Resident's Forum
Dermatological Aspects of immunoglobulin G4 (IgG4)-Related Disease
RF-Perspectiva dermatológica de la enfermedad relacionada con la inmunoglobulina G4 (IgG4)
O. Yélamos
Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Leído
6068
Vecesse ha leído el artículo
2074
Total PDF
3994
Total HTML
Compartir estadísticas
array:25 [ "pii" => "S1578219015000232" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.01.010" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "1051" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2014" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2015;106:231-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1052 "formatos" => array:3 [ "EPUB" => 50 "HTML" => 542 "PDF" => 460 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731014004104" "issn" => "00017310" "doi" => "10.1016/j.ad.2014.08.007" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "1051" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2015;106:231-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1190 "formatos" => array:3 [ "EPUB" => 2 "HTML" => 545 "PDF" => 643 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Foro De Residentes</span>" "titulo" => "FR-Perspectiva dermatológica de la enfermedad relacionada con la inmunoglobulina G4 (IgG4)" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "231" "paginaFinal" => "232" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Dermatological Aspects of immunoglobulin G4 (IgG4)-Related Disease" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "O. Yélamos" "autores" => array:1 [ 0 => array:2 [ "nombre" => "O." "apellidos" => "Yélamos" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219015000232" "doi" => "10.1016/j.adengl.2015.01.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000232?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004104?idApp=UINPBA000044" "url" => "/00017310/0000010600000003/v3_202209240525/S0001731014004104/v3_202209240525/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S1578219015000244" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.01.011" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "1038" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2015;106:233-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1099 "formatos" => array:3 [ "EPUB" => 46 "HTML" => 638 "PDF" => 415 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Reconstruction of the Ala Nasi Using a Malar Turnover Island Pedicle Flap" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "233" "paginaFinal" => "235" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Reconstrucción del ala nasal mediante colgajo malar invertido de pedículo subcutáneo" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1473 "Ancho" => 2501 "Tamanyo" => 510335 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Outcome. A, Immediate outcome after suture of the flap. B, Outcome at 3 weeks after the intervention.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Godoy-Gijón, L. Palacio-Aller, M. González-Sabin" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Godoy-Gijón" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Palacio-Aller" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "González-Sabin" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731014003834" "doi" => "10.1016/j.ad.2014.07.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014003834?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000244?idApp=UINPBA000044" "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000244/v3_202209240641/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S1578219015000220" "issn" => "15782190" "doi" => "10.1016/j.adengl.2015.01.009" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "1005" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2015;106:229-30" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 869 "formatos" => array:3 [ "EPUB" => 53 "HTML" => 510 "PDF" => 306 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>" "titulo" => "Asymptomatic Nodule on the Leg" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "229" "paginaFinal" => "230" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nódulo asintomático en la pierna" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 751 "Ancho" => 1089 "Tamanyo" => 94314 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. González Fernández, B. Vivanco Allende, S. Gómez Díez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "González Fernández" ] 1 => array:2 [ "nombre" => "B." "apellidos" => "Vivanco Allende" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Gómez Díez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731014002129" "doi" => "10.1016/j.ad.2014.04.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014002129?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000220?idApp=UINPBA000044" "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000220/v3_202209240641/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Resident's Forum</span>" "titulo" => "Dermatological Aspects of immunoglobulin G4 (IgG4)-Related Disease" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "231" "paginaFinal" => "232" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "O. Yélamos" "autores" => array:1 [ 0 => array:3 [ "nombre" => "O." "apellidos" => "Yélamos" "email" => array:1 [ 0 => "oyelamos@santpau.cat" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "RF-Perspectiva dermatológica de la enfermedad relacionada con la inmunoglobulina G4 (IgG4)" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Immunoglobulin G4-related disease (IgG4-RD) is a systemic disease characterized by lymphoplasmacytic inflammation, fibrosis, and elevated levels of IgG4 in tissues and eventually in the blood. IgG4-RD is a recently described disease and encompasses classic entities such as Riedel's thyroiditis, Mikulicz syndrome, and Küttner's tumor.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> It is a rare disease that affects middle-aged men, especially Asians.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The etiology of IgG4-RD is poorly understood. Several potential triggers have been proposed, including genetic susceptibility, malignant tumors, and even some microorganisms such as <span class="elsevierStyleItalic">Helicobacter pylori</span>.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Pathophysiologically, an increase in the Th2 and Treg responses has been described. This induces the release of cytokines such as IL-10 and TGF-β, which are responsible for the inflammation and the fibrosis characteristic of this disease.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">IgG4-RD predominantly affects the pancreas, presenting with autoimmune pancreatitis, but can affect virtually every organ, including the salivary glands, the lacrimal glands, the orbits, the lungs, the kidneys, the liver, the thyroid, the hypophysis, the retroperitoneum, and the prostate.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Skin involvement is less common, and usually occurs after the onset of systemic symptoms. However, cutaneous involvement prior to the appearance of systemic symptoms has been described, as well as cases with exclusive involvement of the skin.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Cutaneous IgG4-RD presents with erythematous papules, plaques, and particularly nodules, predominantly located on the head and neck.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4,5</span></a> The differential diagnosis includes cutaneous lymphomas and pseudolymphomas, sarcoidosis, lupus, cutaneous metastases, and even deep skin infections such as syphilis and micobacteriosis.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Histologically, the lesions are characterized by an infiltrate rich in lymphocytes and plasma cells, storiform fibrosis, obliterative phlebitis, and less frequently an infiltrate with few eosinophils.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,4,5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Various diagnostic criteria for IgG4-RD have been proposed. These include the presence of compatible signs (mass or swelling in one or more organs) and a biopsy compatible with elevated levels of IgG4+ plasma cells (IgG4/IgG ratio <span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>40%;<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>10 IgG4+ cells per high-power field), associated with elevated serum levels of IgG4 (><span class="elsevierStyleHsp" style=""></span>135<span class="elsevierStyleHsp" style=""></span>mg/dL).<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> However, these criteria remain under discussion, as normal serum IgG4 levels can be found in patients with exclusive skin or single organ involvement.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> It is also important to note that an increase in serum IgG4 levels is not a pathognomonic finding in IgG4-RD as such increases have been described in other dermatoses such as pemphigus vulgaris, atopic dermatitis, some parasitic infections,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> and recently in marginal zone lymphomas.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">IgG4-RD has been treated using systemic corticosteroids, azathioprine, thalidomide, and even biologics such as rituximab and infliximab.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,3,4</span></a> The prognosis depends on the degree of dysfunction caused by the inflammation and fibrosis in the organs affected by the disease.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In summary, it is important that dermatologists consider IgG4-RD in patients presenting with a nodule or mass with an infiltrate rich in plasma cells. However, as IgG4-RD is a recently described and little-known disease, the diagnostic limitations should be borne in mind. Further characterization of this disease is necessary to establish definitive diagnostic criteria.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1558320" "palabras" => array:2 [ 0 => "Immunoglobulin G4 (IgG4)" 1 => "IgG4-related disease" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Yélamos O. RF-Perspectiva dermatológica de la enfermedad relacionada con la inmunoglobulina G4 (IgG4). Actas Dermosifiliogr. 2015;106:231–232.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IgG4-related disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.H. Stone" 1 => "Y. Zen" 2 => "V. Deshpande" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra1104650" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2012" "volumen" => "366" "paginaInicial" => "539" "paginaFinal" => "551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22316447" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Umehara" 1 => "K. Okazaki" 2 => "Y. Masaki" 3 => "M. Kawano" 4 => "M. Yamamoto" 5 => "T. Saeki" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10165-011-0571-z" "Revista" => array:6 [ "tituloSerie" => "Mod Rheumatol" "fecha" => "2012" "volumen" => "22" "paginaInicial" => "21" "paginaFinal" => "30" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22218969" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0045" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms and assessment of IgG4-related disease: Lessons for the rheumatologist" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Yamamoto" 1 => "H. Takahashi" 2 => "Y. Shinomura" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nat Rev Rheumatol" "fecha" => "2014" "volumen" => "10" "paginaInicial" => "148" "paginaFinal" => "159" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0050" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IgG4-related skin lesions: Case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Kempeneers" 1 => "E. Hauben" 2 => "P. de Haes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ced.12325" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2014" "volumen" => "39" "paginaInicial" => "479" "paginaFinal" => "483" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24758575" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of IgG4 in cutaneous pathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Fernandez-Flores" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rom J Morphol Embryol" "fecha" => "2012" "volumen" => "53" "paginaInicial" => "221" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22732790" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous marginal zone lymphomas with plasmacytic differentiation show frequent IgG4 expression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I. Brenner" 1 => "S. Roth" 2 => "B. Puppe" 3 => "M. Wobser" 4 => "A. Rosenwald" 5 => "E. Geissinger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/modpathol.2013.106" "Revista" => array:6 [ "tituloSerie" => "Mod Pathol" "fecha" => "2013" "volumen" => "26" "paginaInicial" => "1568" "paginaFinal" => "1576" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23765244" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000232/v3_202209240641/en/main.assets" "Apartado" => array:4 [ "identificador" => "34945" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Resident's Forum" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000003/v3_202209240641/S1578219015000232/v3_202209240641/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000232?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 12 | 7 | 19 |
| 2024 Octubre | 89 | 32 | 121 |
| 2024 Septiembre | 103 | 21 | 124 |
| 2024 Agosto | 112 | 69 | 181 |
| 2024 Julio | 108 | 34 | 142 |
| 2024 Junio | 89 | 20 | 109 |
| 2024 Mayo | 92 | 36 | 128 |
| 2024 Abril | 100 | 31 | 131 |
| 2024 Marzo | 70 | 28 | 98 |
| 2024 Febrero | 79 | 33 | 112 |
| 2024 Enero | 75 | 37 | 112 |
| 2023 Diciembre | 67 | 12 | 79 |
| 2023 Noviembre | 85 | 30 | 115 |
| 2023 Octubre | 93 | 22 | 115 |
| 2023 Septiembre | 95 | 30 | 125 |
| 2023 Agosto | 82 | 25 | 107 |
| 2023 Julio | 81 | 35 | 116 |
| 2023 Junio | 58 | 20 | 78 |
| 2023 Mayo | 78 | 25 | 103 |
| 2023 Abril | 78 | 30 | 108 |
| 2023 Marzo | 79 | 36 | 115 |
| 2023 Febrero | 70 | 19 | 89 |
| 2023 Enero | 45 | 31 | 76 |
| 2022 Diciembre | 53 | 32 | 85 |
| 2022 Noviembre | 26 | 26 | 52 |
| 2022 Octubre | 25 | 21 | 46 |
| 2022 Septiembre | 40 | 38 | 78 |
| 2022 Agosto | 41 | 32 | 73 |
| 2022 Julio | 21 | 26 | 47 |
| 2022 Junio | 18 | 23 | 41 |
| 2022 Mayo | 67 | 33 | 100 |
| 2022 Abril | 71 | 45 | 116 |
| 2022 Marzo | 91 | 47 | 138 |
| 2022 Febrero | 61 | 20 | 81 |
| 2022 Enero | 77 | 50 | 127 |
| 2021 Diciembre | 36 | 47 | 83 |
| 2021 Noviembre | 69 | 50 | 119 |
| 2021 Octubre | 74 | 51 | 125 |
| 2021 Septiembre | 72 | 36 | 108 |
| 2021 Agosto | 49 | 28 | 77 |
| 2021 Julio | 65 | 32 | 97 |
| 2021 Junio | 50 | 35 | 85 |
| 2021 Mayo | 44 | 20 | 64 |
| 2021 Abril | 94 | 53 | 147 |
| 2021 Marzo | 102 | 19 | 121 |
| 2021 Febrero | 72 | 20 | 92 |
| 2021 Enero | 42 | 16 | 58 |
| 2020 Diciembre | 30 | 15 | 45 |
| 2020 Noviembre | 24 | 15 | 39 |
| 2020 Octubre | 15 | 7 | 22 |
| 2020 Septiembre | 21 | 10 | 31 |
| 2020 Agosto | 14 | 23 | 37 |
| 2020 Julio | 30 | 10 | 40 |
| 2020 Junio | 31 | 27 | 58 |
| 2020 Mayo | 25 | 15 | 40 |
| 2020 Abril | 27 | 12 | 39 |
| 2020 Marzo | 33 | 17 | 50 |
| 2020 Febrero | 2 | 0 | 2 |
| 2020 Enero | 4 | 2 | 6 |
| 2019 Diciembre | 8 | 5 | 13 |
| 2019 Noviembre | 4 | 0 | 4 |
| 2019 Octubre | 0 | 5 | 5 |
| 2019 Septiembre | 4 | 1 | 5 |
| 2019 Agosto | 4 | 2 | 6 |
| 2019 Julio | 4 | 7 | 11 |
| 2019 Junio | 4 | 24 | 28 |
| 2019 Mayo | 6 | 34 | 40 |
| 2019 Abril | 2 | 7 | 9 |
| 2019 Marzo | 4 | 6 | 10 |
| 2019 Febrero | 4 | 2 | 6 |
| 2019 Enero | 4 | 0 | 4 |
| 2018 Diciembre | 2 | 0 | 2 |
| 2018 Noviembre | 5 | 0 | 5 |
| 2018 Octubre | 4 | 0 | 4 |
| 2018 Septiembre | 4 | 1 | 5 |
| 2018 Agosto | 0 | 4 | 4 |
| 2018 Julio | 0 | 5 | 5 |
| 2018 Junio | 0 | 1 | 1 |
| 2018 Mayo | 0 | 7 | 7 |
| 2018 Abril | 0 | 9 | 9 |
| 2018 Febrero | 29 | 3 | 32 |
| 2018 Enero | 37 | 10 | 47 |
| 2017 Diciembre | 33 | 9 | 42 |
| 2017 Noviembre | 19 | 8 | 27 |
| 2017 Octubre | 19 | 10 | 29 |
| 2017 Septiembre | 20 | 7 | 27 |
| 2017 Agosto | 16 | 7 | 23 |
| 2017 Julio | 7 | 11 | 18 |
| 2017 Junio | 30 | 19 | 49 |
| 2017 Mayo | 15 | 14 | 29 |
| 2017 Abril | 20 | 17 | 37 |
| 2017 Marzo | 16 | 16 | 32 |
| 2017 Febrero | 13 | 15 | 28 |
| 2017 Enero | 16 | 14 | 30 |
| 2016 Diciembre | 23 | 8 | 31 |
| 2016 Noviembre | 43 | 14 | 57 |
| 2016 Octubre | 28 | 15 | 43 |
| 2016 Septiembre | 0 | 10 | 10 |
| 2016 Agosto | 0 | 2 | 2 |
| 2016 Julio | 7 | 1 | 8 |
| 2016 Junio | 11 | 6 | 17 |
| 2016 Mayo | 9 | 19 | 28 |
| 2016 Abril | 11 | 30 | 41 |
| 2016 Marzo | 11 | 17 | 28 |
| 2016 Febrero | 8 | 1 | 9 |
| 2016 Enero | 5 | 13 | 18 |
| 2015 Diciembre | 6 | 7 | 13 |
| 2015 Noviembre | 5 | 1 | 6 |
| 2015 Octubre | 8 | 7 | 15 |
| 2015 Septiembre | 0 | 6 | 6 |
| 2015 Agosto | 0 | 1 | 1 |
| 2015 Julio | 6 | 2 | 8 |
| 2015 Junio | 2 | 2 | 4 |
| 2015 Mayo | 2 | 4 | 6 |
| 2015 Abril | 0 | 12 | 12 |
Mostrar todo
