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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The red line shows the patient&#39;s CD4 count during follow-up&#46; The <span class="elsevierStyleItalic">y</span> axis shows the CD4 count as cell s&#47;&#956;L&#44; and the <span class="elsevierStyleItalic">x</span> axis&#44; the month and year each sample was taken&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Bowenoid papulosis of the genitalia in immunocompromised patients is associated with a high risk of recurrence and transformation to infiltrating squamous cell carcinoma on the one hand&#44; and poor response to treatment on the other&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe the case of a 50-year-old female smoker diagnosed with human immunodeficiency virus &#40;HIV&#41; infection in 1989 and invasive cervical cancer in 2000&#46; She also had chronic hepatitis C infection complicated by cirrhosis&#46; She had had histopathologically confirmed bowenoid papulosis since 2004&#46; Treatments had included electrocoagulation&#44; cryotherapy&#44; podophyllin resin&#44; as well as imiquimod&#44; but with poor response and tolerance&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">When the patient first visited our hospital in March 2005&#44; she had a brownish plaque with well-defined borders and a verrucous surface covering almost the entire area of the external genitalia and the perianal area &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; A new biopsy confirmed the diagnosis of bowenoid papulosis&#46; In December 2005&#44; we decided to administer continuous-wave carbon dioxide &#40;CO<span class="elsevierStyleInf">2</span>&#41; laser therapy at a power of 7&#46;5&#160;W to treat the affected area and the acetowhite lesions identified&#59; a lateral safety margin of 4 to 5&#160;mm was also treated due to the possible presence of subclinical human papillomavirus &#40;HPV&#41; infection&#46; The procedure was performed with the patient under epidural anesthesia&#46; The treated areas were subsequently cleaned and dressed with an antibiotic ointment&#44; and prophylactic valacyclovir was prescribed at a dose of 500&#160;mg every 8<span class="elsevierStyleHsp" style=""></span>hours until complete reepithelization&#46; Total clinical resolution of the lesions was observed at 1 month&#46; The patient underwent follow-up examinations every 3 to 6 months&#44; in addition to 4 treatment sessions with the same anesthesia&#44; fluence&#44; and postoperative care in October 2006&#44; December 2007&#44; April 2009&#44; and June 2009&#46; Complete clinical resolution was achieved each time &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> B-G&#41;&#46; The patient&#39;s CD4 count during follow-up is shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46; The control biopsies showed typical features of bowenoid papulosis&#44; with no signs of infiltrating squamous cell carcinoma&#46; During follow-up&#44; the patient was diagnosed with hepatocellular carcinoma in 2008 and with a high-grade anal neoplasm in 2009&#46; The respective treatments were chemoembolization and surgery followed by consolidation radiation therapy&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In all&#44; over a period of 6 years we performed 5 sessions of CO<span class="elsevierStyleInf">2</span> laser therapy&#44; the last of which was in April 2009&#59; no adverse effects were observed in any of the sessions&#46; The patient remained free of lesions in the vulvar area from September 2009 until December 2010&#44; when she died following progression of her hepatocellular carcinoma&#46; The only treatment required during this period was cryotherapy of isolated lesions in the area&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">CO<span class="elsevierStyleInf">2</span> laser therapy causes minimal postoperative pain<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and produces better cosmetic results than other methods&#44; especially when used on the external genitals&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> It has been used since 1988 to treat large bowenoid papulosis lesions that are difficult to treat with other methods&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The primary complications described to date are vesicovaginal fistulas<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and vulvodynia&#44; especially of the posterior commissure or the vulval vestibule&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> CO<span class="elsevierStyleInf">2</span> laser therapy for bowenoid papulosis lesions achieves complete response&#44; and the rate of recurrence is between 12&#46;5&#37; and 21&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The cure rate appears to be lower &#40;just 34&#46;5&#37;&#41; in HIV-positive patients&#44; in whom HPV infection persists&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Differences in cure rates are less substantial in condylomas treated with CO<span class="elsevierStyleInf">2</span> laser&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In our case&#44; due to the slight fluctuations in CD4 count during follow-up&#44; it is reasonable to rule out an improvement in symptoms due to immune recovery&#46; A number of approaches have been used to treat bowenoid papulosis in immunocompromised patients&#44; such as electrocoagulation&#44; cryotherapy&#44; 5-fluorouracil&#44; intralesional interferon gamma&#44; imiquimod&#44; podophyllin resin&#44; CO<span class="elsevierStyleInf">2</span> laser&#44; and Nd&#58;YAG laser&#46; However&#44; the effectiveness of these treatments is difficult to assess due to the scarcity of cases in the literature&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">As evidenced in the present case&#44; immunocompromised patients are more susceptible to HPV-related neoplasms&#46; We have presented this case because we achieved a good clinical response and high patient satisfaction with the cosmetic outcome after only 5 treatment cycles and with no adverse effects&#46; In light of these results&#44; CO<span class="elsevierStyleInf">2</span> laser therapy may be considered an appropriate treatment for immunocompromised patients with extensive and recurrent lesions&#46;</p></span>"
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Case and Research Letter
Extensive Bowenoid Papulosis of the Vulva Treated by Carbon Dioxide Laser in a Patient With AIDS
Tratamiento con láser de dióxido de carbono de una papulosis bowenoide vulvar extensa en paciente con sida
M. Llamas-Velasco
Autor para correspondencia
mar.llamasvelasco@gmail.com

Corresponding author.
, E. Vargas, Y. Delgado, A. García-Diez
Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, Spain
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    "titulo" => "Extensive Bowenoid Papulosis of the Vulva Treated by Carbon Dioxide Laser in a Patient With AIDS"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Bowenoid papulosis of the genitalia in immunocompromised patients is associated with a high risk of recurrence and transformation to infiltrating squamous cell carcinoma on the one hand&#44; and poor response to treatment on the other&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe the case of a 50-year-old female smoker diagnosed with human immunodeficiency virus &#40;HIV&#41; infection in 1989 and invasive cervical cancer in 2000&#46; She also had chronic hepatitis C infection complicated by cirrhosis&#46; She had had histopathologically confirmed bowenoid papulosis since 2004&#46; Treatments had included electrocoagulation&#44; cryotherapy&#44; podophyllin resin&#44; as well as imiquimod&#44; but with poor response and tolerance&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">When the patient first visited our hospital in March 2005&#44; she had a brownish plaque with well-defined borders and a verrucous surface covering almost the entire area of the external genitalia and the perianal area &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; A new biopsy confirmed the diagnosis of bowenoid papulosis&#46; In December 2005&#44; we decided to administer continuous-wave carbon dioxide &#40;CO<span class="elsevierStyleInf">2</span>&#41; laser therapy at a power of 7&#46;5&#160;W to treat the affected area and the acetowhite lesions identified&#59; a lateral safety margin of 4 to 5&#160;mm was also treated due to the possible presence of subclinical human papillomavirus &#40;HPV&#41; infection&#46; The procedure was performed with the patient under epidural anesthesia&#46; The treated areas were subsequently cleaned and dressed with an antibiotic ointment&#44; and prophylactic valacyclovir was prescribed at a dose of 500&#160;mg every 8<span class="elsevierStyleHsp" style=""></span>hours until complete reepithelization&#46; Total clinical resolution of the lesions was observed at 1 month&#46; The patient underwent follow-up examinations every 3 to 6 months&#44; in addition to 4 treatment sessions with the same anesthesia&#44; fluence&#44; and postoperative care in October 2006&#44; December 2007&#44; April 2009&#44; and June 2009&#46; Complete clinical resolution was achieved each time &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> B-G&#41;&#46; The patient&#39;s CD4 count during follow-up is shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46; The control biopsies showed typical features of bowenoid papulosis&#44; with no signs of infiltrating squamous cell carcinoma&#46; During follow-up&#44; the patient was diagnosed with hepatocellular carcinoma in 2008 and with a high-grade anal neoplasm in 2009&#46; The respective treatments were chemoembolization and surgery followed by consolidation radiation therapy&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In all&#44; over a period of 6 years we performed 5 sessions of CO<span class="elsevierStyleInf">2</span> laser therapy&#44; the last of which was in April 2009&#59; no adverse effects were observed in any of the sessions&#46; The patient remained free of lesions in the vulvar area from September 2009 until December 2010&#44; when she died following progression of her hepatocellular carcinoma&#46; The only treatment required during this period was cryotherapy of isolated lesions in the area&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">CO<span class="elsevierStyleInf">2</span> laser therapy causes minimal postoperative pain<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and produces better cosmetic results than other methods&#44; especially when used on the external genitals&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> It has been used since 1988 to treat large bowenoid papulosis lesions that are difficult to treat with other methods&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The primary complications described to date are vesicovaginal fistulas<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and vulvodynia&#44; especially of the posterior commissure or the vulval vestibule&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> CO<span class="elsevierStyleInf">2</span> laser therapy for bowenoid papulosis lesions achieves complete response&#44; and the rate of recurrence is between 12&#46;5&#37; and 21&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The cure rate appears to be lower &#40;just 34&#46;5&#37;&#41; in HIV-positive patients&#44; in whom HPV infection persists&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Differences in cure rates are less substantial in condylomas treated with CO<span class="elsevierStyleInf">2</span> laser&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In our case&#44; due to the slight fluctuations in CD4 count during follow-up&#44; it is reasonable to rule out an improvement in symptoms due to immune recovery&#46; A number of approaches have been used to treat bowenoid papulosis in immunocompromised patients&#44; such as electrocoagulation&#44; cryotherapy&#44; 5-fluorouracil&#44; intralesional interferon gamma&#44; imiquimod&#44; podophyllin resin&#44; CO<span class="elsevierStyleInf">2</span> laser&#44; and Nd&#58;YAG laser&#46; However&#44; the effectiveness of these treatments is difficult to assess due to the scarcity of cases in the literature&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">As evidenced in the present case&#44; immunocompromised patients are more susceptible to HPV-related neoplasms&#46; We have presented this case because we achieved a good clinical response and high patient satisfaction with the cosmetic outcome after only 5 treatment cycles and with no adverse effects&#46; In light of these results&#44; CO<span class="elsevierStyleInf">2</span> laser therapy may be considered an appropriate treatment for immunocompromised patients with extensive and recurrent lesions&#46;</p></span>"
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