Letter to the Editor
Response to: “Orofacial Granulomatosis in Spain”
Réplica a: «Granulomatosis orofacial en España»
M.L. Martínez Martínez
, J.M. Azaña Defez
Autor para correspondencia
Servicio de Dermatología, Complejo Hospitalario Universitario de Albacete, Albacete, España
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Marcoval Caus" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Marcoval Caus" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731013000057" "doi" => "10.1016/j.ad.2012.12.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013000057?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000759?idApp=UINPBA000044" "url" => "/15782190/0000010400000004/v1_201304291101/S1578219013000759/v1_201304291101/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Response to: “Orofacial Granulomatosis in Spain”" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "361" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.L. Martínez Martínez, J.M. Azaña Defez" "autores" => array:2 [ 0 => array:4 [ "nombre" => "M.L." "apellidos" => "Martínez Martínez" "email" => array:1 [ 0 => "mlmartinezm@sescam.jccm.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Azaña Defez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Complejo Hospitalario Universitario de Albacete, Albacete, España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Réplica a: «Granulomatosis orofacial en España»" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We are grateful for Dr Marcoval's comments concerning our recently published article in <span class="elsevierStyleItalic">Actas Dermosifiliográficas<span class="elsevierStyleSmallCaps">:</span></span> “Granulomatous Cheilitis: A Report of 6 Cases and a Review of the Literature.”<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">As in the series published by Marcoval et al.,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and with the limitations noted (the small number of patients in our series and the retrospective nature of the study), none of our patients had Crohn disease. In our opinion, rather than raising doubts about our medical practice, such a finding can probably be explained, as Marcoval suggests, by the epidemiologic variation of this disease across the different populations that have been studied.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In both Europe and the United States, the incidence and prevalence of this disease is higher in the north, and this north-south variation is present even within the same country.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> A 1996 study found that the incidence of Crohn disease was 80% higher in northern Europe than in Mediterranean countries.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Moreover, the risk of developing inflammatory bowel disease in the United States is lowest in the population of Hispanic origin.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> We agree with Marcoval on the question of colonoscopies in patients with granulomatous cheilitis and reiterate that this procedure is not justified in patients who have no signs or symptoms suggestive of inflammatory bowel disease.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Despite the limitations that our two simultaneously published studies<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> may present, it is interesting to observe that we reached very similar conclusions. However, a larger sample size would serve to confirm the conclusions, and a multicenter study would be needed to achieve such a sample.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Martínez Martínez ML, Azaña Defez JM. Réplica a: «Granulomatosis orofacial en España». Actas Dermosifiliogr. 2014;104:361.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Queilitis granulomatosa. Presentación de 6 casos y revisión de la literatura" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.L. Martínez Martínez" 1 => "J.M. Azaña-Defez" 2 => "L.J. Pérez-García" 3 => "M.T. López-Villaescusa" 4 => "M. Rodríguez Vázquez" 5 => "C. Faura Berruga" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2012.02.005" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2012" "volumen" => "103" "paginaInicial" => "718" "paginaFinal" => "724" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22657098" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Orofacial granulomatosis: clinical study of 20 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Marcoval" 1 => "M. Viñas" 2 => "X. Bordas" 3 => "A. Jucglà" 4 => "O. Servitje" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.oooo.2011.10.015" "Revista" => array:6 [ "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol" "fecha" => "2012" "volumen" => "113" "paginaInicial" => "e12" "paginaFinal" => "e17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22668635" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology and clinical course of Crohn's disease; results from observacional studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "O. Hovde" 1 => "B.A. Moum" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3748/wjg.v18.i15.1723" "Revista" => array:6 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2012" "volumen" => "18" "paginaInicial" => "1723" "paginaFinal" => "1731" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22553396" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Geographical variations of inflammatory bowel disease in France: a study based on national health insurance data" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Nerich" 1 => "E. Monnet" 2 => "A. Etienne" 3 => "S. Louafi" 4 => "C. Ramée" 5 => "S. 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