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obstetricians&#44; and pediatricians&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">This letter describes the case of a 3-month-old infant who presented several skin dimples as a result of amniocentesis-related puncture&#46; A search of the literature found no other cases of this entity in which a histopathologic study had been performed&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">A male infant aged 3 months with no relevant medical history presented for assessment of a number of skin lesions on the abdomen and left thigh which were first noticed during the first month of life&#46; The infant had no congenital abnormalities and had been born following a full-term pregnancy by unassisted vaginal delivery in cephalic presentation&#46; One of the techniques performed on the mother during gestation and delivery was an amniocentesis in the 18th week which required several punctures&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A physical examination revealed 2 dimples measuring 2&#160;mm in diameter on the left side of the abdomen and a linear depression 1&#46;2&#160;cm long on the anterior aspect of the proximal third of the left thigh &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; The patient did not present any other skin lesions&#44; involvement of the oral or genital mucosae&#44; or abnormalities of the hair or nails&#46; The infant&#39;s weight and height were normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">A diagnosis of skin dimpling as a complication of amniocentesis was established&#46; The parents were informed of the benign nature of the skin condition&#44; although they decided to request a biopsy of the thigh lesion so as to rule out other pathologies&#46; The histopathologic study revealed a dermis with collagen bundles having an abnormal morphology and distribution &#40;fine bundles arranged in multiple directions&#41;&#46; A reduction and fragmentation of elastic fibers was observed using orcein staining&#46; No abnormalities were seen in the epidermis or the subcutaneous tissue &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The skin lesions remained unchanged over the subsequent 8 months&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Amniocentesis is the most frequently used technique for prenatal diagnosis of genetic alterations&#46; It is usually performed during the second trimester of pregnancy&#46; One of the possible complications of the procedure is fetal puncture&#44; the most frequent manifestation of which is skin dimpling&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Amniocentesis may also cause injury to underlying structures&#44; such as peripheral nerves&#44; tendons&#44; or the eyeball&#44; and result in ileocutaneous or arteriovenous fistulas&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Skin dimpling as a complication of amniocentesis presents as punctate depressions or linear scars measuring 1 to 5&#160;mm in diameter&#46; These manifestations may be isolated or multiple&#59; when multiple&#44; they are sometimes grouped and sometimes follow a linear path due to fetal puncture along a single plane&#46; Clearer observation may be achieved by pinching the surrounding skin&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Skin dimples caused by amniocentesis are present at birth&#44; although some are not clearly visible until weeks or months later&#59; they do not resolve spontaneously&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The most common site is the thigh&#44; followed by the abdomen&#44; buttocks&#44; and upper limbs&#46; These dimples tend to be found by chance during examination and are not usually the reason for consultation&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> It has been speculated that dimpling results from localized lipoatrophy or a loss of subcutaneous tissue&#46; The histopathologic findings in this case&#44; namely&#44; fine collagen bundles and a reduction in elastic fibers&#44; are consistent with localized depressed scarring secondary to skin retraction caused by a puncture wound&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The advent of ultrasound guidance during amniocentesis reduced the incidence of skin dimpling from nearly 9&#37; to under 1&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; the unpredictability of fetal movement&#8212;especially of the limbs&#8212;makes some instances of puncture inevitable&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;8</span></a> Several factors increase the risk of this complication&#44; such as performing the technique in the third trimester&#44; when the fetus is of a larger size in proportion to the amniotic cavity&#59; repeated puncture attempts&#59; and lack of obstetrician experience&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The diagnosis&#44; although never absolutely certain&#44; is established by ruling out other associated findings&#44; the location of the dimples&#44; and a history of amniocentesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;7</span></a> These indicators allow clinicians to rule out other iatrogenic and traumatic injuries resulting from fetal monitoring&#44; amniotomy&#44; episiotomy&#44; venous and arterial puncture&#44; assisted delivery &#40;i&#46;e&#46;&#44; vacuum-assisted&#44; forceps&#44; or spatula-assisted&#41;&#44; or cesarean section &#40;long but very superficial scalpel related lacerations&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;6</span></a> Additionally&#44; diagnosis must take into consideration other congenital causes of skin dimpling&#46; These congenital causes can be either dermal sinuses with cutaneous openings or deep cutaneous depressions&#46; Congenital skin dimples are almost always variations of normality and are situated over bony prominences&#44; especially those of the face&#46; They may be familial forms or related to infection&#44; metabolic disorders&#44; or the use of certain drugs during pregnancy&#59; occasionally they are signs of an underlying abnormality&#44; a polymalformative syndrome&#44; or a neurological or bone and muscle disorder&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Other processes that should be taken into consideration include cutaneous aplasia&#44; focal dermal hypoplasia&#44; amniotic band syndrome&#44; and supernumerary nipples&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In summary&#44; dermatologists should be aware of the presence of skin dimpling as a complication of amniocentesis both to avoid incorrect diagnostic presumption and to limit the number of additional and potentially aggressive tests performed&#46;</p></span>"
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Case and Research Letter
Skin Dimpling as a Complication of Amniocentesis: Histopathologic Findings
Hoyuelos cutáneos como consecuencia de amniocentesis: hallazgos histopatológicos
B. Monteagudoa,
Autor para correspondencia
, J. del Pozob, B. Suárez-Trabac, F. Sacristánd
a Servicio de Dermatología, Hospital Arquitecto Marcide, Área Sanitaria de Ferrol, SERGAS, Ferrol, A Coruña, Spain
b Servicio de Dermatología, Complejo Hospitalario Universitario A Coruña, SERGAS, A Coruña, Spain
c Pediatría, Centro de Salud de Mugardos, Área Sanitaria de Ferrol, SERGAS, Mugardos, A Coruña, Spain
d Servicio de Anatomía Patológica, Complejo Hospitalario Universitario A Coruña, SERGAS, A Coruña, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">During pregnancy&#44; delivery&#44; and postpartum&#44; a series of diagnostic and therapeutic procedures are currently performed which have led to reduced neonatal morbidity and mortality but which have also increased the risk of certain iatrogenic cutaneous and traumatic injuries&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The incidence of fetal puncture due to amniocentesis has declined since the introduction of ultrasound guidance<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a>&#59; however&#44; increasing maternal age has led to more frequent use of amniocentesis&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> thus making awareness of fetal puncture a matter of importance for dermatologists&#44; obstetricians&#44; and pediatricians&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">This letter describes the case of a 3-month-old infant who presented several skin dimples as a result of amniocentesis-related puncture&#46; A search of the literature found no other cases of this entity in which a histopathologic study had been performed&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">A male infant aged 3 months with no relevant medical history presented for assessment of a number of skin lesions on the abdomen and left thigh which were first noticed during the first month of life&#46; The infant had no congenital abnormalities and had been born following a full-term pregnancy by unassisted vaginal delivery in cephalic presentation&#46; One of the techniques performed on the mother during gestation and delivery was an amniocentesis in the 18th week which required several punctures&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A physical examination revealed 2 dimples measuring 2&#160;mm in diameter on the left side of the abdomen and a linear depression 1&#46;2&#160;cm long on the anterior aspect of the proximal third of the left thigh &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; The patient did not present any other skin lesions&#44; involvement of the oral or genital mucosae&#44; or abnormalities of the hair or nails&#46; The infant&#39;s weight and height were normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">A diagnosis of skin dimpling as a complication of amniocentesis was established&#46; The parents were informed of the benign nature of the skin condition&#44; although they decided to request a biopsy of the thigh lesion so as to rule out other pathologies&#46; The histopathologic study revealed a dermis with collagen bundles having an abnormal morphology and distribution &#40;fine bundles arranged in multiple directions&#41;&#46; A reduction and fragmentation of elastic fibers was observed using orcein staining&#46; No abnormalities were seen in the epidermis or the subcutaneous tissue &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The skin lesions remained unchanged over the subsequent 8 months&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Amniocentesis is the most frequently used technique for prenatal diagnosis of genetic alterations&#46; It is usually performed during the second trimester of pregnancy&#46; One of the possible complications of the procedure is fetal puncture&#44; the most frequent manifestation of which is skin dimpling&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Amniocentesis may also cause injury to underlying structures&#44; such as peripheral nerves&#44; tendons&#44; or the eyeball&#44; and result in ileocutaneous or arteriovenous fistulas&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Skin dimpling as a complication of amniocentesis presents as punctate depressions or linear scars measuring 1 to 5&#160;mm in diameter&#46; These manifestations may be isolated or multiple&#59; when multiple&#44; they are sometimes grouped and sometimes follow a linear path due to fetal puncture along a single plane&#46; Clearer observation may be achieved by pinching the surrounding skin&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Skin dimples caused by amniocentesis are present at birth&#44; although some are not clearly visible until weeks or months later&#59; they do not resolve spontaneously&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The most common site is the thigh&#44; followed by the abdomen&#44; buttocks&#44; and upper limbs&#46; These dimples tend to be found by chance during examination and are not usually the reason for consultation&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> It has been speculated that dimpling results from localized lipoatrophy or a loss of subcutaneous tissue&#46; The histopathologic findings in this case&#44; namely&#44; fine collagen bundles and a reduction in elastic fibers&#44; are consistent with localized depressed scarring secondary to skin retraction caused by a puncture wound&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The advent of ultrasound guidance during amniocentesis reduced the incidence of skin dimpling from nearly 9&#37; to under 1&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; the unpredictability of fetal movement&#8212;especially of the limbs&#8212;makes some instances of puncture inevitable&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;8</span></a> Several factors increase the risk of this complication&#44; such as performing the technique in the third trimester&#44; when the fetus is of a larger size in proportion to the amniotic cavity&#59; repeated puncture attempts&#59; and lack of obstetrician experience&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The diagnosis&#44; although never absolutely certain&#44; is established by ruling out other associated findings&#44; the location of the dimples&#44; and a history of amniocentesis&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;7</span></a> These indicators allow clinicians to rule out other iatrogenic and traumatic injuries resulting from fetal monitoring&#44; amniotomy&#44; episiotomy&#44; venous and arterial puncture&#44; assisted delivery &#40;i&#46;e&#46;&#44; vacuum-assisted&#44; forceps&#44; or spatula-assisted&#41;&#44; or cesarean section &#40;long but very superficial scalpel related lacerations&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;6</span></a> Additionally&#44; diagnosis must take into consideration other congenital causes of skin dimpling&#46; These congenital causes can be either dermal sinuses with cutaneous openings or deep cutaneous depressions&#46; Congenital skin dimples are almost always variations of normality and are situated over bony prominences&#44; especially those of the face&#46; They may be familial forms or related to infection&#44; metabolic disorders&#44; or the use of certain drugs during pregnancy&#59; occasionally they are signs of an underlying abnormality&#44; a polymalformative syndrome&#44; or a neurological or bone and muscle disorder&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Other processes that should be taken into consideration include cutaneous aplasia&#44; focal dermal hypoplasia&#44; amniotic band syndrome&#44; and supernumerary nipples&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In summary&#44; dermatologists should be aware of the presence of skin dimpling as a complication of amniocentesis both to avoid incorrect diagnostic presumption and to limit the number of additional and potentially aggressive tests performed&#46;</p></span>"
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