Original Article
Risk of Reactivation of Hepatitis B Virus Infection in Psoriasis Patients Treated With Biologics: A Retrospective Analysis of 20 Cases From the BIOBADADERM Database
Riesgo de reactivación de hepatitis B pasada en pacientes con psoriasis tratados con biológicos. Análisis retrospectivo de 20 casos. Registro de BIOBADADERM
J. Sanz-Buenoa,
, F. Vanaclochaa, I. García-Dovalb,c, R. Torradod, G. Carreterod, E. Daudéne, D. Patricia Ruiz-Genaof, M.M. Alsina-Gibertg, B. Pérez-Zafrillac,h, G. Pérez-Riali, R. Riveraa, miembros del grupo BIOBADADERM
Autor para correspondencia
a Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, Spain
b Servicio de Dermatología, Complexo Hospitalario Universitario de Vigo y Unidad de Investigación, Vigo, Spain
c Fundación de la Academia Española de Dermatología, Madrid, Spain
d Servicio de Dermatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
e Servicio de Dermatología. Hospital Universitario La Princesa, Madrid, Spain
f Servicio de Dermatología, Hospital Fundación de Alcorcón, Alcorcón, Madrid, Spain
g Servicio de Dermatología, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
h Unidad de Investigación, Complejo Hospitalario Universitario de Albacete, Albacete, Spain
i Servicio de Medicina del Aparato Digestivo, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Ver másLeído
6407
Vecesse ha leído el artículo
2316
Total PDF
4091
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S1578219015001535" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.05.013" "estado" => "S300" "fechaPublicacion" => "2015-07-01" "aid" => "1135" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2014" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2015;106:477-82" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1059 "formatos" => array:3 [ "EPUB" => 45 "HTML" => 539 "PDF" => 475 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731015000733" "issn" => "00017310" "doi" => "10.1016/j.ad.2015.01.010" "estado" => "S300" "fechaPublicacion" => "2015-07-01" "aid" => "1135" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2015;106:477-82" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1164 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 639 "PDF" => 522 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Riesgo de reactivación de hepatitis B pasada en pacientes con psoriasis tratados con biológicos. Análisis retrospectivo de 20 casos. Registro de BIOBADADERM" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "477" "paginaFinal" => "482" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Risk of Reactivation of Hepatitis B Virus Infection in Psoriasis Patients Treated With Biologics: A Retrospective Analysis of 20 Cases From the BIOBADADERM Database" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1424 "Ancho" => 1662 "Tamanyo" => 111580 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Algoritmo de actuación para pacientes con serología VHB+ que vayan a someterse a terapia biológica.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Sanz-Bueno, F. Vanaclocha, I. García-Doval, R. Torrado, G. Carretero, E. Daudén, D. Patricia Ruiz-Genao, M.M. Alsina-Gibert, B. Pérez-Zafrilla, G. Pérez-Rial, R. Rivera" "autores" => array:12 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Sanz-Bueno" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Vanaclocha" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "García-Doval" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Torrado" ] 4 => array:2 [ "nombre" => "G." "apellidos" => "Carretero" ] 5 => array:2 [ "nombre" => "E." "apellidos" => "Daudén" ] 6 => array:2 [ "nombre" => "D." "apellidos" => "Patricia Ruiz-Genao" ] 7 => array:2 [ "nombre" => "M.M." "apellidos" => "Alsina-Gibert" ] 8 => array:2 [ "nombre" => "B." "apellidos" => "Pérez-Zafrilla" ] 9 => array:2 [ "nombre" => "G." "apellidos" => "Pérez-Rial" ] 10 => array:2 [ "nombre" => "R." "apellidos" => "Rivera" ] 11 => array:1 [ "colaborador" => "miembros del grupo BIOBADADERM" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219015001535" "doi" => "10.1016/j.adengl.2015.05.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015001535?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015000733?idApp=UINPBA000044" "url" => "/00017310/0000010600000006/v1_201506300045/S0001731015000733/v1_201506300045/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219015001547" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.05.014" "estado" => "S300" "fechaPublicacion" => "2015-07-01" "aid" => "1127" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2015;106:483-92" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1280 "formatos" => array:3 [ "EPUB" => 55 "HTML" => 663 "PDF" => 562 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Predictors of Tumor Response to Cetuximab and Panitumumab in 116 Patients and a Review of Approaches to Managing Skin Toxicity" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "483" "paginaFinal" => "492" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Factores predictores de respuesta y revisión de la toxicidad cutánea de cetuximab y panitumumab en 116 pacientes" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 545 "Ancho" => 1500 "Tamanyo" => 200133 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Papulopustular rash before (A) and after (B) treatment with tetracyclines for 2 months. The rash improved after 2 months’ treatment with doxycycline 100<span class="elsevierStyleHsp" style=""></span>mg/d. The rash remained similar in size but improved in terms of severity.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Jaka, A. Gutiérrez-Rivera, A. López-Pestaña, E. del Alcázar, J. Zubizarreta, S. Vildosola, M.A. Arregui, C. Sarasqueta, C. Lobo, A. Tuneu" "autores" => array:10 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Jaka" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Gutiérrez-Rivera" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "López-Pestaña" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "del Alcázar" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Zubizarreta" ] 5 => array:2 [ "nombre" => "S." "apellidos" => "Vildosola" ] 6 => array:2 [ "nombre" => "M.A." "apellidos" => "Arregui" ] 7 => array:2 [ "nombre" => "C." "apellidos" => "Sarasqueta" ] 8 => array:2 [ "nombre" => "C." "apellidos" => "Lobo" ] 9 => array:2 [ "nombre" => "A." "apellidos" => "Tuneu" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731015000654" "doi" => "10.1016/j.ad.2015.01.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015000654?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015001547?idApp=UINPBA000044" "url" => "/15782190/0000010600000006/v1_201506260207/S1578219015001547/v1_201506260207/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219015001523" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.05.012" "estado" => "S300" "fechaPublicacion" => "2015-07-01" "aid" => "1138" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2015;106:470-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2224 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 610 "PDF" => 1571 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Liver Injury in Psoriasis Patients Receiving Ustekinumab: A Retrospective Study of 44 Patients Treated in the Clinical Practice Setting" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "470" "paginaFinal" => "476" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Análisis de la hepatotoxicidad en psoriasis tratada con ustekinumab. Estudio retrospectivo de 44 pacientes en práctica clínica habitual" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Llamas-Velasco, M.J. Concha-Garzón, A. García-Diez, E. Daudén" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Llamas-Velasco" ] 1 => array:2 [ "nombre" => "M.J." "apellidos" => "Concha-Garzón" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "García-Diez" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Daudén" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731015001222" "doi" => "10.1016/j.ad.2015.02.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001222?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015001523?idApp=UINPBA000044" "url" => "/15782190/0000010600000006/v1_201506260207/S1578219015001523/v1_201506260207/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Risk of Reactivation of Hepatitis B Virus Infection in Psoriasis Patients Treated With Biologics: A Retrospective Analysis of 20 Cases From the BIOBADADERM Database" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "477" "paginaFinal" => "482" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Sanz-Bueno, F. Vanaclocha, I. García-Doval, R. Torrado, G. Carretero, E. Daudén, D. Patricia Ruiz-Genao, M.M. Alsina-Gibert, B. Pérez-Zafrilla, G. Pérez-Rial, R. Rivera" "autores" => array:12 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Sanz-Bueno" "email" => array:1 [ 0 => "jsanzbueno@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "F." "apellidos" => "Vanaclocha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "I." "apellidos" => "García-Doval" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "R." "apellidos" => "Torrado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "G." "apellidos" => "Carretero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "E." "apellidos" => "Daudén" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 6 => array:3 [ "nombre" => "D." "apellidos" => "Patricia Ruiz-Genao" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] 7 => array:3 [ "nombre" => "M.M." "apellidos" => "Alsina-Gibert" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] ] ] 8 => array:3 [ "nombre" => "B." "apellidos" => "Pérez-Zafrilla" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff0040" ] ] ] 9 => array:3 [ "nombre" => "G." "apellidos" => "Pérez-Rial" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">i</span>" "identificador" => "aff0045" ] ] ] 10 => array:3 [ "nombre" => "R." "apellidos" => "Rivera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 11 => array:1 [ "colaborador" => "miembros del grupo BIOBADADERM" ] ] "afiliaciones" => array:9 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Complexo Hospitalario Universitario de Vigo y Unidad de Investigación, Vigo, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Fundación de la Academia Española de Dermatología, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Dermatología. Hospital Universitario La Princesa, Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Fundación de Alcorcón, Alcorcón, Madrid, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Unidad de Investigación, Complejo Hospitalario Universitario de Albacete, Albacete, Spain" "etiqueta" => "h" "identificador" => "aff0040" ] 8 => array:3 [ "entidad" => "Servicio de Medicina del Aparato Digestivo, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "i" "identificador" => "aff0045" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Riesgo de reactivación de hepatitis B pasada en pacientes con psoriasis tratados con biológicos. Análisis retrospectivo de 20 casos. Registro de BIOBADADERM" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1424 "Ancho" => 1662 "Tamanyo" => 110821 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Algorithm for action for HBV+ patients who are to receive biologic therapy.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Infection with the hepatitis B virus (HBV) is a worldwide health issue. An estimated 350 million individuals are carriers, although there are marked differences in their geographic distribution.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a> Spain is a country with an intermediate prevalence of affected individuals. After establishing universal vaccination programs against HBV, the prevalence in 2007 of carriers of the HB surface antigen (HBsAg) and those with past hepatitis B infection decreased to 0.7% and 8.7%, respectively, although the prevalences are higher in elderly individuals and immigrants.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">2</span></a> Chronic infection with HBV is a dynamic process. Individuals with past hepatitis B infection are HBsAg- although a low viral replication rate may persist.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Psoriasis is an inflammatory skin disease whose prevalence varies considerably according to the populations studied.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">4</span></a> In Spain, the most recent study reported that 2.3% of the population were affected.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a> Biologic agents targeting tumor necrosis factor (TNF) or interleukin 12/23 have revolutionized the treatment of severe psoriasis. Given their immunosuppressive properties, these agents may favor reactivation of viral infections, with occasionally fulminant outcomes.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">6</span></a> Reactivation can occur at any time during treatment, although it is most likely on initiation or after termination due to an immune reconstitution phenomenon.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a> The objective of this study was to assess the risk of reactivation of HBV in HBsAg+ patients with psoriasis who were treated with biologic agents.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">Patients were selected from those included in the Spanish Registry of Adverse Systemic Drug Reactions in Psoriasis (BIOBADADERM). The methodology used in this prospective registry has been described previously.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a> The following study inclusion criteria were applied:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0020" class="elsevierStylePara elsevierViewall">Treatment with anti-TNF or ustekinumab</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0025" class="elsevierStylePara elsevierViewall">Serological evidence of past HBV infection before treatment (presence in serum of antibodies against the hepatitis B core antigen [antiHBc] and absence of HBsAg, with presence or absence of hepatitis B surface antibody [antiHBs])<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a></p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0030" class="elsevierStylePara elsevierViewall">At least one assessment of HBV DNA during biologic therapy</p></li></ul></p><p id="par0035" class="elsevierStylePara elsevierViewall">Reactivation of HBV was defined as detection of HBV DNA in blood<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>conversion to HBsAg+.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Hepatitis was defined as alanine aminotransferase (ALT) elevation to 5 times the upper limit of normal.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">8</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Demographic variables (sex), personal history, type of psoriasis, hepatotoxic and/or concomitant immunosuppressive therapies, and type and duration of biologic therapy received (adalimumab [ADA], etanercept [ETA], efalizumab [EFA], infliximab [IFX], and ustekinumab) were extracted retrospectively from the patients’ medical records. In addition, we also extracted laboratory data (ALT, antiHBc, antiHBs, HBsAg, HVB viral load) to determine serological status at the start of treatment, during treatment at various intervals, and at the end of treatment.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The confidence intervals for the incidence of reactivations in the absence of events were calculated using the rule of three, according to the method described by Hanly et al.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">Of the 1030 patients with psoriasis treated with biologic agents included in the BIOBADADERM registry up until October 2013, 20 met the aforementioned inclusion criteria (5 women and 15 men). A further 24 patients who had psoriasis treated with a biologic agent with serology findings indicative of past HBV infection were identified but not included in this study as no information was available on viral load (viral reactivation could not be ruled out). These patients did not, however, have any clinical manifestations of hepatitis.</p><p id="par0060" class="elsevierStylePara elsevierViewall">All patients were antiHBc+ and no patient was a carrier of HBsAg at the start of treatment. The median duration of follow-up was 40 months (9-84 months). Patients received a mean of 2 biologic treatments. Thirteen patients received ADA, 14 ETA, 7 IFX, 6 UST, and 1 EFA. The median duration of treatment was 13 months for ADA, 16 months for ETA, 22 months for IFX, 3 months for EFA, and 18 months for ustekinumab. At the end of treatment, no patient had converted to HBsAg+. Of the 13 patients who were antiHBs+ at the start of treatment, 2 had converted to antiHBs- at the end of treatment. Three patients who were antiHBs– at the start of treatment had positive serological titers at the end of treatment. Transaminase levels remained within normal range at the start and end of treatment in all patients. The median number of serological assessments during follow-up was 5. All patients had information on viral load available at the end of treatment and in all cases, the virus was undetectable. The initial viral load was measured in only 7 patients, and the virus was undetectable in all of them (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). No patient received prophylaxis for hepatitis B during therapy. Reactivation according to the definition given above of hepatitis B was not detected in any patients. The risk of HBV reactivation during the study was 0% (95% confidence interval, 0%-14%).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0065" class="elsevierStylePara elsevierViewall">Currently guidelines for the management of psoriasis list hepatitis B infection as a relative contraindication for the use of anti-TNF agents.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a> They recommend that seropositive patients for HBsAg are treated with antiviral therapy before starting treatment. In addition, close monitoring of hepatic function and viral load is recommended in patients with serology suggestive of HBV infection, given that increased viral load is usually the first event in the reactivation process, before increased transaminases and seroconversion.<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">3,11</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Anti-TNF drugs are a risk factor for reactivation of hepatitis B, as TNF appears to inhibit viral replication and stimulate T lymphocte cytotoxic response.<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a> Most cases of HBV reactivation with use of anti-TNF agents have been reported in patients affected by diseases other than psoriasis (inflammatory bowel disease and rheumatic diseases). In the review published by Pérez-Álvarez et al.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a> in 2011 (168 patients with past hepatitis B in treatment with anti-TNF agents), the risk of reactivation is reported as 5%, with a mortality rate in these cases of 11%. Lee et al.<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">14</span></a> published a meta-analysis of 468 antiHBc+<span class="elsevierStyleHsp" style=""></span>and HBsAg+<span class="elsevierStyleHsp" style=""></span>patients from 9 different studies. The authors found 8 cases of HBV reactivation (1.7%) and in 7 of these HBV DNA was detected.</p><p id="par0075" class="elsevierStylePara elsevierViewall">However, the experience in psoriasis is much less extensive, with reports only of sporadic cases or small series, and most reactivations occurred in chronic HBV carriers (HBsAg+).<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">15–22</span></a> These patients constitute the group with highest risk of reactivation (20%-50%), and HBV prophylaxis is mandatory.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">23</span></a> In past infection (antiHBc+<span class="elsevierStyleHsp" style=""></span>with HBsAg–), reactivation is rare, although the risk can increase by up to 10% when antiHBs status is lost over time.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">23</span></a> In our study, 2 patients lost antiHBs status, but HBV reactivation did not occur. We have only found 4 studies of patients with psoriasis treated with anti-TNF agents and past hepatitis B (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">17,19,24,25</span></a> As in our series of cases, no hepatitis reactivation was observed with the use of anti-TNF agents.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The relationship between HBV and ustekinumab is less well known. It has been suggested that IL12 could be necessary to maintain control over viral replication, promoting Th-1 response, and stimulating interferon gamma production.<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">26</span></a> Recently, an isolated case of hepatitis B reactivation was reported in an antiHBc+ and HBsAg– patient in treatment with ustekinumab for psoriasis.<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">27</span></a> We have only found 2 studies in patients with hepatitis B and psoriasis treated with ustekinumab. Navarro et al.<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">22</span></a> described 5 chronic HBsAg carriers in whom HBV reactivation did not occur with associated antiviral treatment. Chui et al.<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">28</span></a> reported 14 patients treated with ustekinumab, and of these, 3 had past hepatitis B. None of these patients received antiviral prophylaxis and there were no reactivations. The 11 remaining patients were chronic carriers of the virus. Seven had not received any antiviral prophylaxis and 2 experienced hepatitis B reactivation.</p><p id="par0085" class="elsevierStylePara elsevierViewall">From the above, 2 main conclusions can be drawn: the first is that the risk of reactivation depends on serological status, as this reflects the immune control of infection and therefore the risk of reactivation. In chronic HBV carriers (HBsAg+), antiviral prophylaxis is recommended due to the high risk of reactivation. In contrast, this risk is lower in patients with past hepatitis B (HBsAg– with antiHBc+). Thus, in clinical practice, the treating physician does not routinely request viral load assessments during follow-up (in our study, such assessments had been requested in 45% of the patients). However, it would be advisable in these patients with HBV+ serology to have an assessment of viral load before starting biologic therapy to rule out occult carriers, which would be an exceptional though possible occurrence. A study of patients with rheumatoid arthritis treated with anti-TNF agents found 4 patients positive for viral DNA among 12 patients with serology consistent with past hepatitis B (antiHBc+, antiHBs–, and HBsAg–).<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">29</span></a> One of these had HBV reactivation. The authors also found that the risk of reactivation depended on the disease for which the biologic therapy had been indicated. The reason could potentially be related to the concomitant treatment associated with the biologic agent. Concomitant use of immunosuppressants such as methotrexate, azathioprine, and oral corticosteroids is more frequent in rheumatic diseases and inflammatory bowel disease than in psoriasis. In fact, Loras et al.<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">30</span></a> found that the only risk factor for reactivation of hepatitis B in a multivariate analysis was association of 2 or more immunosuppressive agents. Of note, however, is a prospective study published recently with 42 patients with rheumatoid arthritis and past hepatitis B.<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">31</span></a> No cases of viral reactivation were detected despite therapy with anti-TNFα agents and disease-modifying agents.</p><p id="par0090" class="elsevierStylePara elsevierViewall">In our series (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>20), in which no reactivation was reported, the maximum risk of hepatitis B reactivation was 14%, according to the rule of three. According to the authors who reported the method, and on this point we fully agree, the absence of events in a study does not imply that it is impossible for an event to occur. They therefore propose a change of approach in the interpretation of these types of findings, and suggest considering the maximum risk of the event according to the sample size of the study instead focusing on the lack of an event. The maximum risk in our study (14%) is probably an overestimate because the number of patients in our cohort is small. In addition, the observational nature of the study excludes patients who have not undergone any assessment of viral load and these patients probably are at lower risk of reactivation. If we add our cases to those published (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>), in which there were also no cases of reactivation, the sample size is 112. With this number, the maximum estimated risk of hepatitis B reactivation is 2.7 cases per 100 patients with psoriasis and past hepatitis B who receive treatment with biologic agents, without antiviral prophylaxis, and with a mean follow-up of approximately 30 months.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Special mention should be made of patients with serology consistent with past hepatitis B and antiHBs–, in whom it would be advisable to rule out occult carriers (with a higher risk of reactivation and in whom antiviral prophylaxis is recommended, as in chronic carriers) by requesting viral DNA before starting biologic therapy (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">14,28,29</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">The importance of HBV reactivation lies in the fact that it is a preventable event and so the risk of developing a potentially serious or even fatal case of acute hepatitis can be avoided. Close follow-up is recommended in patients with HBV+ serology, and a hepatologist should assess the risk of viral reactivation in these patients before initiating biologic therapy.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Ethical Responsibilities</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Protection of human and animal subjects</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Confidentiality of data</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors declare that they have followed their hospital's protocol on the publication of data concerning patients.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Right to privacy and informed consent</span><p id="par0115" class="elsevierStylePara elsevierViewall">The authors obtained the informed consent of patients and/or subjects mentioned in this article. The informed consent form is located in the archives of the corresponding author.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Funding</span><p id="par0120" class="elsevierStylePara elsevierViewall">BIOBADADERM receives funding from the Spanish Academy of Dermatology and Venereology, the Spanish Medicines and Health Products Agency, and the pharmaceutical industry (Abbott, Merck-Schering Plough, Pfizer-Wyeth). The collaborating companies provide similar amounts of funding and do not participate in the analysis or interpretation of the results.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of Interest</span><p id="par0125" class="elsevierStylePara elsevierViewall">Francisco Vanaclocha has given talks paid for by Abbott, Pfizer, MSD, and Janssen.</p><p id="par0130" class="elsevierStylePara elsevierViewall">Ignacio García-Doval has been paid travel expenses by Merck/Schering-Plough, Pfizer, and Janssen to attend congresses</p><p id="par0135" class="elsevierStylePara elsevierViewall">Gregorio Carretero has acted as a consultant and researcher for Abbott, Janssen-Cilag, MSD, and Pfizer, and has received fees from Abbott, Jannsen and Pfizer and equipment from MSD and Pfizer.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Esteban Daudén has carried out the following activities: advisory board member, consultant, grant recipient, research support, participation in clinical trials, and paid talks with Abbvie/Abbott, Amgen, Janssen-Cilag, Leo Pharma, Novartis, Pfizer, MSD-Schering-Plough, Celgene, and Lilly.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Diana Patricia Ruiz-Genao has been a speaker for by Abbott, Pfizer, MSD, and Janssen. M. Mercè Alsina-Gibert has participated as a consultant for Pfizer, Abbvie, Jannsen, and MSD.</p><p id="par0150" class="elsevierStylePara elsevierViewall">Beatriz Pérez-Zafrilla has given talks paid for by Pfizer and Wyeth.</p><p id="par0155" class="elsevierStylePara elsevierViewall">Raquel Rivera has participated as a consultant and researcher for Abbvie, Janssen, MSD, Pfizer-Wyeth, Celgene, Leo Pharma, and Novartis.</p><p id="par0160" class="elsevierStylePara elsevierViewall">The remaining authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres527248" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction and objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec547561" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres527249" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción y objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec547562" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and Methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:3 [ "identificador" => "sec0025" "titulo" => "Ethical Responsibilities" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Funding" ] 10 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflicts of Interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-11-12" "fechaAceptado" => "2015-01-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec547561" "palabras" => array:3 [ 0 => "Hepatitis B" 1 => "Psoriasis" 2 => "Biologic therapy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec547562" "palabras" => array:3 [ 0 => "Hepatitis B" 1 => "Psoriasis" 2 => "Terapia biológica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A 5% risk of reactivation of hepatitis B virus (HBV) infection has been reported in patients with diseases other than psoriasis treated with tumor necrosis factor inhibitors. The aim of this study was to investigate the risk of HBV reactivation in patients with a past history of HBV infection who were receiving biologic therapy for psoriasis.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This was a multicenter study of 20 patients with psoriasis who were treated with at least 1 biologic agent. All the patients had serologic evidence of past HBV infection (positive total hepatitis B core antibody and negative hepatitis B surface antibody). We analyzed the clinical, serological, and liver function variables recorded before, during, and at the end of follow-up. The viral load at the end of follow-up was also analyzed for all patients.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">None of the patients fulfilled the criteria for HBV reactivation at the end of a median follow-up period of 40 months. Combining our data with data from other studies of psoriasis patients with a past history of HBV infection who were treated with a biologic, we calculated a maximum estimated risk of HBV reactivation for a mean follow-up period of 30 months of 2.7 reactivations per 100 patients.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Biologic therapy did not cause HBV reactivation in our series of patients. Nonetheless, because of the potentially serious complications associated with HBV reactivation, it is important to measure viral load in patients with a history of HBV infection prior to initiation of biologic therapy to rule out occult carriage. These patients should also be monitored regularly in conjunction with a hepatologist.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction and objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se ha reportado un riesgo de reactivación de hepatitis B pasada de hasta el 5% en pacientes tratados con fármacos dirigidos contra el factor de necrosis tumoral para enfermedades distintas a la psoriasis. Nuestro objetivo es investigar el riesgo de reactivación del virus de la hepatitis B en pacientes con hepatitis B pasada y psoriasis tratada con biológicos.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio multicéntrico en el que se incluyeron 20 pacientes con serología sugestiva de hepatitis B pasada (antiHBc+, antígeno HBs–) y diagnóstico de psoriasis tratada con al menos un biológico. Se recogieron variables clínicas, serológicas y de función hepática antes, durante y al final del seguimiento. Se obtuvo una carga viral al final del seguimiento en todos los pacientes.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Ningún paciente mostró criterios de reactivación de hepatitis B al final del estudio, con una mediana de seguimiento de 40 meses. Sumando los datos de otras series publicadas de pacientes con psoriasis y hepatitis B pasada tratados con biológicos, el riesgo máximo sería de 2,7 reactivaciones por 100 pacientes tratados con un seguimiento medio de unos 30 meses.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">En nuestro estudio el tratamiento con biológicos no provocó ninguna reactivación de hepatitis B. Sin embargo, debido a las graves complicaciones asociadas a la misma, se aconseja descartar portadores ocultos en pacientes con hepatitis B pasada antes de iniciar tratamiento biológico (solicitando una carga viral al inicio del mismo), así como un seguimiento conjunto con un hepatólogo.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción y objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as: Sanz-Bueno J, Vanaclocha F, García-Doval I, Torrado R, Carretero G, Daudén E, et al. Riesgo de reactivación de hepatitis B pasada en pacientes con psoriasis tratados con biológicos. Análisis retrospectivo de 20 casos. Registro de BIOBADADERM. Actas Dermosifiliogr. 2015;106:477–482.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1424 "Ancho" => 1662 "Tamanyo" => 110821 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Algorithm for action for HBV+ patients who are to receive biologic therapy.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Baseline \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">End \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">AntiHBc+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 (100%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">HBsAg+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">DNA HVB+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%)<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">AntiHBs+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 (65%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (70%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ALT<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>upper limit \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab849463.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Viral load assessed in 7 of 20 patients.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Patient Serological Characteristics (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>20).</p>" ] ] 2 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Year \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No. of cases \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Prophylaxis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Median Follow-up, mo \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Nosotti et al.<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">17</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2010 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No reactivation \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Cassano et al.<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">19</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2011 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No reactivation \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Prignano et al.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">24</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2011 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No reactivation \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Navarro et al.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">25</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2014 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No reactivation \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Present series \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2014 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No reactivation \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab849462.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Reactivation of Hepatitis B in Patients With Past Hepatitis B (HBsAg–) and Psoriasis in Treatment With Anti-TNF Agents.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:31 [ 0 => array:3 [ "identificador" => "bib0160" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of hepatitis B in Europe and worldwide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.J. Alter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "2003" "volumen" => "39" "paginaInicial" => "S64" "paginaFinal" => "S69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14708680" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0165" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Declining prevalence of hepatitis B virus infection in Catalonia (Spain) 12 years after the introduction of universal vaccination" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Salleras" 1 => "A. Domínguez" 2 => "M. Bruguera" 3 => "P. Plans" 4 => "J. Costa" 5 => "N. Cardeñosa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.vaccine.2007.10.027" "Revista" => array:6 [ "tituloSerie" => "Vaccine" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "8726" "paginaFinal" => "8731" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18045753" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0170" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EASL clinical practice guidelines: Management of chronic hepatitis B virus infection" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "European Association For The Study Of The Liver" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2012.02.010" "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "2012" "volumen" => "57" "paginaInicial" => "167" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22436845" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0175" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis: Epidemiology, clinical features, and quality of life" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.G. Langley" 1 => "G.G. Krueger" 2 => "C.E. Griffiths" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2004.033217" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2005" "volumen" => "64 Suppl 2" "paginaInicial" => "ii18" "paginaFinal" => "ii23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15708928" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0180" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalencia de la psoriasis en España en la era de los agentes biológicos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Ferrándiz" 1 => "J.M. Carrascosa" 2 => "M. Toro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2013.12.008" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2014" "volumen" => "105" "paginaInicial" => "504" "paginaFinal" => "509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24569109" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0185" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of treatment with tumour necrosis factor-alpha antagonists on the course of chronic viral infections: A review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Domm" 1 => "J. Cinatl" 2 => "U. Mrowietz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08851.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "159" "paginaInicial" => "1217" "paginaFinal" => "1228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18945310" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0190" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "BIOBADADERM, the Spanish registry of adverse events associated with biologic drugs in dermatology: First report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Rivera" 1 => "I. García-Doval" 2 => "G. Carretero" 3 => "E. Daudén" 4 => "J. Sánchez-Carazo" 5 => "C. Ferrándiz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2010.10.016" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2011" "volumen" => "102" "paginaInicial" => "132" "paginaFinal" => "141" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21377137" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0195" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spontaneous hepatitis B e antigen to antibody seroconversion and reversion in Chinese patients with chronic hepatitis B virus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.S. Lok" 1 => "C.L. Lai" 2 => "P.C. Wu" 3 => "E.K. Leung" 4 => "T.S. Lam" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "1987" "volumen" => "92" "paginaInicial" => "1839" "paginaFinal" => "1843" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3569757" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0200" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "If nothing goes wrong, is everything all right? Interpreting zero numerators" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Hanley" 1 => "A. Lippman-Hand" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1983" "volumen" => "249" "paginaInicial" => "1743" "paginaFinal" => "1745" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6827763" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0205" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European S3-guidelines on the systemic treatment of psoriasis vulgaris" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Pathirana" 1 => "A. Nast" 2 => "A.D. Ormerod" 3 => "N. Reytan" 4 => "P. Saiag" 5 => "C.H. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Eur Acad DermatolVenereol" "fecha" => "2009" "volumen" => "23" "paginaInicial" => "1" "paginaFinal" => "70" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0210" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Consensus guidelines for the management of plaque psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Hsu" 1 => "K.A. Papp" 2 => "M.G. Lebwohl" 3 => "J. Bagel" 4 => "A. Blauvelt" 5 => "K.C. Duffin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archdermatol.2011.1410" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2012" "volumen" => "148" "paginaInicial" => "95" "paginaFinal" => "102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22250239" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0215" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of tumor necrosis factor-alpha inhibitors in patients with chronic hepatitis B infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.B. Carroll" 1 => "M.I. Bond" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.semarthrit.2007.10.011" "Revista" => array:6 [ "tituloSerie" => "Semin Arthritis Rheum" "fecha" => "2008" "volumen" => "38" "paginaInicial" => "208" "paginaFinal" => "217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18221983" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0220" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatitis B virus (HBV) reactivation in patients receiving tumor necrosis factor (TNF)-targeted therapy: Analysis of 257 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Pérez-Alvarez" 1 => "C. Díaz-Lagares" 2 => "F. García-Hernandez" 3 => "L. Lopez-Roses" 4 => "P. Brito-Zerón" 5 => "M. Pérez-de-Lis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "2011" "volumen" => "90" "paginaInicial" => "359" "paginaFinal" => "371" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0225" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatitis B virus (HBV) reactivation in rheumatic patients with hepatitis core antigen (HBV occult carriers) undergoing anti-tumor necrosis factor therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y.H. Lee" 1 => "S.C. Bae" 2 => "G.G. Song" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2013" "volumen" => "31" "paginaInicial" => "118" "paginaFinal" => "121" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24064025" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0230" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reactivation of hepatitis B treated with adefovir after infliximab administration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.H. Núñez-Rodríguez" 1 => "A. Santamaría-Martínez" 2 => "L. Mata-Román" 3 => "A. Caro-Patón" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2006" "volumen" => "126" "paginaInicial" => "558" "paginaFinal" => "559" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0235" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infliximab treatment for severe psoriasis in a patient with active hepatitis B virus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Conde-Taboada" 1 => "J.P. Muñoz" 2 => "L.C. Muñoz" 3 => "E. López-Bran" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2008.09.057" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2009" "volumen" => "60" "paginaInicial" => "1077" "paginaFinal" => "1080" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19467387" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0240" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety of antitumour necrosis factor-α therapy in psoriatic patients with hepatitis B virus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Nosotti" 1 => "F. Francesconi" 2 => "S. Izzi" 3 => "E. Berardesca" 4 => "A. Morrone" 5 => "C. Bonifati" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2010.09714.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2010" "volumen" => "162" "paginaInicial" => "1408" "paginaFinal" => "1410" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20184582" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0245" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of anti-tumor necrosis factor-α therapy in hepatitis B virus carriers with psoriasis or psoriatic arthritis: A case series in Taiwan" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y.T. Cho" 1 => "C.H. Chen" 2 => "H.Y. Chiu" 3 => "T.F. Tsai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1346-8138.2011.01434.x" "Revista" => array:6 [ "tituloSerie" => "J Dermatol" "fecha" => "2012" "volumen" => "39" "paginaInicial" => "269" "paginaFinal" => "273" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22077677" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0250" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-tumor necrosis factor treatment in occult hepatitis B virus infection: a retrospective analysis of 62 patients with psoriatic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Cassano" 1 => "V. Mastrandrea" 2 => "M. Principi" 3 => "F. Loconsole" 4 => "N. de Tullio" 5 => "A. di Leo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Regul Homeost Agents" "fecha" => "2011" "volumen" => "25" "paginaInicial" => "285" "paginaFinal" => "289" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21880218" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0255" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety of anti-tumour necrosis factor-alpha agents in psoriasis patients who were chronic hepatitis B carriers: A retrospective report of seven patients and brief review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Fotiadou" 1 => "E. Lazaridou" 2 => "D. Ioannides" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2010.03754.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2011" "volumen" => "25" "paginaInicial" => "471" "paginaFinal" => "474" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20561122" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0260" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatitis-B reactivation during treatment with tumor necrosis factor-α blocker adalimumab in a patient with psoriasis arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Kouba" 1 => "S.E. Rudolph" 2 => "P. Hrdlicka" 3 => "M.A. Zuber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-0031-1292885" "Revista" => array:6 [ "tituloSerie" => "Dtsch Med Wochenschr" "fecha" => "2012" "volumen" => "137" "paginaInicial" => "23" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22180279" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0265" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and effectiveness of ustekinumab and antitumour necrosis factor therapy in patients with psoriasis and chronic viral hepatitis B or C: A retrospective, multicentre study in a clinical setting" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Navarro" 1 => "E. Vilarrasa" 2 => "P. Herranz" 3 => "L. Puig" 4 => "X. Bordas" 5 => "J.M. Carrascosa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.12045" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2013" "volumen" => "168" "paginaInicial" => "609" "paginaFinal" => "616" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22985451" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0270" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis, hepatitis B, and the tumor necrosis factor-alpha inhibitory agents: A review and recommendations for management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Abramson" 1 => "A. Menter" 2 => "R. Perrillo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2012.04.036" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2012" "volumen" => "67" "paginaInicial" => "1349" "paginaFinal" => "1361" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22727462" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0275" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumour necrosis factor-α antagonists in patients with concurrent psoriasis and hepatitis B or hepatitis C: A retrospective analysis of 17 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Prignano" 1 => "F. Ricceri" 2 => "L. Pescitelli" 3 => "F. Zanieri" 4 => "T. Lotti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2010.10140.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2011" "volumen" => "164" "paginaInicial" => "645" "paginaFinal" => "647" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21375517" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0280" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome of patients with serology suggestive of past hepatitis B virus infection during antitumor necrosis factor therapy for psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Navarro" 1 => "M.J. Concha-Garzón" 2 => "C. Castaño" 3 => "C. Casal" 4 => "A. Guiu" 5 => "E. Daudén" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ijd.12313" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2014" "volumen" => "53" "paginaInicial" => "909" "paginaFinal" => "911" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24673290" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0285" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum levels of interleukin-12 in various clinical states with hepatitis B virus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. He" 1 => "G. Yan" 2 => "Y. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cellimm.2011.10.016" "Revista" => array:6 [ "tituloSerie" => "Cell Immunol" "fecha" => "2012" "volumen" => "272" "paginaInicial" => "162" "paginaFinal" => "165" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22112982" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0290" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatitis B virus reactivation during therapy with ustekinumab for psoriasis in a hepatitis B surface-antigen-negative anti-HBs-positive patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Koskinas" 1 => "M. Tampaki" 2 => "P.P. Doumba" 3 => "E. Rallis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.12120" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2013" "volumen" => "168" "paginaInicial" => "679" "paginaFinal" => "680" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23121260" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0295" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The safety profile of ustekinumab in the treatment of patients with psoriasis and concurrent hepatitis B or C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.Y. Chiu" 1 => "C.H. Chen" 2 => "M.S. Wu" 3 => "Y.P. Cheng" 4 => "T.F. Tsai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.12461" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2013" "volumen" => "169" "paginaInicial" => "1295" "paginaFinal" => "1303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23746170" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0300" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Kinetics of viral loads and risk of hepatitis B virus reactivation in hepatitis B core antibody-positive rheumatoid arthritis patients undergoing anti-tumour necrosis factor alpha therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.3 Lan" 1 => "Y.M. Chen" 2 => "T.Y. Hsieh" 3 => "Y.H. Chen" 4 => "C.W. Hsieh" 5 => "D.Y. Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2010.148783" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2011" "volumen" => "70" "paginaInicial" => "1719" "paginaFinal" => "1725" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21719446" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0305" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Liver dysfunction related to hepatitis B and C in patients with inflammatory bowel disease treated with immunosuppressive therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Loras" 1 => "J.P. Gisbert" 2 => "M. Mínguez" 3 => "O. Merino" 4 => "L. Bujanda" 5 => "C. Saro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/gut.2010.208413" "Revista" => array:6 [ "tituloSerie" => "Gut" "fecha" => "2010" "volumen" => "59" "paginaInicial" => "1340" "paginaFinal" => "1346" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20577000" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0310" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy: Evaluation of both HBsAg-positive and HBsAg-negative cohorts" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Tamori" 1 => "T. Koike" 2 => "H. Goto" 3 => "S. Wakitani" 4 => "M. Tada" 5 => "H. Morikawa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00535-010-0367-5" "Revista" => array:6 [ "tituloSerie" => "J Gastroenterol" "fecha" => "2011" "volumen" => "46" "paginaInicial" => "556" "paginaFinal" => "564" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21246383" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010600000006/v1_201506260207/S1578219015001535/v1_201506260207/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000006/v1_201506260207/S1578219015001535/v1_201506260207/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015001535?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 8 | 9 | 17 |
| 2024 Octubre | 91 | 36 | 127 |
| 2024 Septiembre | 119 | 27 | 146 |
| 2024 Agosto | 149 | 68 | 217 |
| 2024 Julio | 145 | 35 | 180 |
| 2024 Junio | 129 | 30 | 159 |
| 2024 Mayo | 116 | 44 | 160 |
| 2024 Abril | 96 | 17 | 113 |
| 2024 Marzo | 85 | 36 | 121 |
| 2024 Febrero | 104 | 36 | 140 |
| 2024 Enero | 77 | 33 | 110 |
| 2023 Diciembre | 71 | 27 | 98 |
| 2023 Noviembre | 87 | 28 | 115 |
| 2023 Octubre | 82 | 37 | 119 |
| 2023 Septiembre | 71 | 36 | 107 |
| 2023 Agosto | 52 | 17 | 69 |
| 2023 Julio | 109 | 38 | 147 |
| 2023 Junio | 64 | 27 | 91 |
| 2023 Mayo | 99 | 24 | 123 |
| 2023 Abril | 57 | 16 | 73 |
| 2023 Marzo | 74 | 27 | 101 |
| 2023 Febrero | 67 | 27 | 94 |
| 2023 Enero | 45 | 20 | 65 |
| 2022 Diciembre | 79 | 42 | 121 |
| 2022 Noviembre | 59 | 24 | 83 |
| 2022 Octubre | 21 | 22 | 43 |
| 2022 Septiembre | 19 | 38 | 57 |
| 2022 Agosto | 31 | 41 | 72 |
| 2022 Julio | 21 | 34 | 55 |
| 2022 Junio | 16 | 24 | 40 |
| 2022 Mayo | 49 | 52 | 101 |
| 2022 Abril | 64 | 36 | 100 |
| 2022 Marzo | 69 | 55 | 124 |
| 2022 Febrero | 47 | 39 | 86 |
| 2022 Enero | 58 | 40 | 98 |
| 2021 Diciembre | 28 | 41 | 69 |
| 2021 Noviembre | 45 | 54 | 99 |
| 2021 Octubre | 59 | 61 | 120 |
| 2021 Septiembre | 46 | 47 | 93 |
| 2021 Agosto | 49 | 22 | 71 |
| 2021 Julio | 61 | 36 | 97 |
| 2021 Junio | 75 | 34 | 109 |
| 2021 Mayo | 44 | 26 | 70 |
| 2021 Abril | 76 | 79 | 155 |
| 2021 Marzo | 71 | 13 | 84 |
| 2021 Febrero | 51 | 31 | 82 |
| 2021 Enero | 44 | 25 | 69 |
| 2020 Diciembre | 64 | 26 | 90 |
| 2020 Noviembre | 26 | 23 | 49 |
| 2020 Octubre | 19 | 13 | 32 |
| 2020 Septiembre | 30 | 19 | 49 |
| 2020 Agosto | 28 | 20 | 48 |
| 2020 Julio | 35 | 17 | 52 |
| 2020 Junio | 45 | 37 | 82 |
| 2020 Mayo | 34 | 21 | 55 |
| 2020 Abril | 56 | 26 | 82 |
| 2020 Marzo | 31 | 22 | 53 |
| 2020 Febrero | 5 | 9 | 14 |
| 2020 Enero | 0 | 3 | 3 |
| 2019 Diciembre | 2 | 2 | 4 |
| 2019 Septiembre | 4 | 1 | 5 |
| 2019 Agosto | 0 | 5 | 5 |
| 2019 Julio | 0 | 6 | 6 |
| 2019 Junio | 2 | 14 | 16 |
| 2019 Mayo | 3 | 18 | 21 |
| 2019 Abril | 0 | 14 | 14 |
| 2019 Marzo | 2 | 4 | 6 |
| 2019 Enero | 2 | 4 | 6 |
| 2018 Diciembre | 2 | 0 | 2 |
| 2018 Noviembre | 2 | 0 | 2 |
| 2018 Octubre | 2 | 0 | 2 |
| 2018 Septiembre | 4 | 0 | 4 |
| 2018 Agosto | 0 | 1 | 1 |
| 2018 Julio | 0 | 2 | 2 |
| 2018 Junio | 0 | 1 | 1 |
| 2018 Mayo | 0 | 8 | 8 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 27 | 8 | 35 |
| 2018 Enero | 35 | 10 | 45 |
| 2017 Diciembre | 31 | 13 | 44 |
| 2017 Noviembre | 28 | 8 | 36 |
| 2017 Octubre | 41 | 11 | 52 |
| 2017 Septiembre | 18 | 17 | 35 |
| 2017 Agosto | 19 | 8 | 27 |
| 2017 Julio | 19 | 11 | 30 |
| 2017 Junio | 34 | 21 | 55 |
| 2017 Mayo | 33 | 19 | 52 |
| 2017 Abril | 20 | 30 | 50 |
| 2017 Marzo | 9 | 37 | 46 |
| 2017 Febrero | 17 | 9 | 26 |
| 2017 Enero | 26 | 14 | 40 |
| 2016 Diciembre | 38 | 16 | 54 |
| 2016 Noviembre | 36 | 30 | 66 |
| 2016 Octubre | 26 | 32 | 58 |
| 2016 Septiembre | 0 | 6 | 6 |
| 2016 Agosto | 0 | 9 | 9 |
| 2016 Julio | 7 | 1 | 8 |
| 2016 Junio | 11 | 5 | 16 |
| 2016 Mayo | 10 | 7 | 17 |
| 2016 Abril | 1 | 4 | 5 |
| 2016 Marzo | 11 | 7 | 18 |
| 2016 Febrero | 11 | 6 | 17 |
| 2016 Enero | 3 | 13 | 16 |
| 2015 Diciembre | 2 | 4 | 6 |
| 2015 Octubre | 0 | 7 | 7 |
| 2015 Septiembre | 0 | 9 | 9 |
| 2015 Agosto | 0 | 12 | 12 |
| 2015 Julio | 1 | 3 | 4 |
Mostrar todo
