array:24 [
  "pii" => "S1578219014000316"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2013.02.017"
  "estado" => "S300"
  "fechaPublicacion" => "2014-03-01"
  "aid" => "824"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2014;105:202-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2112
    "formatos" => array:3 [
      "EPUB" => 45
      "HTML" => 1429
      "PDF" => 638
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731013001075"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2013.02.010"
      "estado" => "S300"
      "fechaPublicacion" => "2014-03-01"
      "aid" => "824"
      "copyright" => "Elsevier España, S.L. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2014;105:202-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5291
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 2911
          "PDF" => 2377
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "202"
            "paginaFinal" => "203"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Sevoflurane&#58; A Valid Alternative for the Treatment of Vascular Ulcers&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "R&#46;F&#46; Lafuente-Urrez, Y&#46; Gilaberte"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "R&#46;F&#46;"
                "apellidos" => "Lafuente-Urrez"
              ]
              1 => array:2 [
                "nombre" => "Y&#46;"
                "apellidos" => "Gilaberte"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219014000316"
          "doi" => "10.1016/j.adengl.2013.02.017"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000316?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013001075?idApp=UINPBA000044"
      "url" => "/00017310/0000010500000002/v1_201403120205/S0001731013001075/v1_201403120205/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219014000274"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.02.015"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "808"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:204-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2965
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 2515
        "PDF" => 408
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Disseminated Sporotrichosis With Cutaneous and Testicular Involvement"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "204"
          "paginaFinal" => "206"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Esporotricosis diseminada con afecci&#243;n cut&#225;nea y testicular"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 857
              "Ancho" => 1500
              "Tamanyo" => 189235
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; PAS-stained smear showing cigar-shaped yeast cells &#40;original magnification &#215;100&#41;&#46; B&#44; Microscopic analysis of the culture showing sympodial conidia &#40;lactophenol blue&#44; original magnification &#215;40&#41;&#46; C&#44; Culture of <span class="elsevierStyleItalic">Sporothrix</span> species&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46;J&#46; Espinoza-Hern&#225;ndez, A&#46; Jes&#250;s-Silva, S&#46; Toussaint-Caire, R&#46; Arenas"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;J&#46;"
              "apellidos" => "Espinoza-Hern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Jes&#250;s-Silva"
            ]
            2 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Toussaint-Caire"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Arenas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731013000616"
        "doi" => "10.1016/j.ad.2013.02.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000616?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000274?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000274/v1_201403090058/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219014000328"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.03.013"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "849"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:200-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1705
      "formatos" => array:3 [
        "EPUB" => 47
        "HTML" => 1319
        "PDF" => 339
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Restoration of Response to Ustekinumab With Narrowband UV-B Phototherapy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "200"
          "paginaFinal" => "202"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Recuperaci&#243;n de la respuesta a ustekinumab mediante fototerapia con ultravioleta B de banda estrecha"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 727
              "Ancho" => 1001
              "Tamanyo" => 132845
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Patient 1&#46; Recurrence of psoriasis 30 weeks after initiation of ustekinumab &#40;PASI&#44; 9&#46;8&#41;&#46; B&#44; Patient 1&#46; PASI 75 after combining 17 sessions of narrowband UV-B therapy &#40;12&#46;9<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#41; with ustekinumab &#40;PASI&#44; 2&#46;1&#41;&#46; PASI indicates Psoriasis Area and Severity Index&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Soro Mart&#237;nez, I&#46; Belinch&#243;n Romero, M&#46;P&#46; Arribas Granados"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Soro Mart&#237;nez"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Belinch&#243;n Romero"
            ]
            2 => array:2 [
              "nombre" => "M&#46;P&#46;"
              "apellidos" => "Arribas Granados"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173101300207X"
        "doi" => "10.1016/j.ad.2013.03.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101300207X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000328?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000328/v1_201403090058/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Sevoflurane&#58; A Valid Alternative for the Treatment of Vascular Ulcers&#63;"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "202"
        "paginaFinal" => "203"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46;F&#46; Lafuente-Urrez, Y&#46; Gilaberte"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "R&#46;F&#46;"
            "apellidos" => "Lafuente-Urrez"
            "email" => array:2 [
              0 => "fati1997&#64;gmail&#46;com"
              1 => "rfz97&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Y&#46;"
            "apellidos" => "Gilaberte"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Reina Sof&#237;a&#44; Tudela&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Vascular ulcers are a major health problem because of their frequency&#44; chronic nature&#44; and high recurrence rate&#46; The standard treatment&#44; which consists of cleansing&#44; debridement&#44; and application of dressings&#44; achieves cure rates of 65&#37; to 85&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The approaches used to accelerate scarring of these ulcers include dressings &#40;biologic&#44; synthetic&#44; or biosynthetic&#41;&#44; human amniotic membrane transplantation&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and autologous platelet-rich plasma&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Options for analgesia to control the pain associated with vascular ulcers include topical anesthetics such as the creams Emla &#40;lidocaine and prilocaine&#41; and Lambdalina &#40;lidocaine&#41;&#44; oral analgesics&#44; and even opiates&#46; These products aid in the healing process and in pain control&#44; although they can produce undesirable effects&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Sevoflurane is an inhaled general anesthetic from the halogenated ether family that is indicated for induction and maintenance of general anesthesia during hospital or outpatient surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Its analgesic effect is both central<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and peripheral&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> although it has traditionally been thought that halogenated anesthetics lack a peripheral analgesic effect&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Topical sevoflurane has been reported to be effective in the treatment of long-standing venous ulcers<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and ischemic ulcers<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> that are refractory to standard treatment&#59; when irrigated topically over the painful ulcer bed&#44; it produces a rapid&#44; intense&#44; and lasting analgesic effect&#44; with a suitable safety profile that is well accepted by patients&#46; In addition&#44; it significantly reduces the size of the ulcer and the time necessary for epithelialization&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> Its effect can be so intense that it is even possible to perform surgical debridement without the need for further analgesia&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Similarly&#44; it has been suggested that direct application of sevoflurane has an antimicrobial effect on ulcers that are superinfected by multiresistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and a bactericidal effect has been reported in vitro against <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#44; <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#44; and <span class="elsevierStyleItalic">Escherichia coli</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Sevoflurane &#40;Sevorane&#41; is marketed as a colorless volatile liquid with no additives or preservatives in a 250-mL amber-colored polyethylene naphthalate bottle with a safety cap and a filling adapter&#46; Each milliliter of liquid contains 1<span class="elsevierStyleHsp" style=""></span>mL of sevoflurane &#40;INN&#41;&#46; It should be kept at room temperature and protected from sunlight&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Once the ulcer has been cleansed with saline solution&#44; sevoflurane is applied directly on the ulcer bed&#44; ensuring that the liquid is distributed throughout the tissue and taking care that it does not come into contact with the surrounding healthy skin&#46; It is necessary to wait 2<span class="elsevierStyleHsp" style=""></span>minutes before applying standard wound care<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> and placing the dressing&#46; A compression bandage should also be applied when necessary&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To date&#44; 12 patients have been treated with topical sevoflurane&#44; and 2 of these cases have been published&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The case of an immunodepressed patient with a postsurgical wound superinfected by multiresistant <span class="elsevierStyleItalic">P&#46; aeruginosa</span> who was cured after several applications of sevoflurane is pending publication&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> At the 17<span class="elsevierStyleSup">th</span> Annual Meeting of the European Society of Regional Anesthesia in Barcelona in October 2011&#44; a series of 9 patients was presented &#40;6 women and 3 men with diabetes&#41;&#46; The patients had painful venous ulcers on the lower limbs that were refractory to regular analgesics and were treated with sevoflurane on an outpatient basis to control the pain&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In all cases&#44; the reduction in pain at rest was rapid &#40;less than 2 minutes&#41;&#44; intense &#40;7&#46;4<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;5&#93; to 2&#46;1<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;6&#93; points with the first application and 7&#46;2<span class="elsevierStyleHsp" style=""></span>&#91;1&#46;3&#93; to 1&#46;1<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;6&#93; points with all of the remaining 67 applications&#41;&#44; and lasting &#40;from 7 to 16<span class="elsevierStyleHsp" style=""></span>hours&#41;&#46; The ulcers were cured in 4 cases&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The risk-benefit ratio of sevoflurane has proven very favorable to date&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> The only undesirable effects of topical application are pruritus at the borders of the wound and irritation of the surrounding skin with repeated applications&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Sevoflurane has not been reported to have sensitizing potential&#46; Similarly&#44; local irrigation with sevoflurane was well tolerated in patients with heart disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> Systemic absorption of sevoflurane applied to an ulcer involving circulatory compromise is thought to be slow and incomplete&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> although blood levels have not been measured in patients treated with this procedure&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The mechanism underlying the analgesic&#44; epithelializing&#44; and antimicrobial effects of sevoflurane remains unknown&#46; Inhaled sevoflurane has no peripheral analgesic effect<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#59; however&#44; topical or subcutaneous administration does produce a peripheral effect&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> When a halogenated agent is inhaled&#44; the partial pressure reached in the peripheral nociceptors may not be sufficient to block transmission of a painful stimulus&#59; however&#44; with direct application&#44; the nociceptors are exposed to sufficient partial pressure to block transmission of painful stimuli&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; topical sevoflurane could prove to be a promising strategy for analgesia and epithelialization in the treatment of vascular ulcers&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lafuente-Urrez RF&#44; Gilaberte Y&#46; Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;&#46; Actas Dermosifiliogr&#46; 2014&#59;105&#58;202&#8211;203&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aplicaci&#243;n de membrana amni&#243;tica en el tratamiento de las &#250;lceras cr&#243;nicas de extremidades inferiores"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Alsina-Gibert"
                            1 => "S&#46; Pedregosa-Fauste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2012.01.010"
                      "Revista" => array:7 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2012"
                        "volumen" => "103"
                        "paginaInicial" => "608"
                        "paginaFinal" => "613"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22578292"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tratamiento de &#250;lceras cut&#225;neas cr&#243;nicas con plasma aut&#243;logo rico en plaquetas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Bur&#243;n"
                            1 => "A&#46; Fern&#225;ndez-Tresguerres"
                            2 => "M&#46; Calvo"
                            3 => "F&#46; Alfageme"
                            4 => "C&#46; Villega"
                            5 => "R&#46; Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "429"
                        "paginaFinal" => "434"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673605675733"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Abbott&#44; FT-4456&#46; 2006&#46; Ficha t&#233;cnica del producto &#40;Sevorane&#174;&#41;&#46;"
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of propofol and sevoflurane on the excitability of rat spinal motoneurones and nociceptive reflexes in vitro"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Matute"
                            1 => "I&#46; Rivera-Arconada"
                            2 => "J&#46;A&#46; L&#243;pez-Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bja/aeh217"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2004"
                        "volumen" => "93"
                        "paginaInicial" => "422"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15277303"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673602119118"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analgesic effect of topical sevoflurane on venous ulcer intractable pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Ger&#243;nimo-Pardo"
                            1 => "A&#46; Mart&#237;nez-Monsalve"
                            2 => "M&#46; Mart&#237;nez-Serrano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Phlebologie"
                        "fecha" => "2011"
                        "volumen" => "40"
                        "paginaInicial" => "95"
                        "paginaFinal" => "97"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sevoflurano como anest&#233;sico local en herida isqu&#233;mica de paciente cardi&#243;pata con insuficiencia respiratoria secundaria a morfina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Martinez Monsalve"
                            1 => "M&#46; Ger&#243;nimo Pardo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Heridas y cicatrizaci&#243;n"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "46"
                        "paginaFinal" => "49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usos alternativos del sevoflurano&#46; Efecto analg&#233;sico t&#243;pico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Ger&#243;nimo Pardo"
                            1 => "M&#46; Martinez Serrano"
                            2 => "A&#46; Mart&#237;nez Molsalve"
                            3 => "J&#46;L&#46; Rueda Mart&#237;nez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev Electron Anestesia R"
                        "fecha" => "2012"
                        "volumen" => "4"
                        "paginaInicial" => "181"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potency &#40;minimum alveolar anesthetic concentration&#41; of isoflurane is independent of peripheral anesthetic effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;F&#46; Antognini"
                            1 => "N&#46;D&#46; Kien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Anesth Analg"
                        "fecha" => "1995"
                        "volumen" => "81"
                        "paginaInicial" => "69"
                        "paginaFinal" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7598285"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Actividad bactericida del sevoflurano frente a <span class="elsevierStyleItalic">Stafilococcus aureus&#44; Pseudomonas aeruginosa</span> y <span class="elsevierStyleItalic">Escherichia coli</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mart&#237;nez"
                            1 => "M&#46; Ger&#243;nimo"
                            2 => "M&#46;D&#46; Crespo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "120"
                        "paginaFinal" => "121"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous injection of inhaled anesthetics produces cutaneous analgesia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;C&#46; Chu"
                            1 => "S&#46;Z&#46; Wu"
                            2 => "W&#46;L&#46; Su"
                            3 => "J&#46;P&#46; Shieh"
                            4 => "C&#46;H&#46; Kao"
                            5 => "S&#46;T&#46; Ho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03017206"
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Anaesth"
                        "fecha" => "2008"
                        "volumen" => "55"
                        "paginaInicial" => "290"
                        "paginaFinal" => "294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18451117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000316/v1_201403090058/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010500000002/v1_201403090058/S1578219014000316/v1_201403090058/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000316?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letter
Sevoflurane: A Valid Alternative for the Treatment of Vascular Ulcers?
Sevoflurano, ¿una alternativa en el tratamiento de las úlceras vasculares?
R.F. Lafuente-Urreza,
Autor para correspondencia
, Y. Gilaberteb
a Servicio de Dermatología, Hospital Reina Sofía, Tudela, Spain
b Servicio de Dermatología, Hospital San Jorge, Huesca, Spain
Leído
7077
Veces
se ha leído el artículo
2444
Total PDF
4633
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S1578219014000316"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2013.02.017"
  "estado" => "S300"
  "fechaPublicacion" => "2014-03-01"
  "aid" => "824"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2012"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2014;105:202-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2112
    "formatos" => array:3 [
      "EPUB" => 45
      "HTML" => 1429
      "PDF" => 638
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731013001075"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2013.02.010"
      "estado" => "S300"
      "fechaPublicacion" => "2014-03-01"
      "aid" => "824"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2014;105:202-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5291
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 2911
          "PDF" => 2377
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "202"
            "paginaFinal" => "203"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Sevoflurane&#58; A Valid Alternative for the Treatment of Vascular Ulcers&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "R&#46;F&#46; Lafuente-Urrez, Y&#46; Gilaberte"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "R&#46;F&#46;"
                "apellidos" => "Lafuente-Urrez"
              ]
              1 => array:2 [
                "nombre" => "Y&#46;"
                "apellidos" => "Gilaberte"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219014000316"
          "doi" => "10.1016/j.adengl.2013.02.017"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000316?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013001075?idApp=UINPBA000044"
      "url" => "/00017310/0000010500000002/v1_201403120205/S0001731013001075/v1_201403120205/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219014000274"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.02.015"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "808"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:204-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2965
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 2515
        "PDF" => 408
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Disseminated Sporotrichosis With Cutaneous and Testicular Involvement"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "204"
          "paginaFinal" => "206"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Esporotricosis diseminada con afecci&#243;n cut&#225;nea y testicular"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 857
              "Ancho" => 1500
              "Tamanyo" => 189235
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; PAS-stained smear showing cigar-shaped yeast cells &#40;original magnification &#215;100&#41;&#46; B&#44; Microscopic analysis of the culture showing sympodial conidia &#40;lactophenol blue&#44; original magnification &#215;40&#41;&#46; C&#44; Culture of <span class="elsevierStyleItalic">Sporothrix</span> species&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46;J&#46; Espinoza-Hern&#225;ndez, A&#46; Jes&#250;s-Silva, S&#46; Toussaint-Caire, R&#46; Arenas"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;J&#46;"
              "apellidos" => "Espinoza-Hern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Jes&#250;s-Silva"
            ]
            2 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Toussaint-Caire"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Arenas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731013000616"
        "doi" => "10.1016/j.ad.2013.02.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000616?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000274?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000274/v1_201403090058/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219014000328"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2013.03.013"
    "estado" => "S300"
    "fechaPublicacion" => "2014-03-01"
    "aid" => "849"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2014;105:200-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1705
      "formatos" => array:3 [
        "EPUB" => 47
        "HTML" => 1319
        "PDF" => 339
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Restoration of Response to Ustekinumab With Narrowband UV-B Phototherapy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "200"
          "paginaFinal" => "202"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Recuperaci&#243;n de la respuesta a ustekinumab mediante fototerapia con ultravioleta B de banda estrecha"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 727
              "Ancho" => 1001
              "Tamanyo" => 132845
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Patient 1&#46; Recurrence of psoriasis 30 weeks after initiation of ustekinumab &#40;PASI&#44; 9&#46;8&#41;&#46; B&#44; Patient 1&#46; PASI 75 after combining 17 sessions of narrowband UV-B therapy &#40;12&#46;9<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#41; with ustekinumab &#40;PASI&#44; 2&#46;1&#41;&#46; PASI indicates Psoriasis Area and Severity Index&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Soro Mart&#237;nez, I&#46; Belinch&#243;n Romero, M&#46;P&#46; Arribas Granados"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Soro Mart&#237;nez"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Belinch&#243;n Romero"
            ]
            2 => array:2 [
              "nombre" => "M&#46;P&#46;"
              "apellidos" => "Arribas Granados"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S000173101300207X"
        "doi" => "10.1016/j.ad.2013.03.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101300207X?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000328?idApp=UINPBA000044"
    "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000328/v1_201403090058/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Sevoflurane&#58; A Valid Alternative for the Treatment of Vascular Ulcers&#63;"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "202"
        "paginaFinal" => "203"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46;F&#46; Lafuente-Urrez, Y&#46; Gilaberte"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "R&#46;F&#46;"
            "apellidos" => "Lafuente-Urrez"
            "email" => array:2 [
              0 => "fati1997&#64;gmail&#46;com"
              1 => "rfz97&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Y&#46;"
            "apellidos" => "Gilaberte"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Reina Sof&#237;a&#44; Tudela&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital San Jorge&#44; Huesca&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Vascular ulcers are a major health problem because of their frequency&#44; chronic nature&#44; and high recurrence rate&#46; The standard treatment&#44; which consists of cleansing&#44; debridement&#44; and application of dressings&#44; achieves cure rates of 65&#37; to 85&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The approaches used to accelerate scarring of these ulcers include dressings &#40;biologic&#44; synthetic&#44; or biosynthetic&#41;&#44; human amniotic membrane transplantation&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and autologous platelet-rich plasma&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Options for analgesia to control the pain associated with vascular ulcers include topical anesthetics such as the creams Emla &#40;lidocaine and prilocaine&#41; and Lambdalina &#40;lidocaine&#41;&#44; oral analgesics&#44; and even opiates&#46; These products aid in the healing process and in pain control&#44; although they can produce undesirable effects&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Sevoflurane is an inhaled general anesthetic from the halogenated ether family that is indicated for induction and maintenance of general anesthesia during hospital or outpatient surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Its analgesic effect is both central<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and peripheral&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> although it has traditionally been thought that halogenated anesthetics lack a peripheral analgesic effect&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Topical sevoflurane has been reported to be effective in the treatment of long-standing venous ulcers<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and ischemic ulcers<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> that are refractory to standard treatment&#59; when irrigated topically over the painful ulcer bed&#44; it produces a rapid&#44; intense&#44; and lasting analgesic effect&#44; with a suitable safety profile that is well accepted by patients&#46; In addition&#44; it significantly reduces the size of the ulcer and the time necessary for epithelialization&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> Its effect can be so intense that it is even possible to perform surgical debridement without the need for further analgesia&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Similarly&#44; it has been suggested that direct application of sevoflurane has an antimicrobial effect on ulcers that are superinfected by multiresistant <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and a bactericidal effect has been reported in vitro against <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#44; <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#44; and <span class="elsevierStyleItalic">Escherichia coli</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Sevoflurane &#40;Sevorane&#41; is marketed as a colorless volatile liquid with no additives or preservatives in a 250-mL amber-colored polyethylene naphthalate bottle with a safety cap and a filling adapter&#46; Each milliliter of liquid contains 1<span class="elsevierStyleHsp" style=""></span>mL of sevoflurane &#40;INN&#41;&#46; It should be kept at room temperature and protected from sunlight&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Once the ulcer has been cleansed with saline solution&#44; sevoflurane is applied directly on the ulcer bed&#44; ensuring that the liquid is distributed throughout the tissue and taking care that it does not come into contact with the surrounding healthy skin&#46; It is necessary to wait 2<span class="elsevierStyleHsp" style=""></span>minutes before applying standard wound care<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> and placing the dressing&#46; A compression bandage should also be applied when necessary&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To date&#44; 12 patients have been treated with topical sevoflurane&#44; and 2 of these cases have been published&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The case of an immunodepressed patient with a postsurgical wound superinfected by multiresistant <span class="elsevierStyleItalic">P&#46; aeruginosa</span> who was cured after several applications of sevoflurane is pending publication&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> At the 17<span class="elsevierStyleSup">th</span> Annual Meeting of the European Society of Regional Anesthesia in Barcelona in October 2011&#44; a series of 9 patients was presented &#40;6 women and 3 men with diabetes&#41;&#46; The patients had painful venous ulcers on the lower limbs that were refractory to regular analgesics and were treated with sevoflurane on an outpatient basis to control the pain&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In all cases&#44; the reduction in pain at rest was rapid &#40;less than 2 minutes&#41;&#44; intense &#40;7&#46;4<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;5&#93; to 2&#46;1<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;6&#93; points with the first application and 7&#46;2<span class="elsevierStyleHsp" style=""></span>&#91;1&#46;3&#93; to 1&#46;1<span class="elsevierStyleHsp" style=""></span>&#91;0&#46;6&#93; points with all of the remaining 67 applications&#41;&#44; and lasting &#40;from 7 to 16<span class="elsevierStyleHsp" style=""></span>hours&#41;&#46; The ulcers were cured in 4 cases&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The risk-benefit ratio of sevoflurane has proven very favorable to date&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> The only undesirable effects of topical application are pruritus at the borders of the wound and irritation of the surrounding skin with repeated applications&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Sevoflurane has not been reported to have sensitizing potential&#46; Similarly&#44; local irrigation with sevoflurane was well tolerated in patients with heart disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5-7</span></a> Systemic absorption of sevoflurane applied to an ulcer involving circulatory compromise is thought to be slow and incomplete&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> although blood levels have not been measured in patients treated with this procedure&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The mechanism underlying the analgesic&#44; epithelializing&#44; and antimicrobial effects of sevoflurane remains unknown&#46; Inhaled sevoflurane has no peripheral analgesic effect<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#59; however&#44; topical or subcutaneous administration does produce a peripheral effect&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> When a halogenated agent is inhaled&#44; the partial pressure reached in the peripheral nociceptors may not be sufficient to block transmission of a painful stimulus&#59; however&#44; with direct application&#44; the nociceptors are exposed to sufficient partial pressure to block transmission of painful stimuli&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; topical sevoflurane could prove to be a promising strategy for analgesia and epithelialization in the treatment of vascular ulcers&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lafuente-Urrez RF&#44; Gilaberte Y&#46; Sevoflurano&#44; &#191;una alternativa en el tratamiento de las &#250;lceras vasculares&#63;&#46; Actas Dermosifiliogr&#46; 2014&#59;105&#58;202&#8211;203&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aplicaci&#243;n de membrana amni&#243;tica en el tratamiento de las &#250;lceras cr&#243;nicas de extremidades inferiores"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Alsina-Gibert"
                            1 => "S&#46; Pedregosa-Fauste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2012.01.010"
                      "Revista" => array:7 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2012"
                        "volumen" => "103"
                        "paginaInicial" => "608"
                        "paginaFinal" => "613"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22578292"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tratamiento de &#250;lceras cut&#225;neas cr&#243;nicas con plasma aut&#243;logo rico en plaquetas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Bur&#243;n"
                            1 => "A&#46; Fern&#225;ndez-Tresguerres"
                            2 => "M&#46; Calvo"
                            3 => "F&#46; Alfageme"
                            4 => "C&#46; Villega"
                            5 => "R&#46; Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "429"
                        "paginaFinal" => "434"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673605675733"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Abbott&#44; FT-4456&#46; 2006&#46; Ficha t&#233;cnica del producto &#40;Sevorane&#174;&#41;&#46;"
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of propofol and sevoflurane on the excitability of rat spinal motoneurones and nociceptive reflexes in vitro"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Matute"
                            1 => "I&#46; Rivera-Arconada"
                            2 => "J&#46;A&#46; L&#243;pez-Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bja/aeh217"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2004"
                        "volumen" => "93"
                        "paginaInicial" => "422"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15277303"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673602119118"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analgesic effect of topical sevoflurane on venous ulcer intractable pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Ger&#243;nimo-Pardo"
                            1 => "A&#46; Mart&#237;nez-Monsalve"
                            2 => "M&#46; Mart&#237;nez-Serrano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Phlebologie"
                        "fecha" => "2011"
                        "volumen" => "40"
                        "paginaInicial" => "95"
                        "paginaFinal" => "97"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sevoflurano como anest&#233;sico local en herida isqu&#233;mica de paciente cardi&#243;pata con insuficiencia respiratoria secundaria a morfina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Martinez Monsalve"
                            1 => "M&#46; Ger&#243;nimo Pardo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Heridas y cicatrizaci&#243;n"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "46"
                        "paginaFinal" => "49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usos alternativos del sevoflurano&#46; Efecto analg&#233;sico t&#243;pico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Ger&#243;nimo Pardo"
                            1 => "M&#46; Martinez Serrano"
                            2 => "A&#46; Mart&#237;nez Molsalve"
                            3 => "J&#46;L&#46; Rueda Mart&#237;nez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Rev Electron Anestesia R"
                        "fecha" => "2012"
                        "volumen" => "4"
                        "paginaInicial" => "181"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potency &#40;minimum alveolar anesthetic concentration&#41; of isoflurane is independent of peripheral anesthetic effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;F&#46; Antognini"
                            1 => "N&#46;D&#46; Kien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Anesth Analg"
                        "fecha" => "1995"
                        "volumen" => "81"
                        "paginaInicial" => "69"
                        "paginaFinal" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7598285"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Actividad bactericida del sevoflurano frente a <span class="elsevierStyleItalic">Stafilococcus aureus&#44; Pseudomonas aeruginosa</span> y <span class="elsevierStyleItalic">Escherichia coli</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mart&#237;nez"
                            1 => "M&#46; Ger&#243;nimo"
                            2 => "M&#46;D&#46; Crespo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "120"
                        "paginaFinal" => "121"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612613439"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous injection of inhaled anesthetics produces cutaneous analgesia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;C&#46; Chu"
                            1 => "S&#46;Z&#46; Wu"
                            2 => "W&#46;L&#46; Su"
                            3 => "J&#46;P&#46; Shieh"
                            4 => "C&#46;H&#46; Kao"
                            5 => "S&#46;T&#46; Ho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03017206"
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Anaesth"
                        "fecha" => "2008"
                        "volumen" => "55"
                        "paginaInicial" => "290"
                        "paginaFinal" => "294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18451117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010500000002/v1_201403090058/S1578219014000316/v1_201403090058/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010500000002/v1_201403090058/S1578219014000316/v1_201403090058/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219014000316?idApp=UINPBA000044"
]
Información del artículo
ISSN: 15782190
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 7 9 16
2024 Octubre 72 49 121
2024 Septiembre 66 27 93
2024 Agosto 89 63 152
2024 Julio 84 31 115
2024 Junio 77 35 112
2024 Mayo 77 51 128
2024 Abril 77 24 101
2024 Marzo 68 20 88
2024 Febrero 64 27 91
2024 Enero 58 34 92
2023 Diciembre 60 14 74
2023 Noviembre 78 34 112
2023 Octubre 79 21 100
2023 Septiembre 84 27 111
2023 Agosto 53 18 71
2023 Julio 50 32 82
2023 Junio 52 23 75
2023 Mayo 54 27 81
2023 Abril 52 26 78
2023 Marzo 54 21 75
2023 Febrero 47 24 71
2023 Enero 52 32 84
2022 Diciembre 53 69 122
2022 Noviembre 28 32 60
2022 Octubre 38 29 67
2022 Septiembre 45 42 87
2022 Agosto 88 34 122
2022 Julio 35 45 80
2022 Junio 33 38 71
2022 Mayo 72 39 111
2022 Abril 63 36 99
2022 Marzo 53 46 99
2022 Febrero 40 35 75
2022 Enero 72 34 106
2021 Diciembre 37 39 76
2021 Noviembre 46 42 88
2021 Octubre 49 66 115
2021 Septiembre 41 44 85
2021 Agosto 38 40 78
2021 Julio 35 32 67
2021 Junio 39 36 75
2021 Mayo 33 34 67
2021 Abril 93 42 135
2021 Marzo 95 30 125
2021 Febrero 81 31 112
2021 Enero 56 27 83
2020 Diciembre 65 11 76
2020 Noviembre 35 20 55
2020 Octubre 49 16 65
2020 Septiembre 50 18 68
2020 Agosto 44 19 63
2020 Julio 38 18 56
2020 Junio 60 42 102
2020 Mayo 52 18 70
2020 Abril 40 17 57
2020 Marzo 50 16 66
2020 Febrero 10 0 10
2019 Diciembre 8 8 16
2019 Noviembre 4 7 11
2019 Octubre 0 7 7
2019 Septiembre 4 13 17
2019 Agosto 4 11 15
2019 Julio 8 11 19
2019 Junio 2 17 19
2019 Mayo 6 27 33
2019 Abril 2 17 19
2019 Marzo 0 10 10
2019 Febrero 4 9 13
2019 Enero 0 1 1
2018 Diciembre 1 3 4
2018 Noviembre 3 8 11
2018 Octubre 2 0 2
2018 Marzo 0 1 1
2018 Febrero 36 7 43
2018 Enero 35 6 41
2017 Diciembre 40 7 47
2017 Noviembre 26 10 36
2017 Octubre 38 10 48
2017 Septiembre 35 26 61
2017 Agosto 28 14 42
2017 Julio 21 12 33
2017 Junio 47 17 64
2017 Mayo 30 20 50
2017 Abril 26 28 54
2017 Marzo 27 28 55
2017 Febrero 20 13 33
2017 Enero 22 15 37
2016 Diciembre 31 16 47
2016 Noviembre 53 16 69
2016 Octubre 59 21 80
2016 Septiembre 49 18 67
2016 Agosto 50 10 60
2016 Julio 48 12 60
2016 Junio 16 8 24
2016 Mayo 8 11 19
2016 Abril 2 14 16
2016 Marzo 3 1 4
2016 Febrero 14 1 15
2016 Enero 11 3 14
2015 Diciembre 12 1 13
2015 Noviembre 7 4 11
2015 Octubre 11 12 23
2015 Septiembre 8 7 15
2015 Agosto 10 4 14
2015 Julio 30 7 37
2015 Junio 33 12 45
2015 Mayo 51 18 69
2015 Abril 28 7 35
2015 Marzo 33 4 37
2015 Febrero 28 4 32
2015 Enero 40 4 44
2014 Diciembre 30 6 36
2014 Noviembre 20 4 24
2014 Octubre 41 4 45
2014 Septiembre 31 2 33
2014 Agosto 20 6 26
2014 Julio 20 4 24
2014 Junio 26 6 32
2014 Mayo 37 12 49
2014 Abril 76 8 84
2014 Marzo 8 8 16
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?