CASE AND RESEARCH LETTER
Aprepitant in the Treatment of Refractory Pruritus Secondary to Cutaneous T-Cell Lymphoma
Tratamiento con aprepitant del prurito refractario secundario a linfoma cutáneo de células T
Leído
6189
Vecesse ha leído el artículo
1970
Total PDF
4219
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S1578219014001905" "issn" => "15782190" "doi" => "10.1016/j.adengl.2014.07.006" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "894" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2013" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2014;105:716-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1812 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 1357 "PDF" => 412 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731013003220" "issn" => "00017310" "doi" => "10.1016/j.ad.2013.07.007" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "894" "copyright" => "Elsevier España, S.L.U. y AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2014;105:716-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2632 "formatos" => array:3 [ "EPUB" => 2 "HTML" => 1699 "PDF" => 931 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => "Tratamiento con aprepitant del prurito refractario secundario a linfoma cutáneo de células T" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "716" "paginaFinal" => "718" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Aprepitant in the Treatment of Refractory Pruritus Secondary to Cutaneous T-Cell Lymphoma" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1111 "Ancho" => 1667 "Tamanyo" => 206668 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Placas y tumores en el tronco.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "H.A. Borja-Consigliere, A. López-Pestaña, M.J. Vidal-Manceñido, A. Tuneu-Valls" "autores" => array:4 [ 0 => array:2 [ "nombre" => "H.A." "apellidos" => "Borja-Consigliere" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "López-Pestaña" ] 2 => array:2 [ "nombre" => "M.J." "apellidos" => "Vidal-Manceñido" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Tuneu-Valls" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219014001905" "doi" => "10.1016/j.adengl.2014.07.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014001905?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013003220?idApp=UINPBA000044" "url" => "/00017310/0000010500000007/v2_201409200140/S0001731013003220/v2_201409200140/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219014001899" "issn" => "15782190" "doi" => "10.1016/j.adengl.2014.07.005" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "923" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2014;105:718-20" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1334 "formatos" => array:3 [ "EPUB" => 36 "HTML" => 870 "PDF" => 428 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Wooly Pattern as a Characteristic Ultrasound Finding in Angiolymphoid Hyperplasia With Eosinophilia" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "718" "paginaFinal" => "720" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Patrón en ovillo de lana como hallazgo ecográfico característico de hiperplasia angiolinfoide con eosinofilia" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 949 "Ancho" => 1344 "Tamanyo" => 347103 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, At low magnification, the superficial layers show no changes, and lymphocyte aggregates are seen in the deeper layers (hematoxylin-eosin, original magnification ×<span class="elsevierStyleHsp" style=""></span>25). B, Detail showing the presence of numerous eosinophils throughout the stroma (hematoxylin-eosin, original magnification ×<span class="elsevierStyleHsp" style=""></span>200).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Lorente-Luna, F. Alfageme-Roldán, D. Suárez-Massa, E. Jiménez-Blázquez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Lorente-Luna" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Alfageme-Roldán" ] 2 => array:2 [ "nombre" => "D." "apellidos" => "Suárez-Massa" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Jiménez-Blázquez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731013003839" "doi" => "10.1016/j.ad.2013.10.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013003839?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014001899?idApp=UINPBA000044" "url" => "/15782190/0000010500000007/v1_201408281012/S1578219014001899/v1_201408281012/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219014001966" "issn" => "15782190" "doi" => "10.1016/j.adengl.2014.07.012" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "902" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2014;105:714-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1434 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 1118 "PDF" => 278 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Cutaneous Leishmaniasis in a Patient Receiving Infliximab for Psoriatic Arthritis: Treatment with Cryotherapy and Intralesional Meglumine Antimonate" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "714" "paginaFinal" => "716" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Leishmaniasis cutánea en un paciente con artritis psoriásica tratado con infliximab: tratamiento con crioterapia y Glucantime® intralesional" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 712 "Ancho" => 951 "Tamanyo" => 293052 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histologic examination of a biopsy specimen from the edge of the ulcer showed a mixed inflammatory infiltrate with lymphocytes, histiocytes, and several macrophages with intracellular and extracellular amastigotes (red arrows) (hematoxylin-eosin, original magnification ×4).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Català, M.A. Barnadas, C. Muñoz, L. Puig" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Català" ] 1 => array:2 [ "nombre" => "M.A." "apellidos" => "Barnadas" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Muñoz" ] 3 => array:2 [ "nombre" => "L." "apellidos" => "Puig" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731013003566" "doi" => "10.1016/j.ad.2013.08.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013003566?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014001966?idApp=UINPBA000044" "url" => "/15782190/0000010500000007/v1_201408281012/S1578219014001966/v1_201408281012/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CASE AND RESEARCH LETTER</span>" "titulo" => "Aprepitant in the Treatment of Refractory Pruritus Secondary to Cutaneous T-Cell Lymphoma" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "716" "paginaFinal" => "718" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "H.A. Borja-Consigliere, A. López-Pestaña, M.J. Vidal-Manceñido, A. Tuneu-Valls" "autores" => array:4 [ 0 => array:4 [ "nombre" => "H.A." "apellidos" => "Borja-Consigliere" "email" => array:2 [ 0 => "hborja@uc.cl" 1 => "hernanborja@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "López-Pestaña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M.J." "apellidos" => "Vidal-Manceñido" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Tuneu-Valls" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Sección de Dermatología, Hospital Universitario Donostia, San Sebastián, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Hematología, Hospital Universitario Donostia, San Sebastián, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento con aprepitant del prurito refractario secundario a linfoma cutáneo de células T" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 622 "Ancho" => 1000 "Tamanyo" => 203063 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Acanthotic epidermis with an intense pagetoid infiltrate of lymphocytes with an atypical morphology (hematoxylin and eosin, original magnification ×<span class="elsevierStyleHsp" style=""></span>20).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Patients with cutaneous T-cell lymphoma frequently develop intense pruritus, which can often be refractory to anticancer and symptomatic treatments and can affect quality of life to a significant degree.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Aprepitant, an antiemetic that is a substance P antagonist, has been used successfully to manage refractory pruritus.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 61-year-old woman who was a smoker with a history of chronic obstructive pulmonary disease and who required home oxygen. In August 2011 she was seen for a 5-month history of skin lesions that she described as very itchy. The lesions, which were present on the head, trunk, and limbs, consisted of plaques and nodules with areas of necrosis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Biopsy revealed acanthosis and partial necrosis of the epidermis, which was infiltrated by lymphocytes with an atypical morphology and marked epidermotropism (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Immunohistochemistry was positive for CD3, CD7, CD8, TIA1, and Ki67 (50%) and negative for CD4, CD5, CD56, T-cell receptor β-F1, CD79a, and CD20, and Epstein-Barr virus RNA was not detected. Serology for Human T-Lymphotrophic Virus I/II and <span class="elsevierStyleItalic">Borrelia burgdorferi</span> was negative. The study of tumor spread was negative. Based on the above data, a diagnosis of aggressive primary cutaneous cytotoxic T-cell lymphoma was made. The patient received treatment with various chemotherapy protocols—cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP); bexarotene; gemcitabine plus oxaliplati; alemtuzumab; and cyclophosphamide, unpegylated liposomal adriamycin, vincristine, and prednisone (COMP)—without achieving control of disease progression or of the associated pruritus. She was administered symptomatic treatment for the pruritus with 0.1% triamcinolone acetonide cream once a day plus cetirizine 10<span class="elsevierStyleHsp" style=""></span>mg in the morning and dexchlorpheniramine 2<span class="elsevierStyleHsp" style=""></span>mg at night, with no improvement. This treatment was subsequently changed to 0.05% clobetasol cream once a day, plus bilastine 20<span class="elsevierStyleHsp" style=""></span>mg in the morning and dexchlorpheniramine 4<span class="elsevierStyleHsp" style=""></span>mg at night. Due to persistence of the pruritus (score of 10/10 on a verbal numerical scale), it was decided to prescribe aprepitant for off-label use. After using aprepitant for 3 consecutive days (125<span class="elsevierStyleHsp" style=""></span>mg on the first day and 80<span class="elsevierStyleHsp" style=""></span>mg on the second and third days)—there was a marked symptomatic improvement at each 2-weekly evaluation (score of 3/10 on the verbal numerical scale), and this led to a considerable improvement in the patient's quality of life until her death 13 months after diagnosis of the lymphoma.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Substance P is a potent inducer of pruritus. It activates the neurokinin-1 receptors present on keratinocytes and mast cells and also on the neurons of the sensory dorsal root ganglion. Aprepitant inhibits the effect of substance P by blocking the neurokinin receptors.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a> It acts by blocking signal conduction along peripheral nerve C fibers—inhibiting the release of nerve growth factor from keratinocytes—or by blocking signal transmission in the dorsal horn.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In 2009, Duval et al.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> reported 3 patients with pruritus secondary to Sézary syndrome in whom aprepitant was used at a dose of 80<span class="elsevierStyleHsp" style=""></span>mg/d continuously and led to successful control of the pruritus. Subsequently, Booken et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> published the cases of 5 patients with pruritus secondary to erythrodermic cutaneous T-cell lymphoma who were treated with aprepitant on a 3-day regimen (125<span class="elsevierStyleHsp" style=""></span>mg on day 1 and 80<span class="elsevierStyleHsp" style=""></span>mg on days 2 and<span class="elsevierStyleHsp" style=""></span>3) every 2 weeks, with improvement of the pruritus in 4 cases. Later, Torres et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> described 2 patients with pruritus secondary to Sézary syndrome; both responded well to aprepitant at a dose of 80<span class="elsevierStyleHsp" style=""></span>mg/d. Most recently, Ladizinski et al.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> were the first to report the efficacy of aprepitant in a patient with nonerythrodermic cutaneous T-cell lymphoma; they administered the drug at a dose of 80<span class="elsevierStyleHsp" style=""></span>mg 3 times a week (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Aprepitant has also been effective in the control of chronic itching in patients with atopic dermatitis or nodular pruritus,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> in patients with solid tumors,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and in those with erlotinib-induced pruritus.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Aprepitant has a good pharmacological safety profile. It is important to remember that this drug is able to inhibit CYP3A4, and it must not therefore be administered to patients on treatment with pimozide, terfenadine, astemizole, or cisapride. It can also induce elevations of the aminotransferases and must be used with caution in patients with altered liver function. The common side effects of aprepitant include hiccup, fatigue, constipation, headache, and anorexia.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In summary, we have presented the case of a patient in whom aprepitant was used successfully to treat refractory pruritus secondary to cutaneous T-cell lymphoma. This treatment produced a marked improvement in patient's quality of life.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Borja-Consigliere HA, López-Pestaña A, Vidal-Manceñido MJ, Tuneu-Valls A. Tratamiento con aprepitant del prurito refractario secundario a linfoma cutáneo de células T. Actas Dermosifiliogr. 2014;105:716–718.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 659 "Ancho" => 990 "Tamanyo" => 98420 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Plaques and tumors on the trunk.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 622 "Ancho" => 1000 "Tamanyo" => 203063 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Acanthotic epidermis with an intense pagetoid infiltrate of lymphocytes with an atypical morphology (hematoxylin and eosin, original magnification ×<span class="elsevierStyleHsp" style=""></span>20).</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviation: VAS, visual analogue scale.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Reference \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">No. of Cases \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Aprepitant Regimen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">VAS (0-10)Pretreatment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">VAS (0-10)After Treatment \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Duval et al.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7, 8, 9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2, 3, 2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Booken et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">125<span class="elsevierStyleHsp" style=""></span>mg, 80<span class="elsevierStyleHsp" style=""></span>mg, and 80<span class="elsevierStyleHsp" style=""></span>mg on 3 consecutive days every 2 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.3<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Torres et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8, 9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2, 3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ladizinski et al.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80<span class="elsevierStyleHsp" style=""></span>mg/d 3 times a week \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab549028.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Published Cases of the Use of Aprepitant to Treat Pruritus Secondary to Cutaneous Lymphoma.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality of life and psychological distress in patients with cutaneous lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Sampogna" 1 => "M. Frontani" 2 => "G. Baliva" 3 => "G.A. Lombardo" 4 => "G. Alvetreti" 5 => "C. Di Pietro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08992.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2009" "volumen" => "160" "paginaInicial" => "815" "paginaFinal" => "822" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19120325" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Targeting the neurokinin receptor 1 with aprepitant: A novel antipruritic strategy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Ständer" 1 => "D. Siepmann" 2 => "I. Herrgott" 3 => "C. Sunderkötter" 4 => "T.A. Luger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0010968" "Revista" => array:5 [ "tituloSerie" => "PLoS One" "fecha" => "2010" "volumen" => "5" "paginaInicial" => "e10968" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20532044" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology of itch and new treatments" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "U. Raap" 1 => "S. Ständer" 2 => "M. Metz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ACI.0b013e32834a41c2" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Allergy Clin Immunol" "fecha" => "2011" "volumen" => "11" "paginaInicial" => "420" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21772138" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.E. Carstens" 1 => "M.I. Carstens" 2 => "C.T. Simons" 3 => "S.L. Jinks" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/WNR.0b013e328337310a" "Revista" => array:6 [ "tituloSerie" => "Neuroreport" "fecha" => "2010" "volumen" => "21" "paginaInicial" => "303" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20125052" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aprepitant as an antipruritic agent" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Duval" 1 => "L. Dubertret" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMc0906670" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2009" "volumen" => "361" "paginaInicial" => "1415" "paginaFinal" => "1416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19797294" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oral aprepitant in the therapy of refractory pruritus in erythrodermic cutaneous T-cell lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. Booken" 1 => "M. Heck" 2 => "J.P. Nicolay" 3 => "C.D. Klemke" 4 => "S. Goerdt" 5 => "J. Utikal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2010.10108.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2011" "volumen" => "164" "paginaInicial" => "665" "paginaFinal" => "667" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21039410" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aprepitant: Evidence of its effectiveness in patients with refractory pruritus continues" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T. Torres" 1 => "I. Fernandes" 2 => "M. Selores" 3 => "R. Alves" 4 => "M. Lima" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2011.01.016" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2012" "volumen" => "66" "paginaInicial" => "e14" "paginaFinal" => "e15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22177649" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aprepitant: A novel neurokinin-1 receptor/substance P antagonist as antipruritic therapy in cutaneous T-cell lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Ladizinski" 1 => "A. Bazakas" 2 => "E.A. Olsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2012.02.008" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2012" "volumen" => "67" "paginaInicial" => "e198" "paginaFinal" => "e199" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23062910" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aprepitant against pruritus in patients with solid tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Vincenzi" 1 => "M.E. Fratto" 2 => "D. Santini" 3 => "G. Tonini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00520-010-0895-9" "Revista" => array:6 [ "tituloSerie" => "Support Care Cancer" "fecha" => "2010" "volumen" => "18" "paginaInicial" => "1229" "paginaFinal" => "1230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20544226" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aprepitant for erlotinib-induced pruritus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Vincenzi" 1 => "G. Tonini" 2 => "D. Santini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMc1003937" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2010" "volumen" => "363" "paginaInicial" => "397" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20660413" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010500000007/v1_201408281012/S1578219014001905/v1_201408281012/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010500000007/v1_201408281012/S1578219014001905/v1_201408281012/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014001905?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 2 | 0 | 2 |
| 2024 Octubre | 77 | 52 | 129 |
| 2024 Septiembre | 71 | 35 | 106 |
| 2024 Agosto | 99 | 63 | 162 |
| 2024 Julio | 90 | 45 | 135 |
| 2024 Junio | 114 | 41 | 155 |
| 2024 Mayo | 77 | 36 | 113 |
| 2024 Abril | 88 | 24 | 112 |
| 2024 Marzo | 74 | 27 | 101 |
| 2024 Febrero | 63 | 40 | 103 |
| 2024 Enero | 62 | 33 | 95 |
| 2023 Diciembre | 59 | 17 | 76 |
| 2023 Noviembre | 79 | 26 | 105 |
| 2023 Octubre | 65 | 23 | 88 |
| 2023 Septiembre | 65 | 33 | 98 |
| 2023 Agosto | 60 | 17 | 77 |
| 2023 Julio | 73 | 29 | 102 |
| 2023 Junio | 63 | 23 | 86 |
| 2023 Mayo | 64 | 31 | 95 |
| 2023 Abril | 43 | 23 | 66 |
| 2023 Marzo | 47 | 31 | 78 |
| 2023 Febrero | 49 | 19 | 68 |
| 2023 Enero | 43 | 23 | 66 |
| 2022 Diciembre | 45 | 31 | 76 |
| 2022 Noviembre | 31 | 19 | 50 |
| 2022 Octubre | 34 | 25 | 59 |
| 2022 Septiembre | 57 | 31 | 88 |
| 2022 Agosto | 48 | 28 | 76 |
| 2022 Julio | 37 | 36 | 73 |
| 2022 Junio | 28 | 28 | 56 |
| 2022 Mayo | 68 | 25 | 93 |
| 2022 Abril | 66 | 33 | 99 |
| 2022 Marzo | 62 | 53 | 115 |
| 2022 Febrero | 49 | 18 | 67 |
| 2022 Enero | 53 | 40 | 93 |
| 2021 Diciembre | 39 | 33 | 72 |
| 2021 Noviembre | 49 | 50 | 99 |
| 2021 Octubre | 39 | 40 | 79 |
| 2021 Septiembre | 25 | 36 | 61 |
| 2021 Agosto | 30 | 33 | 63 |
| 2021 Julio | 16 | 29 | 45 |
| 2021 Junio | 33 | 26 | 59 |
| 2021 Mayo | 27 | 39 | 66 |
| 2021 Abril | 92 | 41 | 133 |
| 2021 Marzo | 55 | 21 | 76 |
| 2021 Febrero | 68 | 22 | 90 |
| 2021 Enero | 34 | 9 | 43 |
| 2020 Diciembre | 27 | 12 | 39 |
| 2020 Noviembre | 18 | 6 | 24 |
| 2020 Octubre | 20 | 7 | 27 |
| 2020 Septiembre | 28 | 9 | 37 |
| 2020 Agosto | 21 | 13 | 34 |
| 2020 Julio | 24 | 14 | 38 |
| 2020 Junio | 28 | 15 | 43 |
| 2020 Mayo | 21 | 13 | 34 |
| 2020 Abril | 31 | 19 | 50 |
| 2020 Marzo | 28 | 13 | 41 |
| 2020 Febrero | 4 | 0 | 4 |
| 2020 Enero | 6 | 3 | 9 |
| 2019 Diciembre | 8 | 2 | 10 |
| 2019 Noviembre | 4 | 0 | 4 |
| 2019 Octubre | 2 | 2 | 4 |
| 2019 Septiembre | 6 | 0 | 6 |
| 2019 Agosto | 4 | 0 | 4 |
| 2019 Julio | 4 | 5 | 9 |
| 2019 Junio | 4 | 7 | 11 |
| 2019 Mayo | 6 | 16 | 22 |
| 2019 Abril | 1 | 2 | 3 |
| 2019 Marzo | 5 | 3 | 8 |
| 2019 Enero | 5 | 0 | 5 |
| 2018 Diciembre | 5 | 0 | 5 |
| 2018 Noviembre | 1 | 0 | 1 |
| 2018 Octubre | 11 | 0 | 11 |
| 2018 Septiembre | 4 | 0 | 4 |
| 2018 Mayo | 0 | 2 | 2 |
| 2018 Abril | 0 | 8 | 8 |
| 2018 Marzo | 2 | 1 | 3 |
| 2018 Febrero | 23 | 7 | 30 |
| 2018 Enero | 41 | 7 | 48 |
| 2017 Diciembre | 43 | 10 | 53 |
| 2017 Noviembre | 30 | 11 | 41 |
| 2017 Octubre | 38 | 6 | 44 |
| 2017 Septiembre | 43 | 14 | 57 |
| 2017 Agosto | 56 | 15 | 71 |
| 2017 Julio | 43 | 7 | 50 |
| 2017 Junio | 55 | 17 | 72 |
| 2017 Mayo | 59 | 9 | 68 |
| 2017 Abril | 52 | 6 | 58 |
| 2017 Marzo | 40 | 33 | 73 |
| 2017 Febrero | 33 | 9 | 42 |
| 2017 Enero | 22 | 12 | 34 |
| 2016 Diciembre | 42 | 16 | 58 |
| 2016 Noviembre | 59 | 24 | 83 |
| 2016 Octubre | 53 | 18 | 71 |
| 2016 Septiembre | 47 | 14 | 61 |
| 2016 Agosto | 0 | 1 | 1 |
| 2016 Julio | 5 | 1 | 6 |
| 2016 Junio | 8 | 7 | 15 |
| 2016 Mayo | 5 | 2 | 7 |
| 2016 Abril | 5 | 2 | 7 |
| 2016 Marzo | 1 | 3 | 4 |
| 2016 Febrero | 6 | 2 | 8 |
| 2016 Enero | 10 | 1 | 11 |
| 2015 Diciembre | 16 | 1 | 17 |
| 2015 Noviembre | 10 | 7 | 17 |
| 2015 Octubre | 8 | 8 | 16 |
| 2015 Septiembre | 8 | 0 | 8 |
| 2015 Agosto | 8 | 2 | 10 |
| 2015 Julio | 48 | 6 | 54 |
| 2015 Junio | 53 | 7 | 60 |
| 2015 Mayo | 48 | 13 | 61 |
| 2015 Abril | 38 | 2 | 40 |
| 2015 Marzo | 31 | 6 | 37 |
| 2015 Febrero | 46 | 5 | 51 |
| 2015 Enero | 22 | 14 | 36 |
| 2014 Diciembre | 32 | 6 | 38 |
| 2014 Noviembre | 21 | 11 | 32 |
| 2014 Octubre | 47 | 12 | 59 |
| 2014 Septiembre | 24 | 7 | 31 |
Mostrar todo
