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Respuesta al tratamiento combinado con crioterapia y terbinafina" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 650 "Ancho" => 976 "Tamanyo" => 81953 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Firm contiguous plaques with crusted areas on a erythematous base and a larger area with a scar-like appearance.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Bassas-Vila, M.J. Fuente, R. Guinovart, C. Ferrándiz" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Bassas-Vila" ] 1 => array:2 [ "nombre" => "M.J." "apellidos" => "Fuente" ] 2 => array:2 [ "nombre" => "R." 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Valladares-Narganes, A. Pérez-Bustillo, G. Pérez-Paredes, M.Á. Rodríguez-Prieto" "autores" => array:4 [ 0 => array:4 [ "nombre" => "L.M." "apellidos" => "Valladares-Narganes" "email" => array:1 [ 0 => "lmvalladares84@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Pérez-Bustillo" ] 2 => array:2 [ "nombre" => "G." "apellidos" => "Pérez-Paredes" ] 3 => array:2 [ "nombre" => "M.Á." "apellidos" => "Rodríguez-Prieto" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Complejo Asistencial Universitario de León, León, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Colgajo glabelar combinado con colgajo de transposición para la reconstrucción de 2 defectos nasales discontinuos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1125 "Ancho" => 1394 "Tamanyo" => 176688 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinomas on the dorsum and root of the nose. The circles indicate the size of the surgical defects after excision with adequate margins.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Description</span><p id="par0005" class="elsevierStylePara elsevierViewall">The reconstruction of multiple surgical defects of the nasal pyramid is not a common situation and can be a challenge for the dermatologic surgeon, as the reconstructive techniques are limited. The problem is further compounded when the surgical defects are anatomically independent and cannot be united into a single defect.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In such reconstructions, it is essential to take into account the color, texture, and morphology of the different anatomical subunits of the nose, as well as the tension lines in each region, making the situation yet more complex.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The skin of the glabellar region is frequently used to close defects of the external nose because of its excellent blood supply, its ample reserve of tissue, and its satisfactory mobility. Over the years, the classic glabellar flap, first described by Gillies and subsequently modified by Reiger, has become a flap of choice for defects on the lateral surfaces of the root of the nose and in the area of the medial canthus.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Variants of this flap can be used to repair defects of the dorsum, tip, or lateral walls of the nose and of the ala nasi. A large range of movement of the skin of the glabella and of the dorsum of the nose is possible without distorting the anatomy of the lateral wall of the nose on the same side, although a Burow triangle must be created on the opposite side.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Transposition flaps, which have numerous morphological variants, are moved into the surgical defect by rotation and/or advancement.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> On the external nose, these flaps have the advantage of an excellent blood supply derived from nasal branches of the angular artery, a branch of the facial artery, which supplies the lateral walls of the nose. There is therefore a low risk of necrosis.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The great advantage of these flaps is their versatility, as their design can be varied in each patient according to surgical considerations, such as the site, size, and depth of the defect and cosmetic factors.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Both flaps are therefore highly versatile, easy to design and perform, and provide excellent functional and cosmetic results; we have capitalized on these advantages to combine the 2 flaps in the following case.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Technique</span><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was a 63-year-old man with a history of hypertension and dyslipidemia on medical treatment. He was seen in our outpatient clinic because of 2 progressively enlarging tumors that had arisen some months earlier on the dorsum of the nose and close to the root of the nose (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>); the tumors were clinically compatible with basal cell carcinomas and did not infiltrate deeply. The lesion on the root of the nose was approximately 0.5<span class="elsevierStyleHsp" style=""></span>cm in diameter and the one on the dorsum measured 1.2<span class="elsevierStyleHsp" style=""></span>cm. Both lesions were excised with adequate margins, with dissection to the depth of the supraperichondrial plane.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">To reconstruct the 2 defects in a single operation, we designed a superior glabellar flap combined with an inferior transposition flap with a vascular pedicle from the lateral wall of the nose. The defects were triangulated on the side opposite to the surgical incisions.</p><p id="par0045" class="elsevierStylePara elsevierViewall">In order to avoid tension in the suture, it is important to free the deep plane of the flap completely to the lateral border of the pedicle, using the same plane as the surgical defect. The secondary glabellar defect is easily closed using a V-Y technique.</p><p id="par0050" class="elsevierStylePara elsevierViewall">It should be emphasized that this combined flap, if well designed, is very unlikely to develop necrosis, as it has a very high base to height ratio, providing a pedicle that is more than sufficient.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The postoperative result was excellent from a functional point of view, the scar was almost imperceptible, and, at the 12-month follow-up, the patient presented no signs of tumor recurrence (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Indications</span><p id="par0060" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall">This combined flap is indicated for the reconstruction of multiple, medium-sized, noncontiguous surgical defects on the dorsum and/or root of the nose, in which the separation of the defects permits the 2 flaps to be mobilized without risk of necrosis.</p></li></ul></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Contraindications</span><p id="par0070" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0075" class="elsevierStylePara elsevierViewall">Small surgical defects that can be closed by primary suture or with smaller individual flaps.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall">Very large defects that require more complex combined flaps or closure in 2 operations.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0085" class="elsevierStylePara elsevierViewall">Defects that, due to their proximity, can be made into a single surgical defect, which can be repaired using a more suitable flap.</p></li></ul></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Benefits</span><p id="par0090" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0095" class="elsevierStylePara elsevierViewall">This method provides a simple and rapid technique for the reconstruction of multiple defects on the dorsum of the nose in a single operation, with a low risk of necrosis.</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0100" class="elsevierStylePara elsevierViewall">The anatomical features of the different subunits of the external nose are respected.</p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Risks</span><p id="par0105" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">-</span><p id="par0110" class="elsevierStylePara elsevierViewall">Postoperative infection.</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">-</span><p id="par0115" class="elsevierStylePara elsevierViewall">Postsurgical hematomas in the periorbital and interciliary regions.</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">-</span><p id="par0120" class="elsevierStylePara elsevierViewall">Tenting.</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">-</span><p id="par0125" class="elsevierStylePara elsevierViewall">Unsightly scar.</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">-</span><p id="par0130" class="elsevierStylePara elsevierViewall">Introduction of hair from the interciliary region onto the root of the nose.</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">-</span><p id="par0135" class="elsevierStylePara elsevierViewall">Risk of distal necrosis—this is low but could be increased by poor flap design.</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">-</span><p id="par0140" class="elsevierStylePara elsevierViewall">Approximation of the eyebrows.</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Alternatives</span><p id="par0145" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">-</span><p id="par0150" class="elsevierStylePara elsevierViewall">Closure of the 2 surgical defects using individual flaps.</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">-</span><p id="par0155" class="elsevierStylePara elsevierViewall">Full-thickness skin grafts or Burow graft.</p></li><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">-</span><p id="par0160" class="elsevierStylePara elsevierViewall">Advancement flaps from the perialar region, triangular advancement flaps, A-T advancement flaps, or transposition flaps.</p></li></ul></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0165" class="elsevierStylePara elsevierViewall">The glabellar flap and its variants have been described extensively in the literature for the repair of defects of the nose or canthus. The flap is very simple to design, has a good blood supply, and provides excellent functional and cosmetic results.</p><p id="par0170" class="elsevierStylePara elsevierViewall">In the literature we have been unable to find any description of the use of the glabellar flap in combination with other types of transposition flap for the reconstruction of multiple, independent surgical defects of the nasal pyramid.</p><p id="par0175" class="elsevierStylePara elsevierViewall">We have presented a variant of the glabellar flap combined with a transposition flap with a lateral pedicle. This modification enabled us to close 2 surgical defects in a single operation using a simple technique that is within the scope of all dermatologists with experience in reconstructive surgery.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflicts of Interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Description" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Technique" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Indications" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Contraindications" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Benefits" ] 5 => array:2 [ "identificador" => "sec0030" "titulo" => "Risks" ] 6 => array:2 [ "identificador" => "sec0035" "titulo" => "Alternatives" ] 7 => array:2 [ "identificador" => "sec0040" "titulo" => "Conclusions" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflicts of Interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Valladares-Narganes L, Pérez-Bustillo A, Pérez-Paredes G, Rodríguez-Prieto M. Colgajo glabelar combinado con colgajo de transposición para la reconstrucción de 2 defectos nasales discontinuos. Actas Dermosifiliogr. 2014;105:193–195.</p>" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0185" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0050" ] ] ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1125 "Ancho" => 1394 "Tamanyo" => 176688 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinomas on the dorsum and root of the nose. The circles indicate the size of the surgical defects after excision with adequate margins.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1030 "Ancho" => 1500 "Tamanyo" => 194167 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Postoperative result 12 months after the operation.</p>" ] ] 2 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.doc" "ficheroTamanyo" => 78336 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glabellar flaps in nasal reconstruction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.A. Koch" 1 => "D.J. Archibald" 2 => "O. Friedman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.fsc.2010.10.003" "Revista" => array:7 [ "tituloSerie" => "Facial Plast Surg Clin North Am" "fecha" => "2011" "volumen" => "19" "paginaInicial" => "113" "paginaFinal" => "122" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21112514" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1474442208701698" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The nasal glabellar flap" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.M. Fliss" 1 => "J.L. 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Yébenes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2007" "volumen" => "98" "paginaInicial" => "302" "paginaFinal" => "311" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17555672" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cirugía topográfica del dorso nasal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.A. Rodríguez-Prieto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Cirugía dermatológica de la pirámide nasal" "paginaInicial" => "122" "paginaFinal" => "124" "edicion" => "2<span class="elsevierStyleSup">nd</span> ed." "serieFecha" => "2012" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new glabellar flap modification for the reconstruction of medial canthal and nasal dorsal defects: “Flap in flap” technique" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Turgut" 1 => "A. Ozcan" 2 => "N. Yesiloglu" 3 => "L. 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2020 Noviembre | 50 | 22 | 72 |
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2020 Septiembre | 38 | 10 | 48 |
2020 Agosto | 27 | 16 | 43 |
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2020 Mayo | 21 | 12 | 33 |
2020 Abril | 31 | 12 | 43 |
2020 Marzo | 31 | 14 | 45 |
2020 Febrero | 6 | 3 | 9 |
2020 Enero | 2 | 1 | 3 |
2019 Diciembre | 8 | 6 | 14 |
2019 Noviembre | 8 | 0 | 8 |
2019 Octubre | 3 | 0 | 3 |
2019 Septiembre | 8 | 1 | 9 |
2019 Agosto | 8 | 0 | 8 |
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2019 Mayo | 10 | 20 | 30 |
2019 Abril | 4 | 7 | 11 |
2019 Marzo | 4 | 5 | 9 |
2019 Febrero | 6 | 3 | 9 |
2019 Enero | 5 | 0 | 5 |
2018 Diciembre | 5 | 1 | 6 |
2018 Noviembre | 1 | 2 | 3 |
2018 Octubre | 8 | 1 | 9 |
2018 Septiembre | 7 | 0 | 7 |
2018 Agosto | 0 | 1 | 1 |
2018 Junio | 0 | 4 | 4 |
2018 Mayo | 0 | 3 | 3 |
2018 Abril | 0 | 8 | 8 |
2018 Marzo | 0 | 2 | 2 |
2018 Febrero | 52 | 6 | 58 |
2018 Enero | 77 | 5 | 82 |
2017 Diciembre | 66 | 13 | 79 |
2017 Noviembre | 53 | 6 | 59 |
2017 Octubre | 61 | 16 | 77 |
2017 Septiembre | 65 | 12 | 77 |
2017 Agosto | 94 | 15 | 109 |
2017 Julio | 73 | 19 | 92 |
2017 Junio | 73 | 20 | 93 |
2017 Mayo | 58 | 12 | 70 |
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2017 Marzo | 30 | 8 | 38 |
2017 Febrero | 44 | 19 | 63 |
2017 Enero | 49 | 16 | 65 |
2016 Diciembre | 118 | 18 | 136 |
2016 Noviembre | 78 | 14 | 92 |
2016 Octubre | 105 | 11 | 116 |
2016 Septiembre | 130 | 13 | 143 |
2016 Agosto | 111 | 13 | 124 |
2016 Julio | 75 | 8 | 83 |
2016 Junio | 16 | 7 | 23 |
2016 Mayo | 8 | 9 | 17 |
2016 Abril | 3 | 1 | 4 |
2016 Marzo | 5 | 1 | 6 |
2016 Febrero | 14 | 17 | 31 |
2016 Enero | 12 | 17 | 29 |
2015 Diciembre | 17 | 1 | 18 |
2015 Noviembre | 13 | 1 | 14 |
2015 Octubre | 17 | 1 | 18 |
2015 Septiembre | 10 | 1 | 11 |
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2015 Julio | 74 | 15 | 89 |
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2015 Mayo | 52 | 7 | 59 |
2015 Abril | 45 | 3 | 48 |
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2015 Febrero | 26 | 2 | 28 |
2015 Enero | 21 | 2 | 23 |
2014 Diciembre | 28 | 8 | 36 |
2014 Noviembre | 21 | 2 | 23 |
2014 Octubre | 38 | 4 | 42 |
2014 Septiembre | 23 | 1 | 24 |
2014 Agosto | 16 | 5 | 21 |
2014 Julio | 26 | 5 | 31 |
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2014 Mayo | 30 | 12 | 42 |
2014 Abril | 25 | 5 | 30 |
2014 Marzo | 19 | 4 | 23 |