Case and Research Letter
Successful Treatment of Leiomyoma of the Nipple With Carbon Dioxide Laser
Buenos resultados tras tratamiento con láser CO2 de leiomioma en el pezón
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Epidermis hiperqueratósica bajo la que se observa una tumoración dérmica no encapsulada formada por haces entremezclados de células fusiformes y eosinófilas (H-E ×<span class="elsevierStyleHsp" style=""></span>5). B. Positividad a la tinción de actina de músculo liso (×<span class="elsevierStyleHsp" style=""></span>5).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "V. López, I. López, J. Alcacer, J.M. Ricart" "autores" => array:4 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "López" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "López" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Alcacer" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Ricart" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219013002461" "doi" => "10.1016/j.adengl.2013.05.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002461?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013002068?idApp=UINPBA000044" "url" => "/00017310/0000010400000010/v1_201311281152/S0001731013002068/v1_201311281152/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219013002473" "issn" => "15782190" "doi" => "10.1016/j.adengl.2012.10.019" "estado" => "S300" "fechaPublicacion" => "2013-12-01" "aid" => "756" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2013;104:930-1" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2052 "formatos" => array:3 [ "EPUB" => 47 "HTML" => 1388 "PDF" => 617 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Acute Generalized Exanthematous Pustulosis Induced by Galantamine" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "930" "paginaFinal" => "931" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pustulosis exantemática aguda generalizada inducida por galantamina" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 750 "Ancho" => 1000 "Tamanyo" => 227994 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Subcorneal pustule and perivascular infiltrate of lymphocytes and eosinophils. Hematoxylin-eosin, original magnification ×40.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.P. Pérez-García, J.M. Sánchez Motillas, A. Mateu-Puchades, T. Díaz-Corpas" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M.P." "apellidos" => "Pérez-García" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Sánchez Motillas" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Mateu-Puchades" ] 3 => array:2 [ "nombre" => "T." "apellidos" => "Díaz-Corpas" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731012004863" "doi" => "10.1016/j.ad.2012.10.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004863?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013002473?idApp=UINPBA000044" "url" => "/15782190/0000010400000010/v1_201311281142/S1578219013002473/v1_201311281142/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S157821901300245X" "issn" => "15782190" "doi" => "10.1016/j.adengl.2012.12.011" "estado" => "S300" "fechaPublicacion" => "2013-12-01" "aid" => "794" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2013;104:926-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2766 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 2386 "PDF" => 336 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Usefulness of Immunohistochemial Staining With Antitrepenomal Antibodies in the Diagnosis of Syphilis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "926" "paginaFinal" => "928" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Utilidad de la inmunohistoquímica con anticuerpos antitreponema en el diagnóstico de la sífilis" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 950 "Ancho" => 951 "Tamanyo" => 233516 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Biopsy of the lesion shown in Figure 1. Upper image: intense inflammatory infiltrate with a predominance of plasma cells (hematoxylin-eosin, original magnification × 50). Lower panel: IHC of the same biopsy (original magnification × 400) showing infiltration of treponemata, which appear as brownish bead-like structures.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Hernández, R. Fúnez, B. Repiso, M. Frieyro" "autores" => array:4 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Hernández" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Fúnez" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Repiso" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Frieyro" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731013000161" "doi" => "10.1016/j.ad.2012.12.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000161?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901300245X?idApp=UINPBA000044" "url" => "/15782190/0000010400000010/v1_201311281142/S157821901300245X/v1_201311281142/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Successful Treatment of Leiomyoma of the Nipple With Carbon Dioxide Laser" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "928" "paginaFinal" => "930" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "V. López, I. López, J. Alcacer, J.M. Ricart" "autores" => array:4 [ 0 => array:4 [ "nombre" => "V." "apellidos" => "López" "email" => array:2 [ 0 => "veronica_17@live.com" 1 => "veronical_c@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Alcacer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "J.M." "apellidos" => "Ricart" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Dermiláser, Hospital Quirón, Valencia, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Quirón, Valencia, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Buenos resultados tras tratamiento con láser CO<span class="elsevierStyleInf">2</span> de leiomioma en el pezón" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 982 "Ancho" => 1488 "Tamanyo" => 614107 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Hyperkeratotic epidermis under which there is an unencapsulated dermal tumor composed of interwoven bundles of eosinophilic spindle cells (hematoxylin-eosin, original magnification ×100; inset, further magnification ×5). B, Positive staining for smooth muscle actin (hematoxylin-eosin, original magnification ×100; inset, further magnification ×5).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Genital leiomyomas are the least common type of leiomyomas and those located on the nipple or areola are extremely rare.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4</span></a> To date, their treatment with carbon dioxide (CO<span class="elsevierStyleInf">2</span>) laser has not been reported in the literature.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe the case of a 33-year-old woman with no relevant past medical history who presented with a skin lesion on the left nipple; the lesion had been stable since its appearance in adolescence. The patient reported mild tenderness and great impact on personal appearance as the reasons for seeking treatment. The examination revealed elongation of the left nipple secondary to the presence of a well-defined, firm nodular lesion that was the same color as the nipple and about 15<span class="elsevierStyleHsp" style=""></span>mm in diameter; there were no signs of nipple retraction (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The rest of the left breast and the right breast revealed no significant findings.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Histopathology of the lesion revealed a hyperkeratotic epidermis with increased pigmentation of the basal layer and, in the dermis, the presence of a poorly defined, unencapsulated tumor composed of multiple interwoven bundles of smooth muscle formed by cells with ovoid nuclei and eosinophilic cytoplasm (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). No atypical cells or mitoses were observed. Staining for smooth muscle actin was positive (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B). In view of these clinical and histologic findings, the lesions was diagnosed as a genital leiomyoma. Under local anesthesia with mepivacaine 2%, the rest of the lesion was removed with a Sharplan CO<span class="elsevierStyleInf">2</span> laser in unfocused mode with an irradiance of 55<span class="elsevierStyleHsp" style=""></span>W/cm<span class="elsevierStyleSup">2</span> and a spot size of 3<span class="elsevierStyleHsp" style=""></span>mm. The lesion was treated in a single session with 5 to 8 passes; between each pass the coagulated tissue was removed until there was no visible sign of the leiomyoma. After 1 treatment session much of the lesion had been removed with good cosmetic and functional results. No recurrence was detected 20 months after treatment (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Cutaneous leiomyomas are rare, benign tumors. They are classified into 3 categories according to the muscle fibers from which they originate: piloleiomyoma, originating from the smooth muscle fibers of the arrector pili muscle; angioleiomyoma, originating from the tunica media of the blood vessels; and dartoic or genital leiomyoma, originating from the smooth muscles of the scrotum, vulva, nipple, or areola. Genital leiomyomas are the least common type and those located on the nipple or areola are extremely rare.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4</span></a> Leiomyomas of the nipple and areola, first described in 1854 by Virchow, present as small, solitary nodular lesions covered with healthy skin that can exceptionally cause nipple retraction and spread to the underlying breast tissue.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The lesions are usually asymptomatic but in rare cases can cause pain spontaneously or in response to stimuli such as cold, pressure, or emotional stress.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Histologically, they are poorly defined, unencapsulated skin tumors composed of bundles of spindle cells with abundant eosinophilic cytoplasm and elongated nuclei with blunt ends, arranged in an interwoven pattern. The epidermis is usually unaffected because it is separated from the tumors by a free zone of dermis; cellular mitosis and atypia are rare.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Leiomyomas are positive for vimentin, desmin, and smooth muscle actin.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Differential diagnosis with the following diseases should be considered: Paget disease, fibroma, adenoma of the nipple, lymphadenosis benigna cutis, leiomyosarcoma of the areola, erosive adenomatosis of the nipple, and myoid hamartoma.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Several treatment modalities are used. In cases involving pain it can be useful to use calcium channel blockers or α–blockers, which inhibit contraction of muscle fibers. Isolated cases have been treated with cryotherapy, nitroglycerin, hyoscine hydrobromide, lidocaine, and analgesics.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In addition to medical treatment, surgical excision is also an option. However, surgery is sometimes contraindicated because of patient factors or because the lesions, as in our patient, are located in areas that require a good cosmetic result. CO<span class="elsevierStyleInf">2</span> laser removal has been used to treat cutaneous leiomyoma with good results,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> but to date no cases of genital leiomyoma treated with this modality have been reported. CO<span class="elsevierStyleInf">2</span> laser emits light in the infrared spectrum at a wavelength of 10 600<span class="elsevierStyleHsp" style=""></span>nm, which is absorbed by water. The laser vaporizes the skin and causes coagulative necrosis in the remaining dermis. CO<span class="elsevierStyleInf">2</span> laser treatment is advantageous mainly because the procedure is rapid and enables precise selection of tissue. The technique is safe, as tissue damage is specific, with highly localized destruction, minimal damage to surrounding tissue, and minimal bleeding because it promotes coagulation. An alternative to the CO<span class="elsevierStyleInf">2</span> laser is the erbium-doped yttrium aluminum garnet (Er:YAG) laser, which emits light in the infrared spectrum at a wavelength of 2900<span class="elsevierStyleHsp" style=""></span>nm and can vaporize the skin at a lower penetration depth than the CO<span class="elsevierStyleInf">2</span> laser. The Er:YAG laser produces little thermal damage to the underlying tissue because of its high water absorption coefficient. However, this effective absorption limits the transmission of heat to the deep layers, where it may be insufficient to promote coagulation and prevent bleeding during surgery.</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion, we have presented a case of a rare disease in which CO<span class="elsevierStyleInf">2</span> laser treatment provided very satisfactory cosmetic results. We believe that this technique can be considered a good option in cases in which surgery is not possible or is contraindicated.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: López V, López I, Alcacer J, Ricart JM. Buenos resultados tras tratamiento con láser CO<span class="elsevierStyleInf">2</span> de leiomioma en el pezón. Actas Dermosifiliogr. 2013;104:928–930.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 707 "Ancho" => 1001 "Tamanyo" => 87636 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Skin lesion located on the patient's left nipple.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 982 "Ancho" => 1488 "Tamanyo" => 614107 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Hyperkeratotic epidermis under which there is an unencapsulated dermal tumor composed of interwoven bundles of eosinophilic spindle cells (hematoxylin-eosin, original magnification ×100; inset, further magnification ×5). B, Positive staining for smooth muscle actin (hematoxylin-eosin, original magnification ×100; inset, further magnification ×5).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 375 "Ancho" => 1001 "Tamanyo" => 53715 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Excellent result 12 months after treatment with CO<span class="elsevierStyleInf">2</span> laser.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple cutaneous leiomyomas of the nipple" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Gokdemir" 1 => "D. Sakiz" 2 => "A. Koslu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2006.01451.x" "Revista" => array:6 [ "tituloSerie" => "J. Eur. Acad. Dermatol. Venereol." "fecha" => "2006" "volumen" => "20" "paginaInicial" => "468" "paginaFinal" => "469" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16643155" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nódulo solitario en la areola mamaria de un varón" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Fernández-Jorge" 1 => "T. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 16 | 8 | 24 |
| 2024 Octubre | 123 | 56 | 179 |
| 2024 Septiembre | 148 | 24 | 172 |
| 2024 Agosto | 164 | 58 | 222 |
| 2024 Julio | 118 | 42 | 160 |
| 2024 Junio | 124 | 35 | 159 |
| 2024 Mayo | 105 | 28 | 133 |
| 2024 Abril | 96 | 26 | 122 |
| 2024 Marzo | 90 | 27 | 117 |
| 2024 Febrero | 101 | 39 | 140 |
| 2024 Enero | 83 | 34 | 117 |
| 2023 Diciembre | 82 | 12 | 94 |
| 2023 Noviembre | 98 | 28 | 126 |
| 2023 Octubre | 84 | 15 | 99 |
| 2023 Septiembre | 83 | 32 | 115 |
| 2023 Agosto | 55 | 23 | 78 |
| 2023 Julio | 75 | 38 | 113 |
| 2023 Junio | 67 | 33 | 100 |
| 2023 Mayo | 69 | 31 | 100 |
| 2023 Abril | 72 | 25 | 97 |
| 2023 Marzo | 75 | 29 | 104 |
| 2023 Febrero | 82 | 27 | 109 |
| 2023 Enero | 72 | 32 | 104 |
| 2022 Diciembre | 87 | 49 | 136 |
| 2022 Noviembre | 57 | 29 | 86 |
| 2022 Octubre | 56 | 22 | 78 |
| 2022 Septiembre | 57 | 42 | 99 |
| 2022 Agosto | 69 | 52 | 121 |
| 2022 Julio | 60 | 37 | 97 |
| 2022 Junio | 77 | 22 | 99 |
| 2022 Mayo | 163 | 45 | 208 |
| 2022 Abril | 124 | 41 | 165 |
| 2022 Marzo | 122 | 51 | 173 |
| 2022 Febrero | 75 | 22 | 97 |
| 2022 Enero | 114 | 40 | 154 |
| 2021 Diciembre | 97 | 33 | 130 |
| 2021 Noviembre | 108 | 57 | 165 |
| 2021 Octubre | 92 | 60 | 152 |
| 2021 Septiembre | 78 | 45 | 123 |
| 2021 Agosto | 83 | 28 | 111 |
| 2021 Julio | 77 | 39 | 116 |
| 2021 Junio | 78 | 20 | 98 |
| 2021 Mayo | 92 | 33 | 125 |
| 2021 Abril | 161 | 53 | 214 |
| 2021 Marzo | 141 | 22 | 163 |
| 2021 Febrero | 72 | 17 | 89 |
| 2021 Enero | 51 | 22 | 73 |
| 2020 Diciembre | 82 | 15 | 97 |
| 2020 Noviembre | 32 | 11 | 43 |
| 2020 Octubre | 38 | 5 | 43 |
| 2020 Septiembre | 54 | 5 | 59 |
| 2020 Agosto | 27 | 21 | 48 |
| 2020 Julio | 28 | 14 | 42 |
| 2020 Junio | 28 | 25 | 53 |
| 2020 Mayo | 27 | 19 | 46 |
| 2020 Abril | 29 | 14 | 43 |
| 2020 Marzo | 37 | 16 | 53 |
| 2020 Febrero | 4 | 6 | 10 |
| 2019 Diciembre | 4 | 1 | 5 |
| 2019 Octubre | 0 | 1 | 1 |
| 2019 Septiembre | 6 | 2 | 8 |
| 2019 Agosto | 0 | 4 | 4 |
| 2019 Julio | 0 | 2 | 2 |
| 2019 Junio | 0 | 6 | 6 |
| 2019 Mayo | 3 | 8 | 11 |
| 2019 Abril | 0 | 8 | 8 |
| 2019 Marzo | 0 | 5 | 5 |
| 2019 Febrero | 2 | 1 | 3 |
| 2018 Diciembre | 0 | 6 | 6 |
| 2018 Noviembre | 2 | 0 | 2 |
| 2018 Octubre | 4 | 0 | 4 |
| 2018 Septiembre | 2 | 0 | 2 |
| 2018 Junio | 0 | 2 | 2 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 2 | 1 | 3 |
| 2018 Febrero | 28 | 3 | 31 |
| 2018 Enero | 23 | 5 | 28 |
| 2017 Diciembre | 47 | 8 | 55 |
| 2017 Noviembre | 20 | 5 | 25 |
| 2017 Octubre | 26 | 1 | 27 |
| 2017 Septiembre | 33 | 15 | 48 |
| 2017 Agosto | 38 | 9 | 47 |
| 2017 Julio | 25 | 9 | 34 |
| 2017 Junio | 52 | 22 | 74 |
| 2017 Mayo | 28 | 12 | 40 |
| 2017 Abril | 28 | 12 | 40 |
| 2017 Marzo | 27 | 48 | 75 |
| 2017 Febrero | 20 | 6 | 26 |
| 2017 Enero | 32 | 7 | 39 |
| 2016 Diciembre | 49 | 7 | 56 |
| 2016 Noviembre | 64 | 18 | 82 |
| 2016 Octubre | 77 | 20 | 97 |
| 2016 Septiembre | 94 | 2 | 96 |
| 2016 Agosto | 53 | 5 | 58 |
| 2016 Julio | 33 | 5 | 38 |
| 2016 Junio | 7 | 4 | 11 |
| 2016 Mayo | 6 | 3 | 9 |
| 2016 Abril | 4 | 11 | 15 |
| 2016 Marzo | 15 | 8 | 23 |
| 2016 Febrero | 11 | 10 | 21 |
| 2016 Enero | 6 | 1 | 7 |
| 2015 Diciembre | 13 | 5 | 18 |
| 2015 Noviembre | 12 | 1 | 13 |
| 2015 Octubre | 7 | 5 | 12 |
| 2015 Septiembre | 10 | 1 | 11 |
| 2015 Agosto | 8 | 1 | 9 |
| 2015 Julio | 195 | 3 | 198 |
| 2015 Junio | 159 | 3 | 162 |
| 2015 Mayo | 188 | 5 | 193 |
| 2015 Abril | 143 | 13 | 156 |
| 2015 Marzo | 197 | 3 | 200 |
| 2015 Febrero | 167 | 1 | 168 |
| 2015 Enero | 140 | 4 | 144 |
| 2014 Diciembre | 120 | 4 | 124 |
| 2014 Noviembre | 102 | 3 | 105 |
| 2014 Octubre | 132 | 6 | 138 |
| 2014 Septiembre | 105 | 1 | 106 |
| 2014 Agosto | 116 | 9 | 125 |
| 2014 Julio | 165 | 4 | 169 |
| 2014 Junio | 122 | 4 | 126 |
| 2014 Mayo | 102 | 12 | 114 |
| 2014 Abril | 100 | 7 | 107 |
| 2014 Marzo | 106 | 4 | 110 |
| 2014 Febrero | 66 | 7 | 73 |
| 2014 Enero | 55 | 5 | 60 |
| 2013 Diciembre | 39 | 5 | 44 |
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