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González-Ramos, M.L. Alonso-Pacheco, A. Mayor-Ibarguren, P. Herranz-Pinto" "autores" => array:4 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "González-Ramos" "email" => array:1 [ 0 => "gnzalezramosjessica@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M.L." "apellidos" => "Alonso-Pacheco" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Mayor-Ibarguren" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Herranz-Pinto" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Linfoma gástrico de tejido linfoide asociado a mucosa en un paciente con psoriasis grave en tratamiento con ustekinumab" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Ustekinumab is a human monoclonal antibody directed against interleukins (IL) 12 and 23, which are involved in the control of infections and tumors and the pathogenesis of psoriasis. Animal model studies have shown that inhibition of IL-12 and IL-23 might promote carcinogenesis.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Biologic therapies are considered to be both safe and well tolerated, but there is concern about their carcinogenic potential. There have been several reports of lymphoproliferative disorders developing in patients under treatment with tumor necrosis factor (TNF) inhibitors.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2–4</span></a> We present the case of a 68-year-old man with a history of hypertension, type 2 diabetes mellitus, hypertriglyceridemia, overweight, and ischemic heart disease diagnosed with plaque psoriasis 13 years earlier. Given the severity of his psoriasis, the patient was administered psoralen plus UV-A therapy and methotrexate 15<span class="elsevierStyleHsp" style=""></span>mg/wk for a year; the treatment showed moderate effectiveness, and rapid recurrence was observed following discontinuation of treatment. In May 2008, the patient was started on concomitant efalizumab and methotrexate (7.5<span class="elsevierStyleHsp" style=""></span>mg/wk) therapy, which was continued with satisfactory results until efalizumab was withdrawn from the market in 2009. In March 2010, the patient experienced a relapse and was administered ustekinumab, which achieved adequate control of his psoriasis.</p><p id="par0015" class="elsevierStylePara elsevierViewall">In November 2012, the patient was seen at the emergency department of our hospital with complaints of melena and upper abdominal pain. A gastroscopy revealed a gastric tumor with signs of malignancy. The tumor, however, was studied and monitored at another hospital “resultando infructuoso el intento de recuperar las muestras histologicas”. The results showed a dense infiltrate composed of atypical lymphocytes without identifiable clusters of nodes. In the immunohistochemical study, the cells were positive for CD20 and BCL2, and negative for CD10, CD30, cyclin D1, and CD5. The use of appropriate histological stains did not identify <span class="elsevierStyleItalic">Helicobacter pylori</span> or other microorganisms. A diagnosis of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma was established, with no metastases identified by positron electron tomography/computed tomography. The patient underwent 19 sessions of radiation therapy, which resulted in complete remission according to a report dated April 2013, which is when he came for a follow-up visit at our hospital. On examination of this and other reports on the tumor, it was decided to discontinue treatment with ustekinumab. The patient's psoriasis, however, was kept under control with topical treatment, which resulted in almost complete whitening of the lesions. Nevertheless, in August 2013, the patient died suddenly of cerebral infarction.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The risk of malignancy in patients with psoriasis is a hotly debated topic. Some authors have postulated that the risk might be higher than in the general population, even in the absence of treatment, due to the underlying chronic inflammation associated with psoriasis, particularly in patients with comorbidities.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">There is also controversy surrounding the risk of lymphomas in patients with psoriasis. It has been postulated that this potentially increased risk might be related to both the pathophysiology of psoriasis and the use of immunosuppressant therapy in this setting.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">There have been isolated reports of lymphomas developing in patients treated with a biologic,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> and even of regression following withdrawal of the drug, pointing to a possible causal relationship.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The development of lymphomas in patients treated with ustekinumab is rare. Data from landmark trials and a recent study of the safety of ustekinumab in psoriasis over a 5-year follow-up period showed that the risk of malignancy per 9000 patient-years was similar to that seen in the general population, with just 1 patient presenting a possible Hodgkin lymphoma.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In our review of the literature, we found just 2 cases of MALT lymphoma that developed during infliximab therapy.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8,9</span></a> Both patients had <span class="elsevierStyleItalic">H pylori</span> infection. Lymphoma remission was observed in the 2 cases following interruption of the biologic and administration of <span class="elsevierStyleItalic">H pylori</span> eradication therapy (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The authors of both reports speculated that the TNF inhibitor might have acted by promoting <span class="elsevierStyleItalic">H pylori</span> infection and/or by directly inducing the lymphoproliferative process. They also did not rule out that previous immunosuppressant therapy or the patients’ underlying diseases may have had a carcinogenic role.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">MALT lymphoma is a B-cell non-Hodgkin lymphoma. It is usually low-grade and located in the gastrointestinal tract. Ninety percent of patients with gastric MALT lymphoma have concomitant <span class="elsevierStyleItalic">H pylori</span> infection. <span class="elsevierStyleItalic">H pylori</span> eradication therapy achieves remission in 80% of low-grade lymphomas and in just 50% of high-grade lymphomas. This remission is maintained for many years following the eradication of infection. Recurrence, however, is observed in 10% of cases, hence the need for lifetime endoscopic follow-up. Radiation therapy is the next best option for patients who do not respond to eradication therapy.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion, we have presented the third case of a patient who developed gastric MALT lymphoma during biologic therapy and the first case involving a patient treated with ustekinumab.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8,9</span></a> We cannot, however, rule out that the lymphoma may have been triggered by the patient's chronic inflammatory state induced by psoriasis, or by previous use of immunosuppressant therapy. It is, of course, also possible that the association was merely coincidential. We stress the importance of treatment discontinuation in patients like ours who develop a lymphoma during biologic therapy.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: González-Ramos J, Alonso-Pacheco M, Mayor-Ibarguren A, Herranz-Pinto P. Linfoma gástrico de tejido linfoide asociado a mucosa en un paciente con psoriasis grave en tratamiento con ustekinumab. Actas Dermosifiliogr. 2015;106:326–327.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: F, female; <span class="elsevierStyleItalic">Hp</span>, <span class="elsevierStyleItalic">Helicobacter pylori;</span> IS, immunosuppressant; M, male; PUVA, psoralen plus UV-A therapy; RA, rheumatoid arthritis.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Reference \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex/Age, y \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Disease \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Previous IS Therapy \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Current Treatment \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Latency, mo \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">MALT Lymphoma \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Management \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Response, mo \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Thonhofer et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F/64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">RA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MethotrexateSulfasalazine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">InfliximabMethotrexate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Paranasal sinus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Interruption of infliximab and methotrexateEradication <span class="elsevierStyleItalic">Hp</span> therapy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Complete, 3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Girard et al.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M/50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Psoriasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">PUVACiclosporinMethotrexateEtanerceptEfalizumab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Infliximab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Stomach \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Interruption of infliximabEradication <span class="elsevierStyleItalic">Hp</span> therapyMethotrexate (psoriasis) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Partial, 1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Current case \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M/68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Psoriasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">PUVAMethotrexateEfalizumab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Ustekinumab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Stomach \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Radition therapyInterruption of ustekinumab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Complete, 4 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab785726.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in Patients Receiving Biologic Therapy.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => 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año/Mes | Html | Total | |
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2024 Noviembre | 5 | 7 | 12 |
2024 Octubre | 66 | 40 | 106 |
2024 Septiembre | 94 | 29 | 123 |
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2024 Marzo | 77 | 29 | 106 |
2024 Febrero | 63 | 34 | 97 |
2024 Enero | 52 | 30 | 82 |
2023 Diciembre | 55 | 14 | 69 |
2023 Noviembre | 60 | 26 | 86 |
2023 Octubre | 60 | 20 | 80 |
2023 Septiembre | 69 | 31 | 100 |
2023 Agosto | 42 | 20 | 62 |
2023 Julio | 58 | 40 | 98 |
2023 Junio | 40 | 22 | 62 |
2023 Mayo | 37 | 22 | 59 |
2023 Abril | 42 | 20 | 62 |
2023 Marzo | 49 | 17 | 66 |
2023 Febrero | 45 | 22 | 67 |
2023 Enero | 45 | 37 | 82 |
2022 Diciembre | 54 | 31 | 85 |
2022 Noviembre | 24 | 34 | 58 |
2022 Octubre | 24 | 28 | 52 |
2022 Septiembre | 17 | 45 | 62 |
2022 Agosto | 34 | 39 | 73 |
2022 Julio | 19 | 33 | 52 |
2022 Junio | 18 | 20 | 38 |
2022 Mayo | 30 | 34 | 64 |
2022 Abril | 46 | 32 | 78 |
2022 Marzo | 49 | 51 | 100 |
2022 Febrero | 23 | 30 | 53 |
2022 Enero | 38 | 36 | 74 |
2021 Diciembre | 43 | 29 | 72 |
2021 Noviembre | 42 | 46 | 88 |
2021 Octubre | 32 | 50 | 82 |
2021 Septiembre | 38 | 33 | 71 |
2021 Agosto | 23 | 36 | 59 |
2021 Julio | 29 | 28 | 57 |
2021 Junio | 22 | 20 | 42 |
2021 Mayo | 19 | 15 | 34 |
2021 Abril | 45 | 55 | 100 |
2021 Marzo | 44 | 20 | 64 |
2021 Febrero | 55 | 31 | 86 |
2021 Enero | 28 | 20 | 48 |
2020 Diciembre | 32 | 21 | 53 |
2020 Noviembre | 31 | 23 | 54 |
2020 Octubre | 10 | 7 | 17 |
2020 Septiembre | 33 | 5 | 38 |
2020 Agosto | 29 | 13 | 42 |
2020 Julio | 21 | 14 | 35 |
2020 Junio | 44 | 28 | 72 |
2020 Mayo | 34 | 29 | 63 |
2020 Abril | 61 | 28 | 89 |
2020 Marzo | 37 | 20 | 57 |
2020 Febrero | 9 | 8 | 17 |
2020 Enero | 4 | 12 | 16 |
2019 Diciembre | 6 | 6 | 12 |
2019 Noviembre | 4 | 2 | 6 |
2019 Octubre | 0 | 7 | 7 |
2019 Septiembre | 0 | 6 | 6 |
2019 Agosto | 6 | 6 | 12 |
2019 Julio | 4 | 8 | 12 |
2019 Junio | 4 | 2 | 6 |
2019 Mayo | 5 | 9 | 14 |
2019 Abril | 3 | 8 | 11 |
2019 Marzo | 2 | 8 | 10 |
2019 Febrero | 0 | 6 | 6 |
2019 Enero | 6 | 1 | 7 |
2018 Diciembre | 0 | 8 | 8 |
2018 Octubre | 4 | 0 | 4 |
2018 Septiembre | 3 | 2 | 5 |
2018 Agosto | 0 | 25 | 25 |
2018 Julio | 0 | 7 | 7 |
2018 Junio | 0 | 3 | 3 |
2018 Mayo | 0 | 6 | 6 |
2018 Abril | 0 | 3 | 3 |
2018 Marzo | 0 | 8 | 8 |
2018 Febrero | 14 | 6 | 20 |
2018 Enero | 26 | 9 | 35 |
2017 Diciembre | 33 | 6 | 39 |
2017 Noviembre | 30 | 17 | 47 |
2017 Octubre | 25 | 12 | 37 |
2017 Septiembre | 21 | 17 | 38 |
2017 Agosto | 17 | 9 | 26 |
2017 Julio | 24 | 12 | 36 |
2017 Junio | 36 | 17 | 53 |
2017 Mayo | 28 | 15 | 43 |
2017 Abril | 18 | 24 | 42 |
2017 Marzo | 10 | 10 | 20 |
2017 Febrero | 16 | 24 | 40 |
2017 Enero | 14 | 16 | 30 |
2016 Diciembre | 47 | 16 | 63 |
2016 Noviembre | 45 | 18 | 63 |
2016 Octubre | 29 | 11 | 40 |
2016 Septiembre | 0 | 5 | 5 |
2016 Agosto | 0 | 8 | 8 |
2016 Julio | 9 | 2 | 11 |
2016 Junio | 13 | 3 | 16 |
2016 Mayo | 11 | 1 | 12 |
2016 Abril | 12 | 1 | 13 |
2016 Marzo | 13 | 1 | 14 |
2016 Febrero | 9 | 3 | 12 |
2016 Enero | 1 | 6 | 7 |
2015 Diciembre | 10 | 0 | 10 |
2015 Noviembre | 8 | 1 | 9 |
2015 Octubre | 1 | 1 | 2 |
2015 Agosto | 0 | 2 | 2 |
2015 Julio | 10 | 1 | 11 |
2015 Junio | 7 | 2 | 9 |
2015 Mayo | 12 | 8 | 20 |