&#44; which was present in 35 patients &#40;5&#46;64&#37;&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows the percentages corresponding to other histologic subtypes of BCC and SCC&#44; as well as the other types of tumors treated&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Taken together&#44; lentigo maligna melanoma&#44; acral lentiginous melanoma&#44; dermatofibrosarcoma protuberans&#44; microcystic adnexal carcinoma&#44; sebaceous carcinoma&#44; and eccrine mucinous carcinoma were present in 29 patients &#40;4&#46;41&#37;&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">In 630 cases &#40;96&#46;18&#37;&#41;&#44; the surgery was used to treat tumors on the face or scalp&#44; with the nose being the most frequent site &#40;326 cases&#44; 49&#46;85&#37;&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> shows the frequencies and percentages of the various affected areas&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">MMS was indicated for primary tumors in 410 patients &#40;62&#46;60&#37;&#41;&#44; for recurrent tumors in 164 patients &#40;25&#46;04&#37;&#41;&#44; and for persistent tumors in 81 &#40;12&#46;37&#37;&#41;&#46; The mean tumor size before surgery &#40;among patients for whom this information was collected&#41; was 13&#46;9 &#40;14&#46;78&#41;&#160;mm along the long axis and 9&#46;8 &#40;9&#46;47&#41;&#160;mm along the short axis&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Prior to receiving MMS&#44; 99 patients &#40;15&#46;2&#37;&#41; received medical treatment&#44; 297 &#40;45&#46;5&#37;&#41; underwent surgery&#44; and 9 &#40;1&#46;4&#37;&#41; received radiation therapy &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;&#46; Some patients underwent more than 1 previous surgery&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">None of the patients had nodal or metastatic disease&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">MMS was contraindicated in 25 patients &#40;3&#46;7&#37;&#41;&#46; The most frequent reason for contraindication&#44; present in 7 cases &#40;35&#37;&#41;&#44; was the clinical context of the patient&#44; followed by tumor size&#44; histologic findings&#44; and site&#46; Of the patients in whom MMS was contraindicated&#44; 10 &#40;43&#46;48&#37;&#41; underwent conventional surgery&#44; 8 &#40;34&#46;78&#37;&#41; received radiation therapy&#44; and 1 was treated with hedgehog pathway inhibitors&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">MMS is a surgical technique designed for the specific treatment of certain types of skin cancer&#44; mainly tumors in certain sites or with a high risk of recurrence&#46; The technique is based on 2 main principles&#46; Intraoperative microscopic confirmation of the surgical margins of the excised tumor specimen&#44; properly oriented and stained&#44; allows the surgeon to determine the precise location of the tumor foci &#40;in cases of persistent tumors&#41;&#46; Consequently&#44; tumors can be completely excised in a single procedure carried out in 1 or more stages&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In our study&#44; slightly more men &#40;52&#46;06&#37;&#41; received MMS than women &#40;47&#46;94&#37;&#41;&#44; although the difference was not statistically significant&#46; The mean age at the time of the procedure was 68&#46;4 &#40;13&#46;6&#41; years&#44; and immunosuppression was present in only 27 patients &#40;4&#46;27&#37;&#41;&#44; most of whom had received a solid organ transplant&#46; Age at tumor presentation&#44; sex distribution&#44; and tumor type were similar to those found in case series in the United States&#44; Australia&#44; the United Kingdom&#44; and the Netherlands&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In the Australian registry&#44; which contains 11&#160;127 patients diagnosed with BCC who underwent MMS&#44; the procedure was slightly more common in men &#40;52&#46;9&#37;&#41; than in women &#40;47&#46;1&#37;&#41; and the mean age at the time of the surgery was 62 &#40;14&#41; years&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> In a series of 1263 patients diagnosed with SCC&#44; the same authors found that the tumor was present in a higher percentage of men &#40;74&#46;3&#37;&#41; than in women &#40;25&#46;7&#37;&#41;&#44; that the differences were statistically significant &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&#41;&#44; and that the age at presentation was similar in both sexes to that found in the previous study&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> In a British case series in which 751 patients underwent MMS for various types of skin tumors&#44; the surgery was more common in men &#40;53&#37;&#41; than in women &#40;47&#37;&#41; and the mean age was 69 years &#40;range 22-92&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">In the most recent report on the Dutch registry&#44; MMS was more common in men than in women&#44; and the mean age at presentation&#8212;and also at the time of surgery&#8212;was more than 65 years&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In a Dutch series of 633 patients with 737 BCCs published in 2004&#44; Smeets et al found that MMS was slightly more common in men &#40;345 cases&#44; 56&#37;&#41; than in women &#40;275 cases&#44; 44&#37;&#41; and that the mean age was 65 years &#40;range 22-94&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> A recent American series&#44; in which 12&#160;344 patients were treated for BCCs and SCCs at Brown University in Rhode Island&#44; was the only study to find a slightly higher mean age at the time of surgery&#44; with women being slightly younger &#40;70 &#91;14&#93; years&#41; than men &#40;72 &#91;12&#93; years&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">In the studies cited above&#44; as in our registry&#44; some form of immunosuppression was present in only a minority of patients&#44; most of whom were solid organ transplant recipients&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In our series&#44; the most common tumor type was BCC&#44; present in 589 patients &#40;89&#46;93&#37;&#41;&#44; and the most common histologic subtype was infiltrative BCC&#44; present in 256 &#40;39&#46;08&#37;&#41;&#46; The second most common tumor type was SCC&#44; present in 35 patients &#40;5&#46;64&#37;&#41;&#44; followed by lentigo maligna melanoma&#44; in 13 patients &#40;1&#46;98&#37;&#41;&#44; and dermatofibrosarcoma protuberans&#44; in 12 patients &#40;1&#46;83&#37;&#41;&#46; Less frequent tumors&#8212;such as acral lentiginous melanoma&#44; microcystic adnexal carcinoma&#44; sebaceous carcinoma&#44; and eccrine mucinous carcinoma&#8212;accounted for 4 cases &#40;0&#46;6&#37;&#41;&#46; In all 5 series cited above&#44; BCC was the most prevalent type of skin tumor&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#8211;10</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">In 630 patients &#40;96&#46;18&#37;&#41;&#44; the site of the tumor&#8212;whether primary&#44; recurrent&#44; or persistent&#8212;was on the face or scalp&#44; and the most common site&#44; in 326 patients &#40;49&#46;85&#37;&#41;&#44; was the nose&#46; The next most frequent sites were the medial canthus&#44; in 60 cases &#40;9&#46;17&#37;&#41;&#44; the malar region&#44; in 55 &#40;8&#46;41&#37;&#41;&#44; the forehead&#44; in 48 &#40;7&#46;34&#37;&#41;&#44; and the auricular and preauricular region&#44; in 41 &#40;6&#46;27&#37;&#41;&#46; The trunk&#44; extremities&#44; and genitals were less frequent sites&#44; together accounting for 20 cases &#40;3&#46;05&#37;&#41;&#46; These results are similar to those of the series mentioned above&#44; with minor variations&#46; In the Australian series&#44; the most common site for BCCs and SCCs &#40;primary and recurrent&#41; was the nose &#40;39&#46;1&#37; and 20&#37; of cases&#44; respectively&#41;&#46; Among patients with BCCs&#44; the second most common site was the periocular region for primary tumors &#40;935 cases&#44; 14&#46;9&#37;&#41; and the malar region for recurrent tumors &#40;1050 cases&#44; 21&#46;05&#37;&#41;&#46; The third most common site was the malar region for primary BCCs &#40;789 cases&#44; 12&#46;6&#37;&#41; and the auricular region for recurrent BCCs &#40;543 cases&#44; 11&#46;1&#37;&#41;&#46; Among patients with SCCs&#44; the second most common site was the malar region for primary tumors &#40;145 cases&#44; 18&#46;8&#37;&#41; and the auricular region for recurrent tumors &#40;89 cases&#44; 18&#46;1&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;6</span></a> In the British series&#44; the most frequent site for both primary and recurrent tumors was the head and scalp &#40;446 cases&#44; 98&#37;&#41;&#46; The most common sites for primary tumors were the nose &#40;39&#37;&#41; and the periocular region &#40;21&#37;&#41;&#44; whereas the temporal region was the most common site for recurrent tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> The Dutch registry had similar findings&#44; with the most common site being the head and neck&#44; followed by the trunk and the extremities in both sexes&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Similarly&#44; in the case series of Smeets et al&#44; the most common site for BCCs was the nose &#40;219 cases&#44; 30&#37;&#41; followed by the forehead and the temporal region &#40;167 cases&#44; 23&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">In the American series&#44; SCCs were more common in men &#40;24&#37;&#41; than in women &#40;16&#37;&#41; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#44; a finding consistent with data in the literature&#46; The most common site for primary BCCs and SCCs was the nose &#40;27&#37; in women&#44; 19&#37; in men&#41;&#44; followed by the auricular region in men &#40;15&#37;&#41; and the malar region in women &#40;14&#37;&#41; and&#44; in third place&#44; the malar region in men &#40;14&#37;&#41; and the forehead in women &#40;12&#37;&#41;&#46; In general&#44; the American study found that men were more likely to present nonmelanoma skin cancer on the scalp and auricular region&#44; whereas women were more likely to have tumors in the central facial area and lower limbs&#46; The same study found that superficial BCCs were slightly more common in women &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; whereas the British and Dutch series found that this tumor type was more common in men&#46; The American authors suggested that more frequent clinical check-ups might explain the higher frequency of superficial BCCs in women&#44; as these check-ups would allow the early detection of smaller and less invasive tumors&#46; They also suggested that intense intermittent exposure to UV radiation&#8212;closely related to the development of superficial BCCs&#8212;may be more prevalent in women&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In our series&#44; MMS was used to treat primary tumors in 410 cases &#40;62&#46;60&#37;&#41;&#44; recurrent tumors in 164 cases &#40;25&#46;04&#37;&#41;&#44; and persistent tumors in 81 cases &#40;12&#46;37&#37;&#41;&#46; These data are comparable to those of the Australian series&#44; in which primary tumors were the most common indication for MMS in BCCs &#40;56&#46;2&#37; of cases&#41; and in SCCs &#40;61&#46;1&#37; of cases&#41;&#59; in cases in which MMS was used to treat recurrent tumors&#44; the most common previous treatment was simple surgery&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;6</span></a> In the Dutch series of Smeets et al&#44; very similar percentages of patients received MMS for primary BCCs &#40;365 cases&#44; 50&#46;8&#37;&#41; and for recurrent or persistent BCCs &#40;355 cases&#44; 49&#46;2&#37;&#41;&#44; and the most frequent prior treatment in recurrent tumors was simple surgical excision&#44; used in 115 cases &#40;45&#46;3&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">The most common prior treatment in the REGESMOHS registry was cryotherapy&#44; used in 43 patients &#40;6&#46;6&#37;&#41;&#44; followed by topical imiquimod&#44; used in 25 patients &#40;3&#46;8&#37;&#41;&#46; Two patients &#40;0&#46;3&#37;&#41; were treated with hedgehog pathway inhibitors&#46; Among REGESMOHS patients who had previously received surgical treatment&#44; the most common technique&#44; used in 185 cases &#40;28&#46;3&#37;&#41;&#44; was simple surgical excision&#44; whereas only 24 patients &#40;3&#46;7&#37;&#41; had previously undergone MMS&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">As mentioned above&#44; the mean tumor size before surgery&#8212;taking into account all tumor types&#8212;was 13&#46;9 &#40;14&#46;78&#41;&#160;mm along the long axis and 9&#46;8 &#40;9&#46;47&#41;&#160;mm along the short axis&#46; These data are also comparable to those of other series&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">MMS was contraindicated in only 25 cases &#40;3&#46;7&#37;&#41;&#44; mainly because of the clinical context of the patient &#40;multiple conditions&#44; multiple-drug regimens&#44; difficulty of movement&#44; or high degree of dependence for basic activities of daily living&#41;&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Advantages of the study</span>&#58; Compared with previous studies&#44; ours is much more representative of the current use of MMS in Spain because we collected data in a prospective&#44; standardized manner from a majority of the Spanish hospitals that perform the procedure&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Limitations of the study&#58;</span> Some hospitals are missing from the registry and the current sample size does not allow the most common variables to be quantified with great precision&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusion</span><p id="par0170" class="elsevierStylePara elsevierViewall">Our data show that BCCs are the tumors most frequently treated with MMS&#44; that nearly 40&#37; of treated tumors are recurrent or persistent&#44; and that tumor size before surgery in Spain is similar to that reported elsewhere in Europe and in Australia&#46; These data will be useful in assessing whether studies conducted in other countries are applicable to the Spanish context&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethical Disclosures</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Protection of persons and animals</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for the purpose of this study&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Data confidentiality</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that they followed their hospitals&#8217; regulations regarding the publication of patient information&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Right to privacy and informed consent</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors obtained informed consent from the patients and&#47;or subjects referred to in this article&#46; The signed forms are in the possession of the corresponding author&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Funding</span><p id="par0190" class="elsevierStylePara elsevierViewall">REGESMOHS is funded by the Foundation of the Spanish Academy of Dermatology and Venereology&#44; with the collaboration of Roche Farma&#46; The funding laboratory did not participate in the preparation of the article&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicts of Interest</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The Spanish registry of Mohs micrographic surgery started collecting data in July 2013&#46; The aim of the registry is to report on the use of this technique in Spain and the outcomes achieved&#46; In the present article&#44; we describe the characteristics of patients and the tumors treated&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This is a prospective cohort study of patients treated with Mohs micrographic surgery&#46; The participating centers are hospitals where at least one intervention of this type is performed each week&#46; All patients considered for Mohs micrographic surgery in participating centers are included in the registry except those who have been declared legally incompetent&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Between July 2013 and October 2014&#44; data from 655 patients were included in the registry&#46; The most common tumor involved was basal cell carcinoma&#44; and the most common histological subtype was infiltrative basal cell carcinoma&#46; Most of the tumors treated were located on the face or scalp&#44; and the most common site was the nose&#46; Almost 40&#37; of the tumors treated were recurrent or persistent&#44; and preoperative tumor size was similar to that reported in other European studies and in Australia&#46; In total&#44; 45&#46;5&#37; of patients had received previous surgical treatment&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The findings are similar to those reported in other studies&#44; and the data collected are useful for assessing whether the results of studies carried out elsewhere are applicable in Spain&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En julio de 2013 se inici&#243; la recogida de datos del registro espa&#241;ol de cirug&#237;a microgr&#225;fica de Mohs&#44; que describe la aplicaci&#243;n y los resultados de esta t&#233;cnica en Espa&#241;a&#46; En este art&#237;culo se describen las caracter&#237;sticas del paciente y de los tumores tratados&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se trata de un estudio de cohortes prospectivo en el que participan centros en los que se practica al menos una intervenci&#243;n semanal de cirug&#237;a microgr&#225;fica de Mohs&#46; En cada centro se incluyen todos los pacientes que son valorados para realizar cirug&#237;a de Mohs&#44; excepto los declarados judicialmente incapaces&#46; En este art&#237;culo describimos las caracter&#237;sticas de los pacientes y los tumores incluidos en la cohorte&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El n&#250;mero de pacientes incluidos desde julio de 2013 hasta octubre de 2014 es de 655&#46; La mayor&#237;a de los tumores cut&#225;neos intervenidos correspondieron a carcinoma basocelular&#44; siendo el infiltrante el subtipo histol&#243;gico m&#225;s frecuente&#46; La mayor&#237;a de las cirug&#237;as se practicaron en tumores localizados en la cara y el cuero cabelludo&#44; siendo la localizaci&#243;n m&#225;s frecuente la nariz&#46; Casi el 40&#37; de los tumores operados son recurrentes o persistentes&#44; y el tama&#241;o tumoral prequir&#250;rgico es similar en nuestro medio al descrito en otros estudios australianos o europeos&#46; Hasta el 45&#44;5&#37; de los pacientes hab&#237;a recibido alg&#250;n tratamiento quir&#250;rgico previo&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los datos observados son similares a los de otras series publicadas&#44; y son relevantes para poder valorar la aplicabilidad en nuestro contexto de estudios realizados en otros medios&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ruiz-Salas V&#44; Garc&#233;s JR&#44; Mi&#241;ano Medrano R&#44; Alonso-Alonso T&#44; Rodr&#237;guez-Prieto M&#193;&#44; L&#243;pez-Estebaranz JL&#44; et al&#46; Descripci&#243;n de los pacientes intervenidos mediante cirug&#237;a de Mohs en Espa&#241;a&#46; Datos basales del registro espa&#241;ol de cirug&#237;a de Mohs &#40;REGESMOHS&#41;&#46; Actas Dermosifiliogr&#46; 2015&#59;10&#58;562&#8211;568&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No&#46; of Patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#37; of Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hospital de la Santa Creu i Sant Pau&#44; Barcelona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">113&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Instituto Valenciano de Oncolog&#237;a&#44; Valencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">108&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Complejo Asistencial Universitario de Le&#243;n&#44; Le&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">104&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hospital Universitario Fundaci&#243;n de Alcorc&#243;n&#44; Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">99&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Cl&#237;nica Universitaria de Navarra&#44; Pamplona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Cl&#237;nica Quir&#243;n&#44; Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hospital de La Princesa&#44; Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hospital del Mar&#44; Barcelona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hospital de Manises&#44; Valencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hospital La Zarzuela&#44; Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hospital Universitario de Cruces&#44; Barakaldo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Complejo Hospitalario Universitario de Guadalajara&#44; Guadalajara&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hospital Quir&#243;n Teknon&#44; Barcelona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Complexo Hospitalario Universitario de Santiago&#44; Santiago de Compostela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hospital Gregorio Mara&#241;&#243;n&#44; Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">655&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab873633.png"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Number and Percentage of Patients From Each Participating Center&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Type of Immunosuppression&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No&#46; of Patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#37; of Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Transplant recipient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hematologic malignancy <span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Immunosuppressant therapy<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>3 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">HIV-positive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab873631.png"
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Type of Immunosuppression in the Evaluated Patients&#46;</p>"
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      ]
      2 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; BCC&#44; basal cell carcinoma&#59; SCC&#44; squamous cell carcinoma&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Histologic Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No&#46; of Patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#37; of Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Infiltrative BCC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">256&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Nonaggressive histologic subtype of BCC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">128&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Morpheaform or sclerosing BCC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Micronodular BCC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">No data available&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Other&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Metatypical BCC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Nonaggressive histologic subtype of SCC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Lentigo maligna melanoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Dermatofibrosarcoma protuberans&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Infiltrative SCC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Basosquamous carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">BCC with perineural invasion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">SCC with Breslow depth<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">SCC with perineural or perivascular invasion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Small cell carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Undifferentiated carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Clear cell carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Clark level IV carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Acral lentiginous melanoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Microcystic adnexal carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sebaceous carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Eccrine mucinous carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">655&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab873630.png"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Frequency and Percentage Distribution by Histologic Tumor Type&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No&#46; of Patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#37; of Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Nose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">326&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Medial canthus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Cheek&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Forehead&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Auricular or periauricular region&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Lower eyelid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Lip &#40;cutaneous or mucosal&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Lateral canthus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Eyebrow&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Limbs &#40;excluding pretibial region and hands&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Trunk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Genitals &#40;including perineal and perianal regions&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hands&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Neck&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Upper eyelid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Pretibial region&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">No data available&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">655&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Tumor Site&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No&#46; of Patients&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Electrodesiccation and curettage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Photodynamic therapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Imiquimod&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Fluoropyrimidines&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hedgehog pathway inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Direct suture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">185&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Plasty&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Graft&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Radiation therapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Mohs micrographic surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Treatments Prior to Mohs Micrographic Surgery&#46;</p>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "AAD&#47;ACMS&#47;ASDSA&#47;ASMS 2012 appropriate use criteria for Mohs micrographic surgery&#58; A report of the American Academy of Dermatology&#44; American College of Mohs Surgery&#44; American Society for Dermatologic Surgery Association&#44; and the American Society for Mohs Surgery"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Ad Hoc Task Force"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;M&#46; Connolly"
                            1 => "D&#46;R&#46; Baker"
                            2 => "B&#46;M&#46; Coldiron"
                            3 => "M&#46;J&#46; Fazio"
                            4 => "P&#46;A&#46; Storrs"
                            5 => "A&#46;T&#46; Vidimos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2012.06.009"
                      "Revista" => array:6 [
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                        "volumen" => "67"
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                        "link" => array:1 [
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                            "web" => "Medline"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Re-ex&#233;resis de carcinomas basocelulares de la cabeza previamente extirpados con afectaci&#243;n de m&#225;rgenes &#91;Mohs micrographic surgery for repeat excision of basal cell carcinomas on the head with positive margins&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Angulo"
                            1 => "C&#46; Serra-Guill&#233;n"
                            2 => "V&#46; Traves"
                            3 => "R&#46; Botella-Estrada"
                            4 => "O&#46; Sanmart&#237;n"
                            5 => "B&#46; Llombart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An&#225;lisis de costes de la cirug&#237;a microgr&#225;fica de Mohs en el carcinoma basocelular facial de alto riesgo &#91;Cost analysis of Mohs micrographic surgery in high-risk facial basal cell carcinoma&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46; Bl&#225;zquez-S&#225;nchez"
                            1 => "M&#46; de Troya-Mart&#237;n"
                            2 => "M&#46; Frieyro-Elicegui"
                            3 => "R&#46; F&#250;nez-Li&#233;bana"
                            4 => "L&#46; Mart&#237;n-M&#225;rquez"
                            5 => "F&#46; Rivas-Ruiz"
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                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2010"
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                          ]
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                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlation between preoperative magnetic resonance imaging and surgical margins with modified Mohs for dermatofibrosarcoma protuberans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Serra-Guill&#233;n"
                            1 => "O&#46; Sanmart&#237;n"
                            2 => "B&#46; Llombart"
                            3 => "E&#46; Nagore"
                            4 => "C&#46; Deltoro"
                            5 => "I&#46; Mart&#237;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1524-4725.2011.02077.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg"
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                        "volumen" => "37"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21679274"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Basal cell carcinoma treated with Mohs surgery in Australia I&#46; Experience over 10 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46; Leibovitch"
                            1 => "S&#46;C&#46; Huilgol"
                            2 => "D&#46; Selva"
                            3 => "S&#46; Richards"
                            4 => "R&#46; Paver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2005.04.083"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16112351"
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                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia I&#46; Experience over 10 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Leibovitch"
                            1 => "S&#46;C&#46; Huilgol"
                            2 => "D&#46; Selva"
                            3 => "D&#46; Hill"
                            4 => "S&#46; Richards"
                            5 => "R&#46; Paver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2005.02.059"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2005"
                        "volumen" => "53"
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                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Seven years&#8217; experience of Mohs micrographic surgery in a UK centre&#44; and development of a UK minimum dataset and audit standards"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Macfarlane"
                            1 => "A&#46; Waters"
                            2 => "A&#46; Evans"
                            3 => "A&#46; Affleck"
                            4 => "C&#46; Fleming"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.12108"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2013"
                        "volumen" => "38"
                        "paginaInicial" => "262"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23517356"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
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            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
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        "texto" => "<p id="par0200" class="elsevierStylePara elsevierViewall">The following REGESMOHS members participated in data collection&#58; Luc&#237;a Ascanio Armada and Dolores Caro Gutierrez &#40;Hospital Universitario Fundaci&#243;n Alcorc&#243;n&#41;&#59; Carlos Serra Guill&#233;n&#44; Eduardo Nagore Enguidanos&#44; Beatriz Llombart Cussac&#44; and Celia Requena Caballero &#40;Instituto Valenciano de Oncolog&#237;a&#41;&#59; Victoriano Morales Gordillo &#40;Hospital Quir&#243;n&#44; Pozuelo&#44; Madrid&#41;&#59; Luis Hueso Gabriel and Antonio Martorell &#40;Hospital de Manises&#41;&#59; M&#46; Jos&#233; Seoane Pose &#40;Complexo Hospitalario Universitario de Santiago&#41;&#59; Ricardo Su&#225;rez and Natividad Cano &#40;Hospital Gregorio Mara&#241;&#243;n&#44; Madrid&#41;&#59; and Beatriz P&#233;rez Zafrilla &#40;registry monitor&#41;&#46; We also thank the staff of all the departments participating in the registry&#46;</p>"
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